KEGG   PATHWAY: hahs00260
Entry
hahs00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Halanaeroarchaeum sp. HSR-CO
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
hahs00260  Glycine, serine and threonine metabolism
hahs00260

Module
hahs_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hahs00260]
hahs_M00621  Glycine cleavage system [PATH:hahs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Halanaeroarchaeum sp. HSR-CO [GN:hahs]
Gene
HSRCO_0007  lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]
HSRCO_0029  serA; Phosphoglycerate dehydrogenase or related dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HSRCO_0366  thrC; Threonine synthase and cysteate synthase [KO:K01733] [EC:4.2.3.1]
HSRCO_0371  ilvA; Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
HSRCO_0555  thrA; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HSRCO_0629  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
HSRCO_0863  metC; Cystathionine beta-lyase/cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
HSRCO_0968  trpB2; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
HSRCO_0969  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
HSRCO_1015  gckA; Glycerate kinase [KO:K11529] [EC:2.7.1.165]
HSRCO_1174  thrC2; Threonine synthase and cysteate synthase [KO:K01733] [EC:4.2.3.1]
HSRCO_1802  serA4; Phosphoglycerate dehydrogenase or related dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HSRCO_1878  thrC3; Threonine synthase and cysteate synthase [KO:K01733] [EC:4.2.3.1]
HSRCO_2007  gabT; 4-aminobutyrate aminotransferase or related aminotransferase [KO:K00836] [EC:2.6.1.76]
HSRCO_2166  glyA; Glycine/serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HSRCO_2224  pucG; Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HSRCO_2248  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HSRCO_2293  gcvP; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [KO:K00283] [EC:1.4.4.2]
HSRCO_2294  gcvP2; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [KO:K00282] [EC:1.4.4.2]
HSRCO_2295  gcvH; Glycine cleavage system H protein (lipoate-binding) [KO:K02437]
HSRCO_2296  gcvT; Glycine cleavage system T protein (aminomethyltransferase) [KO:K00605] [EC:2.1.2.10]
HSRCO_2488  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
HSRCO_2551  gpmI; Phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
HSRCO_2691  lpd3; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme [KO:K00382] [EC:1.8.1.4]
HSRCO_2847  csdA3; Selenocysteine lyase/Cysteine desulfurase [KO:K01620] [EC:4.1.2.48]
HSRCO_2864  thrC4; Threonine synthase and cysteate synthase [KO:K01733] [EC:4.2.3.1]
HSRCO_2866  serA6; Phosphoglycerate dehydrogenase or related dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HSRCO_2867  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
C23135  (2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate
C23136  4-Amino-L-allothreonine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
hahs00010  Glycolysis / Gluconeogenesis
hahs00020  Citrate cycle (TCA cycle)
hahs00230  Purine metabolism
hahs00250  Alanine, aspartate and glutamate metabolism
hahs00270  Cysteine and methionine metabolism
hahs00290  Valine, leucine and isoleucine biosynthesis
hahs00300  Lysine biosynthesis
hahs00330  Arginine and proline metabolism
hahs00460  Cyanoamino acid metabolism
hahs00470  D-Amino acid metabolism
hahs00564  Glycerophospholipid metabolism
hahs00620  Pyruvate metabolism
hahs00630  Glyoxylate and dicarboxylate metabolism
hahs00640  Propanoate metabolism
hahs00680  Methane metabolism
hahs00860  Porphyrin metabolism
hahs00920  Sulfur metabolism
KO pathway
ko00260   

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