KEGG ORTHOLOGY: K10031

ORTHOLOGY: K10031

Entry

K10031                      KO

Symbol

CXCL12

Name

C-X-C motif chemokine 12

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04360

Axon guidance

map04670

Leukocyte transendothelial migration

map04672

Intestinal immune network for IgA production

map04810

Regulation of actin cytoskeleton

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05323

Rheumatoid arthritis

Disease

H01563

HIV infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K10031  CXCL12; C-X-C motif chemokine 12
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K10031  CXCL12; C-X-C motif chemokine 12
   04061 Viral protein interaction with cytokine and cytokine receptor
    K10031  CXCL12; C-X-C motif chemokine 12
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K10031  CXCL12; C-X-C motif chemokine 12
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K10031  CXCL12; C-X-C motif chemokine 12
   04672 Intestinal immune network for IgA production
    K10031  CXCL12; C-X-C motif chemokine 12
   04062 Chemokine signaling pathway
    K10031  CXCL12; C-X-C motif chemokine 12
  09158 Development and regeneration
   04360 Axon guidance
    K10031  CXCL12; C-X-C motif chemokine 12
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10031  CXCL12; C-X-C motif chemokine 12
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K10031  CXCL12; C-X-C motif chemokine 12
  09163 Immune disease
   05323 Rheumatoid arthritis
    K10031  CXCL12; C-X-C motif chemokine 12
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K10031  CXCL12; C-X-C motif chemokine 12
   00536 Glycosaminoglycan binding proteins
    K10031  CXCL12; C-X-C motif chemokine 12
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Chemokines
   K10031  CXCL12; C-X-C motif chemokine 12
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Chemokines
   K10031  CXCL12; C-X-C motif chemokine 12

Genes

HSA:	6387(CXCL12)

PTR:	741624(CXCL12)

GGO:

101124266

PON:	100173045(CXCL12)

PPYG:

129006249(CXCL12)

NLE:	100580964(CXCL12)

HMH:	116461227(CXCL12)

SSYN:

129480855(CXCL12)

MCC:	574334(CXCL12)

MCF:	102124268(CXCL12)

MTHB:

126962810

MNI:	105486587(CXCL12)

CSAB:

103215781(CXCL12)

CATY:

105571555(CXCL12)

PANU:

101001096

TGE:	112631584(CXCL12)

RRO:	104664320(CXCL12)

RBB:	108541957(CXCL12)

TFN:	117082122(CXCL12)

PTEH:

111531323(CXCL12)

CANG:

105520175(CXCL12)

CJC:	100402880(CXCL12)

SBQ:	101050663(CXCL12)

CIMI:

108293223(CXCL12)

ANAN:

105733255

CSYR:

103269764 103277206

MMUR:

105863684(CXCL12)

LCAT:

123649875(CXCL12)

PCOQ:

105818048(CXCL12)

OGA:	100946548(CXCL12)

MMU:	20315(Cxcl12)

MCAL:

110296032(Cxcl12)

MPAH:

110316423(Cxcl12)

RNO:	24772(Cxcl12)

MCOC:

116099458(Cxcl12)

ANU:	117701531 117715074(Cxcl12)

MUN:	110565182(Cxcl12)

CGE:	100759082(Cxcl12)

MAUA:

101838717(Cxcl12)

PROB:

127236246(Cxcl12)

PLEU:

114689656(Cxcl12)

MORG:

121437111(Cxcl12)

MFOT:

126505459

AAMP:

119806470(Cxcl12)

NGI:	103745020(Cxcl12)

HGL:	101722912(Cxcl12)

CPOC:

100721137(Cxcl12)

CCAN:

109700677(Cxcl12)

DORD:

105998905(Cxcl12)

DSP:	122122261(Cxcl12)

PLOP:

125346572(Cxcl12)

MMMA:

107153384(Cxcl12)

OCU:

103345545

OPI:	101532824(CXCL12)

TUP:	102499711(CXCL12)

GVR:	103608094(CXCL12)

CFA:	449622(CXCL12)

CLUD:

112672005(CXCL12)

VLG:	121484208(CXCL12)

NPO:	129522889(CXCL12)

