KEGG   Homo sapiens (human): 6256
Entry
6256              CDS       T01001                                 
Symbol
RXRA, NR2B1, RXR-alpha, RXRalpha
Name
(RefSeq) retinoid X receptor alpha
  KO
K08524  retinoid X receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04659  Th17 cell differentiation
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04932  Non-alcoholic fatty liver disease
hsa04976  Bile secretion
hsa05160  Hepatitis C
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05216  Thyroid cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05226  Gastric cancer
hsa05417  Lipid and atherosclerosis
Network
nt06163  Hepatitis C virus (HCV)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06274  Thyroid cancer
nt06322  TRH-TSH-TH signaling
nt06535  Efferocytosis
  Element
N00126  PAX8-PPARG fusion to PPARG-mediated transcription
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
N00798  Thyroid hormone signaling pathway
N01751  Macrophage EPO signaling
Drug target
Acitretin: D02754<US>
Alitretinoin: D02815<US>
Bexarotene: D03106<JP/US>
Etretinate: D00316<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    6256 (RXRA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    6256 (RXRA)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    6256 (RXRA)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    6256 (RXRA)
   03320 PPAR signaling pathway
    6256 (RXRA)
   04919 Thyroid hormone signaling pathway
    6256 (RXRA)
   04928 Parathyroid hormone synthesis, secretion and action
    6256 (RXRA)
  09154 Digestive system
   04976 Bile secretion
    6256 (RXRA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6256 (RXRA)
   05202 Transcriptional misregulation in cancer
    6256 (RXRA)
   05207 Chemical carcinogenesis - receptor activation
    6256 (RXRA)
  09162 Cancer: specific types
   05226 Gastric cancer
    6256 (RXRA)
   05216 Thyroid cancer
    6256 (RXRA)
   05222 Small cell lung cancer
    6256 (RXRA)
   05223 Non-small cell lung cancer
    6256 (RXRA)
  09172 Infectious disease: viral
   05160 Hepatitis C
    6256 (RXRA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    6256 (RXRA)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    6256 (RXRA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6256 (RXRA)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    6256 (RXRA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 hepatocyte nuclear factor 4-like
    6256 (RXRA)
Nuclear receptors [BR:hsa03310]
 2. Hepatocyte nuclear factor 4 like
  2B. Retinoid X receptor (RXR)
   6256 (RXRA)
SSDB
Motif
Pfam: Hormone_recep Nuc_recep-AF1 zf-C4 tRNA_bind_3
Other DBs
NCBI-GeneID: 6256
NCBI-ProteinID: NP_002948
OMIM: 180245
HGNC: 10477
Ensembl: ENSG00000186350
UniProt: P19793 F1D8Q5 Q6P3U7
Structure
LinkDB
Position
9:134326455..134440585
AA seq 462 aa
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggacaccaaacatttcctgccgctcgatttctccacccaggtgaactcctccctcacc
tccccgacggggcgaggctccatggctgccccctcgctgcacccgtccctggggcctggc
atcggctccccgggacagctgcattctcccatcagcaccctgagctcccccatcaacggc
atgggcccgcctttctcggtcatcagctcccccatgggcccccactccatgtcggtgccc
accacacccaccctgggcttcagcactggcagcccccagctcagctcacctatgaacccc
gtcagcagcagcgaggacatcaagccccccctgggcctcaatggcgtcctcaaggtcccc
gcccacccctcaggaaacatggcttccttcaccaagcacatctgcgccatctgcggggac
cgctcctcaggcaagcactatggagtgtacagctgcgaggggtgcaagggcttcttcaag
cggacggtgcgcaaggacctgacctacacctgccgcgacaacaaggactgcctgattgac
aagcggcagcggaaccggtgccagtactgccgctaccagaagtgcctggccatgggcatg
aagcgggaagccgtgcaggaggagcggcagcgtggcaaggaccggaacgagaatgaggtg
gagtcgaccagcagcgccaacgaggacatgccggtggagaggatcctggaggctgagctg
