| Entry |
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| Symbol |
EIF2AK2, DYT33, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR
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| Name |
(RefSeq) interferon-induced, double-stranded RNA-activated protein kinase isoform a
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| KO |
| K16195 | eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1] |
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| Organism |
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| Pathway |
| hsa04156 | Integrated stress response (ISR) signaling pathway |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
| hsa05168 | Herpes simplex virus 1 infection |
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| Network |
nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06171 SARS coronavirus 2 (SARS-CoV-2) nt06222 IFN signaling (cancer) nt06263 Hepatocellular carcinoma nt06517 TLR signaling nt06552 Integrated stress response (ISR) signaling pathway |
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| Element |
| N00150 | Type I IFN signaling pathway |
| N00571 | PKR-eIF2alpha signaling pathway |
| N00573 | HSV US11 to PKR-eIF2alpha signaling pathway |
| N00696 | MV C to PKR-eIF2alpha signaling pathway |
| N00725 | IAV NS1 to PKR-eIF2alpha signaling pathway |
| N00726 | IAV NP to PKR-eIF2alpha signaling pathway |
| N02047 | EIF2B inhibition by phosphorylation of eIF2alpha |
| N02048 | Inactive complex formation by phosphorylation of eIF2alpha |
| N02049 | Dephosphorylation of p-eIF2alpha |
| N02053 | Adaptive response of the ISR during mitochondrial stress |
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| Disease |
| H02457 | Developmental delay, leukoencephalopathy, and neurologic decompensation |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
5610 (EIF2AK2)
04156 Integrated stress response (ISR) signaling pathway
5610 (EIF2AK2)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
5610 (EIF2AK2)
09172 Infectious disease: viral
05160 Hepatitis C
5610 (EIF2AK2)
05171 Coronavirus disease
5610 (EIF2AK2)
05164 Influenza A
5610 (EIF2AK2)
05162 Measles
5610 (EIF2AK2)
05168 Herpes simplex virus 1 infection
5610 (EIF2AK2)
05167 Kaposi sarcoma-associated herpesvirus infection
5610 (EIF2AK2)
05169 Epstein-Barr virus infection
5610 (EIF2AK2)
05165 Human papillomavirus infection
5610 (EIF2AK2)
09164 Neurodegenerative disease
05010 Alzheimer disease
5610 (EIF2AK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5610 (EIF2AK2)
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5610 (EIF2AK2)
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:hsa03019]
5610 (EIF2AK2)
03012 Translation factors [BR:hsa03012]
5610 (EIF2AK2)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
5610 (EIF2AK2)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
PEK family [OT]
5610 (EIF2AK2)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
5610 (EIF2AK2)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
P-body specific factors
5610 (EIF2AK2)
Translation factors [BR:hsa03012]
Eukaryotic type
Initiation factors
Initiation associated factors
5610 (EIF2AK2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
2:complement(37099210..37156980)
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| AA seq |
551 aa
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC |
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| NT seq |
1656 nt +upstreamnt +downstreamnt
atggctggtgatctttcagcaggtttcttcatggaggaacttaatacataccgtcagaag
cagggagtagtacttaaatatcaagaactgcctaattcaggacctccacatgataggagg
tttacatttcaagttataatagatggaagagaatttccagaaggtgaaggtagatcaaag
aaggaagcaaaaaatgccgcagccaaattagctgttgagatacttaataaggaaaagaag
gcagttagtcctttattattgacaacaacgaattcttcagaaggattatccatggggaat
tacataggccttatcaatagaattgcccagaagaaaagactaactgtaaattatgaacag
tgtgcatcgggggtgcatgggccagaaggatttcattataaatgcaaaatgggacagaaa
gaatatagtattggtacaggttctactaaacaggaagcaaaacaattggccgctaaactt
gcatatcttcagatattatcagaagaaacctcagtgaaatctgactacctgtcctctggt
tcttttgctactacgtgtgagtcccaaagcaactctttagtgaccagcacactcgcttct
gaatcatcatctgaaggtgacttctcagcagatacatcagagataaattctaacagtgac
agtttaaacagttcttcgttgcttatgaatggtctcagaaataatcaaaggaaggcaaaa
agatctttggcacccagatttgaccttcctgacatgaaagaaacaaagtatactgtggac
aagaggtttggcatggattttaaagaaatagaattaattggctcaggtggatttggccaa
gttttcaaagcaaaacacagaattgacggaaagacttacgttattaaacgtgttaaatat
aataacgagaaggcggagcgtgaagtaaaagcattggcaaaacttgatcatgtaaatatt
gttcactacaatggctgttgggatggatttgattatgatcctgagaccagtgatgattct
cttgagagcagtgattatgatcctgagaacagcaaaaatagttcaaggtcaaagactaag
tgccttttcatccaaatggaattctgtgataaagggaccttggaacaatggattgaaaaa
agaagaggcgagaaactagacaaagttttggctttggaactctttgaacaaataacaaaa
ggggtggattatatacattcaaaaaaattaattcatagagatcttaagccaagtaatata
ttcttagtagatacaaaacaagtaaagattggagactttggacttgtaacatctctgaaa
aatgatggaaagcgaacaaggagtaagggaactttgcgatacatgagcccagaacagatt
tcttcgcaagactatggaaaggaagtggacctctacgctttggggctaattcttgctgaa
cttcttcatgtatgtgacactgcttttgaaacatcaaagtttttcacagacctacgggat
ggcatcatctcagatatatttgataaaaaagaaaaaactcttctacagaaattactctca
aagaaacctgaggatcgacctaacacatctgaaatactaaggaccttgactgtgtggaag
aaaagcccagagaaaaatgaacgacacacatgttag |
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