KEGG   PATHWAY: ecz00630
Entry
ecz00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli O45:K1:H7 S88 (ExPEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
ecz00630  Glyoxylate and dicarboxylate metabolism
ecz00630

Module
ecz_M00012  Glyoxylate cycle [PATH:ecz00630]
ecz_M00621  Glycine cleavage system [PATH:ecz00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli O45:K1:H7 S88 (ExPEC) [GN:ecz]
Gene
ECS88_4480  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
ECS88_4562  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
ECS88_3350  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
ECS88_4479  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
ECS88_3612  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
ECS88_0745  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
ECS88_1416  acnA; aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
ECS88_0788  ybhJ; putative enzyme [KO:K01681] [EC:4.2.1.3]
ECS88_0127  acnB; bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ECS88_2373  atoB; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECS88_3141  yqeF; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ECS88_3354  glcD; glycolate oxidase subunit, FAD-linked [KO:K00104] [EC:1.1.99.14]
ECS88_3353  glcE; glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
ECS88_3352  glcF; glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
ECS88_1784  katE; hydroperoxidase HPII(III) (catalase) [KO:K03781] [EC:1.11.1.6]
ECS88_1044  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECS88_3972  tiaE; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECS88_3770  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ECS88_4320  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ECS88_2721  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECS88_3182  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
ECS88_3184  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
ECS88_0125  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
ECS88_4536  putative dihydrolipoyl dehydrogenase, E3 component (lpd-like) [KO:K00382] [EC:1.8.1.4]
ECS88_3183  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECS88_0506  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ECS88_0507  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ECS88_3513  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
ECS88_0508  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
ECS88_0513  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECS88_3512  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECS88_1511  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
ECS88_3068  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
ECS88_3459  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
ECS88_3460  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
ECS88_1906  eda; multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ECS88_4342  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
ECS88_4341  fdoH; formate dehydrogenase-O, Fe-S subunit [KO:K00124]
ECS88_4340  fdoI; formate dehydrogenase-O, cytochrome b556 subunit [KO:K00127]
ECS88_1300  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
ECS88_2568  oxc; putative oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
ECS88_2569  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
ecz00010  Glycolysis / Gluconeogenesis
ecz00020  Citrate cycle (TCA cycle)
ecz00030  Pentose phosphate pathway
ecz00053  Ascorbate and aldarate metabolism
ecz00071  Fatty acid degradation
ecz00230  Purine metabolism
ecz00250  Alanine, aspartate and glutamate metabolism
ecz00260  Glycine, serine and threonine metabolism
ecz00620  Pyruvate metabolism
ecz00710  Carbon fixation by Calvin cycle
ecz00750  Vitamin B6 metabolism
ecz00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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