KEGG   Homo sapiens (human): 5426
Entry
5426              CDS       T01001                                 
Symbol
POLE, CRCS12, FILS, IMAGEI, POLE1
Name
(RefSeq) DNA polymerase epsilon, catalytic subunit
  KO
K02324  DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Disease
H00020  Colorectal cancer
H02369  IMAGE-I syndrome
H02370  FILS syndrome
H02568  Polymerase proofreading-associated polyposis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5426 (POLE)
   03410 Base excision repair
    5426 (POLE)
   03420 Nucleotide excision repair
    5426 (POLE)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5426 (POLE)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5426 (POLE)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5426 (POLE)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5426 (POLE)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5426 (POLE)
SSDB
Motif
Pfam: DUF1744 POL2_thumb DNA_pol_B_exo1 zf_DPOE_2 zf-DPOE DNA_pol_B DNA_pol_B_exo2 RNase_H_2 APP_N Translat_reg
Other DBs
NCBI-GeneID: 5426
NCBI-ProteinID: NP_006222
OMIM: 174762
HGNC: 9177
Ensembl: ENSG00000177084
UniProt: Q07864
Structure
LinkDB
Position
12:complement(132623762..132687342)
AA seq 2286 aa
MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKT
GWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFL
SKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQ
DHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHV
AHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMI
DGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMV
TYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVG
SHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFA
LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYV
GGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVC
DEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPG
ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEK
RRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLS
AAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGA
NIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIM
VKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFN
EDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSK
AANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYII
SRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSA
IQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEA
SEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPA
LGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR
RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGAS
YRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVH
LGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALF
GIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETD
LKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYG
VLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRH
NHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTIL
QSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVV
GWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLG
SSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPS
NYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNW
NILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGA
VGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNP
ALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRS
CNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLV
CLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQK
NPQLGH
NT seq 6861 nt   +upstreamnt  +downstreamnt
atgtctctgaggagcggcgggcggcggcgcgcggacccaggcgcggatggcgaggccagc
agggatgatggcgccacttcctcagtttcggcactcaagcgcctggaacggagtcagtgg
acggataagatggatttgcggtttggttttgagcggctgaaggagcctggtgagaagaca
ggctggctcattaacatgcatcctaccgagattttagatgaagataagcgcttaggcagt
gcagtggattactactttattcaagatgacggaagcagatttaaggtggctttgccctat
aaaccgtatttctacattgcgaccagaaagggttgtgagcgagaagtttcatcttttctc
tccaagaagtttcagggcaaaattgcaaaagtggagactgtccccaaagaggatctggac
ttgccaaatcacttggtgggtttgaagcgaaattacatcaggctgtccttccacactgtg
gaggatcttgtcaaagtgaggaaggagatctcccctgccgtgaagaagaacagggagcag
gatcacgccagcgacgcgtacacagctctgctttccagtgttctgcagaggggcggtgtc
attactgatgaagaggaaacctctaagaagatagctgaccagttggacaacattgtggac
atgcgcgagtacgatgttccctaccacatccgcctctccattgacctgaagatccacgtg
gctcattggtacaatgtcagataccgaggaaatgcttttccggtagaaatcacccgccga
gatgaccttgttgaacgacctgaccctgtggttttggcatttgacattgagacgaccaaa
ctgcccctcaagtttcctgatgctgagacagaccagattatgatgatttcctacatgatc
gatggccagggctacctcatcaccaacagggagattgtttcagaagatattgaagatttt
gagttcacccccaagccagaatatgaaggccccttttgtgtcttcaatgaacccgatgag
gctcatctgatccaaaggtggtttgaacacgtccaggagaccaaacccaccatcatggtc
acctacaacggggacttttttgactggccatttgtggaggcccgggcagcagtccacggt
ctgagcatgcagcaggagataggcttccagaaggacagccagggggagtacaaggcgccc
cagtgcatccacatggactgcctcaggtgggtgaagagggacagttaccttcctgtgggc
agtcataatctcaaggcggccgccaaggccaagctaggctatgatcccgtggagctagac
ccggaggacatgtgccggatggccacggagcagccccagactctggccacgtattctgtg
tcagatgctgtcgccacttactacctgtacatgaagtacgtccacccattcatctttgct
ctgtgcaccattattcccatggagcccgacgaggtgctgcggaagggctctggcactctg
tgtgaggccttgctgatggtgcaggccttccacgccaacatcatcttccccaacaagcaa
gagcaggagttcaataagctgacggacgacggacacgtgctggactctgagacctacgtc
gggggccacgtggaggccctcgagtctggggttttccgcagcgatatcccttgccggttt
aggatgaatcctgccgcctttgacttcctgctgcagcgggttgagaagaccttgcgccac
gcccttgaggaagaggagaaagtgcctgtggagcaagtcaccaactttgaagaggtgtgt
gatgagattaagagcaagcttgcctccctgaaggacgttcccagccgcatcgagtgtcca
