KEGG   PATHWAY: ecw00260
Entry
ecw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli O139:H28 E24377A (ETEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ecw00260  Glycine, serine and threonine metabolism
ecw00260

Module
ecw_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecw00260]
ecw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ecw00260]
ecw_M00555  Betaine biosynthesis, choline => betaine [PATH:ecw00260]
ecw_M00621  Glycine cleavage system [PATH:ecw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli O139:H28 E24377A (ETEC) [GN:ecw]
Gene
EcE24377A_4572  lysC; aspartokinase III, lysine-sensitive [KO:K00928] [EC:2.7.2.4]
EcE24377A_0001  thrA; aspartokinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EcE24377A_4480  metL; aspartokinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EcE24377A_3912  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EcE24377A_0002  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
EcE24377A_0003  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
EcE24377A_0943  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EcE24377A_2836  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EcE24377A_4049  tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EcE24377A_3602  garK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
EcE24377A_0551  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EcE24377A_0782  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EcE24377A_4995  phosphoglycerate mutase family protein [KO:K15634] [EC:5.4.2.11]
EcE24377A_4116  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EcE24377A_3240  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EcE24377A_1004  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
EcE24377A_4987  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EcE24377A_1748  NADP-dependent l-serine/l-allo-threonine dehydrogenase ydfg [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EcE24377A_4121  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
EcE24377A_4120  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EcE24377A_1571  tynA; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
EcE24377A_3230  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
EcE24377A_3232  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
EcE24377A_0118  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
EcE24377A_3231  gcvH; glycine cleavage system H protein [KO:K02437]
EcE24377A_2872  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
EcE24377A_0326  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EcE24377A_0327  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EcE24377A_3586  tdcG; L-serine dehydratase tdcG [KO:K01752] [EC:4.3.1.17]
EcE24377A_3102  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
EcE24377A_2042  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
EcE24377A_4284  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EcE24377A_3591  tdcB; threonine dehydratase, catabolic [KO:K01754] [EC:4.3.1.19]
EcE24377A_2652  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EcE24377A_3160  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
EcE24377A_1459  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
EcE24377A_1460  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ecw00010  Glycolysis / Gluconeogenesis
ecw00020  Citrate cycle (TCA cycle)
ecw00230  Purine metabolism
ecw00250  Alanine, aspartate and glutamate metabolism
ecw00270  Cysteine and methionine metabolism
ecw00290  Valine, leucine and isoleucine biosynthesis
ecw00300  Lysine biosynthesis
ecw00330  Arginine and proline metabolism
ecw00460  Cyanoamino acid metabolism
ecw00470  D-Amino acid metabolism
ecw00564  Glycerophospholipid metabolism
ecw00600  Sphingolipid metabolism
ecw00620  Pyruvate metabolism
ecw00630  Glyoxylate and dicarboxylate metabolism
ecw00640  Propanoate metabolism
ecw00680  Methane metabolism
ecw00860  Porphyrin metabolism
ecw00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system