KEGG   Homo sapiens (human): 5029
Entry
5029              CDS       T01001                                 
Symbol
P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R
Name
(RefSeq) purinergic receptor P2Y2
  KO
K04269  P2Y purinoceptor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04148  Efferocytosis
hsa04750  Inflammatory mediator regulation of TRP channels
Network
nt06535  Efferocytosis
  Element
N01747  Find-me signal (nucleotide)
Drug target
Denufosol tetrasodium: D03685
Diquafosol tetrasodium: D03864<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5029 (P2RY2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5029 (P2RY2)
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5029 (P2RY2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5029 (P2RY2)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Purine / pyrimidine
    5029 (P2RY2)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srx
Other DBs
NCBI-GeneID: 5029
NCBI-ProteinID: NP_002555
OMIM: 600041
HGNC: 8541
Ensembl: ENSG00000175591
Pharos: P41231(Tclin)
UniProt: P41231
LinkDB
Position
11:73218281..73242427
AA seq 377 aa
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLC
RLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCS
ILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGR
VTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAK
RKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSC
LDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSR
RTESTPAGSENTKDIRL
NT seq 1134 nt   +upstreamnt  +downstreamnt
atggcagcagacctgggcccctggaatgacaccatcaatggcacctgggatggggatgag
ctgggctacaggtgccgcttcaacgaggacttcaagtacgtgctgctgcctgtgtcctac
ggcgtggtgtgcgtgcctgggctgtgtctgaacgccgtggcgctctacatcttcttgtgc
cgcctcaagacctggaatgcgtccaccacatatatgttccacctggctgtgtctgatgca
ctgtatgcggcctccctgccgctgctggtctattactacgcccgcggcgaccactggccc
ttcagcacggtgctctgcaagctggtgcgcttcctcttctacaccaacctttactgcagc
atcctcttcctcacctgcatcagcgtgcaccggtgtctgggcgtcttacgacctctgcgc
tccctgcgctggggccgggcccgctacgctcgccgggtggccggggccgtgtgggtgttg
gtgctggcctgccaggcccccgtgctctactttgtcaccaccagcgcgcgcgggggccgc
gtaacctgccacgacacctcggcacccgagctcttcagccgcttcgtggcctacagctca
gtcatgctgggcctgctcttcgcggtgccctttgccgtcatccttgtctgttacgtgctc
atggctcggcgactgctaaagccagcctacgggacctcgggcggcctgcctagggccaag
cgcaagtccgtgcgcaccatcgccgtggtgctggctgtcttcgccctctgcttcctgcca
ttccacgtcacccgcaccctctactactccttccgctcgctggacctcagctgccacacc
ctcaacgccatcaacatggcctacaaggttacccggccgctggccagtgctaacagttgc
cttgaccccgtgctctacttcctggctgggcagaggctcgtacgctttgcccgagatgcc
aagccacccactggccccagccctgccaccccggctcgccgcaggctgggcctgcgcaga
tccgacagaactgacatgcagaggatagaagatgtgttgggcagcagtgaggactctagg
cggacagagtccacgccggctggtagcgagaacactaaggacattcggctgtag

KEGG   Homo sapiens (human): 5031
Entry
5031              CDS       T01001                                 
Symbol
P2RY6, P2Y6
Name
(RefSeq) pyrimidinergic receptor P2Y6
  KO
K04272  P2Y purinoceptor 6
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04148  Efferocytosis
Network
nt06535  Efferocytosis
  Element
N01747  Find-me signal (nucleotide)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5031 (P2RY6)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5031 (P2RY6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    5031 (P2RY6)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Purine / pyrimidine
    5031 (P2RY6)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srv
Other DBs
NCBI-GeneID: 5031
NCBI-ProteinID: NP_001264133
OMIM: 602451
HGNC: 8543
Ensembl: ENSG00000171631
Pharos: Q15077(Tchem)
UniProt: Q15077
LinkDB
Position
11:73264506..73298625
AA seq 328 aa
MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTR
TAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCI
SFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDL
SPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARM
AVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPIL
FYFTQKKFRRRPHELLQKLTAKWQRQGR
NT seq 987 nt   +upstreamnt  +downstreamnt
atggaatgggacaatggcacaggccaggctctgggcttgccacccaccacctgtgtctac
cgcgagaacttcaagcaactgctgctgccacctgtgtattcggcggtgctggcggctggc
ctgccgctgaacatctgtgtcattacccagatctgcacgtcccgccgggccctgacccgc
acggccgtgtacaccctaaaccttgctctggctgacctgctatatgcctgctccctgccc
ctgctcatctacaactatgcccaaggtgatcactggccctttggcgacttcgcctgccgc
ctggtccgcttcctcttctatgccaacctgcacggcagcatcctcttcctcacctgcatc
agcttccagcgctacctgggcatctgccacccgctggccccctggcacaaacgtgggggc
cgccgggctgcctggctagtgtgtgtagccgtgtggctggccgtgacaacccagtgcctg
cccacagccatcttcgctgccacaggcatccagcgtaaccgcactgtctgctatgacctc
agcccgcctgccctggccacccactatatgccctatggcatggctctcactgtcatcggc
ttcctgctgccctttgctgccctgctggcctgctactgtctcctggcctgccgcctgtgc
cgccaggatggcccggcagagcctgtggcccaggagcggcgtggcaaggcggcccgcatg
gccgtggtggtggctgctgcctttgccatcagcttcctgccttttcacatcaccaagaca
gcctacctggcagtgcgctcgacgccgggcgtcccctgcactgtattggaggcctttgca
gcggcctacaaaggcacgcggccgtttgccagtgccaacagcgtgctggaccccatcctc
ttctacttcacccagaagaagttccgccggcgaccacatgagctcctacagaaactcaca
gccaaatggcagaggcagggtcgctga