ctcatctaccacctggacgtgggggccatgtaccccaacatcatcctgaccaaccgcctg
cagccctctgccatggtggacgaagccacctgtgctgcctgtgacttcaataagcctgga
gcaaactgccagcggaagatggcctggcagtggaggggcgagttcatgccagccagtcgc
agcgaataccatcggatccagcaccagctggagtcagagaagttcccccccttgttccca
gaggggccagctcgggcctttcatgaactgtcccgcgaggaacaggcgaaatacgagaag
agaaggctggcggattactgccggaaagcctacaagaagatccacatcaccaaggtggaa
gagcgtctcaccaccatctgccagcgggaaaactccttctacgtggacaccgtgcgtgcc
ttccgggacaggcgttacgagttcaaagggctccacaaggtgtggaaaaagaagctctcg
gcggccgtggaggtgggcgacgcggctgaggtgaagcgctgcaagaacatggaggtgctg
tatgactcgctgcagctggcccacaagtgcatcctgaactccttctatggctatgtcatg
cgcaagggggctcgctggtactccatggagatggctggcatcgtctgcttcacaggggcc
aacatcatcacccaggcacgggagctgatcgagcagattgggaggcccttagagctggac
acagatggtatatggtgcgtcctgcccaacagcttcccagaaaattttgtcttcaagacg
accaatgtgaagaagcccaaagtgaccatctcctacccaggcgccatgttgaacatcatg
gtcaaggaaggcttcaccaatgaccagtaccaggagctggctgagccgtcctcactcacc
tacgtcacccgctcagagaacagcatcttttttgaggttgatgggccctaccttgccatg
attcttccagcctccaaggaagaaggcaagaaattgaagaagaggtatgctgtgttcaat
gaagacggttctctggctgagctcaagggctttgaggtcaaacgccgcggggaactgcag
ctgattaagatcttccaatcctcggtgtttgaggccttcctcaagggcagcacgctggaa
gaggtgtatggctctgtagccaaggtggctgactactggctggacgtgctgtacagcaag
gcagccaacatgcctgactctgagctattcgagctcatctctgagaaccgttccatgtct
cggaagctggaagattacggggagcagaagtctacgtccatcagcacagcaaagcgcctg
gccgagttcctgggagaccagatggtcaaggatgcagggctgagttgccgctacatcatc
tcccgcaagcccgagggctcccctgtcacggagagggccatcccacttgccattttccaa
gcagagcccacggtgaggaagcactttctccggaaatggctcaagagctcttcccttcaa
gactttgatattcgagcaattctggattgggactactacattgagcggctgggaagcgcc
atccagaagatcatcaccatccctgcggccctgcagcaggtaaagaacccagtgccacgt
gtcaaacaccccgactggctgcacaaaaaactgctggagaagaatgatgtctacaagcag
aagaagatcagtgagctcttcaccctggagggcaggagacaggtcacgatggccgaggcc
tcagaagacagtccgaggccaagtgctcctgacatggaggacttcggcctcgtaaagctg
cctcacccagcagcccctgtcactgtgaagaggaagcgagttctttgggagagccaggag
gagtcccaggacctcacgccgactgtgccctggcaggaaatcttggggcagcctcccgcc
ctgggaaccagccaggaggaatggcttgtctggctccggttccacaagaagaagtggcag
ctgcaggcccggcagcgcctcgcccgcaggaagaggcagcgtctggagtcggcagagggt
gtgctcaggcccggggccatccgggatggtcctgccacggggctggggagcttcttgcga
agaactgcccgcagcatcctggaccttccgtggcagattgtgcagatcagcgagaccagc
caggccggcctgttcaggctgtgggcgctcgttggcagtgacttgcactgcatcaggctg
agcatcccccgtgtgttctacgtgaaccagcgagtcgctaaagcggaggagggtgcttcg
tatcgcaaggtaaatcgggtccttcctcgctccaacatggtctacaatctctatgagtat
tcagtgccagaggacatgtaccaggaacacatcaacgagatcaacgctgagctgtcagcg
ccagacatcgagggcgtatatgagactcaggttccgttactgttccgggccctggtgcac
ctgggctgtgtgtgtgtggtcaataaacagctggtgaggcacctttcaggctgggaagca
gagacctttgctcttgagcacctggagatgcgctctctggcccagttcagctacctggaa
ccagggagtatccgccatatctacctgtaccaccacgcacaggcccacaaagcgctcttc
gggatcttcatcccctcacagcgcagggcatccgtctttgtgctggacactgtgcgcagc
aaccagatgcccagccttggcgccctgtactcagcagagcacggcctcctcctggagaag
gtgggccctgagctcctgccaccccccaaacacaccttcgaagttcgggcagaaactgac
ctgaagaccatctgcagagccatccagcgattcctgctcgcctacaaggaggagcgccgg
gggcccacactcatcgctgttcagtccagctgggagctgaagaggctggccagtgaaatt
cctgtcttggaggaattcccactggtgcctatctgtgtggctgacaagatcaactatggg
gtcctggactggcagcgccatggagcccggcgcatgatccgtcactacctcaacctggac
acctgcctgtcgcaggccttcgagatgagcaggtactttcacattcccattgggaaccta
ccagaggacatctccacattcggctccgacctcttctttgcccgccacctccagcgccac
aaccacctgctctggctgtcccctacagcccgccctgacctgggtggaaaggaggctgat
gacaactgtcttgtcatggagttcgatgaccaagccactgttgagatcaacagttcaggc
tgttactccacagtgtgtgtggagctggaccttcagaacctggccgtcaacaccattctc
cagtctcaccatgtcaacgacatggagggggccgacagcatggggatcagcttcgacgtg
atccagcaggcctccctggaggacatgatcacgggtggtcaggctgccagtgccccggcc
agctacgatgagacagccctgtgctctaacaccttcaggatcctgaagagcatggtcgtg
ggctgggtgaaggagatcacccagtaccacaacatctatgcagacaaccaggtgatgcac
ttctaccgctggcttcggtcgccatcctctctgcttcatgaccctgccctgcaccgcaca
ctccacaacatgatgaagaagctcttcctgcagctcatcgctgagttcaagcgcctgggg
tcatcagtcatctacgccaacttcaaccgcatcatcctctgtacaaagaagcgccgtgtg
gaagatgccatcgcttacgtggagtacatcaccagcagcatccattcaaaggagaccttc
cattctctgacaatttctttctctcgatgctgggaatttcttctctggatggatccatct
aactatggcggaatcaaaggaaaagtttcatctcgtattcactgtggactgcaagactcc
cagaaagcagggggagcagaggatgagcaggaaaatgaggacgatgaggaggaaagagat
ggggaggaggaggaagaggcggaggaatccaacgtggaggatttactggaaaacaactgg
aacattttgcagtttttgccacaggcagcctcctgccagaactacttcctcatgattgtt
tcagcgtacatcgtggccgtgtaccactgcatgaaggacgggctgaggcgcagtgctcca
gggagcacccccgtgaggaggaggggggccagccagctctcccaggaggccgagggggcg
gtcggagcccttcccggaatgatcaccttctctcaggattatgtcgcaaatgagctcact
cagagcttcttcaccatcactcagaagattcagaagaaagtcacaggctctcggaactcc
actgagctctcagagatgtttcctgtcctccccggttcccacttgctgctcaataaccct
gccctggagttcatcaaatacgtgtgcaaggtgctgtccctggacaccaacatcacaaac
caggtgaataagctgaaccgagacctgcttcgcctggtggatgtcggcgagttctccgag
gaggcccagttccgagacccctgccgctcctacgtgcttcctgaggtcatctgccgcagc
tgtaacttctgccgcgacctggacctgtgtaaagactcttccttctcagaggatggggcg
gtcctgcctcagtggctctgctccaactgtcaggcgccctacgactcctctgccatcgag
atgacgctggtggaagttctacagaagaagctgatggccttcaccctgcaggacctggtc
tgcctgaagtgccgcggggtgaaggagaccagcatgcctgtgtactgcagctgcgcggga
gacttcgccctcaccatccacacccaggtcttcatggaacagatcggaatattccggaac
attgcccagcactacggcatgtcgtacctcctggagaccctggagtggctgctgcagaag
aacccacagctgggccattag

KEGG   Homo sapiens (human): 5427
Entry
5427              CDS       T01001                                 
Symbol
POLE2, DPE2
Name
(RefSeq) DNA polymerase epsilon 2, accessory subunit
  KO
K02325  DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    5427 (POLE2)
