Homo sapiens (human): 5371
Help
Entry
5371 CDS
T01001
Symbol
PML, MYL, PP8675, RNF71, TRIM19
Name
(RefSeq) PML nuclear body scaffold
KO
K10054
E3 SUMO-protein ligase PML [EC:2.3.2.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04144
Endocytosis
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05221
Acute myeloid leukemia
Network
nt06240
Transcription (cancer)
nt06275
Acute myeloid leukemia
Element
N00109
PML-RARA fusion to transcriptional activtion
N00113
PML-RARA fusion to transcriptional repression
Disease
H00003
Acute myeloid leukemia
H02542
Acute promyelocytic leukemia
Drug target
Arsenic trioxide:
D02106
<JP/US>
Tretinoin (
DG00433
):
D00094
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
5371 (PML)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
5371 (PML)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5371 (PML)
05202 Transcriptional misregulation in cancer
5371 (PML)
09162 Cancer: specific types
05221 Acute myeloid leukemia
5371 (PML)
09172 Infectious disease: viral
05164 Influenza A
5371 (PML)
05168 Herpes simplex virus 1 infection
5371 (PML)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
5371 (PML)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
UBL E3 ligases
5371 (PML)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DUF3583
zf-B_box
zf-C3HC4
zf-RING_5
Imm71
zf-RING_UBOX
Cep57_CLD_2
ExoU_mid_dom
Motif
Other DBs
NCBI-GeneID:
5371
NCBI-ProteinID:
NP_150241
OMIM:
102578
HGNC:
9113
Ensembl:
ENSG00000140464
UniProt:
P29590
Structure
PDB
LinkDB
All DBs
Position
15:73994716..74047827
Genome browser
AA seq
882 aa
AA seq
DB search
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ
HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS
LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA
FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS
NT seq
2649 nt
NT seq
+upstream
nt +downstream
nt
atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag
cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc
cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc
caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc
ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac
acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg
cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc
tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag
cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc
acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc
agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc
agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg
gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag
atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc
gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct
gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat
gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc
tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc
caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag
gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag
aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag
gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg
gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa
ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc
cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg
ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc
cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc
aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc
agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt
gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt
gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa
acccagaagattagccagctggctgcggtgaaccgggaaagcaagttccgcgtggtcatc
cagcctgaagccttcttcagcatctactccaaggccgtgtccctggaggtggggctgcag
cacttcctcagctttctgagctccatgcgccgccctatcttggcctgctacaagctgtgg
gggcctggcctcccaaacttcttccgggccctggaggacattaacaggctgtgggaattc
