KEGG ORTHOLOGY: K08536

ORTHOLOGY: K08536

Entry

K08536                      KO

Symbol

NR1H3, LXRA

Name

liver X receptor alpha

Pathway

map03320

PPAR signaling pathway

map04148

Efferocytosis

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map05160

Hepatitis C

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K08536  NR1H3, LXRA; liver X receptor alpha
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08536  NR1H3, LXRA; liver X receptor alpha
09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K08536  NR1H3, LXRA; liver X receptor alpha
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08536  NR1H3, LXRA; liver X receptor alpha
   04931 Insulin resistance
    K08536  NR1H3, LXRA; liver X receptor alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08536  NR1H3, LXRA; liver X receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08536  NR1H3, LXRA; liver X receptor alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08536  NR1H3, LXRA; liver X receptor alpha
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1H. Liver X receptor like receptor
   K08536  NR1H3, LXRA; liver X receptor alpha

Genes

HSA:	10062(NR1H3)

PTR:	466507(NR1H3)

PPS:	100971327(NR1H3)

GGO:	101126697(NR1H3)

PON:	100453246(NR1H3)

PPYG:

129008018(NR1H3)

NLE:	100605954(NR1H3)

HMH:	116476281(NR1H3)

SSYN:

129484152(NR1H3)

MCC:	713679(NR1H3)

MCF:	102122176(NR1H3)

MTHB:

126936383

MNI:	105471680(NR1H3)

CSAB:

103236235(NR1H3)

CATY:

105592814(NR1H3)

PANU:

100997292(NR1H3)

TGE:	112606093(NR1H3)

MLEU:

105554814(NR1H3)

RRO:	104668406(NR1H3)

RBB:	108521961(NR1H3)

TFN:	117080144(NR1H3)

PTEH:

111544892(NR1H3)

CANG:

105527125(NR1H3)

CJC:	100388967(NR1H3)

SBQ:	101027381(NR1H3)

CIMI:

108304849(NR1H3)

ANAN:

105717346(NR1H3)

CSYR:

103261207(NR1H3)

MMUR:

105884841(NR1H3)

LCAT:

123642670(NR1H3)

ERUF:

138385270(NR1H3)

PCOQ:

105811098(NR1H3)

OGA:	100963453(NR1H3)

MMU:	22259(Nr1h3)

MCAL:

110290092(Nr1h3)

MPAH:

110319594(Nr1h3)

RNO:	58852(Nr1h3)

MCOC:

116090464(Nr1h3)

ANU:	117703799(Nr1h3)

ASYL:

127685610(Nr1h3)

MUN:	110550752(Nr1h3)

CGE:	100756988(Nr1h3)

MAUA:

101844164(Nr1h3)

PROB:

127222250(Nr1h3)

PLEU:

114699685(Nr1h3)

PMAV:

102923943(Nr1h3)

MORG:

121437670(Nr1h3)

MFOT:

126489768

AAMP:

119815699(Nr1h3)

CNL:	130881774(Nr1h3)

NGI:	103742506(Nr1h3)

HGL:	101709627(Nr1h3)

CPOC:

100725013(Nr1h3)

CCAN:

109696188(Nr1h3)

DORD:

105996055(Nr1h3)

DSP:	122104986(Nr1h3)

DMER:

138833921(Nr1h3)

PLOP:

125362235(Nr1h3)

NCAR:

124960239

MMMA:

107135811(Nr1h3)

ITI:	101976065(Nr1h3)

OCU:	100352900(NR1H3)

OPI:	101526478(NR1H3)

OCZ:	121156462(NR1H3)

TUP:	102470906(NR1H3)

GVR:	103592095(NR1H3)

CFA:	483625(NR1H3)

CLUD:

112663309(NR1H3)

VVP:	112924074(NR1H3)

VLG:	121472219(NR1H3)

NPO:	129499069(NR1H3)

AML:	100474551(NR1H3)

UMR:	103672313(NR1H3)

UAH:	113264967(NR1H3)

UAR:	123785017(NR1H3)

ELK:

111150112

LLV:

125078753

MPUF:

101692562(NR1H3)

MNP:	132008231 132008426

MLK:	131812350(NR1H3)

NVS:	122912893(NR1H3)

ORO:	101378256(NR1H3)

EJU:	114215361(NR1H3)