   03410 Base excision repair
    5427 (POLE2)
   03420 Nucleotide excision repair
    5427 (POLE2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    5427 (POLE2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5427 (POLE2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     5427 (POLE2)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    5427 (POLE2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      5427 (POLE2)
SSDB
Motif
Pfam: DNA_pol_E_B Dpoe2NT DUF3689
Other DBs
NCBI-GeneID: 5427
NCBI-ProteinID: NP_002683
OMIM: 602670
HGNC: 9178
Ensembl: ENSG00000100479
UniProt: P56282
Structure
LinkDB
Position
14:complement(49643555..49688214)
AA seq 527 aa
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSN
MIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLF
GTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGD
AIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAF
GFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEV
LEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSR
FVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLV
NKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVI
ADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
NT seq 1584 nt   +upstreamnt  +downstreamnt
atggcgccggagcggctgcggagccgggcgctctccgccttcaagttgcggggcttgctg
ctccgtggtgaagctattaagtacctcacagaagctcttcagtctatcagtgaattagag
cttgaagataaactggaaaagataattaatgcagttgagaagcaacccttgtcatcaaac
atgattgaacgatctgtggtggaagcagcagtccaggaatgcagtcagtctgttgatgaa
actatagagcacgttttcaatatcataggagcatttgatattccacgctttgtgtacaat
tcagaaagaaaaaaatttcttcctctgttaatgaccaaccaccctgcaccaaatttattt
ggaacaccaagagataaagcagagatgtttcgtgagcgatataccattttgcaccagagg
acccacaggcatgaattatttactcctccggtgataggttctcaccctgatgaaagcgga
agcaaattccagcttaaaacaatagaaaccttattgggtagtacaaccaaaatcggagat
gcgattgttcttggaatgataacgcagttaaaagagggaaaattttttctggaagatcct
actggaacagtccaactagaccttagtaaagctcagttccatagtggtttatacacagag
gcatgctttgtcttagcagaaggttggtttgaagatcaagtgtttcatgtcaatgccttt
ggatttccacccactgagccctctagtactactagggcatactatggaaatattaatttt
tttggaggtccttctaatacatctgtgaagacttctgcaaaactaaaacagctagaagag
gagaataaagatgctatgtttgtgtttttatctgatgtttggttggaccaggtggaagta
ttggaaaaacttcgcataatgtttgctggttattcaccagcacctccaacctgctttatt
ctgtgtggtaatttttcatctgcaccatatggaaaaaatcaagttcaagctttgaaagat
tccctaaaaactttggcagatataatatgtgaatacccagatattcaccaaagtagtcgt
tttgtgtttgtacctggtccagaggatcctggatttggttccatcttaccaaggccacca
cttgctgaaagcatcactaatgaattcagacaaagggtaccattttcagtttttactact
aatccttgcagaattcagtactgtacacaggaaattactgtcttccgtgaagacttagta
aataaaatgtgcagaaactgcgtccgttttcctagcagcaatttggctattcctaatcac
tttgtaaagactatcttatcccaaggacatctgactcccctacctctttatgtctgccca
gtgtattgggcatatgactatgctttgagagtgtatcctgtgcccgatctacttgtcatt
gcagacaaatatgatcctttcactacgacaaataccgaatgcctctgcataaaccctggc
tcttttccaagaagtggattttcattcaaagttttttatccttctaataagacagtagaa
gatagcaaacttcaaggcttttga

KEGG   Homo sapiens (human): 54107
Entry
54107             CDS       T01001                                 
Symbol
POLE3, CHARAC17, CHRAC17, CHRAC2, YBL1, p17
Name
(RefSeq) DNA polymerase epsilon 3, accessory subunit
  KO
K02326  DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03082  ATP-dependent chromatin remodeling
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    54107 (POLE3)
   03410 Base excision repair
    54107 (POLE3)
   03420 Nucleotide excision repair
    54107 (POLE3)
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    54107 (POLE3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    54107 (POLE3)
   03036 Chromosome and associated proteins [BR:hsa03036]
    54107 (POLE3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    54107 (POLE3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     54107 (POLE3)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    54107 (POLE3)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Chromatin remodeling factors
   CHRAC complex
    54107 (POLE3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      54107 (POLE3)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone CENP-T_C BUD22 CIS_TMP DUF5427 SpoU_methylase DUF4746 TAF Myc_N RNA_pol_3_Rpc31 Pox_Ag35 CDC45 DDHD DUF6080 V_ATPase_I NOA36
Other DBs
NCBI-GeneID: 54107
NCBI-ProteinID: NP_001265184
OMIM: 607267
HGNC: 13546
Ensembl: ENSG00000148229
UniProt: Q9NRF9
LinkDB
Position
9:complement(113407235..113410749)
AA seq 147 aa
MAERPEDLNLPNAVITRIIKEALPDGVNISKEARSAISRAASVFVLYATSCANNFAMKGK
RKTLNASDVLSAMEEMEFQRFVTPLKEALEAYRREQKGKKEASEQKKKDKDKKTDSEEQD
KSRDEDNDEDEERLEEEEQNEEEEVDN
NT seq 444 nt   +upstreamnt  +downstreamnt
atggcggagaggcccgaggacctaaacctgcccaatgccgtgatcaccaggatcatcaag
gaggcgctcccggacggtgtcaacatctccaaggaggcccggagcgccatctcccgcgcc
gccagcgtcttcgtgctgtacgccacatcctgtgctaacaactttgcaatgaaaggaaag
cggaagacgctgaatgccagtgatgtgctctcagccatggaagagatggagttccagcgg
ttcgttaccccattgaaagaagctctggaagcatataggcgggagcagaaaggcaagaag
gaggcctcagagcaaaagaagaaggacaaagacaaaaaaacagactcggaagagcaagac
aagagcagggatgaggacaatgatgaagacgaagaaaggctggaagaagaagaacagaat
gaagaggaagaagtagacaactga

KEGG   Homo sapiens (human): 56655
Entry
56655             CDS       T01001                                 
Symbol
POLE4, YHHQ1, p12
Name
(RefSeq) DNA polymerase epsilon 4, accessory subunit
  KO
K03506  DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
nt06503  Mismatch repair
nt06504  Base excision repair
nt06506  Double-strand break repair