AML:	100482629(CXCL12)

UMR:	103667923(CXCL12)

UAH:	113243131(CXCL12)

UAR:	123800307(CXCL12)

ELK:

111145109

LLV:

125084462

MPUF:

101688833(CXCL12)

MNP:	132016597(CXCL12)

MLK:	131828696(CXCL12)

NVS:	122900892(CXCL12)

ORO:	101378047(CXCL12)

EJU:	114205352(CXCL12)

ZCA:	113919912(CXCL12)

MLX:	118023063(CXCL12)

NSU:	110589684(CXCL12)

LWW:	102749610(CXCL12)

FCA:	493806(CXCL12)

PYU:	121036956(CXCL12)

PCOO:

112854348(CXCL12)

PBG:	122492994(CXCL12)

PVIV:

125147958(CXCL12)

LRUF:

124506687

PTG:	102962805(CXCL12)

PPAD:

109264599(CXCL12)

PUC:

125933365

AJU:

106972104

HHV:	120225423(CXCL12)

BTA:	613811(CXCL12)

BOM:	102275373(CXCL12)

BIU:	109553743(CXCL12)

BBUB:

102403960(CXCL12)

BBIS:

104999066(CXCL12)

CHX:	102169556(CXCL12)

OAS:	101121145(CXCL12)

BTAX:

128047373(CXCL12)

CSUM:

138087005(CXCL12)

ODA:	120865492(CXCL12)

CCAD:

122446291(CXCL12)

MREE:

136159936(CXCL12)

MBEZ:

129555606(CXCL12)

SSC:	494460(CXCL12)

CFR:	102515651(CXCL12)

CBAI:

105078516(CXCL12)

CDK:	105084484(CXCL12)

VPC:	102540695(CXCL12)

BACU:

103011229(CXCL12)

BMUS:

118882730(CXCL12)

LVE:

103071897

OOR:	101282620(CXCL12)

DLE:	111172563(CXCL12)

PCAD:

102990097(CXCL12)

PSIU:

116741976(CXCL12)

NASI:

112395745(CXCL12)

ECB:	100049872(CXCL12)

EPZ:	103561655(CXCL12)

EAI:	106842910(CXCL12)

MYB:	102247013(CXCL12)

MYD:	102753863(CXCL12)

MMYO:

118679334(CXCL12)

MLF:	102416999(CXCL12)

MDT:	132214744(CXCL12)

PKL:	118732152(CXCL12)

EFUS:

103292845(CXCL12)

MNA:	107532553(CXCL12)

DRO:	112305553(CXCL12)

SHON:

118979932(CXCL12)

AJM:	119044080(CXCL12)

PDIC:

114496379(CXCL12)

PHAS:

123821064(CXCL12)

MMF:	118632498(CXCL12)

PPAM:

129073182(CXCL12)

HAI:	109395869(CXCL12)

RFQ:	117035885(CXCL12)

PALE:

102881363(CXCL12)

PGIG:

120589905(CXCL12)

PVP:	105304170(CXCL12)

RAY:	107517786(CXCL12)

MJV:	108404560(CXCL12)

TOD:	119233596(CXCL12) 119237830

SARA:

101548656(CXCL12)

SETR:

126020631 126033750(CXCL12)

LAV:	100670325(CXCL12)

TMU:

101347066

ETF:	101643882(CXCL12)

DNM:	101422359(CXCL12)

MDO:	100016207(CXCL12)

GAS:	123232986(CXCL12)

SHR:	100918574(CXCL12)

AFZ:

127552014

PCW:	110213923(CXCL12)

TVP:	118828717(CXCL12)

PBRV:

138148540(CXCL12)

OAA:	100082099(CXCL12)

GGA:	395180(CXCL12)

PCOC:

116238133(CXCL12)

MGP:	100549677(CXCL12)

CJO:	107315894(CXCL12)

TPAI:

128077727(CXCL12)

LMUT:

125693556(CXCL12)

NMEL:

110399639(CXCL12)

APLA:

101792342(CXCL12)

ACYG:

106045387(CXCL12)

CATA:

118249306(CXCL12)

AFUL:

116491233(CXCL12)

