KEGG   PATHWAY: halj00260
Entry
halj00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Haloarcula sp. JP-L23
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
halj00260  Glycine, serine and threonine metabolism
halj00260

Module
halj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:halj00260]
halj_M00621  Glycine cleavage system [PATH:halj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Haloarcula sp. JP-L23 [GN:halj]
Gene
G9465_02430  aspartate kinase [KO:K00928] [EC:2.7.2.4]
G9465_10095  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
G9465_05380  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
G9465_23935  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
G9465_16640  homoserine kinase [KO:K00872] [EC:2.7.1.39]
G9465_02450  threonine synthase [KO:K01733] [EC:4.2.3.1]
G9465_09125  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
G9465_16265  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
G9465_12845  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G9465_20220  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G9465_21780  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G9465_23445  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
G9465_06550  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
G9465_21175  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
G9465_02200  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
G9465_17095  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
G9465_02600  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_06300  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_16625  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_19965  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_23335  C-terminal binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_23955  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
G9465_02700  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
G9465_19550  HAD-IB family phosphatase [KO:K01079] [EC:3.1.3.3]
G9465_15240  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
G9465_21760  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
G9465_15235  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
G9465_21765  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
G9465_05670  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
G9465_15250  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
G9465_21750  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
G9465_01785  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
G9465_21770  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
G9465_15245  gcvH; glycine cleavage system protein GcvH [KO:K02437]
G9465_21755  gcvH; glycine cleavage system protein GcvH [KO:K02437]
G9465_20185  FAD-dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
G9465_06325  methyltransferase domain-containing protein [KO:K18897] [EC:2.1.1.157]
G9465_03520  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
G9465_09860  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
G9465_20180  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
G9465_21745  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
G9465_23450  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
G9465_07470  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
G9465_06780  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
G9465_07465  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
G9465_02955  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
G9465_02950  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
halj00010  Glycolysis / Gluconeogenesis
halj00020  Citrate cycle (TCA cycle)
halj00230  Purine metabolism
halj00250  Alanine, aspartate and glutamate metabolism
halj00270  Cysteine and methionine metabolism
halj00290  Valine, leucine and isoleucine biosynthesis
halj00300  Lysine biosynthesis
halj00330  Arginine and proline metabolism
halj00460  Cyanoamino acid metabolism
halj00470  D-Amino acid metabolism
halj00564  Glycerophospholipid metabolism
halj00620  Pyruvate metabolism
halj00630  Glyoxylate and dicarboxylate metabolism
halj00640  Propanoate metabolism
halj00680  Methane metabolism
halj00860  Porphyrin metabolism
halj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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