nt06509  DNA replication
  Element
N01431  Core NER reaction
N01432  Mismatch repair
N01436  Long patch BER
N01452  Homologous recombination
N01470  Pre-IC formation
N01471  Origin unwinding and elongation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    56655 (POLE4)
   03410 Base excision repair
    56655 (POLE4)
   03420 Nucleotide excision repair
    56655 (POLE4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    56655 (POLE4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    56655 (POLE4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     56655 (POLE4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   DNA polymerase epsilon complex
    56655 (POLE4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     DNA polymerase epsilon complex
      56655 (POLE4)
SSDB
Motif
Pfam: CBFD_NFYB_HMF Histone TAF CENP-T_C
Other DBs
NCBI-GeneID: 56655
NCBI-ProteinID: NP_063949
OMIM: 607269
HGNC: 18755
Ensembl: ENSG00000115350
UniProt: Q9NR33
LinkDB
Position
2:74958643..74970128
AA seq 117 aa
MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAG
QEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
NT seq 354 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggcggcaggaagcgggacgccccgagaggaggagggacctgctggg
gaggcagcggcctcgcagccccaggccccaacgagtgtgcctggggctcgtctctcgagg
ttgcctctggcgcgagtgaaggccttggtgaaggcagatcccgacgtgacgctagcggga
caggaagccatcttcattctggcacgagccgcggaactgtttgtggagaccattgcaaaa
gatgcctactgttgcgctcagcagggaaaaaggaaaacccttcagaggagagacttggat
aatgcaatagaagctgtggatgaatttgcttttctggaaggtactttagattga

KEGG   Homo sapiens (human): 11073
Entry
11073             CDS       T01001                                 
Symbol
TOPBP1, Dpb11, TOP2BP1
Name
(RefSeq) DNA topoisomerase II binding protein 1
  KO
K10728  topoisomerase (DNA) II binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
nt06509  DNA replication
  Element
N01451  ATR signaling
N01464  Fanconi anemia pathway
N01470  Pre-IC formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    11073 (TOPBP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    11073 (TOPBP1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    11073 (TOPBP1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    11073 (TOPBP1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-B complex
     11073 (TOPBP1)
SSDB
Motif
Pfam: BRCT PTCB-BRCT TopBP1_BRCT0 BRCT_2 RTT107_BRCT_5 LIG3_BRCT BRCT_TopB1_SLF1 ECT2_BRCT0
Other DBs
NCBI-GeneID: 11073
NCBI-ProteinID: NP_008958
OMIM: 607760
HGNC: 17008
Ensembl: ENSG00000163781
UniProt: Q92547 A0AV47 A7E2X7 Q05BV8
Structure
LinkDB
Position
3:complement(133600238..133661941)
AA seq 1522 aa
MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
TGLSQKRKAPTEKNKIKRPRVH
NT seq 4569 nt   +upstreamnt  +downstreamnt
atgtccagaaatgacaaagaaccgttttttgtgaagtttttaaagtcttcagacaattcc
aaatgtttttttaaagctctcgagtccataaaagaattccaatcagaagaatatcttcag
attattacagaagaagaggcattgaagataaaggagaatgatagatcactttatatctgt
gacccttttagtggcgttgtctttgatcacctcaaaaagcttggctgcagaattgttggt
cctcaagtagtcatattttgtatgcaccaccagcgatgtgtcccaagagccgaacatcca
gtttataatatggttatgtctgatgtaaccatatcttgtacaagtctggaaaaagaaaaa
agggaagaagttcataaatatgtacaaatgatgggcggacgagtatacagagaccttaat
gtatcagtaactcaccttattgcaggagaagttggtagcaaaaaatatttagttgctgca
aacctgaagaaacctattttgcttccctcttggataaaaacactttgggagaagtcacaa
gagaaaaaaataactagatatactgatataaacatggaagatttcaagtgtcctattttt
cttggttgcataatctgtgtgactggcttatgtggcttagacaggaaagaagttcagcaa
ctcacagttaagcatggaggtcaatacatgggacaattgaaaatgaatgaatgtacacac
ctcattgtgcaagaaccaaaaggtcagaagtatgagtgtgccaagagatggaatgtacac
tgtgtgaccacacagtggttttttgacagtattgagaaaggtttttgtcaggatgaatcc
atatacaagacagaacctagaccagaagcaaagactatgcccaattcttcaactcctacc
agccagatcaacacaattgatagtcgtactctttcagatgtcagcaatatttccaacata
aatgcaagttgcgtaagtgaatcaatatgtaattcacttaacagcaaactggagcctaca
cttgaaaatctagaaaatctggatgtcagtgcatttcaagcacctgaagatttattagat
ggttgtcggatatatctttgcggttttagtggcagaaagctagataaactgagaagactt
attaacagtggaggtggagttcgttttaaccagctaaatgaagatgtaactcatgttatt
gtgggagattatgatgatgaattgaagcagttttggaataaatcagcccacaggcctcat
gtagtgggagcaaagtggttgctagagtgtttcagtaaaggttatatgctttctgaagaa
ccatatatccatgctaattaccagccagtggaaattccagtttcacataagcctgaaagt
aaagcagctcttttaaaaaagaagaacagcagcttctctaagaaagactttgctcctagt
gaaaagcatgagcaagctgatgaagatctgctctctcaatatgaaaatggtagctccaca
gtagttgaggctaagacgtctgaagccaggccctttaatgattctactcatgctgagccc
ttgaatgattctactcacatttctttgcaagaagaaaaccagtcttctgtcagtcattgt
gtccctgatgtttctacaattactgaagaaggcttatttagccaaaagagtttccttgtt
ttgggttttagtaatgaaaatgaatctaacatcgcaaacatcataaaagaaaatgctggg
aaaatcatgtcccttctgagcagaactgttgcggattatgctgtggttcctctgctgggg
tgtgaagtggaagccactgtgggagaagttgttacaaatacatggctggttacttgcata
gactatcagactttgtttgatccaaagtcgaatcctctcttcacaccagttccagtaatg
acaggaatgactcctttagaggattgtgttatttcatttagccagtgtgctggagcagaa
aaagagtctttaacattcctagcaaacctccttggagcaagtgttcaagaatactttgtt
cgcaaatccaatgcaaagaaaggcatgtttgccagtactcatcttatactgaaagaacgt
ggtggctctaaatatgaagctgcaaagaagtggaatttacctgccgttactatagcttgg
ctgttggagactgctagaacgggaaagagagcagacgaaagccattttctgattgaaaat
tcaactaaagaagaacgaagtttggaaacagaaataacaaatggaatcaatctaaattca
gatactgcagagcatcctggcacacgcctgcaaactcacagaaaaaccgtcgttacacct
ttagatatgaaccgctttcagagtaaagctttccgtgctgtggtctcacaacatgccaga
caggtcgcagcctccccagcagtaggacaaccacttcagaaggagccctcgttacacctg
gatacaccatcaaaattcctgtccaaggacaaactcttcaagccttcctttgatgtgaag
gatgcacttgcagccttggaaactccaggacgtcccagccaacagaaaaggaaaccgagt
