KEGG   Homo sapiens (human): 324
Entry
324               CDS       T01001                                 
Symbol
APC, BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46
Name
(RefSeq) adenomatous polyposis coli protein isoform b
  KO
K02085  adenomatosis polyposis coli protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04519  Cadherin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04810  Regulation of actin cytoskeleton
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling
nt06541  Cytoskeleton in neurons
nt06549  Cadherin signaling
  Element
N00056  Wnt signaling pathway, Canonical pathway
N00057  Mutation-inactivated APC to Wnt signaling pathway
N00058  Mutation-activated CTNNB1 to Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
N00242  Mutation-inactivated AXIN to Wnt signaling pathway
N01836  Microtubule plus end regulation network
N02003  deltaPCDH8/10/18/20 to Wnt signaling
Disease
H00017  Esophageal cancer
H00018  Gastric cancer
H00020  Colorectal cancer
H00044  Cancer of the anal canal
H00047  Gallbladder cancer
H00048  Hepatocellular carcinoma
H01025  Familial adenomatous polyposis
H01667  Medulloblastoma
H02049  Bilateral macronodular adrenal hyperplasia
H02302  Hepatoblastoma
H03037  Gastric adenocarcinoma and proximal polyposis of the stomach
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    324 (APC)
   04390 Hippo signaling pathway
    324 (APC)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    324 (APC)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    324 (APC)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    324 (APC)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    324 (APC)
   05206 MicroRNAs in cancer
    324 (APC)
  09162 Cancer: specific types
   05210 Colorectal cancer
    324 (APC)
   05225 Hepatocellular carcinoma
    324 (APC)
   05226 Gastric cancer
    324 (APC)
   05217 Basal cell carcinoma
    324 (APC)
   05213 Endometrial cancer
    324 (APC)
   05224 Breast cancer
    324 (APC)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    324 (APC)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    324 (APC)
   05022 Pathways of neurodegeneration - multiple diseases
    324 (APC)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    324 (APC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    324 (APC)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    324 (APC)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    324 (APC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     324 (APC)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    324 (APC)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     324 (APC)
SSDB
Motif
Pfam: Arm_APC_u3 APC_basic EB1_binding APC_r APC_u5 APC_u14 APC_rep APC_u15 APC_u9 SAMP APC_N_CC Arm APC_u13 APC_15aa Suppressor_APC ARM_ARMC5 ZER1-like_2nd Sec7-like_HUS
Other DBs
NCBI-GeneID: 324
NCBI-ProteinID: NP_000029
OMIM: 611731
HGNC: 583
Ensembl: ENSP00000257430.4
UniProt: P25054 Q4LE70
Structure
LinkDB
Position
5:112707498..112846239
AA seq 2843 aa
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAM
ASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPR
RGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQAT
EAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA
PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETC
WEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQ
VDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAM
GSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS
PKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGS
LDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS
QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSS
NDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE
LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTE
STDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKP
TNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS
SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQ
TYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPV
SEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQET
PLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP
PPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF
SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSE
KDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPS
QNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQ
SGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKP
FRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN
AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRND
SLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINR
GQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENN
NKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQ
ECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD
WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFT
SNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQAN
MPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKS
ELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPN
KLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG
LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESA
SFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDG
RPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES
SEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAES
KTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN
QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERT
PFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKT
DSTESSGTQSPKRHSGSYLVTSV
NT seq 8532 nt   +upstreamnt  +downstreamnt
atggctgcagcttcatatgatcagttgttaaagcaagttgaggcactgaagatggagaac
tcaaatcttcgacaagagctagaagataattccaatcatcttacaaaactggaaactgag
gcatctaatatgaaggaagtacttaaacaactacaaggaagtattgaagatgaagctatg
gcttcttctggacagattgatttattagagcgtcttaaagagcttaacttagatagcagt
aatttccctggagtaaaactgcggtcaaaaatgtccctccgttcttatggaagccgggaa
ggatctgtatcaagccgttctggagagtgcagtcctgttcctatgggttcatttccaaga
agagggtttgtaaatggaagcagagaaagtactggatatttagaagaacttgagaaagag
aggtcattgcttcttgctgatcttgacaaagaagaaaaggaaaaagactggtattacgct
caacttcagaatctcactaaaagaatagatagtcttcctttaactgaaaatttttcctta
caaacagatatgaccagaaggcaattggaatatgaagcaaggcaaatcagagttgcgatg
gaagaacaactaggtacctgccaggatatggaaaaacgagcacagcgaagaatagccaga
attcagcaaatcgaaaaggacatacttcgtatacgacagcttttacagtcccaagcaaca
gaagcagagaggtcatctcagaacaagcatgaaaccggctcacatgatgctgagcggcag
aatgaaggtcaaggagtgggagaaatcaacatggcaacttctggtaatggtcagggttca
actacacgaatggaccatgaaacagccagtgttttgagttctagtagcacacactctgca
cctcgaaggctgacaagtcatctgggaaccaaggtggaaatggtgtattcattgttgtca
atgcttggtactcatgataaggatgatatgtcgcgaactttgctagctatgtctagctcc
caagacagctgtatatccatgcgacagtctggatgtcttcctctcctcatccagctttta
catggcaatgacaaagactctgtattgttgggaaattcccggggcagtaaagaggctcgg
gccagggccagtgcagcactccacaacatcattcactcacagcctgatgacaagagaggc
aggcgtgaaatccgagtccttcatcttttggaacagatacgcgcttactgtgaaacctgt
tgggagtggcaggaagctcatgaaccaggcatggaccaggacaaaaatccaatgccagct
cctgttgaacatcagatctgtcctgctgtgtgtgttctaatgaaactttcatttgatgaa
gagcatagacatgcaatgaatgaactagggggactacaggccattgcagaattattgcaa
gtggactgtgaaatgtatgggcttactaatgaccactacagtattacactaagacgatat
gctggaatggctttgacaaacttgacttttggagatgtagccaacaaggctacgctatgc
tctatgaaaggctgcatgagagcacttgtggcccaactaaaatctgaaagtgaagactta
cagcaggttattgcgagtgttttgaggaatttgtcttggcgagcagatgtaaatagtaaa
aagacgttgcgagaagttggaagtgtgaaagcattgatggaatgtgctttagaagttaaa
aaggaatcaaccctcaaaagcgtattgagtgccttatggaatttgtcagcacattgcact
gagaataaagctgatatatgtgctgtagatggtgcacttgcatttttggttggcactctt
acttaccggagccagacaaacactttagccattattgaaagtggaggtgggatattacgg
aatgtgtccagcttgatagctacaaatgaggaccacaggcaaatcctaagagagaacaac
tgtctacaaactttattacaacacttaaaatctcatagtttgacaatagtcagtaatgca
tgtggaactttgtggaatctctcagcaagaaatcctaaagaccaggaagcattatgggac
atgggggcagttagcatgctcaagaacctcattcattcaaagcacaaaatgattgctatg
ggaagtgctgcagctttaaggaatctcatggcaaataggcctgcgaagtacaaggatgcc
aatattatgtctcctggctcaagcttgccatctcttcatgttaggaaacaaaaagcccta
gaagcagaattagatgctcagcacttatcagaaacttttgacaatatagacaatttaagt
cccaaggcatctcatcgtagtaagcagagacacaagcaaagtctctatggtgattatgtt
tttgacaccaatcgacatgatgataataggtcagacaattttaatactggcaacatgact
gtcctttcaccatatttgaatactacagtgttacccagctcctcttcatcaagaggaagc
ttagatagttctcgttctgaaaaagatagaagtttggagagagaacgcggaattggtcta
ggcaactaccatccagcaacagaaaatccaggaacttcttcaaagcgaggtttgcagatc
tccaccactgcagcccagattgccaaagtcatggaagaagtgtcagccattcatacctct
caggaagacagaagttctgggtctaccactgaattacattgtgtgacagatgagagaaat
gcacttagaagaagctctgctgcccatacacattcaaacacttacaatttcactaagtcg
gaaaattcaaataggacatgttctatgccttatgccaaattagaatacaagagatcttca
aatgatagtttaaatagtgtcagtagtagtgatggttatggtaaaagaggtcaaatgaaa
ccctcgattgaatcctattctgaagatgatgaaagtaagttttgcagttatggtcaatac
ccagccgacctagcccataaaatacatagtgcaaatcatatggatgataatgatggagaa
ctagatacaccaataaattatagtcttaaatattcagatgagcagttgaactctggaagg
caaagtccttcacagaatgaaagatgggcaagacccaaacacataatagaagatgaaata
aaacaaagtgagcaaagacaatcaaggaatcaaagtacaacttatcctgtttatactgag
agcactgatgataaacacctcaagttccaaccacattttggacagcaggaatgtgtttct
ccatacaggtcacggggagccaatggttcagaaacaaatcgagtgggttctaatcatgga
attaatcaaaatgtaagccagtctttgtgtcaagaagatgactatgaagatgataagcct
accaattatagtgaacgttactctgaagaagaacagcatgaagaagaagagagaccaaca
aattatagcataaaatataatgaagagaaacgtcatgtggatcagcctattgattatagt
ttaaaatatgccacagatattccttcatcacagaaacagtcattttcattctcaaagagt
tcatctggacaaagcagtaaaaccgaacatatgtcttcaagcagtgagaatacgtccaca
ccttcatctaatgccaagaggcagaatcagctccatccaagttctgcacagagtagaagt
ggtcagcctcaaaaggctgccacttgcaaagtttcttctattaaccaagaaacaatacag
acttattgtgtagaagatactccaatatgtttttcaagatgtagttcattatcatctttg
tcatcagctgaagatgaaataggatgtaatcagacgacacaggaagcagattctgctaat
accctgcaaatagcagaaataaaagaaaagattggaactaggtcagctgaagatcctgtg
agcgaagttccagcagtgtcacagcaccctagaaccaaatccagcagactgcagggttct
agtttatcttcagaatcagccaggcacaaagctgttgaattttcttcaggagcgaaatct
ccctccaaaagtggtgctcagacacccaaaagtccacctgaacactatgttcaggagacc
ccactcatgtttagcagatgtacttctgtcagttcacttgatagttttgagagtcgttcg
attgccagctccgttcagagtgaaccatgcagtggaatggtaagtggcattataagcccc
agtgatcttccagatagccctggacaaaccatgccaccaagcagaagtaaaacacctcca
ccacctcctcaaacagctcaaaccaagcgagaagtacctaaaaataaagcacctactgct
gaaaagagagagagtggacctaagcaagctgcagtaaatgctgcagttcagagggtccag
gttcttccagatgctgatactttattacattttgccacggaaagtactccagatggattt
tcttgttcatccagcctgagtgctctgagcctcgatgagccatttatacagaaagatgtg
gaattaagaataatgcctccagttcaggaaaatgacaatgggaatgaaacagaatcagag
cagcctaaagaatcaaatgaaaaccaagagaaagaggcagaaaaaactattgattctgaa
aaggacctattagatgattcagatgatgatgatattgaaatactagaagaatgtattatt
tctgccatgccaacaaagtcatcacgtaaagcaaaaaagccagcccagactgcttcaaaa
ttacctccacctgtggcaaggaaaccaagtcagctgcctgtgtacaaacttctaccatca
caaaacaggttgcaaccccaaaagcatgttagttttacaccgggggatgatatgccacgg
gtgtattgtgttgaagggacacctataaacttttccacagctacatctctaagtgatcta
acaatcgaatcccctccaaatgagttagctgctggagaaggagttagaggaggggcacag
tcaggtgaatttgaaaaacgagataccattcctacagaaggcagaagtacagatgaggct
caaggaggaaaaacctcatctgtaaccatacctgaattggatgacaataaagcagaggaa
ggtgatattcttgcagaatgcattaattctgctatgcccaaagggaaaagtcacaagcct
ttccgtgtgaaaaagataatggaccaggtccagcaagcatctgcgtcttcttctgcaccc
aacaaaaatcagttagatggtaagaaaaagaaaccaacttcaccagtaaaacctatacca
caaaatactgaatataggacacgtgtaagaaaaaatgcagactcaaaaaataatttaaat
gctgagagagttttctcagacaacaaagattcaaagaaacagaatttgaaaaataattcc
aaggtcttcaatgataagctcccaaataatgaagatagagtcagaggaagttttgctttt
gattcacctcatcattacacgcctattgaaggaactccttactgtttttcacgaaatgat
tctttgagttctctagattttgatgatgatgatgttgacctttccagggaaaaggctgaa
ttaagaaaggcaaaagaaaataaggaatcagaggctaaagttaccagccacacagaacta
acctccaaccaacaatcagctaataagacacaagctattgcaaagcagccaataaatcga
ggtcagcctaaacccatacttcagaaacaatccacttttccccagtcatccaaagacata
ccagacagaggggcagcaactgatgaaaagttacagaattttgctattgaaaatactccg
gtttgcttttctcataattcctctctgagttctctcagtgacattgaccaagaaaacaac
aataaagaaaatgaacctatcaaagagactgagccccctgactcacagggagaaccaagt
aaacctcaagcatcaggctatgctcctaaatcatttcatgttgaagataccccagtttgt
ttctcaagaaacagttctctcagttctcttagtattgactctgaagatgacctgttgcag
gaatgtataagctccgcaatgccaaaaaagaaaaagccttcaagactcaagggtgataat
