KEGG   PATHWAY: ecz00230
Entry
ecz00230                    Pathway                                
Name
Purine metabolism - Escherichia coli O45:K1:H7 S88 (ExPEC)
Class
Metabolism; Nucleotide metabolism
Pathway map
ecz00230  Purine metabolism
ecz00230

Module
ecz_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecz00230]
ecz_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ecz00230]
ecz_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ecz00230]
ecz_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ecz00230]
ecz_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ecz00230]
ecz_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ecz00230]
ecz_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ecz00230]
Other DBs
GO: 0006163 0042278
Organism
Escherichia coli O45:K1:H7 S88 (ExPEC) [GN:ecz]
Gene
ECS88_3428  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
ECS88_3783  nudE; ADP-ribose diphosphatase [KO:K08312] [EC:3.6.1.-]
ECS88_5064  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
ECS88_3765  yhfW; putative mutase [KO:K01839] [EC:5.4.2.7]
ECS88_0725  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
ECS88_1275  prsA; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
ECS88_2459  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
ECS88_4466  purD; phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
ECS88_2672  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
ECS88_1905  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
ECS88_2729  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
ECS88_2671  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
ECS88_0521  purK; N5-carboxyaminoimidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
ECS88_0522  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
ECS88_2658  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
ECS88_1146  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
ECS88_4467  purH; fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
ECS88_0466  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
ECS88_0477  ushA; bifunctional UDP-sugar hydrolase and 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
ECS88_3014  surE; broad specificity 5'(3')-nucleotidase and polyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
ECS88_0700  nagD; NMP phosphatase [KO:K02566] [EC:3.1.3.5]
ECS88_3785  yrfG; putative hydrolase [KO:K20881] [EC:3.1.3.-]
ECS88_0474  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
ECS88_2596  xapA; purine nucleoside phosphorylase II [KO:K03783] [EC:2.4.2.1]
ECS88_5065  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
ECS88_0386  yaiE; conserved hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
ECS88_2781  yfiH; conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
ECS88_0134  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
ECS88_2680  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
ECS88_2694  ndk; multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
ECS88_5077  yjjX; thiamin metabolism associated protein [KO:K01529] [EC:3.6.1.73]
ECS88_3236  yggV; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
ECS88_0273  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
ECS88_3145  xdhA; xanthine dehydrogenase, molybdenum binding subunit [KO:K00087] [EC:1.17.1.4]
ECS88_3146  xdhB; xanthine dehydrogenase, FAD-binding subunit [KO:K13479] [EC:1.17.1.4]
ECS88_3147  xdhC; xanthine dehydrogenase, Fe-S binding subunit [KO:K13480]
ECS88_2679  guaA; GMP synthetase (glutamine aminotransferase) [KO:K01951] [EC:6.3.5.2]
ECS88_0107  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
ECS88_3162  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
ECS88_4063  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
ECS88_2382  nrdA; ribonucleoside diphosphate reductase 1, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECS88_2941  nrdE; ribonucleoside-diphosphate reductase 2, alpha subunit [KO:K00525] [EC:1.17.4.1]
ECS88_2383  nrdB; ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECS88_2942  nrdF; ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like [KO:K00526] [EC:1.17.4.1]
ECS88_4828  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
ECS88_0171  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
ECS88_2438  yfbR; deoxyribonucleoside 5'-monophosphatase [KO:K08722] [EC:3.1.3.89]
ECS88_5000  yfdR; conserved hypothetical protein; CPS-53 (KpLE1) prophage [KO:K06952] [EC:3.1.3.89]
ECS88_0535  yfdR; conserved hypothetical protein; CPS-53 (KpLE1) prophage [KO:K06952] [EC:3.1.3.89]
ECS88_2913  yfdR; conserved hypothetical protein; CPS-53 (KpLE1) prophage [KO:K06952] [EC:3.1.3.89]
ECS88_4065  spoT; bifunctional (p)ppGpp synthetase II and guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
ECS88_2674  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECS88_4200  gpp; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
ECS88_3052  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
ECS88_2201  hypothetical protein from phage origin [KO:K07816] [EC:2.7.6.5]
ECS88_4229  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
ECS88_4763  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
ECS88_1670  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
ECS88_2050  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
ECS88_3064  ygdH; conserved hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
ECS88_4090  ade; cryptic adenine deaminase [KO:K01486] [EC:3.5.4.2]
ECS88_4807  cpdB; 2':3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
ECS88_0471  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
ECS88_3049  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
ECS88_3426  cpdA; cyclic 3',5'-adenosine monophosphate phosphodiesterase [KO:K03651] [EC:3.1.4.53]
ECS88_0054  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
ECS88_3021  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
ECS88_3022  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
ECS88_3023  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
ECS88_2022  yedX; conserved hypothetical protein [KO:K07127] [EC:3.5.2.17]
ECS88_0511  allB; allantoinase [KO:K01466] [EC:3.5.2.5]
ECS88_0515  allC; allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
ECS88_0514  ylbA; conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
ECS88_0504  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
ECS88_0516  allD; ureidoglycolate dehydrogenase [KO:K00073] [EC:1.1.1.350]
ECS88_0520  ybcF; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECS88_3153  yqeA; amino acid (carbamate) kinase [KO:K00926] [EC:2.7.2.2]
ECS88_0331  yahI; putative carbamate kinase [KO:K00926] [EC:2.7.2.2]
ECS88_4269  Putative Carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ecz00030  Pentose phosphate pathway
ecz00220  Arginine biosynthesis
ecz00250  Alanine, aspartate and glutamate metabolism
ecz00260  Glycine, serine and threonine metabolism
ecz00340  Histidine metabolism
ecz00630  Glyoxylate and dicarboxylate metabolism
ecz00730  Thiamine metabolism
ecz00740  Riboflavin metabolism
ecz00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system