ZCA:	113913862(NR1H3)

MLX:	118015829(NR1H3)

MANO:

123857171(NR1H3)

NSU:	110575771(NR1H3)

LWW:	102739263(NR1H3)

FCA:	101092889(NR1H3)

PYU:	121043456(NR1H3)

PCOO:

112866158(NR1H3)

PBG:	122484437(NR1H3)

PVIV:

125176369(NR1H3)

LRUF:

124504923

LGF:	123601656(NR1H3)

AJU:

106978022

PTG:	102961389(NR1H3)

PPAD:

109245119(NR1H3)

PUC:

125934009

PLEZ:

122199250(NR1H3)

HHV:	120228478(NR1H3)

CCRU:

144234152(NR1H3)

BTA:	507176(NR1H3)

BOM:	102273526(NR1H3)

BIU:	109569543(NR1H3)

BJV:	133227048(NR1H3)

BKE:	129627651(NR1H3)

BBIS:

104990349(NR1H3)

CHX:	100860906(NR1H3)

OAS:	101116762(NR1H3)

OCAN:

138420703(NR1H3)

BTAX:

128060316(NR1H3)

CSUM:

138092512(NR1H3)

ODA:	120876948(NR1H3)

CCAD:

122450467(NR1H3)

MREE:

136174289(NR1H3)

OVR:	110123442(NR1H3)

MBEZ:

129554814(NR1H3)

SSC:	397553(NR1H3)

CFR:	102524294(NR1H3)

CBAI:

105076451(NR1H3)

CDK:	105106874(NR1H3)

VPC:	102531242(NR1H3)

BACU:

103020980(NR1H3)

BMUS:

118899131(NR1H3)

LVE:	103078468(NR1H3)

OOR:	101270749(NR1H3)

LALB:

132525812(NR1H3)

GMF:	115857473(NR1H3)

DDP:	132429916(NR1H3)

SCOO:

307190067(NR1H3)

DLE:	111183967(NR1H3)

PCAD:

102993698(NR1H3)

PSIU:

116757746(NR1H3)

PPHC:

136126362(NR1H3)

NASI:

112402081(NR1H3)

ECB:	100051253(NR1H3)

EPZ:	103566773(NR1H3)

EAI:	106844011(NR1H3)

MYB:	102256806(NR1H3)

MYD:	102755020(NR1H3)

MMYO:

118665063(NR1H3)

MLF:	102423593(NR1H3)

MDT:	132241201(NR1H3)

MYUM:

139018924(NR1H3)

PKL:	118713532(NR1H3)

EFUS:

103290835(NR1H3)

MNA:	107530308(NR1H3)

DRO:	112303327(NR1H3)

SHON:

118974480(NR1H3)

AJM:	119064433(NR1H3)

PDIC:

114499559(NR1H3)

PHAS:

123810168(NR1H3)

MMF:	118627553(NR1H3)

PPAM:

129081432(NR1H3)

HAI:

109390175

RFQ:	117029992(NR1H3)

PALE:

102879732(NR1H3)

PGIG:

120607208(NR1H3)

PVP:	105290031(NR1H3)

RAY:	107511849(NR1H3)

MJV:	108388644(NR1H3)

TOD:	119255300(NR1H3)

SARA:

101547453(NR1H3)

SFUM:

130042970(NR1H3)

SETR:

126017928(NR1H3)

LAV:	100673961(NR1H3)

TMU:

101350241

ETF:	101646597(NR1H3)

DNM:	101426093(NR1H3)

MDO:	100124291(NR1H3)

GAS:	123251084(NR1H3)

SHR:	100916753(NR1H3)

AFZ:

127540913

PCW:	110223918(NR1H3)

TVP:	118853907(NR1H3)

PBRV:

138163892(NR1H3)

MLAO:

141518517(NR1H3)

OAA:	100088231(NR1H3)

TACU:

119943847(NR1H3)

GGA:	395221(NR1H3)

PCOC:

116229157(NR1H3)

MGP:	100548441 104911104

CJO:	107314747(NR1H3)

TPAI:

128086328(NR1H3)

LMUT:

125694605(NR1H3)

NMEL:

110400977(NR1H3)

APLA:

101789691(NR1H3)

AACU:

137857809(NR1H3)

OJA:	118168447(NR1H3)

ACYG:

106043679(NR1H3)

CATA:

118249906(NR1H3)

AFUL:

116489839(NR1H3)

TGU:	100224796(NR1H3)

LSR:	110472063(NR1H3)

VMC:	128808477(NR1H3)

VCHA:

128789078(NR1H3)

AIB:	137475854(NR1H3)

SCAN:

103826694(NR1H3)

PMOA:

120500412(NR1H3)

OTC:	121335095(NR1H3)

PRUF:

121349391(NR1H3)

ATRC:

139590196(NR1H3)

MATE:

118687618(NR1H3)

MAEN:

136557691(NR1H3)

GFR:	102035443(NR1H3)

FAB:	101814161(NR1H3)

OMA:	130253746(NR1H3)

PHI:	102113251(NR1H3)

PMAJ:

107205450(NR1H3)

CCAE:

111930174(NR1H3)

CCW:	104697919(NR1H3)

CBRC:

103620738(NR1H3)

ACOE:

138111452(NR1H3)

ETL:	114058903(NR1H3)

ZAB:	102069499(NR1H3)

ZLE:	135448336(NR1H3)

ACHL:

103798656(NR1H3)

SVG:	106856518(NR1H3)

MMEA:

130572845(NR1H3)

HRT:	120754536(NR1H3)

SATI:

136362514(NR1H3)

CFAI:

136292363(NR1H3)

CCIC:

134044851(NR1H3)

NNT:	104400667(NR1H3)

SHAB:

115606120(NR1H3)

POCC:

134172616(NR1H3)

FPG:	101910810(NR1H3)

FCH:	102048486(NR1H3)

FRS:	119150693(NR1H3)

CCRI:

104162181(NR1H3)

ACUN:

113480619(NR1H3)

ANOC:

141962010(NR1H3)

SURA:

141943090(NR1H3)

TALA:

104356472(NR1H3)

ACHC:

115334352(NR1H3)

HALD:

104321648(NR1H3)

HLE:	104839699(NR1H3)

AGEN:

126049443

HHAR:

128139514(NR1H3)

BBUT:

142032301(NR1H3)

GCL:

127016452

CSTI:

104554091(NR1H3)

LDI:	104344530(NR1H3)

MNB:	103780833(NR1H3)

DPUB:

104297430(NR1H3)

PPUS:

135176217(NR1H3)

IIN:	128966820(NR1H3)

AVIT:

104275732(NR1H3)

BRHI:

104496259(NR1H3)

EGZ:	104134070(NR1H3)

NNI:	104020385(NR1H3)

PCRI:

104032592(NR1H3)

PCAO:

104047836(NR1H3)

PARX:

142062681(NR1H3)

PADL:

103921703(NR1H3)

AFOR:

103897474(NR1H3)

FGA:	104071254(NR1H3)

CBOR:

142083108(NR1H3)

GSTE:

104262588(NR1H3)

CBOY:

140653465(NR1H3)

MAME:

142410308(NR1H3)

CLV:	102086773(NR1H3)

CNIC:

135989950(NR1H3)

MUI:	104541027(NR1H3)

PGUU:

104471742(NR1H3)

PLET:

104623830(NR1H3)

EHS:	104504250(NR1H3)

CMAC:

104474697(NR1H3)

CUCA:

104067303(NR1H3)

PCUR:

138721225(NR1H3)

TEO:	104384218(NR1H3)

BREG:

104639495(NR1H3)

GAME:

129207163(NR1H3)

OHA:	104328087(NR1H3)

ACAR:

104528076

CPEA:

104390408(NR1H3)

CVF:	104295852(NR1H3)

RTD:	128908464(NR1H3)

CRID:

134514318(NR1H3)

LMIC:

141742360(NR1H3)

NARQ:

141465536(NR1H3)

AAM:	106498279(NR1H3)

AROW:

112973929(NR1H3)

NPD:	112943804(NR1H3)

TGT:	104574987(NR1H3)

DNE:	112979212(NR1H3)

SCAM:

104149239(NR1H3)

ASN:	102372676(NR1H3)

AMJ:	102570390(NR1H3)

CPOO:

109321387(NR1H3)

GGN:	109298893(NR1H3)

PSS:	102462146(NR1H3)

CIZ:	142014566(NR1H3)

CMY:	102941155(NR1H3)

CCAY:

125637541(NR1H3)

LKP:	140912911(NR1H3)

NDS:	141989111(NR1H3)

DCC:	119857836(NR1H3)

CPIC:

101942487(NR1H3)

TST:	117876920(NR1H3)

EOB:	135877281(NR1H3)

CABI:

116825875(NR1H3)

MRV:	120403279(NR1H3)

EMQ:	137159423(NR1H3)

ACS:	100567692(nr1h3)

ASAO:

132767940(NR1H3)

PVT:	110082017(NR1H3)

SUND:

121922620(NR1H3)

PBI:	103059096(NR1H3)

PMUR:

107289838(NR1H3)

CTIG:

120314639(NR1H3)

TSR:	106552441(NR1H3)

PGUT:

117665533(NR1H3)

PCAE:

139307886(NR1H3)

APRI:

131187480(NR1H3)

PTEX:

113441139(NR1H3)

NSS:	113414344(NR1H3)

VKO:	123026301(NR1H3)

PMUA:

114595776(NR1H3)

PRAF:

128413004(NR1H3)

ZVI:	118084837(NR1H3)

HCG:	128340430(NR1H3)

GJA:	107123209(NR1H3)

STOW:

125425967(NR1H3)

EMC:	129324312(NR1H3)

PWL:	138283681(NR1H3)

MUO:	115468847(NR1H3)

GSH:	117352172(NR1H3)

DRE:	548341(nr1h3)

DAES:

130232067(nr1h3)

SRX:	107740482 107755109

SANH:

107664377 107689968

SGH:	107553099 107563452

CCAR:

109063142 109063146(nr1h3)

CAUA:

113051496 113106024

CGIB:

127961992 128016889

PTET:

122349293(nr1h3)

LROH:

127168398(nr1h3)

GRF:	141331165(nr1h3)

OMC:	131544398(nr1h3)

PPRM:

120490960(nr1h3)

RKG:	130099649(nr1h3)

MAMB:

125264803(nr1h3)

CIDE:

127515544

CERY:

137031371(nr1h3)

MASI:

127446661 127455588

TDW:	130430103(nr1h3)

MANU:

129444385(nr1h3)

PDAB:

135749317(nr1h3)

IPU:

108259587

IFU:	128602922(nr1h3)

PHYP:

113540920(nr1h3)

SMEO:

124380029(nr1h3)

TFD:	113636740(nr1h3)

TVC:	132838863(nr1h3)

CGAR:

128519251(nr1h3)

NGRA:

132874747(nr1h3)

TRN:	134303977(nr1h3)

AMEX:

103030650(nr1h3)

CMAO:

118817506(nr1h3)

EEE:	113574111(nr1h3)

CHAR:

105906540(nr1h3)

SPIL:

134096264(nr1h3)

ASAD:

121681626(nr1h3)

TRU:	101071817(nr1h3)

TFS:	130521764(nr1h3)

NCC:	104955310(nr1h3)

TBEN:

117471313(nr1h3)

CGOB:

115025058(nr1h3)

PGEO:

117464281(nr1h3)

GACU:

117549429(nr1h3)

EMAC:

134862608(nr1h3)

ELY:	117255500(nr1h3)

EFO:	125902405(nr1h3)

PLEP:

121946124(nr1h3)

SLUC:

116043386(nr1h3)

SVIT:

144528123(nr1h3)

ECRA:

117944866(nr1h3)

ESP:	116691766(nr1h3)

PFLV:

114553848(nr1h3)

PFLT:

120555720(nr1h3)

GAT:	120835797(nr1h3)

PPUG:

119229114(nr1h3)

AFB:	129101707(nr1h3)

CLUM:

117747531(nr1h3)

PSWI:

130192725(nr1h3)

CANA:

137785855(nr1h3)

CVE:	137882116(nr1h3)

AMIR:

142934160(nr1h3)

MSAM:

119889711(nr1h3)

SCHU:

122878755(nr1h3)

EARM:

139283039(nr1h3)

CUD:	121510751(nr1h3)

SPUL:

138587879(nr1h3)

LMIX:

132994812(nr1h3)

HTC:	141788209(nr1h3)

ALAT:

119017958(nr1h3)

ASTR:

137612255(nr1h3)

PKLU:

139212917(nr1h3)

LCO:	104920625(nr1h3)

