PATHWAY: hahs00010 Help
Entry
Name
Glycolysis / Gluconeogenesis - Halanaeroarchaeum sp. HSR-CO
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:
M00001 ]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:
M00307 ]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:
M00002 ], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:
M00003 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Module
Other DBs
Organism
Halanaeroarchaeum sp. HSR-CO [GN:
hahs ]
Gene
HSRCO_0561 porD; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [KO:K00171 ] [EC:1.2.7.1 ]
HSRCO_0564 porB2; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit [KO:K00170 ] [EC:1.2.7.1 ]
HSRCO_0806 aceF2; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [KO:K00627 ] [EC:2.3.1.12 ]
HSRCO_0827 porB3; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit [KO:K00170 ] [EC:1.2.7.1 ]
HSRCO_0828 porA3; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit [KO:K00169 ] [EC:1.2.7.1 ]
HSRCO_0829 porD2; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [KO:K00171 ] [EC:1.2.7.1 ]
HSRCO_0830 porG2; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, gamma subunit [KO:K00172 ] [EC:1.2.7.1 ]
HSRCO_1097 porA4; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit and gamma [KO:K00174 ] [EC:1.2.7.3 1.2.7.11 ]
HSRCO_1974 porB5; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, beta subunit [KO:K00170 ] [EC:1.2.7.1 ]
HSRCO_1975 porA5; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit and gamma [KO:K00169 ] [EC:1.2.7.1 ]
HSRCO_2574 acoA3; Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [KO:K00161 ] [EC:1.2.4.1 ]
HSRCO_2688 acoA4; Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [KO:K00161 ] [EC:1.2.4.1 ]
HSRCO_2689 acoB3; Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component [KO:K00162 ] [EC:1.2.4.1 ]
HSRCO_2690 aceF3; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component or related enzyme [KO:K00627 ] [EC:2.3.1.12 ]
HSRCO_2691 lpd3; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme [KO:K00382 ] [EC:1.8.1.4 ]
Compound
C00118 D-Glyceraldehyde 3-phosphate
C00236 3-Phospho-D-glyceroyl phosphate
C00354 D-Fructose 1,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01159 2,3-Bisphospho-D-glycerate
C01172 beta-D-Glucose 6-phosphate
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
KO pathway