KEGG   PATHWAY: eclz00260
Entry
eclz00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Enterobacter hormaechei subsp. hormaechei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
eclz00260  Glycine, serine and threonine metabolism
eclz00260

Module
eclz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:eclz00260]
eclz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:eclz00260]
eclz_M00555  Betaine biosynthesis, choline => betaine [PATH:eclz00260]
eclz_M00621  Glycine cleavage system [PATH:eclz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Enterobacter hormaechei subsp. hormaechei [GN:eclz]
Gene
LI64_01580  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LI64_03365  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
LI64_21280  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
LI64_20195  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LI64_03370  serine kinase [KO:K00872] [EC:2.7.1.39]
LI64_03375  threonine synthase [KO:K01733] [EC:4.2.3.1]
LI64_07640  threonine aldolase [KO:K01620] [EC:4.1.2.48]
LI64_15805  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LI64_08300  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
LI64_01225  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
LI64_16875  glycerate kinase [KO:K00865] [EC:2.7.1.165]
LI64_18825  glycerate kinase [KO:K00865] [EC:2.7.1.165]
LI64_06895  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
LI64_03325  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
LI64_00840  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
LI64_17470  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LI64_20530  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LI64_07810  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
LI64_03280  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
LI64_10270  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LI64_00810  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
LI64_00815  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
LI64_10380  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
LI64_17425  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LI64_17435  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
LI64_03880  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
LI64_17430  glycine cleavage system protein H [KO:K02437]
LI64_15980  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
LI64_06085  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LI64_06090  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LI64_12805  serine dehydratase [KO:K01752] [EC:4.3.1.17]
LI64_16930  serine dehydratase [KO:K01752] [EC:4.3.1.17]
LI64_18815  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
LI64_21125  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
LI64_00160  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
LI64_17130  racemase [KO:K25316] [EC:5.1.1.10]
LI64_12105  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LI64_12100  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LI64_14185  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
LI64_14190  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
eclz00010  Glycolysis / Gluconeogenesis
eclz00020  Citrate cycle (TCA cycle)
eclz00230  Purine metabolism
eclz00250  Alanine, aspartate and glutamate metabolism
eclz00270  Cysteine and methionine metabolism
eclz00290  Valine, leucine and isoleucine biosynthesis
eclz00300  Lysine biosynthesis
eclz00330  Arginine and proline metabolism
eclz00460  Cyanoamino acid metabolism
eclz00470  D-Amino acid metabolism
eclz00564  Glycerophospholipid metabolism
eclz00600  Sphingolipid metabolism
eclz00620  Pyruvate metabolism
eclz00630  Glyoxylate and dicarboxylate metabolism
eclz00640  Propanoate metabolism
eclz00680  Methane metabolism
eclz00860  Porphyrin metabolism
eclz00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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