gccgtggagcccaagaccgagacctacgtggaggcaaacatggggctgaaccccagctcg
ccgaacgaccctgtcaccaacatttgccaagcagccgacaaacagcttttcaccctggtg
gagtgggccaagcggatcccacacttctcagagctgcccctggacgaccaggtcatcctg
ctgcgggcaggctggaatgagctgctcatcgcctccttctcccaccgctccatcgccgtg
aaggacgggatcctcctggccaccgggctgcacgtccaccggaacagcgcccacagcgca
ggggtgggcgccatctttgacagggtgctgacggagcttgtgtccaagatgcgggacatg
cagatggacaagacggagctgggctgcctgcgcgccatcgtcctctttaaccctgactcc
aaggggctctcgaacccggccgaggtggaggcgctgagggagaaggtctatgcgtccttg
gaggcctactgcaagcacaagtacccagagcagccgggaaggttcgctaagctcttgctc
cgcctgccggctctgcgctccatcgggctcaaatgcctggaacatctcttcttcttcaag
ctcatcggggacacacccattgacaccttccttatggagatgctggaggcgccgcaccaa
atgacttag

KEGG   Homo sapiens (human): 10062
Entry
10062             CDS       T01001                                 
Symbol
NR1H3, LXR-a, LXRA, RLD-1
Name
(RefSeq) nuclear receptor subfamily 1 group H member 3
  KO
K08536  liver X receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04148  Efferocytosis
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06535  Efferocytosis
  Element
N00530  HCV core to RXRA/LXRA-mediated transcription
N01781  Activation of LXRs by oxysterols
Drug target
Abequolixron (DG03218): D12298 D12299
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    10062 (NR1H3)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    10062 (NR1H3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    10062 (NR1H3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    10062 (NR1H3)
   04931 Insulin resistance
    10062 (NR1H3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    10062 (NR1H3)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    10062 (NR1H3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    10062 (NR1H3)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1H. Liver X receptor like receptor
   10062 (NR1H3)
SSDB
Motif
Pfam: Hormone_recep zf-C4
Other DBs
NCBI-GeneID: 10062
NCBI-ProteinID: NP_005684
OMIM: 602423
HGNC: 7966
Ensembl: ENSG00000025434
UniProt: Q13133 B4DXU5 F1D8N1
Structure
LinkDB
Position
11:47248300..47269033
AA seq 447 aa
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
NT seq 1344 nt   +upstreamnt  +downstreamnt
atgtccttgtggctgggggcccctgtgcctgacattcctcctgactctgcggtggagctg
tggaagccaggcgcacaggatgcaagcagccaggcccagggaggcagcagctgcatcctc
agagaggaagccaggatgccccactctgctgggggtactgcaggggtggggctggaggct
gcagagcccacagccctgctcaccagggcagagcccccttcagaacccacagagatccgt
ccacaaaagcggaaaaaggggccagcccccaaaatgctggggaacgagctatgcagcgtg
tgtggggacaaggcctcgggcttccactacaatgttctgagctgcgagggctgcaaggga
ttcttccgccgcagcgtcatcaagggagcgcactacatctgccacagtggcggccactgc
cccatggacacctacatgcgtcgcaagtgccaggagtgtcggcttcgcaaatgccgtcag
gctggcatgcgggaggagtgtgtcctgtcagaagaacagatccgcctgaagaaactgaag
cggcaagaggaggaacaggctcatgccacatccttgccccccagggcttcctcacccccc
caaatcctgccccagctcagcccggaacaactgggcatgatcgagaagctcgtcgctgcc
cagcaacagtgtaaccggcgctccttttctgaccggcttcgagtcacgccttggcccatg
gcaccagatccccatagccgggaggcccgtcagcagcgctttgcccacttcactgagctg
gccatcgtctctgtgcaggagatagttgactttgctaaacagctacccggcttcctgcag
ctcagccgggaggaccagattgccctgctgaagacctctgcgatcgaggtgatgcttctg
gagacatctcggaggtacaaccctgggagtgagagtatcaccttcctcaaggatttcagt
tataaccgggaagactttgccaaagcagggctgcaagtggaattcatcaaccccatcttc
gagttctccagggccatgaatgagctgcaactcaatgatgccgagtttgccttgctcatt
gctatcagcatcttctctgcagaccggcccaacgtgcaggaccagctccaggtagagagg
ctgcagcacacatatgtggaagccctgcatgcctacgtctccatccaccatccccatgac
cgactgatgttcccacggatgctaatgaaactggtgagcctccggaccctgagcagcgtc
cactcagagcaagtgtttgcactgcgtctgcaggacaaaaagctcccaccgctgctctct
gagatctgggatgtgcacgaatga

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