KEGG   DISEASE: 小細胞肺癌
エントリ  
H00013                                                             
名称    
小細胞肺癌
概要    
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  肺および胸膜のがん
   H00013  小細胞肺癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    中耳, 呼吸器または胸腔内臓器の悪性腫瘍
     2C25  気管支または肺の悪性腫瘍
      H00013  小細胞肺癌
パスウェイ 
hsa05222  小細胞肺癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
ネットワーク
nt06267  Small cell lung cancer
病因遺伝子 
MYC (amplification) [HSA:4609] [KO:K04377]
BCL2 (overexpression) [HSA:596] [KO:K02161]
FHIT [HSA:2272] [KO:K01522]
TP53 [HSA:7157] [KO:K04451]
RB1 [HSA:5925] [KO:K06618]
PTEN [HSA:5728] [KO:K01110]
PPP2R1B [HSA:5519] [KO:K03456]
発癌物質  
Arsenic and arsenic compounds [CPD:C06269]
Asbestos [CPD:C16442]
Beryllium and beryllium compounds [CPD:C16460]
Bis(chloromethyl)ether and chloromethyl methyl ether (technical-grade)
N'-Nitrosonornicotine (NNN) and 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone(NNK) [CPD:C16452 C16453]
Radon-222 and its decay products
Silica, crystalline (inhaled in the form of quartz orcristobalite from occupational sources) [CPD:C16459]
Tobacco smoking and tobacco smoke
*Aluminium production
*Benzo[a]pyrene [CPD:C07535]
*Cadmium and cadmium compounds
*Chimney sweeping
*Coal gasification
*Coal-tar pitches [CPD:C16451]
*Coal-tars
*Coke production
*Furniture and cabinet making
*Haematite mining (underground) with exposure to radon
*Household combustion of coal, indoor emissions from
*Involuntary smoking (exposure to secondhand or environmental tobacco smoke)
*Iron and steel founding
*Mineral oils, untreated and mildly treated
*Painter (occupational exposure as a)
*Paving and roofing with coal-tar pitch
*Shale-oils [CPD:C16458]
*Soots
*Strong-inorganic-acid mists containing sulfuric acid
*Talc containing asbestiform fibres
*2,3,7,8-Tetrachlorodibenzo-para-dioxin
*X- and gamma-radiation
*: Although this is a risk factor for lung cancer in general, the strength of association with different histological tumor types is not well understood.
治療薬   
シクロホスファミド水和物 [DR:D00287]
イホスファミド [DR:D00343]
ニムスチン塩酸塩 [DR:D01059]
フルオロウラシル [DR:D00584]
シタラビン [DR:D00168]
テガフール・ウラシル [DR:D02131]
マイトマイシンC [DR:D00208]
ブレオマイシン塩酸塩 [DR:D03229]
ドキソルビシン塩酸塩 [DR:D01275]
アクラルビシン塩酸塩 [DR:D01911]
アムルビシン塩酸塩 [DR:D07100]
ビンデシン硫酸塩 [DR:D01769]
エトポシド [DR:D00125]
ノギテカン塩酸塩 [DR:D02168]
イリノテカン塩酸塩水和物 [DR:D01061]
デュルバルマブ [DR:D10808]
アテゾリズマブ [DR:D10773]
シスプラチン [DR:D00275]
カルボプラチン [DR:D01363]
ネダプラチン [DR:D01416]
タラポルフィンナトリウム [DR:D01985]
ストレプトコックス・ピオゲネス(A群3型)Su株ペニシリン処理凍結乾燥粉末 [DR:D08756]
リンク   
ICD-11: 2C25.1
ICD-10: C34
MeSH: D055752
文献    
  著者
Yokota J, Nishioka M, Tani M, Kohno T.
  タイトル
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
  雑誌
Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215
文献    
  著者
Sanchez-Cespedes M.
  タイトル
Dissecting the genetic alterations involved in lung carcinogenesis.
  雑誌
Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3
文献    
  著者
Mitsuuchi Y, Testa JR.
  タイトル
Cytogenetics and molecular genetics of lung cancer.
  雑誌
Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692
文献    
  著者
Panani AD, Roussos C.
  タイトル
Cytogenetic and molecular aspects of lung cancer.
  雑誌
Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030
文献    
PMID:2983887 (MYC amplification)
  著者
Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K
  タイトル
Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer.
  雑誌
Cancer Res 45:1823-7 (1985)
文献    
PMID:17426248 (BCL2 overexpression)
  著者
Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D
  タイトル
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
  雑誌
Mol Cancer Res 5:331-9 (2007)
DOI:10.1158/1541-7786.MCR-06-0367
文献    
PMID:8620533 (FHIT)
  著者
Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM
  タイトル
The FHIT gene 3p14.2 is abnormal in lung cancer.
  雑誌
Cell 85:17-26 (1996)
DOI:10.1016/s0092-8674(00)81078-8
文献    
PMID:2554494 (TP53)
  著者
Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levitt M, Pass H, Gazdar AF, Minna JD
  タイトル
p53: a frequent target for genetic abnormalities in lung cancer.
  雑誌
Science 246:491-4 (1989)
DOI:10.1126/science.2554494
文献    
PMID:2594029 (RB1)
  著者
Yandell DW, Campbell TA, Dayton SH, Petersen R, Walton D, Little JB, McConkie-Rosell A, Buckley EG, Dryja TP
  タイトル
Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling.
  雑誌
N Engl J Med 321:1689-95 (1989)
DOI:10.1056/NEJM198912213212501
文献    
PMID:9696041 (PTEN)
  著者
Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W
  タイトル
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
  雑誌
Oncogene 17:475-9 (1998)
DOI:10.1038/sj.onc.1201956
文献    
PMID:9765152 (PPP2R1B)
  著者
Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA
  タイトル
Alterations of the PPP2R1B gene in human lung and colon cancer.
  雑誌
Science 282:284-7 (1998)
DOI:10.1126/science.282.5387.284
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