gaaaaacatagtcccagaaatatgggtggcatattaggtgaagatctgacacttgatttg
aaagatatacagagaccagattcagaacatggtctatcccctgattcagaaaattttgat
tggaaagctattcaggaaggtgcaaattccatagtaagtagtttacatcaagctgctgct
gctgcatgtttatctagacaagcttcgtctgattcagattccatcctttccctgaaatca
ggaatctctctgggatcaccatttcatcttacacctgatcaagaagaaaaaccctttaca
agtaataaaggcccacgaattctaaaaccaggggagaaaagtacattggaaactaaaaag
atagaatctgaaagtaaaggaatcaaaggaggaaaaaaagtttataaaagtttgattact
ggaaaagttcgatctaattcagaaatttcaggccaaatgaaacagccccttcaagcaaac
atgccttcaatctctcgaggcaggacaatgattcatattccaggagttcgaaatagctcc
tcaagtacaagtcctgtttctaaaaaaggcccaccccttaagactccagcctccaaaagc
cctagtgaaggtcaaacagccaccacttctcctagaggagccaagccatctgtgaaatca
gaattaagccctgttgccaggcagacatcccaaataggtgggtcaagtaaagcaccttct
agatcaggatctagagattcgaccccttcaagacctgcccagcaaccattaagtagacct
atacagtctcctggccgaaactcaatttcccctggtagaaatggaataagtcctcctaac
aaattatctcaacttccaaggacatcatcccctagtactgcttcaactaagtcctcaggt
tctggaaaaatgtcatatacatctccaggtagacagatgagccaacagaaccttaccaaa
caaacaggtttatccaagaatgccagtagtattccaagaagtgagtctgcctccaaagga
ctaaatcagatgaataatggtaatggagccaataaaaaggtagaactttctagaatgtct
tcaactaaatcaagtggaagtgaatctgatagatcagaaagacctgtattagtacgccag
tcaactttcatcaaagaagctccaagcccaaccttaagaagaaaattggaggaatctgct
tcatttgaatctctttctccatcatctagaccagcttctcccactaggtcccaggcacaa
actccagttttaagtccttcccttcctgatatgtctctatccacacattcgtctgttcag
gctggtggatggcgaaaactcccacctaatctcagtcccactatagagtataatgatgga
agaccagcaaagcgccatgatattgcacggtctcattctgaaagtccttctagacttcca
atcaataggtcaggaacctggaaacgtgagcacagcaaacattcatcatcccttcctcga
gtaagcacttggagaagaactggaagttcatcttcaattctttctgcttcatcagaatcc
agtgaaaaagcaaaaagtgaggatgaaaaacatgtgaactctatttcaggaaccaaacaa
agtaaagaaaaccaagtatccgcaaaaggaacatggagaaaaataaaagaaaatgaattt
tctcccacaaatagtacttctcagaccgtttcctcaggtgctacaaatggtgctgaatca
aagactctaatttatcaaatggcacctgctgtttctaaaacagaggatgtttgggtgaga
attgaggactgtcccattaacaatcctagatctggaagatctcccacaggtaatactccc
ccggtgattgacagtgtttcagaaaaggcaaatccaaacattaaagattcaaaagataat
caggcaaaacaaaatgtgggtaatggcagtgttcccatgcgtaccgtgggtttggaaaat
cgcctgaactcctttattcaggtggatgcccctgaccaaaaaggaactgagataaaacca
ggacaaaataatcctgtccctgtatcagagactaatgaaagttctatagtggaacgtacc
ccattcagttctagcagctcaagcaaacacagttcacctagtgggactgttgctgccaga
gtgactccttttaattacaacccaagccctaggaaaagcagcgcagatagcacttcagct
cggccatctcagatcccaactccagtgaataacaacacaaagaagcgagattccaaaact
gacagcacagaatccagtggaacccaaagtcctaagcgccattctgggtcttaccttgtg
acatctgtttaa

KEGG   Homo sapiens (human): 10297
Entry
10297             CDS       T01001                                 
Symbol
APC2, APCL, MRT74
Name
(RefSeq) adenomatous polyposis coli protein 2 isoform 1
  KO
K02085  adenomatosis polyposis coli protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04519  Cadherin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04810  Regulation of actin cytoskeleton
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05210  Colorectal cancer
hsa05213  Endometrial cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06541  Cytoskeleton in neurons
nt06549  Cadherin signaling
  Element
N01836  Microtubule plus end regulation network
N02003  deltaPCDH8/10/18/20 to Wnt signaling
Disease
H00718  Sotos syndrome
H00768  Autosomal recessive intellectual developmental disorder
H01667  Medulloblastoma
H01881  Complex cortical dysplasia with other brain malformations
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    10297 (APC2)
   04390 Hippo signaling pathway
    10297 (APC2)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    10297 (APC2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    10297 (APC2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10297 (APC2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10297 (APC2)
   05206 MicroRNAs in cancer
    10297 (APC2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    10297 (APC2)
   05225 Hepatocellular carcinoma
    10297 (APC2)
   05226 Gastric cancer
    10297 (APC2)
   05217 Basal cell carcinoma
    10297 (APC2)
   05213 Endometrial cancer
    10297 (APC2)
   05224 Breast cancer
    10297 (APC2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    10297 (APC2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10297 (APC2)
   05022 Pathways of neurodegeneration - multiple diseases
    10297 (APC2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    10297 (APC2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    10297 (APC2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    10297 (APC2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    10297 (APC2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     10297 (APC2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centrosome associated proteins
    10297 (APC2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     10297 (APC2)
SSDB
Motif
Pfam: APC_basic APC_rep APC_N_CC APC_r Arm Arm_APC_u3 Suppressor_APC SAMP ARM_ARMC5 ZER1-like_2nd SSNA1 PEA2_C bZIP_1 Sec7-like_HUS Par-4_C HALZ CCDC138_cc
Other DBs
NCBI-GeneID: 10297
NCBI-ProteinID: NP_005874
OMIM: 612034
HGNC: 24036
Ensembl: ENSP00000467073.2
UniProt: O95996
LinkDB
Position
19:1446230..1473244
AA seq 2303 aa
MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE
ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSF
GELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQM
DLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA
LLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSS
SPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPD
QGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMK
LSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVAN
KATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQC
VLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESG
GGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQ
ELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYV
RKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDD
DDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVA
AKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG
GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG
QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG
ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAG
RPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVE
DATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPD
SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS
VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR
REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP
APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMG
HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT
PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP
PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSP
SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD
LDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ
AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPA
PRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPR
SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQ
HKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS
SGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCS
SRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA
SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRS
TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG
GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPM
VVAATTDSAAEKAPATASATLLE
NT seq 6912 nt   +upstreamnt  +downstreamnt
atggcgagctccgtggcgccctacgagcagctggtgaggcaggtggaggccttgaaggct
gagaacagccacctgaggcaggagctaagggacaactccagccacctgtccaagctggag
acagagacgtcgggcatgaaggaggtcctgaagcacctacagggaaaactggagcaggag
gcccgagtgctggtgtcctcggggcagacggaggtgctggagcagctgaaggccctacag
atggacatcaccagcctgtacaacctcaagttccagccgcccaccctgggcccggagcct
gccgcccggacccccgagggcagcccagtacacggctccgggccctccaaggacagcttt
ggggagctgagccgggccaccatccggctgctggaggaactggaccgggaacggtgtttc
ctgctgaatgagattgagaaggaggagaaggagaagctctggtactactctcagctgcag
ggcctgtccaagcgcctggacgagctgccgcacgtggagacgcagttctcgatgcagatg
gacctgatccggcagcagcttgagttcgaggcccagcacatccgctcgctgatggaggag
cgcttcggcacctcggacgagatggtgcagcgggcacagatccgcgcctcgcgcctggag
cagattgacaaggagctgctggaggcgcaggaccgagtgcagcagacggagccccaggcc
ttgctggcggtgaagtcggtgccggtggacgaggaccccgagacagaggtccccacacac
cctgaggatggcacccctcagccgggcaacagcaaggtggaggtggtcttctggctgttg
tccatgttggcgacgcgcgaccaggaggatacagcgcgcacgctgctggccatgtccagc
tcgcccgagagctgcgtggccatgcgccgctcgggctgtctgcctctgctgctgcaaatc
ctccacggcaccgaggccgcggccgggggtcgcgccggggccccaggggcaccgggcgcc
aaggacgcacgcatgcgcgccaacgcggcgctgcacaacatcgtcttctcgcagccggac
cagggcctggcgcgcaaggagatgcgcgtcctgcacgtgctggagcagatccgggcctac
tgcgagacctgctgggactggctgcaggcccgagacggcgggcccgagggaggtggcgcc
ggcagcgccccgatccccatcgagccgcagatctgccaggccacctgtgctgttatgaag
ctgtcctttgatgaggagtaccgccgtgccatgaacgagctaggtgggctgcaggccgtg
gcagagctgctgcaggttgactatgagatgcacaagatgacccgggacccgctgaacctg
gcgctgcgccgctacgcgggcatgaccctcaccaacctcacctttggggacgttgccaac
aaggccaccctgtgtgcgcgccgcggctgcatggaggccatcgtggcccagctggcctcc
gacagtgaggagctccaccaggtggtgtccagcatccttcggaacttgtcctggagggcc
gacatcaacagcaagaaggtgctgagggaggcgggcagcgtgactgccctggtgcagtgt
gtcctgcgggccaccaaggagtccaccctgaagagcgtgctgagcgccctgtggaatctg
tctgcacacagcacagagaacaaggcggccatctgccaggtggatggcgccctgggcttc
ctggtgagcaccctgacctacaagtgtcagagcaactcgctggccatcatcgagagcggc
ggcggcatcctccgcaatgtgtccagcctcgtcgccacccgtgaggactacaggcaggtg
ctccgggatcacaactgtctgcagacgctgctgcagcatctgacttcgcacagcctgacc
atcgtgagcaacgcgtgcggcacgctctggaacctgtcggcccgcagcgcccgtgaccag
gagctgctgtgggacctgggcgccgtgggcatgctgcgtaatctggtgcactccaagcac
aagatgatcgccatgggcagcgccgccgccctgcgcaacctgctggcccatcggcccgcc
aagcaccaggcggccgccaccgccgtgtccccaggcagctgcgtgcccagcctgtacgtg
cgcaagcagcgggcgctggaggccgagctggacgcacggcacctcgcgcaggcgctggag
cacctggagaagcagggcccgccggcagccgaggccgccactaagaagccgctgccgccc
ctgcgacacctggacggcctggcccaagactatgcttccgattcgggctgctttgacgac
gacgatgcaccgtcatccctggctgcggccgcggccaccggggagccagccagccctgcc
gcgctgtccctcttcctgggcagccccttcctgcaggggcaggcgctggctcgcaccccg
cccacccgccgaggcggcaaggaggcagagaaggacaccagtggggaggcagccgtggcg
gccaaggccaaggccaagctggcgcttgcagtggcgcgcatcgaccagctggtggaggac
atctccgccctgcacacctcgtccgacgatagcttcagcctcagctctggagacccggga
caggaggcgccacgggagggccgcgcccagtcctgctcgccatgccgcggcccggagggc
gggcggcgagaggcaggaagccgggcgcacccgctgctgcggctcaaggcggcccacgcc
agcctctccaacgacagcctcaacagcggcagtgccagcgacgggtactgcccacgcgaa
catatgctgccctgcccgctggccgcactggcttcgcgccgcgaggaccccaggtgtggg
cagcctcggcccagccggcttgaccttgacctgcccggctgccaggccgagcccccggcc
cgcgaggccacctccgccgacgcccgcgtgcgcaccatcaagctgtcgcctacctatcag
cacgtgccactgcttgagggtgcctcaagggcgggtgcagagcccctcgcggggcctgga
atctctccaggggcccggaagcaggcctggctgccggcagaccacctgagcaaggttccc
gagaagctggcggctgccccgctgtctgtggccagcaaggcactgcagaaactggcggcg
caagaggggccactctcgctgtcccgatgcagctccctttcctcgctgtcctcggccggc
cgcccaggccccagcgagggtggtgacctggatgacagtgactcctccctggaggggctg
gaggaggccggccccagcgaggctgagctggacagcacgtggcgggcgcccggggccacc
tcgctgcccgtagccattccggctccccggcgtaaccgaggccggggcctgggggtggaa
gacgccacgccgtccagctcgtcggagaactacgtgcaggagacaccgcttgtgctgagc
cgctgcagctctgtgagctcgctgggcagcttcgagagcccgtccatcgccagctccatc
cccagtgaaccttgcagcgggcagggcagcggcaccatcagccctagcgagctgcccgac
agccccggacagaccatgcctcccagccggagcaagacgccaccgctggcgcccgcgcca
cagggtccccccgaggccacccagttcagcctgcagtgggagagctacgtgaagcgcttc
ctggacatcgccgactgccgggagcgctgccggctgccatctgagctggacgcaggcagc
gtgcgctttaccgtggagaagccagacgagaacttctcgtgcgcctccagcctcagcgcg
ctggccttgcacgagcactacgtgcagcaggacgtggagctgcggctgctgccctcggcc
tgccccgagcgcggcgggggcgccgggggcgccggcctccactttgcagggcaccggcgg
cgggaggaggggccggcgcccacgggttctcgccctcgcggcgccgcggaccaggagctg
gaactgctgcgggagtgcctgggagccgccgtgcctgcccggctgcgcaaggtggcctcc
gcgctggtgccaggtcgccgcgcactccccgtgcccgtctacatgttggtgcccgccccg
gccccggcccaggaggacgactcctgcactgactccgcggagggcacgccggtcaacttc
tctagcgccgcctcgctcagcgacgagacgctgcagggaccccccagggaccagcccggg
ggaccagcgggcaggcaaagacccaccggccgccccacctctgccagacaggccatgggg
caccggcacaaggcgggaggcgccggccgcagcgcggagcagtctcggggcgcgggcaag
aacagagcagggctggagctgcccctgggccggcccccgagcgcccccgcagacaaggac
ggctcaaagcccggccggacccgcggggacggggcgctccagtcgctgtgcctcacgacg