caggaggccatctcgggcttcctggctgccctgcctctcatccgggagcgtgtgcccggg
gccagcagcttcaaactcaagaacctggcccagacctacctggcgagaaacatgagcgag
cgcagcgccatggctgccgtgctggccatgcgtgacctgtgccgcctcctcgaggtctcc
ccgggcccccagctggcccagcatgtctaccccttcagtagcctgcagtgctttgcctcc
ctgcagcccctggtgcaggcagctgtgctgccccgggctgaggcccgcctcctggcccta
cacaacgtgagcttcatggagctgctgagtgcacaccgccgtgaccggcaggggggcctg
aagaagtacagccgctatctaagcctgcagaccaccacgttgccccctgcccagcctgct
ttcaacctgcaggctctgggcacctactttgaaggcctgttggagggtccggcgctggca
cgggcagaaggagtctccaccccacttgctggccgtggcttggcagagagggcctcccag
cagagctga
Homo sapiens (human): 5914
Help
Entry
5914 CDS
T01001
Symbol
RARA, NR1B1, RAR, RARalpha
Name
(RefSeq) retinoic acid receptor alpha
KO
K08527
retinoic acid receptor alpha
Organism
hsa
Homo sapiens (human)
Pathway
hsa04659
Th17 cell differentiation
hsa04915
Estrogen signaling pathway
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05221
Acute myeloid leukemia
Disease
H02542
Acute promyelocytic leukemia
Drug target
Acitretin:
D02754
<US>
Alitretinoin:
D02815
<US>
Arsenic trioxide:
D02106
<JP/US>
Etretinate:
D00316
<JP>
Fenretinide:
D04162
Isotretinoin (
DG00434
):
D00348
<US>
D04636
Retinol (vit A) (
DG00123
):
D00164
<JP/US>
D01621
D06543
<JP>
D08477
Tamibarotene:
D01418
<JP>
Tazarotene:
D01132
<US>
Tretinoin (
DG00433
):
D00094
<JP/US>
D00094
<JP/US>
D01516
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
5914 (RARA)
09152 Endocrine system
04915 Estrogen signaling pathway
5914 (RARA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5914 (RARA)
05202 Transcriptional misregulation in cancer
5914 (RARA)
09162 Cancer: specific types
05221 Acute myeloid leukemia
5914 (RARA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
5914 (RARA)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
5914 (RARA)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 thyroid hormone receptor-like
5914 (RARA)
Nuclear receptors [BR:
hsa03310
]
1. Thyroid hormone like
1B. Retinoic acid receptor (RAR)
5914 (RARA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C4
Hormone_recep
Motif
Other DBs
NCBI-GeneID:
5914
NCBI-ProteinID:
NP_000955
OMIM:
180240
HGNC:
9864
Ensembl:
ENSG00000131759
UniProt:
P10276
Q6I9R7
Structure
PDB
LinkDB
All DBs
Position
17:40309180..40357643
Genome browser
AA seq
462 aa
AA seq
DB search
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
NT seq
1389 nt
NT seq
+upstream
nt +downstream
nt
atggccagcaacagcagctcctgcccgacacctgggggcgggcacctcaatgggtacccg
gtgcctccctacgccttcttcttcccccctatgctgggtggactctccccgccaggcgct
ctgaccactctccagcaccagcttccagttagtggatatagcacaccatccccagccacc
attgagacccagagcagcagttctgaagagatagtgcccagccctccctcgccaccccct
ctaccccgcatctacaagccttgctttgtctgtcaggacaagtcctcaggctaccactat
ggggtcagcgcctgtgagggctgcaagggcttcttccgccgcagcatccagaagaacatg
gtgtacacgtgtcaccgggacaagaactgcatcatcaacaaggtgacccggaaccgctgc
cagtactgccgactgcagaagtgctttgaagtgggcatgtccaaggagtctgtgagaaac
gaccgaaacaagaagaagaaggaggtgcccaagcccgagtgctctgagagctacacgctg
acgccggaggtgggggagctcattgagaaggtgcgcaaagcgcaccaggaaaccttccct
gccctctgccagctgggcaaatacactacgaacaacagctcagaacaacgtgtctctctg
gacattgacctctgggacaagttcagtgaactctccaccaagtgcatcattaagactgtg
gagttcgccaagcagctgcccggcttcaccaccctcaccatcgccgaccagatcaccctc
ctcaaggctgcctgcctggacatcctgatcctgcggatctgcacgcggtacacgcccgag
caggacaccatgaccttctcggacgggctgaccctgaaccggacccagatgcacaacgct
ggcttcggccccctcaccgacctggtctttgccttcgccaaccagctgctgcccctggag
atggatgatgcggagacggggctgctcagcgccatctgcctcatctgcggagaccgccag
gacctggagcagccggaccgggtggacatgctgcaggagccgctgctggaggcgctaaag
gtctacgtgcggaagcggaggcccagccgcccccacatgttccccaagatgctaatgaag
attactgacctgcgaagcatcagcgccaagggggctgagcgggtgatcacgctgaagatg
gagatcccgggctccatgccgcctctcatccaggaaatgttggagaactcagagggcctg
gacactctgagcggacagccggggggtggggggcgggacgggggtggcctggcccccccg
ccaggcagctgtagccccagcctcagccccagctccaacagaagcagcccggccacccac
tccccgtga
DBGET
integrated database retrieval system