acgccactctcagaagttattgtcaaaaacttgcaacttgctttggcaaatagctctcga
aatgctgtcgctctttctgccagccctcaactgaaagaggcccagtcagagaaggaagaa
gccccaaagccacttcacaaagtagtggtatgtgttagtaaaaaactcagtaagaagcag
agtgaactaaatgggatcgcagcctctctaggagcagattacaggtggagttttgatgaa
acagtgactcatttcatctatcaagggcggccaaatgacactaatcgggagtataaatct
gtaaaagaaagaggagtacacattgtttccgagcactggcttttagattgtgcccaagag
tgtaaacatcttcctgaatctctttatccacatacttataatcccaaaatgagcttggat
atcagcgcagtgcaagatggccggctctgtaatagtcgactactctcagctgtgtcttca
acaaaggatgatgagccagatcctttgattttagaagaaaatgatgtagacaatatggcc
accaataataaagagtcagcaccatcaaatggaagtggaaagaatgactctaaaggagtt
ctgacacagaccttagagatgagagagaactttcagaagcagttacaggagataatgtct
gcaacatcaatagtgaaaccccaagggcagaggacttccctttcaagaagtggttgtaac
agcgcatcttcaacccctgacagcactcgctctgctcgcagtggacgaagtagagtccta
gaggcactgaggcagtctcgtcagacagtacctgatgtcaacacagagccttcccaaaat
gaacagatcatttgggatgaccctacagcaagggaggagagagcaaggcttgccagcaat
ttgcagtggcctagttgtcccacacaatactctgagcttcaggttgacattcaaaacttg
gaggattctccttttcaaaagcctttacatgattcagaaattgctaaacaggctgtctgt
gatcctggaaacatacgtgtgactgaagctcccaaacacccaatctctgaagaactggaa
actcccataaaagacagccacctgatccctacgcctcaagcccccagtattgcctttcca
ctcgccaacccccctgtggctccgcaccctagagaaaagattataacgatagaggagact
catgaagaattaaaaaaacagtacatatttcagttatcatctctgaatcctcaagaacgt
attgactattgtcatctgattgagaaactaggtggattggtgatagaaaagcagtgcttt
gatcccacctgtacacacattgttgtgggacatccacttcgaaacgagaagtatttagcc
tcagtggcagctgggaagtgggtgcttcatcgctcctaccttgaagcctgcaggactgct
ggacacttcgtgcaggaagaagactatgaatggggaagtagttccatacttgatgttctg
actggaatcaatgtacagcaacgaagactagcacttgcagcaatgagatggagaaaaaaa
atccagcaaagacaagaatctggcattgttgagggagcatttagtgggtggaaggttatt
ttacatgtggatcagtctcgagaagcaggcttcaaacgccttcttcagtcaggaggagca
aaggtgctacctggtcattctgtacctttatttaaagaggccacacatcttttttctgac
ttgaataaactgaaaccagatgactcaggagttaatatagcagaagctgctgcccagaac
gtgtactgcttgagaacagaatacattgctgattatctcatgcaggaatcacctcctcat
gtagaaaattactgtctaccagaagctatttcatttattcagaataataaggaacttggg
actggattatcacaaaagaggaaagctcctacagaaaaaaataaaatcaaacgacctaga
gtacactaa

KEGG   Homo sapiens (human): 90381
Entry
90381             CDS       T01001                                 
Symbol
TICRR, C15orf42, SLD3, Treslin
Name
(RefSeq) TOPBP1 interacting checkpoint and replication regulator
  KO
K26117  Treslin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
Network
nt06509  DNA replication
  Element
N01468  DNA replication licensing
N01470  Pre-IC formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    90381 (TICRR)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    90381 (TICRR)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    90381 (TICRR)
SSDB
Motif
Pfam: Treslin_N Treslin_STD Treslin_M
Other DBs
NCBI-GeneID: 90381
NCBI-ProteinID: NP_689472
OMIM: 613298
HGNC: 28704
Ensembl: ENSG00000140534
UniProt: Q7Z2Z1
LinkDB
Position
15:89575469..89628023
AA seq 1910 aa
MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPS
RVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITS
PTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQR
LPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGG
TVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFP
RMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTD
SWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILT
VCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQ
ELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAEL
YQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSP
DVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIML
YACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQ
LQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDS
IPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPE
SDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQ
PVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHK
LLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLS
FSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPS
EKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQK
SPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQG
TQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGT
PQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVS
KKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSK
VGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGY
PGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSS
LSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYE
VELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPT
YVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPD
IIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFEL
EGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVS
KSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPS
SQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL
NT seq 5733 nt   +upstreamnt  +downstreamnt
atggcatgctgtcacaaagtaatgctgctgctggacaccgcgggcggcgccgcccgccac
agccgggtccggcgggccgccctgcgcctcctcacctatctgagttgccgattcggcctg
gccagggtccactgggccttcaagttctttgactcgcagggggcgcggagccggccgtcc
cgcgtgtctgacttccgcgagctggggtcccgctcgtgggaggactttgaggaggagctg
gaggccaggctcgaggatcgcgcccacctgcccggcccggcgcccagggccacccacacg
cacggcgccctgatggagacgctgctagactaccagtgggaccggcccgagatcacgtcg
cccacgaagccgatcctgcggagcagcgggaggagactgctggacgtggagagcgaggcc
aaggaggccgaggccgcgctcgggggcttggtgaacgccgtcttcctcctggccccctgt
ccgcactcgcagagggagctgctgcagttcgtgtctgggtgcgaggcccaggcccagcgc
ctgccgcccacccctaagcaggtgatggagaagttgttgcccaagagagtccgggaagtc