cccactgaggaggccgtgtactgcttctacggcaacgactcggacgaggagcccccggcg
gccgcgcccacgccaacccaccggcgcacatcggccatccctcgcgcttttacgcgggag
cgtccgcagggccggaaggaggcccctgccccgtccaaggctgcaccagctgccccgccg
cccgcccggacccagcccagcctcattgctgacgagaccccgccctgctactccctgagc
tcctccgccagctccctcagcgagcccgagccctcggagccgccggccgtccatccacga
ggccgggagcccgcggtcaccaaggacccgggcccaggaggcggacgcgacagctcgccc
agcccgcgggccgcggaggagcttctgcagcggtgcatcagctcggccctgcccaggcgc
cggccccccgtgtctggcctgcggcgccgcaagccccgagccacccggctggatgagcgg
cccgcagaggggtcccgggaacgcggcgaggaggcagcgggctcggaccgggcctccgac
ctggatagcgtggagtggcgcgccatccaggagggcgccaattcaattgtcacgtggctg
caccaggcagcagctgccacgcgggaggcctcgtccgagtccgactccatcctgtccttc
gtatccgggctgtcagtgggatccaccctacagccccccaagcacaggaagggacgacag
gcggagggagaaatgggcagtgcccggcggccagagaaaaggggcgcagcctcagtcaag
accagcgggagcccccgttcccctgcaggccccgagaagccacgtggcacacagaagacc
acgcccggggtgccagctgtgctccggggacgaacagtgatctacgtccccagcccggca
ccccgtgcccagcccaaagggacccccggcccccgcgccacaccgcggaaggtggcgccc
ccttgcctggcacagcccgcggctccagccaaagtcccgagccccgggcagcagcggtcg
cggagcctacaccggcctgccaagacctcggagctggcgacgctgagccagccccccaga
agcgccacaccgcccgcccgcctcgccaagaccccctcctccagctcctcccagacctcg
cccgcctcccagcccctgcccagaaagcgccccccggtcacccaggctgctggggccctg
cccggccccggagcctccccggtgcccaaaacgccggcgcgcacccttctggcgaagcag
cacaagacgcagagatcgcccgtgcggatcccgttcatgcagaggccggcccggcgtggg
ccgccaccgctggctcgggcagtcccggagccgggccccaggggccgggcggggaccgag
gcgggcccgggggcgcgcgggggccgcctgggcctggtgcgtgtggcctcagccctctcc
agcggcagcgagtcctccgaccgctcgggcttccggcgacagctaaccttcatcaaggag
tcgccgggcttgcggcgccgccgctccgagctgtcctcggccgagtccgcggcctctgcc
ccccagggcgcctcgccccgccgcggccggcccgcgctgcccgccgtcttcctctgctcc
tcgcgctgcgaagagctccgagcggcaccccggcagggcccggccccggcccggcagcgg
ccccccgcggcccgacccagccctggcgagcgccctgcccggcgcaccacctccgagagc
ccgtcccgcctgcctgtgcgcgcgcccgccgcccggccggagactgtcaagcgctacgcg
tcgctgccgcacatcagcgtggcccgcaggcccgacggcgccgtccccgcggcccctgcc
tcagccgacgccgcgcgccgcagcagcgacggggagccccggccgctccccagggtggcc
gcgccgggcacgacctggcggcgcatccgagatgaggacgtgccccacatcctgcgcagc
acgcttcccgccacggccctgccactgcggggctccacgcccgaggacgccccggccggg
cccccgccgcgcaagaccagcgacgccgtggtccagaccgaggaggtcgccgcccccaag
accaactccagcacgtccccgagcctggagaccagggagccccccggggcccccgccggc
ggccagctctccctcctcggcagcgacgtggacggtcccagcctcgccaaggctcccatc
tccgcacccttcgtgcacgagggcctgggggtcgccgtggggggcttccccgccagccgg
cacggctcccccagccgctcggcccgagtaccccccttcaactatgtgcccagccccatg
gtggtcgcagccaccaccgactcggccgcggagaaagccccggccactgcctccgccacc
ctcctggaatag

KEGG   Homo sapiens (human): 23499
Entry
23499             CDS       T01001                                 
Symbol
MACF1, ABP620, ACF7, KIAA0754, LIS9, Lnc-PMIF, MACF, OFC4
Name
(RefSeq) microtubule-actin cross-linking factor 1 isoform 3
  KO
K19827  microtuble-actin crosslinking factor 1
Organism
hsa  Homo sapiens (human)
Network
nt06541  Cytoskeleton in neurons
  Element
N01836  Microtubule plus end regulation network
Disease
H00268  Lissencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    23499 (MACF1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Others
     23499 (MACF1)
SSDB
Motif
Pfam: Spectrin SR_desmoplakin_3 GAS2 Spectrin_SYNE1 EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_5 EF-hand_8 EH
Other DBs
NCBI-GeneID: 23499
NCBI-ProteinID: NP_001384402
OMIM: 608271
HGNC: 13664
UniProt: O94854
LinkDB
Position
1:39084167..39487138
AA seq 3515 aa
MGKPLSRPDCLRRNPSCLGKGEEEDGYIEDCYVPQRSIYDTMRINEQIDQGSKLNQTSKS
TMEKMEGSTISSNGTLGAASNVFESRAPEGKKLDERIIFDALKLSSDVQKSAPVPPRRRP
NAERKDNVNRRSWKSFMPPNFPEFAERIEASLSEVSEAGASNPSLQEKKESSSALTESSG
HLDHREPQSESVTLEHVSKSIGIPEVQDFKNLSGDCQDFRFQQHSANPPHEFQPVESEAV
ATSGNTDVMQESRFSSATWPRATKSLAKGGFSEKQHPLGDTACTVEMPPLSPCLSEELLD
PELHVLITPSLREKTESELKFEEDERWIMMEAEGEWEEEKLSDREKTFLMADEKNSLADI
FEEREQANTAVVEDGSDCLAAVLRTFGHLSLGQICCPDDPQPAKDQLATVPKDIPLDCDC
VLTGEDILGEVANRTAQGLEGLVSDSACTVGTIDAEQLSDTDSVQMFLELEKECLCEEGV
TPLVELQNQISSEGLAASQDAENLLVISHFSGAALEKEQHLGLLHVRAKDYDTRLDCGYF
NTLDSSQVPNAVELIAHVDIMRDTSTVSKEECEKVPFSPRTAEFKSRQPADLDSLEKLDP
GGLLNSDHRVSHEEKLSGFIASELAKDNGSLSQGDCSQTEGNGEECIERVTFSFAFNHEL
TDVTSGPEVEVLYESNLLTDEIHLESGNVTVNQENNSLTSMGNVVTCELSVEKVCDEDGE
AKELDYQATLLEDQAPAHFHRNFPEQVFQDLQRKSPESEILSLHLLVEELRLNPDGVETV
NDTKPELNVASSEGGEMERRDSDSFLNIFPEKQVTKAGNTEPVLEEWIPVLQRPSRTAAV
PTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAA
VSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAALAI
TVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAV
PTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTS
PAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTP
EEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAA
SVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAA
VLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPA
IPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPVLEEASSTGMWIKEDLDSLVFGI
KEVTSTVLHGKVPLAATAGLNSDEMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESR
WTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI
IRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA
LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM
EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS
QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS
HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELS
PWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPE
EGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQL
NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH
RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV
LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ
AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL
DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE
FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS
QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH
LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN
FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD
LDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV
CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK
EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRL
ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK
QPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLS
ARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRI
DKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKDAY
RPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFGDSQQLRLVRILRSTVMVRVGG
GWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTR
SSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSP
ASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAA
GGQGNSRRGLNKPSKIPTMSKKTTTASPRTPGPKR
NT seq 10548 nt   +upstreamnt  +downstreamnt
atgggtaagccactcagcagaccagactgtttaaggcggaaccccagctgcctggggaaa
ggagaggaggaggatggctacatagaggactgctatgttccacaacggtctatatatgat
acgatgaggataaatgagcaaattgaccaggggtcaaagcttaaccagacttcaaaaagc
accatggaaaagatggaaggaagtactatatccagcaatggtacattaggagcagcatct
aatgtttttgaatctagagcaccagaaggtaagaagctggatgagaggataatatttgat
gcactaaagctaagcagtgatgtgcagaagtcagcacctgtgccacccagaaggcggcca
aatgcagaacgcaaagacaatgttaacaggagatcgtggaagtccttcatgccacccaac
ttcccagaatttgcagagaggatagaagcttctctcagtgaggtttcagaagctggtgct
tcaaatccttccttgcaagagaagaaggagtccagttctgcattaacagaaagttctggt
catttggaccacagggaacctcagtcagagtcagtaactctggaacatgtgtccaaatcc
ataggtattccagaggtgcaagattttaaaaacttaagtggagactgccaggactttaga
tttcagcagcacagtgcaaaccctcctcatgaattccagcctgtagaatcagaagctgta
gcaacaagtggtaacacagatgtaatgcaggaatccagattctcaagtgcaacctggccg
agggccacaaaaagtttagctaagggaggcttcagtgagaagcagcacccccttggggac
acagcctgcactgtggaaatgccacctctctccccttgcctgagtgaagagctgttagat
ccagaattgcatgttctcataacccccagcctgagagagaaaacagagtctgagctaaag
tttgaggaggatgagcgatggattatgatggaggctgagggagagtgggaggaagagaaa
ctgtcagacagggaaaagacttttctgatggcagatgagaagaacagcctggcagatatt
tttgaagaaagagaacaagcaaacacagcagtggtggaggatggatccgattgcttagct
gctgtcttgaggacttttggccacctatctcttggtcagatttgttgccctgatgaccca
cagccagccaaggaccagttggctactgttcccaaggatatacccctggattgcgattgt
gttcttacaggtgaggatattctcggtgaggtggcaaacagaactgctcaggggttagag
ggacttgtttcagattcagcatgtactgtgggtactattgatgcagaacagctctctgac
acagactcagtgcagatgtttcttgaacttgaaaaggagtgtttatgtgaagaaggagta
actcctctagttgagctacagaatcaaatctcttctgaagggctggctgcatcccaggat
gcagaaaatttactcgtaattagtcatttttcaggggctgccttagaaaaggaacagcat
ttaggccttttacatgtaagggcaaaagattatgatactagattggattgtggatatttt
aataccctggattcttctcaggtgcctaatgctgtggaacttattgcccacgttgatatc
atgagagacacttccactgttagcaaggaggaatgtgaaaaagtgccttttagccccagg
actgcagaatttaagtccagacagccagctgatctggattcactggaaaagctggaccca
ggaggactgctgaactctgatcacagggtttctcatgaagaaaaattatcaggcttcatt
gcttctgagctggccaaagacaatggcagtttgtcccagggagactgcagtcaaactgag
gggaatggtgaggagtgcattgagagggtcaccttcagttttgcttttaatcatgaacta
acagatgttacctcaggacctgaagtagaggtgttatatgaatcaaatttactaacagat
gaaattcatttggaaagtgggaatgtaactgttaatcaagaaaataacagtctgacatca
atgggaaatgtggtcacttgtgaattgtctgtggagaaagtttgtgatgaggatggtgag
gcaaaagagctggattatcaagccacacttttggaggatcaagctccagcacatttccac
agaaacttcccagagcaggtcttccaggatctccagaggaagtccccagagtcagagatt
ctgagtctgcacctgctggttgaagaactgagacttaatccagatggagtggaaactgtg
aatgatacaaagcctgagctgaatgtggcatcatcagagggaggggagatggaaaggaga
gattcagattcattcctaaatatttttccagagaaacaagttaccaaggctggtaatact
gaaccagttttagaggaatggatacccgtcctccagagaccttcccggactgctgcagta
cccactgtcaaagatgccctagatgctgcactgcccagcccagaggagggtacctcaatt
gctgcagtgcctgccccagagggaactgctgtagttgctgctttagtgccctttccacat
gaggacatcctagttgcttcaatagtctccttagaggaggaggatgtcacagctgctgca
gtatcagccccagagagggctactgtcccagctgttacagtatctgtccctgaagggact
gctgcagttgctgcagtgtcctccccagaggagactgctccagctgttgcagcagccatc
acacaggagggtatgtcagctgtcgcagggttctccccagagtgggctgctttagctatt
acagtacccatcacagaggaggatggtacaccagaagggcctgtcaccccagctaccaca
gtgcatgctccagaggagcctgatactgcagctgtcagagtgtccaccccagaggagccc
gcctccccagctgctgcagtgcccaccccagaggagcccacctccccagctgctgcagtg
cccaccccagaggagcccacctccccagctgctgcagtgccccccccagaggagcccacc
tccccagctgctgcagtgcccaccccagaggagcccacctccccagctgctgcagtgccc
accccagaggagcccacctccccagctgctgcagtgcccaccccagaggagcccacctcc
ccagctgctgcagtgcccaccccagaggagcccacctccccagctgctgcagtgcccacc
ccagaggagcccacctccccagctgctgcagtgcccaccccagaggagcccgcctcccca
gctgctgcagtgcccaccccagaggagcccgcctccccagctgctgcagtgcccacccca
gaggagcctgccttcccagctcctgcagtgcccaccccagaggaatccgcctccgcagct
gttgcagtgcccacccccgaggaatctgcctccccagctgctgcagtgcccaccccagca
gaatctgcctcctttgcagctgtggtggccaccctggaggaacccacttccccggcagct
tcagtgcccacccctgcagctatggtggccaccctagaggaattcacttccccggcagct
tcagtgcccacctctgaggagcctgcctccctagcagctgcagtgtccaacccagaggag
cccacctccccagcagcagcagtgcccaccctagaggaacccacctcctcagcagctgca
gtgctcaccccagaggaactcagttccccagcagcttcagtgcccacccccgaggagcct
gcctccccagcagctgcagtgtccaacctagaggagcccgcctccccagcagcagcagtg
cccaccccagaggtggctgccatccctgctgcttcagtgcccaccccagaggtgcctgcc
atcccagctgctgcagtgcctcctatggaggaagtttcccccattggtgtgcccttcctg
ggagtttctgcccacactgactcagtgcctatttcagaagaaggaacacctgttctagag
gaggcttcctccactggaatgtggatcaaggaggaccttgattccctagtatttggcata
aaagaggtgaccagcacagtgctacatgggaaagtgcctctggctgcaaccgctggatta
aattcagatgagatgtttcagaaagaacaagtggatcctcttcagatgaaattgcagcag
gtgaatggacttggccagggattaattcagagtgcaggaaaagactgtgatgtacagggt
ttagaacatgacatggaagagatcaatgctcgatggaatacattgaataaaaaggtcgca
caaagaattgcacagctacaggaagctttgttgcattgtgggaagtttcaagatgccttg
gagccattgctcagctggttggcagataccgaggagctcatagccaatcagaaacctcca
tctgctgagtataaagtggtgaaagcacagatccaagaacagaagttgctccagcggctc
ctagatgatcgaaaggccacagtagacatgcttcaagcagaaggaggcagaatagcccag
tcagcagagctggctgatagagagaaaatcactggacagctggagagtcttgaaagtaga
tggactgaactactcagtaaggcagcagccaggcaaaaacagctggaagacatcctggtt
ctggccaaacagttccatgagacagctgagcctatttctgacttcttatctgtcacagag
aaaaagcttgctaactcagaacctgttggcactcagactgccaaaatacagcagcagatc
attcggcacaaggctttaaatgaagaaattgttaatagaaagaagaatgtagatcaagct
attaaaaatggtcaggctcttctaaaacaaaccacaggtgaggaggtgttacttatccag
gaaaaactagatggtataaagactcgttacgcagacatcacagttactagctccaaggcc
ctcagaactttagagcaagcccggcagctggccaccaagttccagtctacttatgaggaa
ctgaccgggtggctgagggaggtggaggaggagctggcaaccagtggaggacagtctccc
acaggggaacagataccccagtttcagcagagacagaaggaattaaagaaggaggtcatg
