KEGG   PATHWAY: cui00260
Entry
cui00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cronobacter universalis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cui00260  Glycine, serine and threonine metabolism
cui00260

Module
cui_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cui00260]
cui_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cui00260]
cui_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cui00260]
cui_M00555  Betaine biosynthesis, choline => betaine [PATH:cui00260]
cui_M00621  Glycine cleavage system [PATH:cui00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cronobacter universalis [GN:cui]
Gene
AFK65_17710  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AFK65_03225  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
AFK65_00690  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
AFK65_18460  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AFK65_03230  serine kinase [KO:K00872] [EC:2.7.1.39]
AFK65_03235  threonine synthase [KO:K01733] [EC:4.2.3.1]
AFK65_06840  threonine aldolase [KO:K01620] [EC:4.1.2.48]
AFK65_14760  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AFK65_07430  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AFK65_18980  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AFK65_05300  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AFK65_06235  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
AFK65_03185  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
AFK65_19290  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
AFK65_16015  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AFK65_06980  phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
AFK65_03095  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
AFK65_10370  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AFK65_19330  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
AFK65_19325  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AFK65_15970  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AFK65_15980  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AFK65_03720  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AFK65_15975  glycine cleavage system protein H [KO:K02437]
AFK65_14930  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
AFK65_08795  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AFK65_08800  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AFK65_05405  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
AFK65_05410  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
AFK65_15590  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AFK65_11755  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AFK65_00865  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AFK65_15790  racemase [KO:K25316] [EC:5.1.1.10]
AFK65_11125  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AFK65_11120  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cui00010  Glycolysis / Gluconeogenesis
cui00020  Citrate cycle (TCA cycle)
cui00230  Purine metabolism
cui00250  Alanine, aspartate and glutamate metabolism
cui00270  Cysteine and methionine metabolism
cui00290  Valine, leucine and isoleucine biosynthesis
cui00300  Lysine biosynthesis
cui00330  Arginine and proline metabolism
cui00460  Cyanoamino acid metabolism
cui00470  D-Amino acid metabolism
cui00564  Glycerophospholipid metabolism
cui00600  Sphingolipid metabolism
cui00620  Pyruvate metabolism
cui00630  Glyoxylate and dicarboxylate metabolism
cui00640  Propanoate metabolism
cui00680  Methane metabolism
cui00860  Porphyrin metabolism
cui00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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