TGU:	100189973(CXCL12)

LSR:	110475280(CXCL12)

SCAN:

103813941(CXCL12)

PMOA:

120502095(CXCL12)

OTC:	121341792(CXCL12)

PRUF:

121350161(CXCL12)

GFR:	102033194(CXCL12)

FAB:	101820614(CXCL12)

OMA:	130254798(CXCL12)

PHI:	102100846(CXCL12)

PMAJ:

107207018(CXCL12)

CCAE:

111931155(CXCL12)

CCW:	104697928(CXCL12)

CBRC:

103624601(CXCL12)

ACOE:

138112454(CXCL12)

ETL:	114055885(CXCL12)

ZAB:	102069041(CXCL12)

ZLE:	135449417(CXCL12)

ACHL:

103800899(CXCL12)

SVG:	106852637(CXCL12)

MMEA:

130576370(CXCL12)

HRT:	120755698(CXCL12)

SATI:

136364197(CXCL12)

FPG:	101911584(CXCL12)

FCH:	102048813(CXCL12)

CCRI:

104165585(CXCL12)

NNT:	104408654(CXCL12)

SHAB:

115608651(CXCL12)

ACUN:

113481656(CXCL12)

TALA:

104368838(CXCL12)

ACHC:

115348274(CXCL12)

HALD:

104325315(CXCL12)

HLE:	104829311(CXCL12)

AGEN:

126043005

HHAR:

128147179(CXCL12)

GCL:

127017725

CSTI:

104556453(CXCL12)

LDI:	104350673(CXCL12)

DPUB:

104297721(CXCL12)

PPUS:

135176105(CXCL12)

AVIT:

104277999(CXCL12)

BRHI:

104491285(CXCL12)

EGZ:	104129041(CXCL12)

NNI:	104013182(CXCL12)

PCRI:

104037561(CXCL12)

PCAO:

104053721(CXCL12)

PADL:

103913969(CXCL12)

AFOR:

103897829(CXCL12)

FGA:	104074807(CXCL12)

GSTE:

104262394(CXCL12)

CLV:	102090996(CXCL12)

MUI:	104539559(CXCL12)

PGUU:

104467544(CXCL12)

PLET:

104616109(CXCL12)

EHS:	104505339(CXCL12)

CMAC:

104486514(CXCL12)

CUCA:

104067960(CXCL12)

TEO:	104382360(CXCL12)

BREG:

104636404(CXCL12)

ACAR:

104529546(CXCL12)

CPEA:

104391132(CXCL12)

CVF:	104289799(CXCL12)

RTD:	128911686(CXCL12)

AAM:	106486017(CXCL12)

AROW:

112971443(CXCL12)

NPD:	112957978(CXCL12)

DNE:	112989057(CXCL12)

SCAM:

104146046(CXCL12)

ASN:	102387717(CXCL12)

AMJ:	102570463(CXCL12)

CPOO:

109324021(CXCL12)

GGN:	109287464(CXCL12)

PSS:	102444738(CXCL12)

CMY:	102932326(CXCL12)

CCAY:

125640086(CXCL12)

DCC:	119859325(CXCL12)

CPIC:

101934557(CXCL12)

TST:	117880105(CXCL12)

CABI:

116816959(CXCL12)

MRV:	120368645(CXCL12)

ACS:	100562638(cxcl12)

ASAO:

132771391(CXCL12)

PVT:	110087249(CXCL12)

SUND:

121926629(CXCL12)

PBI:	103061515(CXCL12)

CTIG:

120309933(CXCL12)

TSR:	106554744(CXCL12)

PGUT:

117664640 132709266

APRI:

131200031(CXCL12)

PTEX:

113449387(CXCL12)

NSS:	113425201(CXCL12)

VKO:	123018304(CXCL12)

PMUA:

114596977(CXCL12)

PRAF:

128413647(CXCL12)

ZVI:	118096423(CXCL12)

HCG:	128350897(CXCL12)

STOW:

125437871(CXCL12)

EMC:	129331834(CXCL12)

XLA:	108697525(cxcl12.S) 399030(cxcl12.L)

XTR:	548481(cxcl12)

NPR:	108798108(CXCL12)