gagcacaggctggtgttggacacagtgaatgaggtgagccgtgctctcttagagctggtg
ccctggagagccagagaagggctggataaacttgtgtccgatgctaacgagcagtacaaa
ctagtcagtgacactattggacaaagggtggatgaaattgatgctgctattcagagatca
caacagtatgagcaagctgccgatgcagaactagcttgggttgctgaaacaaaacggaaa
ctgatggctctgggtccaattcgcctggaacaggaccagaccacagctcagcttcaggta
cagaaggctttctccattgacattattcgacacaaagattcaatggatgaactcttcagt
caccgtagtgaaatctttggcacatgtggggaggagcaaaaaactgtattacaggaaaag
acagagtctctaatacagcaatatgaagccattagcctactcaattcagagcgttatgcc
cgcctagagcgggcccaggtcttagtaaaccagttttgggaaacttatgaagagctcagc
ccctggattgaggaaactcgggcactaatagcacagttaccctctccagccattgatcat
gagcagctcaggcagcaacaagaggaaatgaggcaattaagggaatctattgctgaacac
aaacctcatattgacaaactactaaagataggcccacaactaaaggaattaaaccctgag
gaaggggaaatggtggaagaaaaataccagaaagcagaaaacatgtatgcccaaataaag
gaggaggtgcgccagcgagccctggctctggatgaagccgtgtcccagtccacacagatt
acagagtttcatgataaaattgagcctatgttggagacactggagaatctttcctctcgc
ctgcgtatgccaccactgatccctgctgaagtagacaagatcagagagtgcatcagtgac
aataagagtgccaccgtggagctagaaaaactgcagccatcctttgaggccttgaagcgc
cgtggagaggagcttattggacgatctcagggagcagacaaggatctggctgcaaaagaa
atccaggataaattggatcaaatggtattcttctgggaggacatcaaagctcgggctgaa
gaacgagaaatcaaatttcttgatgtccttgaattagcagagaagttctggtatgacatg
gcagctctcctgaccaccatcaaagacacccaggatattgtccatgacttggaaagccca
ggcattgatccttccatcatcaaacaacaggttgaagctgctgagactattaaggaagag
acagatggtctgcatgaagagctggagtttattcggatccttggagcagatttgattttt
gcctgtggagaaactgagaagcctgaagtgaggaagagcattgatgagatgaataatgct
tgggagaacttaaacaaaacatggaaagagaggctagaaaaacttgaggatgctatgcaa
gctgctgtgcagtatcaggacactcttcaggctatgtttgactggctagataacactgtg
attaaactctgcaccatgccccctgttggcactgacctcaatactgttaaagatcagtta
aatgaaatgaaggagttcaaagtagaagtttaccaacagcaaattgagatggagaagctt
aatcaccagggtgaactgatgttaaagaaagctactgatgagacggacagagacattata
cgagaaccactgacagaactcaaacacctctgggagaacctgggtgagaaaattgcccac
cgacagcacaaactagaaggggctctgttggcccttggtcagttccagcatgccttagag
gaactaatgagttggctgactcataccgaagagttgttagatgctcagagaccaataagt
ggagacccaaaagtcattgaagttgagctcgcaaagcaccatgtcctaaaaaatgatgtt
ttggctcatcaagccacagtggaaacagtcaacaaagctggcaatgagcttcttgaatcc
agtgctggagatgatgccagcagcttaaggagccgtttggaagccatgaaccaatgctgg
gagtcagtgttacagaaaacagaggagagggagcagcagcttcagtcaactctgcagcag
gcccagggcttccacagtgaaattgaagatttcctcttggaacttactagaatggagagc
cagctttctgcatctaagcccacaggaggacttcctgaaactgctagggaacagcttgat
acacatatggaactctattcccagctgaaagccaaggaagagacttataatcaactactt
gacaagggcagactcatgcttctaagccgtgacgactctgggtctggctccaagacagaa
cagagtgtagcacttttggagcagaagtggcatgtggtcagcagtaagatggaagaaaga
aagtcaaagctggaagaggccctcaacttggcaacagaattccagaattccctacaagaa
tttatcaactggctcactctagcagagcagagtttaaacatcgcttctccaccaagcctg
attctaaatactgtcctttcccagatagaagagcacaaggtttttgctaatgaagtaaat
gctcatcgagaccagatcattgagctggatcaaactgggaatcaattaaagttccttagc
caaaagcaggatgttgttctgatcaagaatttgttggtgagcgtgcagtctcgatgggag
aaggttgtccagcgatctattgaaagagggcgatcactagatgatgccaggaagcgggca
aaacaattccatgaagcttggaaaaaactgattgactggctagaagatgcagagagtcac
ctggactcagaactagagatatccaatgacccagacaaaattaaacttcagctttctaag
cataaggagtttcagaagactcttggtggcaagcagcctgtgtatgataccacaattaga
actggcagagcactgaaagaaaagactttgcttcccgaagatagtcagaaacttgacaat
ttcctaggagaagtcagagacaaatgggatactgtttgtggcaagtctgtggagcggcag
cacaagttggaggaagccctgctcttttcgggtcagttcatggatgctttgcaggcattg
gttgactggttatacaaggtggagccacagctggctgaggaccagcccgtgcacggggac
cttgacctcgtcatgaacctcatggatgcacacaaggttttccagaaggaactgggaaag
cgaacaggaaccgttcaggtcctgaagcggtcaggccgagagctgattgagaatagtcga
gatgacaccacttgggtaaaaggacagctccaggaactgagcactcgctgggacactgtc
tgtaaactctctgtttccaaacaaagccggcttgagcaggccttaaaacaagcggaagtg
tttcgagacacagtccacatgctgttggagtggctttctgaagcagagcaaacgcttcgc
tttcggggagcacttcctgatgacacagaggccctgcagtctctcattgacacccataag
gaattcatgaagaaagtagaagaaaagcgagtggacgttaactcagcagtagccatggga
gaagtcatcctggctgtctgccaccccgattgcatcacaaccatcaaacactggatcacc
atcatccgagctcgcttcgaggaggtcctgacatgggctaagcagcaccagcagcgtctt
gaaacggccttgtcagaactggtggctaatgctgagctcctggaagaacttctggcatgg
atccagtgggctgagaccaccctcattcagcgggatcaggagccaatcccgcagaacatt
gaccgagttaaagcccttatcgctgagcatcagacatttatggaggagatgactcgcaaa
cagcctgacgtggaccgggtcaccaagacatacaaaaggaaaaacatagagcctactcac
gcgcctttcatagagaaatcccgcagcggaggcaggaaatccctaagtcagccaacccct
cctcccatgccaatcctttcacagtctgaagcaaaaaacccacggatcaaccagctttct
gcccgctggcagcaggtgtggctgttagcactggagcggcaaaggaaactgaatgatgcc
ttggatcggctggaggagttgaaagaatttgccaactttgactttgatgtctggaggaaa
aagtatatgcgttggatgaatcacaaaaagtctcgagtgatggatttcttccggcgcatt
gataaggaccaggatgggaagataacacgtcaggagtttatcgatggcattttagcatcc
aagttccccaccaccaagttagagatgactgctgtggctgacattttcgaccgagatggg
gatggttacattgattattatgaatttgtggctgctcttcatcccaacaaggatgcgtat
cgaccaacaaccgatgcagataaaatcgaagatgaggttacaagacaagtggctcagtgc
aaatgtgcaaaaaggtttcaggtggagcagatcggagagaataaataccggtttggggat
tctcagcagttgcggctggtccgtattctgcgcagcaccgtgatggttcgcgttggtgga
ggatggatggccttggatgaatttttagtgaaaaatgatccctgccgagcacgaggtaga
actaacattgaacttagagagaaattcatcctaccagagggagcatcccagggaatgacc
cccttccgctcacggggtcgaaggtccaaaccatcttcccgggcagcttcccctactcgt
tccagctccagtgctagtcagagtaaccacagctgtacatccatgccatcttctccagcc
accccagccagtggaaccaaggttatcccatcatcaggtagcaagttgaaacgaccaaca
ccaacttttcattctagtcggacatcccttgctggtgataccagcaatagttcttccccg
gcctccacaggtgccaaaactaatcgggcagaccctaaaaagtctgccagtcgccctggg
agtcgggctgggagtcgagccgggagtcgagccagcagccggcgaggaagtgacgcttct
gactttgacctcttagagacgcagtctgcttgttccgacacttcagaaagcagcgctgca
gggggccaaggcaactccaggagagggctaaacaaaccttccaaaatcccaaccatgtct
aagaagaccaccactgcctcccccaggactccaggtcccaagcgataa

KEGG   Homo sapiens (human): 667
Entry
667               CDS       T01001                                 
Symbol
DST, BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBS3, EBSB2, HSAN6, MACF2
Name
(RefSeq) dystonin isoform 1e precursor
  KO
K10382  dystonin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
Network
nt06541  Cytoskeleton in neurons
  Element
N01836  Microtubule plus end regulation network
Disease
H00265  Hereditary sensory and autonomic neuropathy
H00584  Epidermolysis bullosa simplex
H00865  Lethal congenital contractural syndrome
H01810  Congenital myopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    667 (DST)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    667 (DST)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    667 (DST)
SSDB
Motif
Pfam: Plectin SR_plectin_7 Spectrin_2 Spectrin_3 SR_desmoplakin_3 SH3_10 Spectrin_4 Spectrin Tropomyosin Frankia_peptide
Other DBs
NCBI-GeneID: 667
NCBI-ProteinID: NP_001714
OMIM: 113810
HGNC: 1090
Ensembl: ENSP00000359801.6
UniProt: Q03001
Structure
LinkDB
Position
6:complement(56457996..56954830)
AA seq 2649 aa
MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEML
QQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVI
DVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSL
NSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPN
FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE
WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAK
LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR
ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA
YFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIAN
LMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS
PTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEI
DRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQ
YYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRI
TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST
YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR
QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE
GIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS
KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR
YTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKI
SELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL
ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD
LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR
RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ
DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE
LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN
IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE
ELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG
FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE
VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLF
QEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI
KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL
VLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQP
LEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRLS
EIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVP
SAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQ
LVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERI
IIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSY
SSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQ
FLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRIS
VVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLH
FNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERI
SVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQC
ELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEAL
QVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT
GISSLYYSS
NT seq 7950 nt   +upstreamnt  +downstreamnt
atgcacagtagtagttatagttaccgtagcagtgattctgtgtttagtaacactaccagc
actcgaaccagtcttgattcaaatgaaaatcttctcttggttcattgtggtccaacactg
atcaactcttgcattagcttcggcagtgaatcctttgatggacacaggttagaaatgttg
caacagattgccaacagagttcagagggacagtgtcatctgtgaagacaaactgattctt
gctggaaatgctcttcagtctgattctaaaagattagaatcaggagtgcagtttcagaat
gaagcagaaattgctgggtatatacttgaatgtgagaaccttttacgccagcatgtaatt
gatgtacagattcttattgatggaaaatactaccaggcagatcaattggtacagagggtt
gcaaaactgcgtgacgaaattatggccttaaggaacgaatgttcttctgtgtacagcaaa
ggacgcatactgacaacagaacagacaaagctcatgatatcaggaatcactcaaagttta
aactcaggatttgcacagaccttacaccctagtctgacctcagggctgacccagagttta
acaccttccctaacctcttctagtatgacttctggcctgtcatcagggatgacttcccgc
ctgactccatctgtcactccagcttatacacctggtttcccatcaggattagttccaaat
ttcagttcaggagtagagccaaattcattgcaaactttgaagttgatgcagatccgaaaa
ccccttctaaagtcttctttgctggatcaaaatttaacagaagaagaaatcaatatgaaa
tttgttcaggatcttttgaattgggttgatgagatgcaggtacaactggaccgcactgag
tggggctcagatttgccaagtgttgaaagccatttagaaaatcataaaaatgttcataga
gctattgaagaatttgaatctagtctcaaagaagctaaaatcagtgagattcaaatgaca
gcacctcttaaactgacttatgcagaaaagttgcacagattagagagtcagtatgcaaaa
ctcttgaatacatccaggaatcaagaacggcaccttgatacactccataattttgtaagt
cgtgcgactaatgaacttatttggttgaatgaaaaagaagaggaggaagttgcttatgac
tggagtgagagaaacaccaacatagctaggaaaaaagattatcatgctgaattaatgaga
gaacttgatcaaaaggaagaaaatattaaatcagttcaggagatagcagagcagctactt
ctagaaaatcatccagcccggttaactattgaggcctacagagcggcaatgcagacgcag
tggagctggatcttacagctctgccagtgtgtggagcagcacataaaggagaacacagcg
tatttcgagtttttcaatgatgccaaagaagctactgattacttaaggaatctaaaagat
gccattcagcggaagtacagctgtgatagatcaagcagcattcacaagctagaagacctt
gttcaggaatcaatggaagagaaagaagaacttctgcagtacaaaagcactatagcaaac
ctaatgggaaaagcaaaaacaataattcaactgaagccaaggaattctgactgtccactc
aaaacttctattccgatcaaagctatctgtgactacagacaaattgagataaccatttac
aaagacgatgaatgtgttttggcgaataactctcatcgtgctaaatggaaggtcattagt
cctactgggaatgaggctatggtcccatctgtgtgcttcaccgttcctccaccaaacaaa
gaagcggtggaccttgccaacagaattgagcaacagtatcagaatgtcctgactctttgg
catgagtctcacataaacatgaagagtgtagtatcctggcattatctcatcaatgaaatt
gatagaattcgagctagcaatgtggcttcaataaagacaatgctacctggtgaacatcag
caagttctaagtaatctacaatctcgttttgaagattttctggaagatagccaggaatcc
caagtcttttcaggctcagatataacacaactggaaaaggaggttaatgtatgtaagcag
tattatcaagaacttcttaaatctgcagaaagagaggagcaagaggaatcagtttataat
ctctacatctctgaagttcgaaacattagacttcggttagagaactgtgaagatcggctg
attagacagattcgaactcccctggaaagagatgatttgcatgaaagtgtgttcagaatc
acagaacaggagaaactaaagaaagagctggaacgacttaaagatgatttgggaacaatc
acaaataagtgtgaggagtttttcagtcaagcagcagcctcttcatcagtccctacccta
cgatcagagcttaatgtggtccttcagaacatgaaccaagtctattctatgtcttccact
tacatagataagttgaaaactgttaacttggtgttaaaaaacactcaagctgcagaagcc
ctcgtaaaactctatgaaactaaactgtgtgaagaagaagcagttatagctgacaagaat
aatattgagaatctaataagtactttaaagcaatggagatctgaagtagatgaaaagaga