atggtcgcccgaaaaatcaccttctactgggtggataccaccgaatggtctaagttgtgg
gaatccccagaccaccttggatactggactgtttgtgaactgctccaccacggaggtggc
actgtcttgccatctgaatctttcagctgggattttgctcaagctggggaaatgctgctc
aggagtggaataaagctgtcaagtgaacctcatctttctccgtggatttcaatgctgcca
actgatgccactttaaaccgtttgctctacaattctcctgagtatgaggcctcgtttcca
cgaatggaaggaatgttatttctccctgttgaagcaggcaaagagattcaagaaacatgg
acagtcaccctagagcccttggccatgcatcagagacattttcagaaaccagtcagaatt
tttctaaaaggctcagtggcccagtggtctctcccaacgagcagcactttgggcactgac
agctggatgctaggaagtccagaggagagcacagcaactcaaaggctgttatttcagcag
ttggtaagcaggctgactgctgaagagttacacctggttgctgatgtggaccctggtgaa
ggccggccccccatcactggagttatttccccactctctgccagtgctatgatcctcact
gtgtgccgcaccaaggaggctgaatttcaacgacatgttctccaaacagctgtggctgac
agcccccgggacacagcttcccttttctcagatgttgtggatagtatattgaatcagact
catgattcgcttgcagatactgcttctgctgcttctcctgttccagagtgggcccagcag
gagcttggccacaccactccctggagtccagctgttgtggaaaagtggtttcctttctgt
aacatcagtggtgccagttccgatttgatggagtcatttgggttactacaggctgcctca
gctaataaggaagagtcttccaaaactgaaggcgaattaatacattgccttgccgagctc
taccagagaaaatctcgtgaagaatccactatagctcatcaagaagacagcaaaaagaaa
cgaggggtccctcgtactccagtgagacagaagatgaataccatgtgccgttccttaaag
atgttgaatgtcgcaaggctgaatgtgaaggcccagaagttacatccagatggcagtccg
gatgtggctggggagaaaggaatccaaaagatacctagtgggagaacagtggataaattg
gaagacagaggaagaacactaagaagttctaaacctaaagattttaaaactgaggaagag
ctgctatcatatatacgtgaaaattaccaaaagactgtggccacaggagaaatcatgttg
tatgcatgtgctcgaaacatgatctcaaccgttaaaatgttcctaaaatcaaaaggcacc
aaggaattagaagtgaactgcctgaatcaagtaaaaagtagtctcttaaaaactagtaaa
agtcttcgacagaatctaggaaaaaaactggataaggaagacaaagttagagagtgccag
cttcaggtatttcttcgtttggagatgtgtctgcaatgcccttcaataaatgaaagtaca
gatgatatggaacaagtagtggaggaggtgacagatttgctgcgcatggtgtgtttaact
gaggattcagcgtacctagcagagtttctggaggaaattttgagattgtatattgactct
atcccaaagacacttggaaatctttacaacagcctagggtttgtgattcctcagaagctg
gctggtgtccttcctacagattttttcagtgatgactccatgacacaagagaacaaatca
ccacttctttctgtgccttttttgtcaagtgctcgtagatcagtgtcaggcagccctgaa
tctgatgaactgcaggaacttcgtaccagatcagccaagaagagaaggaaaaatgcatta
ataagacataaaagcattgctgaggtttcacagaatcttcgacaaattgaaattcctaaa
gtgtcaaagagagctacgaaaaaagagaactctcaccctgctcctcagcagccttcccag
ccagtgaaagatacagtgcaagaagtgaccaaagttcgaagaaatcttttcaaccaggaa
ttgctttccccttcaaagagatcactaaagcgggggttgcctagaagccattctgtgtca
gctgtggatggtctagaggataaacttgacaacttcaagaagaacaaaggttatcacaaa
ctgctgactaagagtgtggccgagactccagtgcataagcagatctccaaaaggctgctg
cacagacaaatcaagggcaggtcctctgatcctggtcctgatattggtgttgttgaagag
tcccctgaaaaaggagatgaaataagtctgagacgaagtcctcgaatcaagcagttgtca
tttagcaggacacattctgcctccttctattctgtgtctcagccgaagtctcgaagtgtg
caaagagtccactctttccagcaagataagtcagaccaaagagaaaattctccagtccaa
agtattcggtctcccaagagtcttctttttggggcaatgtctgagatgatcagcccctca
gaaaagggttcagctcgaatgaaaaagcgttcaagaaacactttggattcggaggtacct
gcagcttaccagactcccaagaagagtcaccagaaatctctgagcttttctaaaactaca
ccaagaaggatctctcatacaccacaaactccgttgtatactccagaaaggctgcagaag
tcccctgcaaaaatgacccctacaaagcaggcagcttttaaggagtccttaaaagactcc
tcctcacccggccatgactcaccattggattcaaaaatcactcctcaaaaacgacatacc
caggcaggagaaggtacctctcttgaaacgaagacaccaagaactcctaagaggcaaggt
actcagccgcctgggtttttgccaaactgtacttggccacattcagtgaattccagtcca
gaaagcccctcctgtccagcccctccaacttcatcgactgcccagcccaggagagagtgt
ctcactcccatcagagaccctctcagaacacctccgagagcagcagccttcatgggcacg
cctcagaatcaaacacaccaacagccccatgtcctcagagctgctcgggcagaggaacca
gcccagaaactaaaggataaagctatcaaaactccaaaaagaccagggaattcaactgtg
acttcttccccacctgttacgccaaagaaactgtttacctctcctttatgtgatgtctcc
aagaagagtccatttaggaaatctaaaatagagtgtccttccccaggagaactggatcag
aaagagccccagatgtcacccagcgtagctgcatctctctcctgccctgttccctcaact
ccccctgaactctcacagagagctacattggacaccgtccctcctccacccccttctaaa
gttgggaaacggtgtagaaagacctctgatcccagaaggagcatcgtggagtgtcagcct
gatgcctccgctactcctggggttggcacagctgacagcccagctgcccccacagactct
agagatgaccagaagggactgagcctctctcctcagtctcctcctgaaagacggggctac
ccaggccctggtctcaggagtgattggcatgcatcctctcctctgctcattacaagtgac
acagagcatgtcactctcctcagtgaagccgaacaccatggcattggtgacttgaaaagt
aacgtcttatcagtggaagagggtgaggggctaaggacagcagatgctgagaagtcttct
ctgtctcaccctgggattcccccatctcctccttcctgtgggcctggctctcctctgatg
ccttcccgtgacgtgcactgtaccacagatgggagacagtgccaggcttcggcacaacta
gacaacctgccagcatcagcttggcattccacagactctgccagcccacagacctatgag
gttgagctggagatgcaagcttctggccttcccaaacttcgaattaagaagatagacccc
agctcttcattagaggctgagcccctcagcaaggaggagagctctctgggagaagagagc
ttcctccctgctctcagcatgcccagggccagcaggtccttaagcaaacctgaacccacc
tatgtgtcacccccctgcccccgcctctcccacagcacacctggcaagagcagggggcaa
acctacatctgccaggcctgtacccccacccacggcccttctagtaccccctctccattt
caaacagatggggttccttggacaccatcccccaagcacagtgggaagacaactccagac
ataattaaagactggcccaggaggaagagggcggtgggctgtggcgccggctcctcttcc
gggaggggcgaggtcggtgcagaccttcctgggagcctgtcactgcttgagtcagagggc
aaggaccacggccttgaactcagcatccacaggacgcccatcttggaggattttgagctc
gagggagtgtgccagctcccagaccagtcgcctcccaggaacagcatgcctaaggccgag
gaagcctcttcctggggacagtttgggttgagttccaggaagagagtcctgttggccaag
gaagaagctgaccgtggagccaaaaggatctgtgacctgagagaagattcagaagttagt
aagagtaaagaggggtctccaagttggagtgcatggcagctaccctccacgggagacgaa
gaggtgtttgtttccggctccaccccacctcccagctgtgccgtgcggagctgcctctct
gccagtgccctccaggctctgacccagtctccgctgctgttccaggggaaaacaccttcc
tctcagagcaaagaccccagagatgaggatgtggatgttcttccctccactgtagaagac
tctcctttcagtcgcgctttctccaggaggcgccccatcagcagaacttatacacggaag
aagctcatgggaacctggctggaggacttatag

KEGG   Homo sapiens (human): 27085
Entry
27085             CDS       T01001                                 
Symbol