RTEM:

120909118(CXCL12)

BBUF:

121003414(CXCL12)

BGAR:

122923898(CXCL12)

MUO:	115470206(CXCL12)

GSH:	117360075(CXCL12)

DRE:	352944(cxcl12a) 799354(cxcl12b)

SRX:	107707253 107742101 107755354 107757152

SANH:

107655346 107659313 107668809 107673912

SGH:	107548639 107566036 107566675 107588617

CCAR:

109048144 109074670 109074671 109108799

CAUA:

113039965 113056860 113065054 113112534

CGIB:

127943442 127970497 127988308 128026127

PTET:

122327802(cxcl12b) 122356591(cxcl12a)

LROH:

127153474(cxcl12b) 127174727(cxcl12a)

OMC:	131531443(cxcl12b) 131552160(cxcl12a)

PPRM:

120479562(cxcl12a) 120495443(cxcl12b)

RKG:	130103548(cxcl12b)

MAMB:

125263708(cxcl12b) 125277036(cxcl12a)

CIDE:

127521556 127524997

CERY:

137020634(cxcl12a) 137029213(cxcl12b)

MASI:

127411904 127413588 127438183 127438959

TROS:

130549193(cxcl12b) 130559410(cxcl12a)

TDW:	130429987(cxcl12b) 130431686(cxcl12a)

MANU:

129416739(cxcl12a) 129453691(cxcl12b)

IPU:	100304642(cxcl12a) 108259449(cxcl12b)

IFU:	128603005(cxcl12b) 128605635(cxcl12a)

PHYP:

113538922(cxcl12) 113547634

SMEO:

124380067(cxcl12b) 124403076(cxcl12a)

TFD:	113639876(cxcl12a) 113657151(cxcl12b)

TVC:	132838853(cxcl12b) 132847311(cxcl12a)

TRN:	134304076(cxcl12b) 134314571(cxcl12a)

AMEX:

103032032(cxcl12a) 111192101(cxcl12b)

CMAO:

118804603(cxcl12b) 118810424(cxcl12a)

EEE:	113580699 113583379

CHAR:

105904370(cxcl12a) 105905820(cxcl12b)

TRU:	101065739 101068933(cxcl12)

TFS:	130527786(cxcl12b) 130533741(cxcl12a)

TNG:	GSTEN00030635G001

LCO:	109136722 109138674

NCC:	104962515 104966307

TBEN:

117474815(cxcl12b) 117499504(cxcl12a)

CGOB:

115014055 115019976

PGEO:

117459499(cxcl12a) 117466686(cxcl12b)

GACU:

117536776(cxcl12a) 117561707(cxcl12b)

EMAC:

134858523(cxcl12a) 134865244(cxcl12b)

ELY:	117247832(cxcl12a) 117255937(cxcl12b)

EFO:	125886050(cxcl12b) 125903682(cxcl12a)

PLEP:

121942298(cxcl12b) 121954455(cxcl12a)

SLUC:

116042972(cxcl12b) 116053293(cxcl12a) 116064556 116065563

ECRA:

117960263(cxcl12a) 117960853(cxcl12b)

ESP:	116697929(cxcl12) 116705372

PFLV:

114570150 114571963

GAT:	120820619(cxcl12a) 120825491(cxcl12b)

PPUG:

119214553(cxcl12a) 119218427(cxcl12b)

AFB:	129092469(cxcl12a) 129095647(cxcl12b)

CLUM:

117733441(cxcl12b) 117743998(cxcl12a)

PSWI:

130190669(cxcl12b) 130207621(cxcl12a)

CANA:

137779797(cxcl12a) 137795099(cxcl12b)

CVE:	137881306(cxcl12a) 137885200(cxcl12b)

MSAM:

119899424(cxcl12b) 119911155 119917251(cxcl12a)

SCHU:

122874112(cxcl12b) 122883934(cxcl12a)

CUD:	121508382(cxcl12b) 121511520(cxcl12a)

ALAT:

119029003(cxcl12b) 119033966(cxcl12a)

ASTR:

137599997(cxcl12b) 137603493(cxcl12a)