KEGG   Homo sapiens (human): 64805
Entry
64805             CDS       T01001                                 
Symbol
P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
Name
(RefSeq) purinergic receptor P2Y12
  KO
K04298  P2Y purinoceptor 12
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04611  Platelet activation
Network
nt06535  Efferocytosis
  Element
N01747  Find-me signal (nucleotide)
Disease
H01235  Bleeding disorder platelet-type
Drug target
Cangrelor (DG01294): D03359 D03361<US>
Clopidogrel (DG00155): D00769<JP/US> D07729 D10823 D10824
Elinogrel (DG01295): D09607 D09608
Prasugrel: D05597<JP/US>
Regrelor disodium: D08983
Ticagrelor: D09017<JP/US>
Ticlopidine (DG00156): D01028<JP> D08594
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    64805 (P2RY12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    64805 (P2RY12)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    64805 (P2RY12)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Base and nucleoside
   Purine / pyrimidine
    64805 (P2RY12)
SSDB
Motif
Pfam: 7tm_1
Other DBs
NCBI-GeneID: 64805
NCBI-ProteinID: NP_073625
OMIM: 600515
HGNC: 18124
Ensembl: ENSG00000169313
Pharos: Q9H244(Tclin)
UniProt: Q9H244 A8K7T1
Structure
LinkDB
Position
3:complement(151336843..151384753)
AA seq 342 aa
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
NT seq 1029 nt   +upstreamnt  +downstreamnt
atgcaagccgtcgacaacctcacctctgcgcctggtaacaccagtctgtgcaccagagac
tacaaaatcacccaggtcctcttcccactgctctacactgtcctgttttttgttggactt
atcacaaatggcctggcgatgaggattttctttcaaatccggagtaaatcaaactttatt
atttttcttaagaacacagtcatttctgatcttctcatgattctgacttttccattcaaa
attcttagtgatgccaaactgggaacaggaccactgagaacttttgtgtgtcaagttacc
tccgtcatattttatttcacaatgtatatcagtatttcattcctgggactgataactatc
gatcgctaccagaagaccaccaggccatttaaaacatccaaccccaaaaatctcttgggg
gctaagattctctctgttgtcatctgggcattcatgttcttactctctttgcctaacatg
attctgaccaacaggcagccgagagacaagaatgtgaagaaatgctctttccttaaatca
gagttcggtctagtctggcatgaaatagtaaattacatctgtcaagtcattttctggatt
aatttcttaattgttattgtatgttatacactcattacaaaagaactgtaccggtcatac
gtaagaacgaggggtgtaggtaaagtccccaggaaaaaggtgaacgtcaaagttttcatt
atcattgctgtattctttatttgttttgttcctttccattttgcccgaattccttacacc
ctgagccaaacccgggatgtctttgactgcactgctgaaaatactctgttctatgtgaaa
gagagcactctgtggttaacttccttaaatgcatgcctggatccgttcatctattttttc
ctttgcaagtccttcagaaattccttgataagtatgctgaagtgccccaattctgcaaca
tctctgtcccaggacaataggaaaaaagaacaggatggtggtgacccaaatgaagagact
ccaatgtaa

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