MTBP, MDM2BP
Name
(RefSeq) MDM2 binding protein
  KO
K26116  Mdm2-binding protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
Network
nt06509  DNA replication
  Element
N01468  DNA replication licensing
N01470  Pre-IC formation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    27085 (MTBP)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    27085 (MTBP)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    27085 (MTBP)
SSDB
Motif
Pfam: MTBP_mid MTBP_C MTBP_N RBD_ZCCHC3_2nd
Other DBs
NCBI-GeneID: 27085
NCBI-ProteinID: NP_071328
OMIM: 605927
HGNC: 7417
Ensembl: ENSG00000172167
UniProt: Q96DY7
LinkDB
Position
8:120445419..120523636
AA seq 904 aa
MDRYLLLVIWGEGKFPSAASREAEHGPEVSSGEGTENQPDFTAANVYHLLKRSISASINP
EDSTFPACSVGGIPGSKKWFFAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEEC
LGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPAPGRAMVDIILLLSDKDPPKL
KDYLPTVGALKHLREWYSAKITIAGNHCEINCQKIAEYLSANVVSLEDLRNVIDSKELWR
GKIQIWERKFGFEISFPEFCLKGVTLKNFSTSNLNTDFLAKKIIPSKDKNILPKVFHYYG
PALEFVQMIKLSDLPSCYMSDIEFELGLTNSTKQNSVLLLEQISSLCSKVGALFVLPCTI
SNILIPPPNQLSSRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHS
ANQINGSFALNLIHGKMKTKTEEAKLSFPFDLLSLPHFSGEQIVQREKQLANVQVLALEE
CLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIKTFNILNDFSP
VEPNSSSLMETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITL
LDAKELLKYFTSDGLPIGDLQPLPIQKGEKTFVLTPELSPGKLQVLPFEKASVCHYHGIE
YCLDDRKALERDGGFSELQSRLIRYETQTTCTRESFPVPTVLSPLPSPVVSSDPGSVPDG
EVLQNELRTEVSRLKRRSKDLNCLYPRKRLVKSESSESLLSQTTGNSNHYHHHVTSRKPQ
TERSLPVTCPLVPIPSCETPKLATKTSSGQKSMHESKTSRQIKESRSQKHTRILKEVVTE
TLKKHSITETHECFTACSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNAVQVIDWVLEK
TSKK
NT seq 2715 nt   +upstreamnt  +downstreamnt
atggatcggtacctgctgctggtgatctggggggaaggaaaattcccgtcggcggccagt
agggaggcagaacatgggccagaggtgtcgtcgggtgagggtactgagaatcagccggac
ttcacagcagcaaatgtttatcacctcttgaaaagaagcattagtgcttcaattaatcca
gaagatagtactttccctgcctgttcagtgggaggtatacctggttccaagaagtggttc
tttgcagtgcaggcaatatatggattttatcagttttgtagttctgattggcaagagata
cattttgatacagaaaaagataaaattgaagatgttcttcaaacgaatatcgaagaatgt
ttgggtgctgttgagtgttttgaagaagaagacagtaatagcagggaatcattatccttg
gctgatctctatgaagaagctgcagaaaatttgcatcagctgtcagacaagcttcctgct
cctggtagagcaatggtagatataatactgttgctttctgacaaagatcctcctaaattg
aaagactatttacctactgtaggagcattaaaacatttgagagaatggtattcagcaaag
atcactatagcaggaaatcattgtgaaataaactgtcagaaaattgcagaatacctttct
gctaatgttgtatctttagaagatctcagaaatgttattgactcaaaggaattatggagg
gggaaaatacagatatgggaaagaaagtttggatttgaaattagttttcctgaattttgt
ttaaagggagtcacacttaagaattttagtacttctaatttaaatactgacttccttgcc
aaaaagatcataccatcaaaggataagaatattttgccaaaggttttccattattatggc
cctgctttagaatttgtgcagatgataaaattatcagatctaccctcctgctatatgtcg
gatattgaatttgagttaggattgacaaacagtaccaaacagaattctgtgttgctgttg
gagcagatttcttctctgtgtagcaaggttggtgctctttttgtattgccatgtaccatt
agtaacatactgattccacctcccaaccaactcagttcaagaaaatggaaggaatatata
gctaaaaagcctaaaacaatcagtgttccagatgttgaagtgaaaggagagtgttctagc
tattatctcttgttacaaggtaatggcaatagaagatgtaaagccacattgattcactca
gccaaccagatcaatggctcatttgcactcaatttaattcatggaaagatgaaaacaaag
acagaagaagccaaattgagttttccttttgacttattatcacttccacatttttctggg
gagcagattgtacagagagagaaacagttagctaatgttcaagttttagctttggaagaa
tgcctaaaaagacgaaagttggcaaagcagcctgaaacagtttctgttgctgaactcaaa
agtctgttagtactcacaaggaaacactttttagattattttgatgctgtgattcctaaa
atgattctaagaaagatggacaaaattaaaaccttcaatatattaaatgattttagtcca
gtggaacctaattcctcaagtctaatggaaaccaatcctctggaatggccagaaaggcat
gttcttcaaaatttggaaacttttgaaaaaactaaacaaaaaatgagaactggttcatta
cctcattcatctgaacagttgctgggccacaaagagggtcctcgggactcaatcacattg
ttggatgctaaagaattgctgaagtactttacctcagatggattacccattggagatctt
caacctttaccgattcaaaagggggaaaagacttttgttttgacaccagaacttagtcct
gggaaacttcaggtcttaccttttgagaaagcctcagtatgtcattatcatggaattgaa
tattgcttggatgaccgaaaagctttggaaagagatggaggattttctgaacttcagtct
cgtcttattcgttatgaaactcaaactacctgcaccagagaaagttttccagtacctact
gtgttgagccctcttccatctcctgtagtttcgtcagatcctggaagtgtccctgacgga
gaagttttacaaaatgaacttcgaactgaagtatcccgattgaaacggagatctaaagat
ctgaattgcctttatcccagaaaaagacttgtgaaatctgaaagttcagagtctcttctt
tctcagacaactggtaatagtaatcactatcatcatcatgtgacatccagaaagccacaa
acagaacggtccttaccagtgacttgtccattggttccaattcctagctgtgaaactcca
aaacttgctacaaagaccagttcaggtcaaaaaagtatgcatgaatcaaaaacatcaagg
caaattaaggaatcaagatcacagaaacacacacggatactgaaagaagtagttactgaa
accctgaagaaacacagtattaccgagactcatgaatgtttcactgcatgcagccagcgt
ctctttgaaatctctaagttctatctaaaggatcttaaaacttcaaggggtctatttgaa
gaaatgaagaaaacagcaaacaacaatgctgtacaggtgattgactgggtattagaaaag
acaagcaagaaatga

KEGG   Homo sapiens (human): 9401
Entry
9401              CDS       T01001                                 
Symbol
RECQL4, RECQ4
Name
(RefSeq) RecQ like helicase 4
  KO
K10730  ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
Organism
hsa  Homo sapiens (human)
Network
nt06509  DNA replication
  Element
N01470  Pre-IC formation
Disease
H00296  Defects in RecQ helicases
H00458  Syndromic craniosynostoses
H00965  RAPADILINO syndrome
H01734  Rothmund-Thomson syndrome
H01993  Baller-Gerold syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    9401 (RECQL4)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9401 (RECQL4)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.4  DNA 3'-5' helicase
     9401 (RECQL4)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   Other initiation factors
    9401 (RECQL4)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    RecQ family DNA helicases