MZE:	101487674(nr1h3)

ONL:	100702741(nr1h3)

OAU:	116324024(nr1h3)

OLA:	101163474(nr1h3)

OML:	112160647(nr1h3)

CSAI:

133459208(nr1h3)

XMA:	102221658(nr1h3)

XCO:	114143060(nr1h3)

XHE:	116718298(nr1h3)

PRET:

103462712(nr1h3)

PFOR:

103149704(nr1h3)

PLAI:

106938308(nr1h3)

PMEI:

106911832(nr1h3)

GAF:	122845880(nr1h3)

PPRL:

129364293(nr1h3)

CVG:	107095562(nr1h3)

CTUL:

119773585(nr1h3)

GMU:	124867022(nr1h3)

NFU:	107381957(nr1h3)

KMR:	108234799(nr1h3)

ALIM:

106523554(nr1h3)

NWH:	119430236(nr1h3)

LTU:	140301536(nr1h3)

MCEP:

125005302(nr1h3)

AOCE:

111571031(nr1h3)

EJA:	138208088(nr1h3)

BFRE:

138633549(nr1h3)

LCF:

108887816

CSEM:

103398631(nr1h3)

POV:	109637258(nr1h3)

SSEN:

122772301(nr1h3)

SSOE:

131459387(nr1h3)

HHIP:

117759195(nr1h3)

HSP:	118112735(nr1h3)

PPLT:

128449291(nr1h3)

SMAU:

118302037(nr1h3)

SDU:	111223407(nr1h3)

SLAL:

111644318(nr1h3)

XGL:	120791626(nr1h3)

HCQ:	109525775(nr1h3)

SSCV:

125967245(nr1h3)

SBIA:

133498421(nr1h3)

PEE:	133399122(nr1h3)

PTAO:

133471869(nr1h3)

BPEC:

110162465(nr1h3)

ENY:	140381295(nr1h3)

MALB:

109965075(nr1h3)

BSPL:

114851792(nr1h3)

SJO:	128379575(nr1h3)

SSCO:

133985524(nr1h3)

TTY:	137172508(nr1h3)

GMH:	115559179(nr1h3)

SASA:

100270809(nr1h3) 106561932

STRU:

115167550 115202857

OTW:	112248987 112263485

OMY:	100286817(nr1h3) 110506299

OGO:	124033933(nr1h3) 124035905

ONE:	115112058 115113472

OKI:	109885055 109895544

OKE:	118357526 118393657

OMM:	135505783 135546570

OCLA:

139385241 139411300

SALP:

111969202 111974002

SNH:	120024726 120045480

SFON:

129834256 129854116

CCLU:

121534848 121573295

ELS:	105025968(nr1h3)

OEP:	134027743(nr1h3)

SFM:	108938803 108940795

PKI:	111843355(nr1h3) 111851925

AANG:

118227325(nr1h3)

AROT:

135255045(nr1h3)

CCOG:

133130325(nr1h3)

LOC:	102684692(nr1h3)

PSPA:

121294502 121329926

ARUT:

117432029 117434977

PSEX:

120529906(nr1h3)

LCM:	102349225(NR1H3)

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

140728754(nr1h3)

PMRN:

BFO:

BBEL:

CIN:

SPU:	574588(Ecr/Fxr)

LPIC:

LVG:

AJJ:

APLC:

ARUN:

SKO:	100313647 102800686

HVI:

MQU:

FCD:

DPZ:

TCF:	131882656 131884821

LPOL:

106457829 106461441 106467738 106472442 106475416

PMEO:

129580766

CBR:

CBG_01321

LGI:	LOTGIDRAFT_122846

BARL:

143277696

BGT:

106052335

GAE:	121380533 121386287

HRF:

HRJ:

HCRA:

CRG:

CANU:

CVN:

OED:

YBA:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LAK:

LLON:

Reference

PMID:19520913

Authors

Zelcer N, Hong C, Boyadjian R, Tontonoz P

Title

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Journal

Science 325:100-4 (2009)
DOI:10.1126/science.1168974

Sequence

[mmu:22259]

Reference

PMID:7744246

Authors

Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ

Title

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

Journal

Genes Dev 9:1033-45 (1995)
DOI:10.1101/gad.9.9.1033

Sequence

[hsa:10062]

LinkDB

DBGET integrated database retrieval system