caggtattccatgccttagaggatgagttgcagaaagctaaagccatcagtgatgaaatg
tttaaaacgtataaagaacgggaccttgattttgactggcacaaagaaaaagcagatcaa
ttagttgaaaggtggcaaaatgttcatgtgcagattgacaacaggttacgggacttagag
ggcattggcaaatcactgaagtactacagagacacttaccatcctttagatgattggatc
cagcaggttgaaactactcagagaaagattcaggaaaatcagcctgaaaatagtaaaacc
ctagccacacagttgaatcaacagaagatgctggtgtccgaaatagaaatgaaacagagc
aaaatggacgagtgtcaaaaatatgcagaacagtactcagctacagtgaaggactatgaa
ttacaaacaatgacctaccgggccatggtagattcacaacaaaaatctccagtgaaacgc
cgaagaatgcagagttcagcagatctcattattcaagagttcatggacctaaggactcga
tatactgccctggtcactctcatgacacaatatattaaatttgctggtgattcattgaag
aggctggaagaggaggagattaaaaggtgtaaggagacttctgaacatggggcatattca
gatctgcttcagcgtcagaaggcaacagtgcttgagaatagcaaacttacaggaaagata
agtgagttggaaagaatggtagctgaactaaagaaacaaaagtcccgagtagaggaagaa
cttccgaaggtcagggaggctgcagaaaatgaattgagaaagcagcagagaaatgtagaa
gatatctctctgcagaagataagggctgaaagtgaagccaagcagtaccgcagggaactt
gaaaccattgtgagagagaaggaagccgctgaaagagaactggagcgggtgaggcagctc
accatagaggccgaggctaaaagagctgccgtggaagagaacctcctgaattttcgcaat
cagttggaggaaaacacctttaccagacgaacactggaagatcatcttaaaagaaaagat
ttaagtctcaatgatttggagcaacaaaaaaataaattaatggaagaattaagaagaaag
agagacaatgaggaagaactcttgaagctgataaagcagatggaaaaagaccttgcattt
cagaaacaggtagcagagaaacagttgaaagaaaagcagaaaattgaattggaagcaaga
agaaaaataactgaaattcagtatacatgtagagaaaatgcattgccagtgtgtccgatc
acacaggctacatcatgcagggcagtaacgggtctccagcaagaacatgacaagcagaaa
gcagaagaactcaaacagcaggtagatgaactaacagctgccaatagaaaggctgaacaa
gacatgagagagctgacatatgaacttaatgccctccagcttgaaaaaacgtcatctgag
gaaaaggctcgtttgctaaaagataaactagatgaaacaaataatacactcagatgcctt
aagttggagctggaaaggaaggatcaggcggagaaagggtattctcaacaactcagagag
cttggtaggcaattgaatcaaaccacaggtaaagctgaagaagccatgcaagaagctagt
gatctcaagaaaataaagcgcaattatcagttagaattagaatctcttaatcatgaaaaa
gggaaactacaaagagaagtagacagaatcacaagggcacatgctgtagctgagaagaat
attcagcatttaaattcacaaattcattcttttcgagatgagaaagaattagaaagacta
caaatctgccagagaaaatcagatcatctaaaagaacaatttgagaaaagccatgagcag
ttgcttcaaaatatcaaagctgaaaaagaaaataatgataaaatccaaaggctcaatgaa
gaattggagaaaagtaatgagtgtgcagagatgctaaaacaaaaagtagaggagcttact
aggcagaataatgaaaccaaattaatgatgcagagaattcaggcagaatcagagaatata
gttttagagaaacaaactatccagcaaagatgtgaagcactgaaaattcaggcagatggt
tttaaagatcagctacgcagcacaaatgaacacttgcataaacagacaaaaacagagcag
gattttcaaagaaaaattaaatgcctagaagaagacctggcgaaaagtcaaaatttggta
agtgaatttaagcaaaagtgtgaccaacagaacattatcatccagaataccaagaaagaa
gttagaaatctgaatgcggaactgaatgcttccaaagaagagaagcgacgcggggagcag
aaagttcagctacaacaagctcaggtgcaagagttaaataacaggttgaaaaaagtacaa
gacgaattacacttaaagaccatagaggagcagatgacccacagaaagatggttctgttt
caggaagaatctggtaaattcaaacaatcagcagaggagtttcggaagaagatggaaaaa
ttaatggagtccaaagtcatcactgaaaatgatatttcaggcattaggcttgactttgtg
tctcttcaacaagaaaactctagagcccaagaaaatgctaagctttgtgaaacaaacatt
aaagaacttgaaagacagcttcaacagtatcgtgaacaaatgcagcaagggcagcacatg
gaagcaaatcattaccaaaaatgtcagaaacttgaggatgagctgatagcccagaagcgt
gaggttgaaaacctgaagcaaaaaatggaccaacagatcaaagagcatgaacatcaatta
gttttgctccagtgtgaaattcaaaaaaagagcacagccaaagactgtaccttcaaacca
gattttgagatgacagtgaaggagtgccagcactctggagagctgtcctctagaaacact
ggacaccttcacccaacacccagatcccctctgttgagatggactcaagaaccacagcca
ttggaagagaagtggcagcatcgggttgttgaacagatacccaaagaagtccaattccag
ccaccaggggctccactcgagaaagagaaaagccagcagtgttactctgagtacttttct
cagacaagcaccgagttacagataacttttgatgagacaaaccccattacaagactgtct
gaaattgagaagataagagaccaagccctgaacaattctagaccacctgttaggtatcaa
gataacgcatgtgaaatggaactggtgaaggttttgacacccttagagatagctaagaac
aagcagtatgatatgcatacagaagtcacaacattaaaacaagaaaagaacccagttccc
agtgctgaagaatggatgcttgaagggtgcagagcatctggtggactcaagaaaggggat
ttccttaagaagggcttagaaccagagaccttccagaactttgatggtgatcatgcatgt
tcagtcagggatgatgaatttaaattccaagggcttaggcacactgtgactgccaggcag
ttggtggaagctaagcttctggacatgagaacaattgagcagctgcgactcggtcttaag
actgttgaagaagttcagaaaactcttaacaagtttctgacgaaagccacctcaattgca
gggctttacctagaatctacaaaagaaaagatttcatttgcctcagcggccgagagaatc
ataatagacaaaatggtggctttggcatttttagaagctcaggctgcaacaggttttata
attgatcccatttcaggtcagacatattctgttgaagatgcagttcttaaaggagttgtt
gaccccgaattcagaattaggcttcttgaggcagagaaggcagctgtgggatattcttat
tcttctaagacattgtcagtgtttcaagctatggaaaatagaatgcttgacagacaaaaa
ggtaaacatatcttggaagcccagattgccagtgggggtgtcattgaccctgtgagaggc
attcgtgttcctccagaaattgctctgcagcaggggttgttgaataatgccatcttacag
tttttacatgagccatccagcaacacaagagttttccctaatcccaataacaagcaagct
ctgtattactcagaattactgcgaatgtgtgtatttgatgtagagtcccaatgctttctg
tttccatttggggagaggaacatttccaatctcaatgtcaagaaaacacatagaatttct
gtagtagatactaaaacaggatcagaattgaccgtgtatgaggctttccagagaaacctg
attgagaaaagtatatatcttgaactttcagggcagcaatatcagtggaaggaagctatg
ttttttgaatcctatgggcattcttctcatatgctgactgatactaaaacaggattacac
ttcaatattaatgaggctatagagcagggaacaattgacaaagccttggtcaaaaagtat
caggaaggcctcatcacacttacagaacttgctgattctttgctgagccggttagtcccc
aagaaagatttgcacagtcctgttgcagggtattggctgactgctagtggggaaaggatc
tctgtactaaaagcctcccgtagaaatttggttgatcggattactgccctccgatgcctt
gaagcccaagtcagtacagggggcataattgatcctcttactggcaaaaagtaccgggtg
gccgaagctttgcatagaggcctggttgatgaggggtttgcccagcagctgcgacagtgt
gaattagtaatcacagggattggccatcccatcactaacaaaatgatgtcagtggtggaa
gctgtgaatgcaaatattataaataaggaaatgggaatccgatgtttggaatttcagtac
ttgacaggagggttgatagagccacaggttcactctcggttatcaatagaagaggctctc
caagtaggtattatagatgtcctcattgccacaaaactcaaagatcaaaagtcatatgtc
agaaatataatatgccctcagacaaaaagaaagttgacatataaagaagccttagaaaaa
gctgattttgatttccacacaggacttaaactgttagaagtatctgagcccctgatgaca
ggaatttctagcctctactattcttcctaa

KEGG   Homo sapiens (human): 9793
Entry
9793              CDS       T01001                                 
Symbol
CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG
Name
(RefSeq) cytoskeleton-associated protein 5 isoform a
  KO
K16803  cytoskeleton-associated protein 5
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N01544  Microtubule nucleation
N01547  Kinetochore fiber organization
N01836  Microtubule plus end regulation network
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9793 (CKAP5)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    9793 (CKAP5)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Spindle formation proteins
    9793 (CKAP5)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    XMAP215
     9793 (CKAP5)
SSDB
Motif
Pfam: XMAP215_CLASP_TOG CLASP_N HEAT HEAT_MROH2B_C HEAT_EF3_N TOR1L1_N HEAT_GCN1 Cnd1 HEAT_ECM29 TAN TPR_CAND1 SSAP_Sak
Other DBs
NCBI-GeneID: 9793
NCBI-ProteinID: NP_001008938
OMIM: 611142
HGNC: 28959
Ensembl: ENSP00000432768.1
UniProt: Q14008
Structure
LinkDB
Position
11:complement(46743048..46846280)
AA seq 2032 aa
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDS
NAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYIEIE
KGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEA
KLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEAL
ESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFI
ARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLA
DVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVL
PPTCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQM
KLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLG
VMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQSPPAPTRGISKHSTSGTDEGEDGDE
PDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAA
ALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCV
PHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNM
PAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPGLSSKAKSAQ
GKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQM
SSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSV
LMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVY
PASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDN
AVRNAALNTIVTVYNVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQ
RAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDNGTVRC
EMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQA
LTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGN
MISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSD
QTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFM
KVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKH
SMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKY
SDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVS
SIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHS
KLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSRK
NT seq 6099 nt   +upstreamnt  +downstreamnt
atgggagatgacagtgagtggttgaaactgccagttgatcagaaatgtgaacacaagctg
tggaaagcaaggttaagtgggtatgaagaggccctgaagatcttccagaaaataaaggat
gaaaagagcccagagtggtccaaatttttaggattgatcaaaaaatttgtcactgattcc
aatgcagtggttcaattgaaaggattagaagctgcacttgtttatgttgaaaatgcccat
gtagcaggaaaaaccacaggagaagttgtgtcaggtgttgtaagtaaggtgttcaatcaa
cctaaagctaaagccaaggagctgggcatagagatctgtcttatgtacatagagattgag
aaaggagaggctgttcaagaagagctcctgaaaggcttggacaataagaatcccaagatc
atagtggcctgtatagagacactgaggaaagccttaagtgaatttggttccaaaatcatc
ttgcttaagccaattatcaaagtgttgccaaaactctttgagtctcgagagaaggctgtt
cgagatgaagccaaactaattgctgtggagatttacagatggattcgggatgctctgaga
cccccattacaaaatataaactctgttcagttgaaagaactagaagaagaatgggtcaaa
ctgccaacaagtgctcctagacctactcgatttcttcgttcccaacaagaactagaagct
aaattggaacaacaacagtctgctggtggagatgctgaaggaggtggtgatgatggtgat
gaggtgccacaaatagatgcttatgagcttttagaagctgtagaaatcctttccaaactt
cccaaagacttttatgacaaaattgaggcaaaaaaatggcaagagagaaaagaggccctg
gagtctgtagaagtactaataaaaaaccccaaactggaagctggcgattatgcagattta
gtaaaagcattaaagaaggttgttggaaaggacaccaatgtcatgttggtggctttggca
gcaaaatgtcttactggcctggctgttgggctaaggaagaaatttggacaatatgcagga
catgttgtgccaaccatcttggagaaattcaaagagaagaaacctcaagtggtacaagcc
ctgcaggaggcaattgatgcaatcttccttactaccacactacagaacatcagtgaggat
gttttagcagtaatggataataaaaatccaaccatcaagcagcagacatctctttttatt
gcaagaagtttccgccactgcactgcttctaccctgccaaagagcttgctaaagcccttt
tgtgctgcactacttaagcacatcaatgattctgctcctgaagtcagagatgccgcattt
gaagcattgggtactgctttgaaggtggttggcgagaaagcagtaaacccattcctagct
gatgtggacaaactcaagcttgataagatcaaagaatgttcagaaaaggtagaactgata
catggtaagaaagctggactagctgctgataagaaggaattcaaacctctgcctggaagg
actgctgcttcaggggctgcaggagataaggacacaaaggacatttctgcacccaaacca
ggacctctaaaaaaggcacctgctgctaaggctggtgggccaccaaaaaaggggaaacca
gctgcaccaggaggcgcagggaatactggaaccaagaacaagaaaggactggagactaaa
gaaatagtggagcctgagctctcgatagaagtatgtgaagaaaaagcttcagctgttctt
ccccctacctgtatacagcttcttgacagcagtaactggaaagaaaggctggcttgtatg
gaagagttccagaaggctgttgagctaatggaccgaactgaaatgccatgccaggcatta
gtgaggatgctagccaagaaacctggatggaaagaaactaattttcaggtgatgcaaatg
aagcttcatatagttgctttgattgcccagaagggaaatttttccaaaacgtcagctcag
gttgtattagatggccttgtggacaagattggagatgtgaaatgtgggaacaatgcaaaa
gaagctatgacagcaatagccgaagcctgtatgttaccatggactgctgaacaggttgtg
tcaatggctttctcacaaaagaatcccaaaaatcagtcagaaactctgaattggctatca
aatgccataaaagaatttggtttttctgggttgaatgtcaaagctttcattagcaatgtg
aagacagctcttgctgcaacaaacccagctgtgaggactgctgccataaccctgcttggc
gtgatgtatctgtatgttggtccctctttgcgaatgttctttgaggatgagaagcctgcc
ctcctatcccagatagatgcagaatttgagaagatgcagggacaaagtccacctgctcca
accagaggaatttccaagcatagcacaagtggtacagatgaaggagaagatggagatgaa
ccagatgacgggagcaatgatgtcgttgatcttttgccgaggacggagatcagtgataaa
atcacttcagagttggtatctaagattggtgataagaattggaagattaggaaagaaggc
ctagatgaagtggcaggtattattaatgacgcaaaatttatccaaccgaatataggtgaa
cttccaactgccttgaagggtcgactcaatgattcaaataaaatcttggtacagcaaacg
ctgaatatcctgcaacaactggcagtagccatgggcccaaatattaagcaacatgtaaaa
aatttaggcatccctatcatcacagtccttggagacagcaagaacaatgttcgagctgct
gccctagcgactgtgaatgcttgggcagaacagactggcatgaaggaatggctggaagga
gaagatctttctgaagagctcaaaaaggaaaatcctttcttgaggcaagagcttctgggc
tggctggctgagaaactacctactcttcgttccacccctacagaccttatcctttgtgtt
cctcatctctactcctgcctagaagatcgaaatggagatgtgcgaaagaaggcccaagat
gccttgccattcttcatgatgcatttaggatatgaaaaaatggccaaggctactgggaaa
ctaaagccaacttctaaagatcaggtattggccatgctagagaaagccaaagttaacatg
ccagccaagcctgctccacccactaaagcaacttctaaaccaatgggagggtccgctcca
gccaaattccagcctgcatcagcacctgctgaagattgtatttccagcagtacagaaccc
aaacctgatccaaaaaaggccaaagctccaggattatcctctaaagcaaagagtgcacaa
gggaagaagatgccaagcaaaaccagcttaaaggaggatgaagacaaatccgggcctatt
tttattgttgttccaaatggaaaagagcaaaggatgaaagatgaaaaaggattgaaggtg
ctaaagtggaattttactaccccacgggatgaatacattgagcaactaaagactcaaatg