     9401 (RECQL4)
SSDB
Motif
Pfam: DEAD Helicase_C Drc1-Sld2 ResIII
Other DBs
NCBI-GeneID: 9401
NCBI-ProteinID: NP_004251
OMIM: 603780
HGNC: 9949
Ensembl: ENSG00000160957
UniProt: O94761
Structure
LinkDB
Position
8:complement(144511288..144517833)
AA seq 1208 aa
MERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKRTTGQAGGGLR
SSESLPAAAEEAPEPRCWGPHLNRAATKSPQSTPGRSRQGSVPDYGQRLKANLKGTLQAG
PALGRRPWPLGRASSKASTPKPPGTGPVPSFAEKVSDEPPQLPEPQPRPGRLQHLQASLS
QRLGSLDPGWLQRCHSEVPDFLGAPKACRPDLGSEESQLLIPGESAVLGPGAGSQGPEAS
AFQEVSIRVGSPQPSSSGGEKRRWNEEPWESPAQVQQESSQAGPPSEGAGAVAVEEDPPG
EPVQAQPPQPCSSPSNPRYHGLSPSSQARAGKAEGTAPLHIFPRLARHDRGNYVRLNMKQ
KHYVRGRALRSRLLRKQAWKQKWRKKGECFGGGGATVTTKESCFLNEQFDHWAAQCPRPA
SEEDTDAVGPEPLVPSPQPVPEVPSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQA
FRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQ
VSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVA
FACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQHLAVAE
EPDLHGPAPVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALL
RTCLHAAWVPGSGGRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDR
PDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVHADSTDFL
AVKRLVQRVFPACTCTCTRPPSEQEGAVGGERPVPKYPPQEAEQLSHQAAPGPRRVCMGH
ERALPIQLTVQALDMPEEAIETLLCYLELHPHHWLELLATTYTHCRLNCPGGPAQLQALA
HRCPPLAVCLAQQLPEDPGQGSSSVEFDMVKLVDSMGWELASVRRALCQLQWDHEPRTGV
RRGTGVLVEFSELAFHLRSPGDLTAEEKDQICDFLYGRVQARERQALARLRRTFQAFHSV
AFPSCGPCLEQQDEERSTRLKDLLGRYFEEEEGQEPGGMEDAQGPEPGQARLQDWEDQVR
CDIRQFLSLRPEEKFSSRAVARIFHGIGSPCYPAQVYGQDRRFWRKYLHLSFHALVGLAT
EELLQVAR
NT seq 3627 nt   +upstreamnt  +downstreamnt
atggagcggctgcgggacgtgcgggagcggctgcaggcgtgggagcgcgcgttccgacgg
cagcgcgggcggcgaccgagccaggacgacgtggaggcggcgccggaggagacccgcgcg
ctctaccgggaataccgcactctgaagcgtaccacgggccaggccggcggcgggctccgc
agctccgagtcgctccccgcggcggccgaagaggcgccagagccccgctgctgggggccc
catctgaatcgggctgcgaccaagagtccacagtctacgccagggcggagccgccagggc
tcggtgccggactacgggcagcggctcaaggccaatctgaaaggcaccctgcaggccgga
ccagccctgggccgcagaccgtggcctctaggaagagcctcatctaaggcatccacccca
aagcccccaggtacagggcctgtcccctcctttgcagaaaaagtcagtgatgagcctcca
cagctccctgagccccagccaaggccaggccggctccagcatctgcaggcatccctgagc
cagcggctgggctccctagatcctggctggttacagcgatgtcacagtgaggtcccagat
tttctgggggcccccaaagcctgcaggcctgatctaggctcagaggaatcacaacttctg
atccctggtgagtcggctgtccttggtcctggtgctggctcccagggcccagaggcttca
gccttccaagaagtcagcatccgtgtggggagcccccagcccagcagcagtggaggcgag
aagcggagatggaacgaggagccctgggagagccccgcacaggtccagcaggagagcagc
caagctggacccccatcggagggggctggggctgtagcagttgaggaagaccctccaggg
gaacctgtacaggcacagccacctcagccctgcagcagcccatcgaaccccaggtaccac
ggactcagcccctccagtcaagctagggctgggaaggctgagggcacagcccccctgcac
atcttccctcggctggcccgccatgacaggggcaattacgtacggctcaacatgaagcag
aaacactacgtgcggggccgggcactccgtagcaggctcctccgcaagcaggcatggaag
cagaagtggcggaagaaaggggagtgttttgggggtggtggtgccacagtcacaaccaag
gagtcttgtttcctgaacgagcagttcgatcactgggcagcccagtgtccccggccagca
agtgaggaagacacagatgctgttgggcctgagccactggttccttcaccacaacctgta
cctgaggtgcccagcctggaccccaccgtgctgccactctactccctggggccctcaggg
cagttggcagagacgccggctgaggtgttccaggccctggagcagctggggcaccaagcc
tttcgccctgggcaggagcgtgcagtcatgcggatcctgtctggcatctccacgctgctg
gtgctgcctacaggtgccggcaagtccctgtgctaccagctcccagcgctgctctacagc
cggcgcagcccctgcctcacgttggtcgtctctcccctgctgtcactcatggatgaccag
gtgtctggcctgccaccgtgtctcaaggcggcctgcatacactcgggcatgaccaggaag
caacgggaatctgtcctgcagaagattcgggcagcccaggtacacgtgctgatgctgaca
cctgaggcactggtgggggcgggaggcctccctccagccgcacagctgcctccagttgct
tttgcctgcattgatgaggcccactgcctctcccagtggtcccacaacttccggccctgc
tacctgcgcgtctgcaaggtgcttcgggagcgcatgggcgtgcactgcttcctgggcctc
acagccacagccacacgccgcactgccagtgacgtggcacagcacctggctgtggctgaa
gagcctgacctccacgggccagccccagttcccaccaacctgcacctttccgtgtccatg
gacagggacacagaccaggcactgttgacgctgctgcaaggcaaacgttttcaaaacctc
gattccattatcatttactgcaaccggcgcgaggacacagagcggatcgctgcgctcctc
cgaacctgcctgcacgcagcctgggtcccagggtctggaggtcgtgcccccaaaaccaca
gccgaggcctaccacgcgggcatgtgcagccgggaacggcggcgggtacagcgagccttc
atgcagggccagttgcgggtggtggtggccacggtggcctttgggatggggctggaccgg
ccagatgtgcgggctgtgctgcatctggggctgcccccaagcttcgagagctacgtgcag
gccgtgggccgggccgggcgtgacgggcagcctgcccactgccacctcttcctgcagccc
cagggcgaagacctgcgagagctgcgcagacatgtgcacgccgacagcacggacttcctg
gctgtgaagaggctggtacagcgcgtgttcccagcctgcacctgcacctgcaccaggccg
ccctcggagcaggaaggggccgtgggtggggagaggcctgtgcccaagtacccccctcaa
gaggctgagcagcttagccaccaagcagccccaggacccagaagggtctgcatgggccat
gagcgggcactcccaatacagcttaccgtacaggctttggacatgccggaggaggccatc
gagactttgctgtgctacctggagctgcacccacaccactggctggagctgctggcgacc
acctatacccattgccgtctgaactgccctgggggccctgcccagctccaggccctggcc
cacaggtgtccccctttggctgtgtgcttggcccagcagctgcctgaggacccagggcaa
ggcagcagctccgtggagtttgacatggtcaagctggtggactccatgggctgggagctg
gcctctgtgcggcgggctctctgccagctgcagtgggaccacgagcccaggacaggtgtg
cggcgtgggacaggggtgcttgtggagttcagtgagctggccttccaccttcgcagcccg
ggggacttgaccgctgaggagaaggaccagatatgtgacttcctctatggccgtgtgcag
gcccgggagcgccaggccctggcccgtctgcgcagaaccttccaggcctttcacagcgta
gccttccccagctgcgggccctgcctggagcagcaggatgaggagcgcagcaccaggctc
aaggacctgctcggccgctactttgaggaagaggaagggcaggagccgggaggcatggag
gacgcacagggccccgagccagggcaggccagactccaggattgggaggaccaggtccgc
tgcgacatccgccagttcctgtccctgaggccagaggagaagttctccagcagggctgtg
gcccgcatcttccacggcatcggaagcccctgctacccggcccaggtgtacgggcaggac
cgacgcttctggagaaaatacctgcacctgagcttccatgccctggtgggcctggccacg
gaagagctcctgcaggtggcccgctga

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