MZE:	101469013 101481660

ONL:	100695280 100709445

OAU:	116310602(cxcl12b) 116319633(cxcl12a) 120440579

OLA:	100049305(cxcl12) 100170634(a-sdf1a)

OML:	112137545(cxcl12b) 112162037(cxcl12a)

CSAI:

133444133(cxcl12b) 133463750(cxcl12a)

XMA:	102217278 102231893

XCO:	114138337 114145173

XHE:	116713570 116720497

PRET:

103464854 103476956

PFOR:

103134026 103148710 103148711

PLAI:

106944795 106945950 106945951

PMEI:

106915135 106934267 106934273

GAF:	122829738(cxcl12b) 122842328(cxcl12a)

PPRL:

129360105(cxcl12a) 129366951(cxcl12b)

CVG:	107083437 107086564(cxcl12)

CTUL:

119787486(cxcl12b) 119790696(cxcl12a)

GMU:	124858569(cxcl12a) 124868962(cxcl12b)

NFU:	107375628(cxcl12) 107390623

KMR:	108233956(cxcl12a) 108241502(cxcl12b)

ALIM:

106521077 106524057(cxcl12)

NWH:	119412223(cxcl12a) 119422899

AOCE:

111569928 111577430

EJA:	138195401(cxcl12a) 138209232(cxcl12b)

MCEP:

125004378(cxcl12b) 125019140(cxcl12a)

CSEM:

103384081 103387352(cxcl12)

POV:	109627676 109636302(cxcl12)

SSEN:

122771626(cxcl12b) 122781822(cxcl12a)

HHIP:

117765822(cxcl12b) 117775951(cxcl12a)

HSP:	118119334(cxcl12a) 118121246(cxcl12b)

PPLT:

128436834(cxcl12b) 128453223(cxcl12a)

SMAU:

118283653(cxcl12a) 118312837(cxcl12b)

LCF:	108885399(cxcl12b) 108888279(cxcl12a)

SDU:	111229327 111234130

SLAL:

111658169 111665567

XGL:	120796810(cxcl12a) 120800899(cxcl12b)

HCQ:	109512727 109519922

SSCV:

125969257(cxcl12b) 125978598(cxcl12a)

SBIA:

133506494(cxcl12b) 133509990(cxcl12a)

PEE:	133403990(cxcl12b) 133409680(cxcl12a)

PTAO:

133476280(cxcl12b) 133486045(cxcl12a)

BPEC:

110157205(cxcl12) 110166223

MALB:

109972290

BSPL:

114841789(cxcl12a) 114850820 114850821 114853818(cxcl12b)

SJO:	128373017(cxcl12a) 128379275

SASA:

100195758(sdf1) 106576870(cxcl12) 106589772(SDF1) 106604225

STRU:

115147390 115152958 115177846 115194046

OTW:	112238369(cxcl12b) 112252759 112260647

OMY:	101268934(cxcl12a) 101268968(cxcl12b) 110485539 110502234

OGO:	124015101 124015102 124028198 124038085 124041477(cxcl12a)

ONE:	115113420 115127180 115135349

OKI:	109876194 109876502 109889729 116375796

OKE:	118369460 118402441 127927574(cxcl12b)

SALP:

111977450 112076761 112080896

SNH:	120017493(cxcl12a) 120032573(cxcl12b) 120045829

CCLU:

121553219 121554041(cxcl12b) 121568369

ELS:	105012114 105027239

SFM:	108918134 114909439

PKI:	111848490 111850382

AANG:

118217992(cxcl12a) 118221512(cxcl12b)

LOC:	102693349(cxcl12)

PSPA:

121322037 121325839

ARUT:

117415841 117418502

PSEX:

120541869(cxcl12a)

LCM:	102358188(CXCL12)

CMK:	103182167(cxcl12a)

RTP:	109918356 109918357(cxcl12a)

CPLA:

122541822(cxcl12a) 122541823

HOC:	132834992 132834996

LERI:

PMRN:

LRJ:

Reference

PMID:7490086

Authors

Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T

Title

Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene.

Journal

Genomics 28:495-500 (1995)
DOI:10.1006/geno.1995.1180

Sequence

[hsa:6387]

LinkDB

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