tctagctgtgtggctaaatggttacaagatgagatgtttcactcagactttcagcatcat
aacaaagcccttgctgttatggttgatcacttggagagtgaaaaagaaggagttattggt
tgcctggatcttatcttaaagtggcttaccctgaggttttttgacaccaatacaagcgtc
ctgatgaaagcactagaatatttaaaattgctcttcaccttgctaagtgaagaagaatat
catcttactgagaatgaagcatcttccttcatcccctatcttgtcgtcaaggttggagaa
ccaaaggatgtcattcgtaaagatgttcgtgccatcctgaaccggatgtgccttgtctac
ccagctagcaagatgtttccctttatcatggaaggaaccaaatccaaaaactctaagcag
agagcagagtgcctggaagagctgggatgtctggttgagtcctatggcatgaatgtttgc
caaccaaccccaggaaaagccttaaaggaaatagctgttcacataggagaccgtgacaat
gctgtacgcaatgctgcactcaacaccattgtaacggtgtacaatgtacatggggatcag
gtgttcaaactgattggaaatctttctgaaaaggatatgagcatgctcgaggagaggatt
aagcggtcagcaaagagaccctctgctgcaccaataaaacaggtggaagagaaacctcag
cgtgcacagaacataagctccaatgccaacatgttacgcaagggaccagctgaggacatg
tcttccaaactcaaccaagcccgaagcatgagtgggcatcctgaggcagcccagatggtc
cgccgagaattccagctggatctagatgagattgagaatgacaatggtacagtccgatgt
gaaatgccagaacttgttcagcacaaactggatgacatttttgagccagtccttattcct
gaacccaagatccgggctgtttctccacacttcgatgacatgcacagtaatacagcatcc
acaatcaatttcattatctcccaagtagccagtggtgacatcaacacaagtatccaagct
ctgacacagatcgatgaggtcctgagacaggaagacaaagctgaagccatgtccggccat
attgatcagtttctgatagccacttttatgcagctaagactcatctacaacacacacatg
gcagatgagaaattggagaaggacgagatcatcaagttgtatagctgtatcattggcaac
atgatttcgctgtttcagatagagagccttgcccgggaggcctccactggagtactaaaa
gacctaatgcatggcctcatcaccttaatgctggattctcggattgaagatcttgaggaa
ggacaacaggtcatccgctctgtgaacctcttggtggtgaaggttctggagaagtcagac
cagaccaacatcctgagtgccctacttgttttgctccaagacagcctgctagcaacagcc
agttctcccaaattctcagagcttgttatgaagtgtctctggagaatggttcgactgttg
cctgataccatcaatagcattaacctagacagaattcttctggatatccacattttcatg
aaggtcttccccaaagagaaactgaagcaatgcaaaagtgaatttcccataaggacccta
aagaccctgctacacaccttatgcaaattaaaagggcccaagatcctggaccacctaacg
atgatcgacaacaaaaacgagtctgagctggaggcccatctctgccggatgatgaagcac
agtatggaccagactgggagcaagtctgataaggaaacagaaaagggagcatctcgaata
gatgaaaaatcatcaaaggccaaagtgaatgatttcttagctgagatttttaagaagatt
ggctctaaagaaaacactaaagagggactagcagagttatatgaatataagaagaaatac
tcagatgctgacattgaaccatttctgaaaaattcctcacagttcttccagagctatgtc
gaaagaggccttcgggtgattgagatggagagggagggcaaaggtcgtatttccacttca
acaggcatctcccctcagatggaagtcacatgtgtgcccacgcccacaagcacagtgtcc
tccataggtaacacaaatggggaagaagtggggccatctgtctacttggaaaggctaaag
atcctccgacagcgatgtggtctggacaacacaaagcaagatgaccgacctcctttgacc
tctttgctctccaaaccagcagttcctactgtcgcctcttccacagacatgctccacagc
aaactctctcagctccgggagtcacgggagcagcaccagcattcagacctggattctaac
cagactcactcttcaggaactgtgacctcctcctcctccacagctaacatagacgacttg
aaaaaaagactggagagaataaagagcagtcgcaaatga

KEGG   Homo sapiens (human): 23332
Entry
23332             CDS       T01001                                 
Symbol
CLASP1, MAST1
Name
(RefSeq) CLIP-associating protein 1 isoform 1
  KO
K16578  CLIP-associating protein 1/2
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N01553  Promotion of microtubule growth
N01836  Microtubule plus end regulation network
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23332 (CLASP1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    23332 (CLASP1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Microtubule-associated proteins
     23332 (CLASP1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Cytoplasmic linker proteins (CLIPs)
     CLIP-associating proteins
      23332 (CLASP1)
SSDB
Motif
Pfam: CLASP_N HEAT_EF3_N XMAP215_CLASP_TOG HEAT_GCN1 HEAT HEAT_MROH2B_C HEAT_EZ TOR1L1_N Sec7-like_HUS TPR_CAND1 Cnd1 HEAT_2 PIK3R4-like_middle Ltn1_1st TPR_DNAAF5 HEAT_DAAF5 ParcG TAN MMS19_C
Other DBs
NCBI-GeneID: 23332
NCBI-ProteinID: NP_056097
OMIM: 605852
HGNC: 17088
UniProt: Q7Z460
Structure
LinkDB
Position
2:complement(121337776..121649462)
AA seq 1538 aa
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVN
SSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMD
QAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPN
SQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKN
FDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEE
DFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYD
NFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPN
SAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL
ERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHL
KNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRS
DIDVNAAASAKSKVSSSSGTTPFSSAAALPPGSYASLGRIRTRRQSSGSATNVASTPDNR
GRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPPVTPSSEKRSKI
PRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFPPLDRFGLGQ
PGRIPGSVNAMRVLSTSTDLEAAVADALKKPVRRRYEPYGMYSDDDANSDASSVCSERSY
GSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEI
FTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQ
KALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSET
RLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNH
LKNSSNTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLAKHPP
PFSQPNSIPTAPSHKALRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDL
NEPIKRDGKKECDIVSRDGGAASPATEGRGGSEVEGGRTALDNKTSLLNTQPPRAFPGPR
ARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEE
RKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR
FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINL
AAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLK
PHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS
NT seq 4617 nt   +upstreamnt  +downstreamnt
atggagcctcgcatggagtcctgcctggcgcaggtgttgcagaaggatgtggggaaacga
ttgcaggttggccaagaactgatagactatttctcagacaaacagaagtctgctgacctt
gagcatgaccagaccatgttagataaacttgtggatggacttgctacctcttgggtgaac
tctagcaattacaaggtggttctgctgggcatggacatcctgtccgccctggtgacccgg
ctgcaggatcggttcaaggcgcagatcggcacagtgctgccaagtctaatagacagacta
ggagatgctaaagactctgtgagggagcaggaccaaactctgctgctaaagatcatggat
caagctgctaatccccagtacgtatgggacagaatgcttggaggcttcaaacacaagaat
ttccgtactcgagaaggcatctgtctctgccttatagcaacactcaatgcctctggagca
cagactttaacactaagcaagattgtgccacatatatgcaacttacttggagatccaaac
agccaggttcgagatgcagcaataaacagcttagtggaaatttacagacatgtaggagaa
cgtgtgagggcagatctcagtaaaaaaggattgccacagtcccggttgaatgtaattttt
acaaaatttgatgaagtccagaaatctggaaacatgatacaatctgcaaatgataaaaat
ttcgacgatgaagattctgtggatggtaacagaccttcctctgctagttctacatcatcc
aaggctccaccaagttctcggagaaacgttggaatgggaaccacccgccggcttggttca
tccacccttggatccaagtcttcagctgcaaaagaaggagctggtgctgttgatgaagag
gattttattaaagcatttgatgatgtacctgtagtacagatttattccagccgagacctt
gaggaatccataaacaaaattagggaaatattatctgatgacaagcatgattgggagcag
agagtaaatgctctaaaaaagattagatctttacttttggctggtgctgctgagtatgat
aacttctttcaacatttgcgtcttttggatggagcctttaaactctctgctaaggacctg
cggtctcaggtagtgcgggaggcttgtatcacgttggggcatctgtcatcagttctgggg
aataagtttgaccatggagctgaagccattatgccaactatctttaatttaattccaaac
agtgccaaaattatggccacatctggtgttgtagctgttaggttaattattcggcacaca
cacatccctaggttaatacctgtcataacaagcaactgtacctctaagtctgtcgcagtt
agaaggcgctgttttgaatttttagatttgcttttacaagaatggcagacacattcacta
gaacgacacatatcagtattagctgaaacaataaagaagggaatacatgatgctgattcc
gaagcaagaatagaagccagaaaatgttactggggtttccacagtcacttcagcagagaa
gcagagcacttgtaccacaccttggagtcctcctaccagaaagccctgcagtcccacctg
aagaactcagacagcatagtgtctctgcctcagtcagaccgctcatcttccagctctcaa
gagagtctaaatcgtccgctgtctgccaaaagaagtcctactggaagtaccacatctaga
gcttctacagttagtaccaaatctgtgtcaacgactgggtccctccagcgatctcgaagt
gatattgatgtgaacgcagcagccagtgccaaatccaaagtctcctcatcttcgggcacg
acgcctttcagctctgcagcagctttgcctccagggtcatacgcatccttaggtcggatc
cgcacaagacggcaaagctctgggagtgccaccaacgtcgcctctacacctgataaccgg
ggccgcagtcgcgctaaagtggtttcacagtcccagcgatccagatctgctaatcctgct
ggtgctggcagccggtcaagttccccaggaaaattgttgggaagtggttatggtggactt
actgggggctcctcacgaggcccacctgtgacaccgtcttcagaaaagcgaagcaagatt
cccaggagccagggatgtagccgggaaacaagtccaaaccgaataggattagcacggagc
agccgtatccctcgacccagcatgagtcaggggtgcagccgcgataccagccgtgagagc
agccgagatacaagccctgctcggggctttcctccacttgatcggtttgggcttggccag
ccaggaagaatacctggttctgtgaatgccatgagagttctgagcacaagtacagatctt
gaagctgctgttgctgatgctttgaagaagcctgtgaggaggagatatgagccgtatggg
atgtattctgacgatgatgccaacagtgatgcctcaagtgtttgctctgagcgctcatat
ggctccaggaatggtggcattccccattatctgcggcagactgaggatgtagcagaagtt
ctcaaccactgtgctagttcaaactggtcagaaaggaaagaagggcttctgggcctgcag
aacttactgaagagccaaagaacactgagtcgagttgaactgaaaaggttgtgtgagatc
ttcactcggatgtttgctgaccctcatagcaagagagttttcagtatgtttttggagact
cttgtggattttataataattcataaggatgatttacaagactggctttttgttcttctc
acacaattacttaagaaaatgggagcagatttacttggatctgtgcaagcaaaagttcaa
aaggctctagatgtcacaagggactcctttccatttgatcaacaatttaacattttgatg
agatttattgtggatcaaactcaaactccaaacctcaaggtcaaagttgcaatcctgaaa
tacattgagtctctggccagacagatggatccaacagattttgtaaactctagtgagaca
aggcttgctgtttctagaatcataacctggacaacagaaccaaagagttcagacgtgaga
aaggcagcacagattgtgctaatctctctgtttgaattgaatactcctgaatttaccatg
ttacttggtgccttgccaaaaacattccaggatggtgccaccaaactcctgcacaaccac
ctcaagaattccagtaacaccagtgtgggctctccaagcaatacgattggccggacgccc
tcccgacacaccagcagcaggaccagccccctgacctcacccaccaactgttcccatggg
ggtctgtctccaagtcggttatggggttggagtgccgacgggttagcgaagcacccacct
cccttttctcagcctaactccatccccaccgctccctcccacaaggctctcaggcgctct
tactctcccagcatgctggactatgatacagagaacctgaactctgaagaaatctatagt
tctctacgtggagttacagaagccattgaaaagtttagttttcgaagccaagaagatctg
aatgagccaattaaacgagatggcaaaaaggagtgtgatattgtgtcccgcgatgggggc
gctgcctcccctgccactgagggccgggggggtagtgaagtagaaggaggccggacagct
ctggataacaagacctcactactcaacacccagcctccgcgcgccttcccggggccgcgg
gcgcgagactacaacccgtacccctactcagatgccatcaacacctacgacaagaccgcc
ctgaaagaggctgtgttcgatgacgacatggagcagcttcgagacgtgcccatcgaccat
tctgacctggtggctgaccttctgaaagagctgtccaaccacaatgagcgagtggaggaa
cggaagggagccctgctggagctgctcaagatcacgcgggaagacagccttggtgtctgg
gaggagcacttcaagaccattctgctcctgctgctggagacccttggagacaaagaccat
tcaattcgagcactggcgttaagagttttgagggaaattctgagaaatcaaccagcaaga
tttaaaaactacgccgagctgacgattatgaagactctggaagcccacaaagactcccat
aaggaggtggtgagagcggctgaggaggctgcgtccacactggccagttccatccacccg
gagcagtgcatcaaggtgctctgccccatcatccagacggccgactaccccatcaacctt
gctgccatcaagatgcagaccaaagtcgtcgagaggatcgcaaaggagtcattgctgcag
ctccttgtcgacatcatcccaggcttgctgcagggttatgacaacaccgaaagtagtgtg
cgtaaggccagcgtgttttgcttagtggcaatttattccgtaatcggagaagacctgaaa
cctcaccttgcacagctcacagggagcaagatgaagctactaaacttatacataaagagg
gcccagaccaccaacagcaacagcagctcctcctccgatgtctccacgcacagctaa

KEGG   Homo sapiens (human): 23122
Entry
23122             CDS       T01001                                 
Symbol
CLASP2
Name
(RefSeq) CLIP-associating protein 2 isoform 2
  KO
K16578  CLIP-associating protein 1/2
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N01553  Promotion of microtubule growth
N01836  Microtubule plus end regulation network
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    23122 (CLASP2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    23122 (CLASP2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Microtubule-associated proteins
     23122 (CLASP2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Cytoplasmic linker proteins (CLIPs)
     CLIP-associating proteins
      23122 (CLASP2)
SSDB
Motif
Pfam: CLASP_N HEAT_GCN1 HEAT_EF3_N HEAT HEAT_EZ HEAT_MROH2B_C HEAT_DAAF5 TPR_CAND1 RTP1_C1 TOR1L1_N Cnd1 TPR_DNAAF5 MMS19_C Sec7-like_HUS TAN TMCO6 ParcG
Other DBs
NCBI-GeneID: 23122
NCBI-ProteinID: NP_001193973
OMIM: 605853
HGNC: 17078
UniProt: O75122
Structure
LinkDB
Position
3:complement(33496245..33718254)
AA seq 1294 aa
MAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEG
GAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLL
VAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVP
TLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLL
QEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSY
QKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASS
LPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTAS
EDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGV
QRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDT
SPVRSFQPLASRHHSRSTGALYAPEVYGASGPGYGISQSSRLSSSVSAMRVLNTGSDVEE
AVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLN
RCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLV
DFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRF
TVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKA
AQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPR
SPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMN
EPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYN
PYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIA
LYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNY
AELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIK
MQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLS
QLTGSKMKLLNLYIKRAQTGSGGADPTTDVSGQS
NT seq 3885 nt   +upstreamnt  +downstreamnt
atggctatgggagatgataaaagcttcgatgatgaagaatcagtggatggaaataggcca
tcatcagctgcatcagccttcaaggttcctgcacctaaaacatccggaaatcctgccaac
agtgcaaggaagcctggttcagcaggtggccctaaggttggaggtgcttctaaggaagga
ggtgctggagcagttgatgaagatgattttataaaagcttttacagatgtcccttctatt
cagatttattctagtcgagaactcgaagaaacattaaataaaatcagggaaattttgtca
gatgataaacatgactgggatcagcgtgccaatgcactgaagaaaattcgatcactgctt
gttgctggagctgcacagtatgattgcttttttcaacatttacgattgttggatggagca
cttaaactttcagctaaggatcttagatcccaggtggttagagaagcttgtattactgta
gcccacctttcaacagttttgggaaacaagtttgatcatggcgctgaagccattgtacct
acactttttaatctcgtccccaatagtgcaaaagtcatggcaacttctggatgtgcagca
atcagatttatcattcggcatactcatgtacccagacttatacctttaataacaagcaat
tgcacatcaaaatcagttcccgtgaggagacgttcatttgaatttttagatttattgttg
caagagtggcagactcattcattggaaagacatgcagccgtcttggttgaaactattaaa
aagggaattcatgatgctgacgctgaggccagagtggaggcaagaaagacatacatgggt
cttagaaaccactttcctggtgaagctgaaacattatataattcccttgagccatcttat
cagaagagtcttcaaacttacttaaagagttctggcagtgtagcatctcttccacaatca
gacaggtcctcatccagctcacaggaaagtctcaatcgccctttttcttccaaatggtct
acagcaaatccatcaactgtggctggaagagtatcagcaggcagcagcaaagccagttcc
cttccaggaagcctgcagcgttcacgaagtgacattgatgtgaatgctgctgcaggtgcc
aaggcacatcatgctgctggacagtctgtgcgaagcgggcgcttaggtgcaggtgccctg
aatgcaggttcctatgcgtcactagaggatacttctgacaagctggatggaacagcatct
gaagatggccgggtgagagcaaaactttcagcaccacttgctggcatgggaaatgccaag
gcagattctagaggaagaagtcgaacaaaaatggtgtctcaatcacagcctggtagccgg
tctgggtctccaggaagagttctgaccacaacagccctgtccactgtgagctctggtgtt
caaagagtcctggtcaattcagcctcagcacaaaaaagaagcaagataccacggagccag
ggctgtagcagagaggctagtccatctaggctttcagtggcccgaagcagtcgtattcct
cgaccaagtgtgagtcaaggatgcagccgggaagctagtcgggagagcagcagagacaca
agtcctgttcgctcttttcagcccctcgcctccagacaccattccagatcaactggtgcc
ctctacgcccccgaagtgtatggggcctcaggtccaggttatgggatcagccaatcaagt
cgactgtcgtcttctgttagtgccatgcgagtcctgaacacaggttctgatgtggaggag
gcggtggcagatgccttgaaaaaaccagctcgaagaagatatgaatcatatggaatgcat
tcagatgatgacgccaacagcgatgcatctagtgcttgttcagaacgctcctatagttct
cgaaatggtagtattcctacatatatgaggcagacggaagatgtggcagaagtcctcaat
agatgtgctagttccaattggtcagaaaggaaagaaggcctcctaggtctgcagaactta
ttaaaaaatcagagaacactaagtcgagttgaactgaaaagattatgtgaaattttcaca
agaatgtttgctgaccctcatggcaagagagtattcagcatgtttttggagactctagtg
gatttcatacaagtccacaaagatgatcttcaagattggttgtttgtactgctgacacaa
ctactaaaaaaaatgggtgctgatttgcttggatctgttcaggcaaaagttcagaaagcc
cttgatgttacaagagagtcttttccaaatgatcttcagttcaatattctaatgagattt
acagttgatcagacccagacaccaagcttaaaggtgaaggttgctatccttaaatacata
gaaactctggccaaacagatggatccaggagattttataaattccagtgaaactcgccta
gcagtgtctcgggtcatcacttggacaacagaacccaaaagttctgatgttcggaaggca
gcacagtcagtgctgatttcattatttgaactcaataccccagagtttacaatgttatta
ggagctttaccaaaaacttttcaggatggtgctaccaagcttcttcataatcaccttcga
aacactggcaatggaacccagagttccatggggagtcctttgacaagaccaacaccacga
tcaccagctaactggtccagtcctcttacttctcctaccaatacatcacagaatacttta
tctccaagtgcatttgattatgacacagaaaatatgaactctgaagatatttatagctct
cttagaggtgtcactgaagcaatccagaatttcagcttccgtagccaagaagatatgaat
gagccattgaaaagggattctaaaaaagatgatggcgattcaatgtgtggtggtcctggg
atgtctgacccaagagcaggaggtgatgctactgactcaagtcaaacagctcttgataat
aaagcttcattgctccattcaatgcctactcactcctctccacgctctcgagactataat
ccatataactattcagatagcatcagtcccttcaacaagtctgccctcaaggaagccatg
tttgatgatgatgctgaccagtttcctgacgatctttccctagatcattctgacctagtt
gcagagttgttgaaggagctgtctaaccataatgagcgtgtagaagaaagaaaaattgcc
ctctatgaacttatgaaactgacacaggaagaatcttttagtgtttgggatgaacacttc
aaaacaatattgcttttattgcttgaaacgcttggagataaagagcctacaatcagggct
ttggcattaaaggttttaagagaaatcctaaggcatcaaccagcaagatttaaaaactat
gcagaattgactgtcatgaaaacattggaagcacataaagatcctcataaggaggtggtg
agatctgctgaggaagcggcatcagtgttggccacttcaattagtccagagcagtgcatc
aaagtgctttgtcctatcattcaaactgcagactacccaattaatctggctgcaatcaaa
atgcaaacaaaagtgatagagagagtgtccaaggaaaccctaaacctgcttttgccagag
attatgccaggtctaatacagggttatgataattcagagagcagtgttcggaaagcttgt
gtcttctgcctggtggctgttcatgcggtaattggtgatgaactaaaaccacatctcagt
caacttactggcagtaaaatgaagctactgaatctttacatcaaacgtgcacaaacaggt
tctggaggagctgatcccactactgatgtttctggacaaagttag

KEGG   Homo sapiens (human): 6249
Entry
6249              CDS       T01001                                 
Symbol
CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN
Name
(RefSeq) CAP-Gly domain-containing linker protein 1 isoform c
  KO
K10421  CAP-Gly domain-containing linker protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
Network
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N01553  Promotion of microtubule growth
N01836  Microtubule plus end regulation network
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    6249 (CLIP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    6249 (CLIP1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    6249 (CLIP1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Microtubule-associated proteins
     6249 (CLIP1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Cytoplasmic linker proteins (CLIPs)
     6249 (CLIP1)
SSDB
Motif
Pfam: CAP_GLY CLIP1 CLIP1_ZNF CCDC39 Fungal_TACC
Other DBs
NCBI-GeneID: 6249
NCBI-ProteinID: NP_001234926
OMIM: 179838
HGNC: 10461
Ensembl: ENSP00000479322.1
UniProt: P30622
Structure
LinkDB
Position
12:complement(122271469..122422956)
AA seq 1438 aa
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKEL
EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG
DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK
ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK
TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA
EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR
KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS
EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE
NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE
LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN
QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD
KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS
KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLE
EERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLR
GENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQE
SQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD
ICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF
NT seq 4317 nt   +upstreamnt  +downstreamnt
atgagtatgctaaagccaagtgggcttaaggcccccaccaagatcctgaagcctggaagc
acagctctgaagacacctacggctgttgtagctccagtagaaaaaaccatatccagtgaa
aaagcatcaagcactccatcatctgagactcaggaggaatttgtggatgactttcgagtt
ggggagcgagtttgggtgaatggaaataagcctggatttatccagtttcttggagaaacc
cagtttgcaccaggccagtgggctggaattgttttagatgaacccataggcaagaacgat
ggttcggtggcaggagttcggtatttccagtgtgaacctttaaagggcatatttacccga
ccttcaaagttaacaaggaaggtgcaagcagaagatgaagctaatggcctgcagacaacg
cccgcctcccgagctacttcaccgctgtgcacttctacggccagcatggtgtcttcctcc
ccctccaccccttcaaacatccctcagaaaccatcacagccagcagcaaaggaaccttca
gctacgcctccgatcagcaaccttacaaaaactgccagtgaatctatctccaacctttca
gaggctggctcaatcaagaaaggagaaagagagctcaaaatcggagacagagtattggtt
ggtggcactaaggctggtgtagtccggtttcttggggagaccgactttgccaagggggag
tggtgtggcgtggagttagatgagccacttgggaagaatgatggcgctgttgctggaaca
aggtattttcagtgtcaacccaaatatggcttgttcgctcctgtccacaaagttaccaag
attggcttcccttccactacaccagccaaagccaaggccaacgcagtgaggcgagtgatg
gcgaccacgtccgccagcctgaagcgcagcccttctgcctcttccctcagctccatgagc
tcagtggcctcctctgtgagcagcaggcccagtcggacaggactattgactgaaacctcc
tcccgttacgccaggaagatctccggtaccactgccctccaggaggccctgaaggagaag
cagcagcacattgagcagctgctggcggaacgggatctggagagggcggaggtggccaag
gccacgagccacgtgggggagatagagcaggagctagctctggcccgggacggacatgac
cagcatgtcctggaattggaagccaaaatggaccagctgcgaacaatggtggaagctgct
gacagggagaaggtggagcttctcaaccagcttgaagaggagaaaaggaaggttgaggac
cttcagttccgggttgaagaagaatcaattaccaaaggtgatcttgagcaaaagagccag
atttctgaagatcctgagaatacgcagaccaaactggagcatgcccgcattaaggagctt
gaacagagcctgctctttgaaaagaccaaagctgacaaactccagagggagttagaagac
actagggtggctacagtttcagaaaagtcacgtataatggaactggagaaagacctagca
ttgagagtacaggaagtagctgagctccgaagaaggctagagtccaataagcctgctggg
gatgtggacatgtcactttcccttttgcaagagataagctctttgcaagaaaagttagaa
gtcacccgtactgaccaccagagagaaataacttctctgaaggagcattttggagcccgg
gaagaaactcatcagaaggagataaaggctctgtataccgccacggaaaagctttccaaa
gagaacgagtcattgaaaagcaagctggagcatgccaacaaagagaactcagatgtgata
gctctatggaagtccaaactggagactgccatcgcatcccaccagcaggcgatggaagaa
ctgaaggtatctttcagcaaagggcttggaacagagacggcagaatttgctgaactaaaa
acacaaatagagaaaatgagactagattaccaacacgaaatagaaaatttgcagaatcaa
caagactctgaacgggctgcccatgctaaagagatggaagccttgagggctaaactgatg
aaagttattaaagaaaaggaaaacagtctggaagccatcaggtcgaaactggacaaagca
gaagaccagcatctcgtagaaatggaagacacgttaaacaaattacaggaagctgaaata
aaggtaaaggagctagaggtactgcaagccaaatgcaatgaacaaaccaaggttattgat
aattttacatcacagctcaaggctactgaagaaaagctcttggatcttgatgcacttcgg
aaagccagttccgaaggtaaatcggaaatgaagaaacttagacagcagcttgaggcagct
gagaaacagattaaacatttagagattgaaaagaatgctgaaagtagcaaggctagtagc
attaccagagagctccaggggagagagctaaagcttactaaccttcaggaaaatttgagt
gaagtcagtcaagtgaaagagactttggaaaaagaacttcagattttgaaagaaaagttt
gctgaagcttcagaggaggcagtctctgttcagagaagtatgcaagaaactgtaaataag
ttacaccaaaaggaggaacagtttaacatgctgtcttctgacttggagaagctgagagaa
aacttagcagatatggaggcaaaatttagagagaaagatgagagagaagagcagctgata
aaggcaaaggaaaaactggaaaatgacattgcagaaataatgaagatgtcaggagataac
tcttctcagctgacaaaaatgaacgatgaattacgtctgaaagaaagagatgtagaagaa
ttacagctaaaacttacaaaggctaatgaaaatgcaagttttctgcaaaaaagtattgag
gacatgactgtcaaagctgaacagagccagcaagaagcagctaaaaagcatgaggaagaa
aagaaagaattggagaggaaattgtcggacctggaaaagaaaatggaaacaagccacaac
cagtgtcaggagctgaaagccaggtatgagagagccacttctgagacaaaaaccaagcat
gaagaaatcctacagaacctccagaagacgctgctggacacagaggacaagctgaagggc
gcacgggaggagaacagtggcttgctgcaggagctggaggagctgagaaagcaagccgac
aaagccaaagctgctcaaacagcggaagatgccatgcagataatggaacagatgaccaaa
gagaagactgagactctggcctccttggaggacaccaagcaaacaaatgcaaaactacag
aatgaattggacacacttaaagaaaacaacttgaaaaatgtggaagagctgaacaaatca
aaagaactcctgactgtagagaatcaaaaaatggaagaatttaggaaagaaatagaaacc
ctaaagcaggcagcagctcagaagtcccagcagctttcagcgttgcaagaagagaacgtt
aaacttgctgaggagctggggagaagcagggacgaagtcacaagtcatcaaaagctggaa
gaagaaagatctgtgctcaataatcagttgttagaaatgaaaaaaagagaatccaagttc
ataaaagacgcagatgaagagaaagcttccttgcagaaatccatcagtataactagtgcc
ttactcacagaaaaggatgccgagctggagaaactgagaaatgaggtcacagtgctcagg
ggagaaaacgcctctgccaagtccttgcattcagttgttcagactctagagtctgataag
gtgaagctcgagctcaaggtaaagaacttggagcttcaactcaaagaaaacaagaggcag
ctcagcagctcctcaggtaatacagacactcaggcagacgaggatgaaagagcccaggag
agtcagattgatttcctaaattcagtaatagtggaccttcaaaggaagaatcaagacctc
aagatgaaggtggagatgatgtcagaagcagccctgaatgggaacggggatgacctaaac
aattatgacagtgatgatcaggagaaacagtccaagaagaaacctcgcctcttctgtgac
atttgtgactgctttgatctccacgacacagaggattgtcctacccaggcacagatgtca
gaggaccctccccattccacacaccatggcagtcggggtgaggaacgcccatactgtgaa
atctgtgagatgtttggacactgggccaccaactgcaatgacgacgaaaccttctga

KEGG   Homo sapiens (human): 7461
Entry
7461              CDS       T01001                                 
Symbol
CLIP2, CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4
Name
(RefSeq) CAP-Gly domain-containing linker protein 2 isoform 1
  KO
K10422  CAP-Gly domain-containing linker protein 2
Organism
hsa  Homo sapiens (human)
Network
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N01553  Promotion of microtubule growth
N01836  Microtubule plus end regulation network
Disease
H01439  Williams-Beuren syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7461 (CLIP2)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Cytoplasmic linker proteins (CLIPs)
     7461 (CLIP2)
SSDB
Motif
Pfam: CAP_GLY CLIP1 Fungal_TACC Sas10
Other DBs
NCBI-GeneID: 7461
NCBI-ProteinID: NP_003379
OMIM: 603432
HGNC: 2586
Ensembl: ENSP00000223398.6
UniProt: Q9UDT6 A0A140VJG6
Structure
LinkDB
Position
7:74289407..74405935
AA seq 1046 aa
MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA
PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN
DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL
TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE
TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK
TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA
LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL
VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE
KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA
EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ
QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH
QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE
AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV
ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT
ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ
ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL
DKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK
AQTIGNSGSANGIHQQDKAQKQEDKH
NT seq 3141 nt   +upstreamnt  +downstreamnt
atgcagaagcccagcggcctgaagccccccggccgtggggggaagcactccagccccatg
ggccggacatctactgggtcagcttcatcctcggcggcggtggccgctagctccaaggaa
ggctccccactgcacaaacagtcatctggaccctcctcctccccggccgcagctgctgcc
cccgagaagccgggccccaaggcggcggaagtgggggatgacttcctgggggactttgtg
gtgggcgagcgggtgtgggtgaacggcgtgaagccaggcgtggtgcagtatctgggagag
acgcagttcgcaccgggccagtgggctggcgtggtgctggacgacccggtgggcaagaat
gatggcgcggtgggcggcgtgcgctacttcgagtgcccggccctccagggtatcttcacg
cggccctccaagctgacccggcagcccacggccgagggctcggggagtgatgcccactcc
gtggagtcgctgactgcccagaacctgtcattgcattcgggcacggccacgcccccgctg
accagccgcgtcatccccctgcgggagagcgtcctcaacagctccgtgaagactggcaac
gagtcgggatccaacctctcagacagcggctctgtgaagcggggcgaaaaggacctgcgc
ctgggggaccgcgtgctggttggcgggacgaagactggcgtggtgcggtacgtgggggag
acagactttgccaagggcgagtggtgtggcgtggagctggacgagccccttgggaagaat
gatggggcggtggcgggcaccaggtacttccagtgcccacccaagtttggtctcttcgcg
cccatccacaaagtgatccgtatcggcttcccatctaccagcccagccaaggccaagaag
accaagcgtatggccatgggtgtgtcagcactgacccacagtcccagcagttcctccatc
agctccgtcagctctgtggcctcctccgtggggggtcggcccagccgcagtggcctgctc
acggagacctcttcacgctacgcccgcaagatctcgggcaccacggccttgcaggaggca
ctgaaggagaagcagcagcacattgagcagctgctggctgaacgagacctggaacgggct
gaggtggccaaggccacaagccacatctgcgaggtggagaaggagattgccctgctcaag
gcacagcatgagcagtatgttgcagaagccgaggagaagctgcagcgagcccggctgctc
gtggagagcgtgcggaaagagaaggtggacctgtccaaccagctggaggaggagaggagg
aaggtggaggatctgcagttccgcgtggaggaggagtccatcaccaagggagacctggag
acccagacgcagctggagcacgcgcgcattggggagctggaacagagcctgctactggag
aaggcgcaggccgagcggctgctccgagaattagcggacaacaggctgaccacagtggcc
gagaagtcgcgcgtgctgcagctggaggaggagctcaccctgcgccgaggtgaaatcgag
gagctccagcagtgcctgttgcactcgggtcccccacctccggaccacccagacgccgcc
gagatcctgcggctacgggagcggctgctctcggccagcaaggaacaccagagggagagt
ggggtgctgcgggataaatacgagaaggccctgaaggcctaccaggcggaggtggacaag
ctccgcgcggccaacgagaagtacgcacaggaggtggcgggcctgaaggacaaggttcag
caggccaccagcgagaacatggggctaatggacaactggaaatccaagctggactcgctg
gcctcggaccaccagaagtccctggaggacctcaaagccaccctgaactcgggcccaggc
gcccagcagaaggagatcggcgagctgaaggcagtgatggagggcatcaagatggagcac
cagctggagctgggtaacttgcaggccaagcatgacctggagaccgccatgcacgtgaag
gagaaggaggccctgcgagagaagctgcaggaggcccaggaggagctggctgggctgcag
cggcactggcgggcccagctggaggtgcaagccagccagcaccggctggagctgcaggag
gcccaggaccagcgccgggatgccgagctgcgtgtgcacgagctggaaaaactggacgtg
gagtaccggggccaggcgcaggctatcgagttcctcaaggagcagatctcgctggccgag
aagaagatgttggactacgagcggctgcagcgggcagaagcccagggcaaacaggaggtc
gagagtttgcgggagaagctcctggtggctgagaacagactccaggcggtcgaggccctg
tgctcctcccagcacacccacatgattgagtcgaatgacatttcagaggagacgatcagg
acgaaggaaactgtggagggcctgcaggacaagctgaacaagagggacaaagaggtgaca
gccttgacctcccagaccgagatgctcagggcccaagtaagtgcgctggagagcaagtgt
aagtcaggcgagaagaaggtggacgccctcctgaaggagaagcggcgcctggaggcagag
ctggagaccgtgtcccggaagacccatgacgcctcgggccagctagtcctcatcagccag
gagctgctgcggaaggagcggagcctgaacgaactgcgggtgttgctgctggaggccaat
cgtcactccccagggccggagagggacctgagccgtgaggtacacaaggctgagtggcgg
atcaaggagcagaaactcaaggatgacatccggggcctgcgtgaaaagctgaccgggctg
gacaaagagaaatccctgtcggatcagaggcgctactccctcatcgaccggtcctcggcg
cccgagcttctgcggctgcagcaccagctgatgagcacggaggacgccctgcgggatgcg
ctggaccaggctcagcaggtggagaagctgatggaggccatgaggagctgccctgacaag
gcccagaccatcggcaattccggttctgcaaacggcatccaccagcaggacaaagctcag
aaacaagaggacaagcactga

KEGG   Homo sapiens (human): 1639
Entry
1639              CDS       T01001                                 
Symbol
DCTN1, DAP-150, DP-150, HMND14, P135
Name
(RefSeq) dynactin subunit 1 isoform 1
  KO
K04648  dynactin 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04145  Phagocytosis
hsa04814  Motor proteins
hsa04962  Vasopressin-regulated water reabsorption
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05132  Salmonella infection
Network
nt06181  Salmonella
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06515  Regulation of kinetochore-microtubule interactions
nt06541  Cytoskeleton in neurons
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01158  Mutation-caused aberrant DCTN1 to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
N01295  Rab7-regulated microtubule minus-end directed transport
N01534  Dynein recruitment to the kinetochore
N01836  Microtubule plus end regulation network
N01846  Retrograde axonal/dendrite transport, Dynein
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00856  Distal hereditary motor neuropathies
H00879  Perry syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    1639 (DCTN1)
  09142 Cell motility
   04814 Motor proteins
    1639 (DCTN1)
 09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1639 (DCTN1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    1639 (DCTN1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    1639 (DCTN1)
   05016 Huntington disease
    1639 (DCTN1)
   05022 Pathways of neurodegeneration - multiple diseases
    1639 (DCTN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1639 (DCTN1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1639 (DCTN1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1639 (DCTN1)
Membrane trafficking [BR:hsa04131]
 Endosome - Golgi transport
  Rab GTPases and associated proteins
   Rab associated proteins
    1639 (DCTN1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     1639 (DCTN1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     1639 (DCTN1)
SSDB
Motif
Pfam: Dynactin CAP_GLY DUF8221 CCDC39 TMF_DNA_bd
Other DBs
NCBI-GeneID: 1639
NCBI-ProteinID: NP_004073
OMIM: 601143
HGNC: 2711
Ensembl: ENSP00000487279.2
UniProt: Q14203 Q6MZZ3
Structure
LinkDB
Position
2:complement(74361155..74391866)
AA seq 1278 aa
MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGV
ILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKRE
GTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSS
SEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAE
DKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADT
ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL
KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE
STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE
TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA
SVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPG
GDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSL
SLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPL
TKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDI
ALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAV
LQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTM
NKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLK
IKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQ
ADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGS
VPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPG
SELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVE
KLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRH
RLVLTQEQLHQLHSRLIS
NT seq 3837 nt   +upstreamnt  +downstreamnt
atggcacagagcaagaggcacgtgtacagccggacgcccagcggcagcaggatgagtgcg
gaggcaagcgcccggcctctgcgggtgggctcccgtgtagaggtgattggaaaaggccac
cgaggcactgtggcctatgttggagccacactgtttgccactggcaaatgggtaggcgtg
attctggatgaagcaaagggcaaaaatgatggaactgttcaaggcaggaagtacttcact
tgtgatgaagggcatggcatctttgtgcgccagtcccagatccaggtatttgaagatgga
gcagatactacttccccagagacacctgattcttctgcttcaaaagtcctcaaaagagag
ggaactgatacaactgcaaagactagcaaactgcggggactgaagcctaagaaggcaccg
acagcccgaaagaccacaactcggcgacccaagcccacgcgcccagccagtactggggtg
gctggggccagtagctccctgggcccctctggctcagcgtcagcaggtgagctgagcagc
agtgagcccagcaccccggctcagactccgctggcagcacccatcatccccacgccggtc
ctcacctctcctggagcagtccccccgcttccttccccatccaaggaggaggagggacta
agggctcaggtgcgggacctggaggagaaactagagaccctgagactgaaacgggcagaa
gacaaagcaaagctaaaagagctggagaaacacaaaatccagctggagcaggtgcaggaa
tggaagagcaaaatgcaggagcagcaggccgacctgcagcggcgcctcaaggaggcgaga
aaggaagccaaggaggcgctggaggcaaaggaacgctatatggaggagatggctgatact
gctgatgccattgagatggccactttggacaaggagatggctgaagagcgggctgagtcc
ctgcagcaggaggtggaggcactgaaggagcgggtggacgagctcactactgacttagag
atcctcaaggctgagattgaagagaagggctcagatggcgctgcatccagttatcagctc
aagcagcttgaggagcagaatgcccgcctgaaggatgccctggtgaggatgcgggatctt
tcttcctcagagaagcaggagcatgtgaagctccagaagctcatggaaaagaagaaccaa
gagctggaagttgtgaggcaacagcgggagcgtctgcaggaggagctaagccaggcagag
agcaccattgatgagctcaaggagcaggtggatgctgctctgggtgctgaggagatggtg
gagatgctgacagatcggaacctgaatctggaagagaaagtgcgcgagttgagggagact
gtgggagacttggaagcgatgaatgagatgaacgatgagctgcaggagaatgcacgtgag
acagaactggagctgcgggagcagctggacatggcaggcgcgcgggttcgtgaggcccag
aagcgtgtggaggcagcccaggagacggttgcagactaccagcagaccatcaagaagtac
cgccagctgaccgcccatctacaggatgtgaatcgggaactgacaaaccagcaggaagca
tctgtggagaggcaacagcagccacctccagagacctttgacttcaaaatcaagtttgct
gagactaaggcccatgccaaggcaattgagatggaattgaggcagatggaggtggcccag
gccaatcgacacatgtccctgctgacagccttcatgcctgacagcttccttcggccaggt
ggggaccatgactgcgttctggtgctgttgctcatgcctcgtctcatttgcaaggcagag
ctgatccggaagcaggcccaggagaagtttgaactaagtgagaactgttcagagcggcct
gggctgcgaggagctgctggggagcaactcagctttgctgctggactggtgtactcgctg
agcctgctgcaggccacgctacaccgctatgagcatgccctctctcagtgcagtgtggat
gtgtataagaaagtgggcagcctgtaccctgagatgagtgcccatgagcgctccttggat
ttcctcattgaactgctgcacaaggatcagctggatgagactgtcaatgtggagcctctc
accaaggccatcaagtactatcagcatctgtacagcatccaccttgccgaacagcctgag
gactgtactatgcagctggctgaccacattaagttcacgcagagtgctctggactgcatg
agtgtggaggtaggacggctgcgtgccttcttgcagggtgggcaggaggctacagatatt
gccctcctgctccgggatctggaaacttcatgcagtgacatccgccagttctgcaagaag
atccgaaggcgaatgccagggacagatgctcctgggatcccagctgcactggcctttgga
ccacaggtatctgacacgctcctagactgcaggaaacacttgacgtgggtcgtggctgtg
ctgcaggaggtggcagctgctgctgcccagctcattgccccactggcagagaatgagggg
ctacttgtggctgctctggaggaactggctttcaaagcaagcgagcagatctatgggacc
ccctccagcagcccctatgagtgtctgcgccagtcatgcaacatcctcatcagtaccatg
aacaagctggccacagccatgcaggagggggagtatgatgcagagcggccccccagcaag
cctccaccggttgaactgcgggctgctgcccttcgtgcagagatcacagatgctgaaggc
ctgggtttgaagctcgaagatcgagagacagttattaaggagttgaagaagtcactcaag
attaagggagaggagctaagtgaggccaatgtgcggctgagcctcctggagaagaagttg
gacagtgctgccaaggatgcagatgagcgcatcgagaaagtccagactcggctggaggag
acccaggcactgctgcgaaagaaggagaaagagtttgaggagacaatggatgcactccag
gctgacatcgaccagctggaggcagagaaggcagaactaaagcagcgtctgaacagccag
tccaaacgcacgattgagggactccggggccctcctccttcaggcattgctactctggtc
tctggcattgctggtgaagaacagcagcgaggagccatccctgggcaggctccagggtct
gtgccaggcccagggctggtgaaggactcaccactgctgcttcagcagatctctgccatg
aggctgcacatctcccagctccagcatgagaacagcatcctcaagggagcccagatgaag
gcatccttggcatccctgccccctctgcatgttgcaaagctatcccatgagggccctggc
agtgagttaccagctggagcgctgtatcgtaagaccagccagctgctggagacattgaat
caattgagcacacacacgcacgtagtagacatcactcgcaccagccctgctgccaagagc
ccgtcggcccaacttatggagcaagtggctcagcttaagtccctgagtgacaccgtcgag
aagctcaaggatgaggtcctcaaggagacagtatctcagcgccctggagccacagtaccc
actgactttgccaccttcccttcatcagccttcctcagggccaaggaggagcagcaggat
gacacagtctacatgggcaaagtgaccttctcatgtgcggctggttttggacagcgacac
cggctggtgctgacccaggagcagctgcaccagcttcacagtcgcctcatctcctaa

DBGET integrated database retrieval system