KEGG   Homo sapiens (human): 6389
Entry
6389              CDS       T01001                                 
Symbol
SDHA, CMD1GG, FP, MC2DN1, NDAXOA, PGL5, SDH1, SDH2, SDHF
Name
(RefSeq) succinate dehydrogenase complex flavoprotein subunit A
  KO
K00234  succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00148  Succinate dehydrogenase (ubiquinone)
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06252  Mitochondrial ROS formation
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
  Element
N00988  Electron transfer in Complex II
N00989  Mutation-caused aberrant Htt to electron transfer in Complex II
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01402  Manganese to electron transfer in Complex II
N01609  Citrate cycle, second carbon oxidation
Disease
H00294  Dilated cardiomyopathy
H01022  Diseases of the tricarboxylic acid cycle
H01354  Leigh syndrome
H02005  Mitochondrial complex II deficiency
H02538  Paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    6389 (SDHA)
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    6389 (SDHA)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    6389 (SDHA)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    6389 (SDHA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    6389 (SDHA)
   05012 Parkinson disease
    6389 (SDHA)
   05014 Amyotrophic lateral sclerosis
    6389 (SDHA)
   05016 Huntington disease
    6389 (SDHA)
   05020 Prion disease
    6389 (SDHA)
   05022 Pathways of neurodegeneration - multiple diseases
    6389 (SDHA)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    6389 (SDHA)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    6389 (SDHA)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     6389 (SDHA)
SSDB
Motif
Pfam: FAD_binding_2 Succ_DH_flav_C Pyr_redox_2 Thi4 GIDA FAD_binding_3 DAO HI0933_like
Other DBs
NCBI-GeneID: 6389
NCBI-ProteinID: NP_004159
OMIM: 600857
HGNC: 10680
Ensembl: ENSG00000073578
Pharos: P31040(Tbio)
UniProt: P31040 A0A024QZ30
Structure
LinkDB
Position
5:218320..268746
AA seq 664 aa
MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDH
EFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWR
WHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKF
GKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIE
DGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGI
YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPE
KDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ
VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDK
VPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKIS
KLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVR
IDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPA
IRSY
NT seq 1995 nt   +upstreamnt  +downstreamnt
atgtcgggggtccggggcctgtcgcggctgctgagcgctcggcgcctggcgctggccaag
gcgtggccaacagtgttgcaaacaggaacccgaggttttcacttcactgttgatgggaac
aagagggcatctgctaaagtttcagattccatttctgctcagtatccagtagtggatcat
gaatttgatgcagtggtggtaggcgctggaggggcaggcttgcgagctgcatttggcctt
tctgaggcagggtttaatacagcatgtgttaccaagctgtttcctaccaggtcacacact
gttgcagcacagggaggaatcaatgctgctctggggaacatggaggaggacaactggagg
tggcatttctacgacaccgtgaagggctccgactggctgggggaccaggatgccatccac
tacatgacggagcaggcccccgccgccgtggtcgagctagaaaattatggcatgccgttt
agcagaactgaagatgggaagatttatcagcgtgcatttggtggacagagcctcaagttt
ggaaagggcgggcaggcccatcggtgctgctgtgtggctgatcggactggccactcgcta
ttgcacaccttatatggaaggtctctgcgatatgataccagctattttgtggagtatttt
gccttggatctcctgatggagaatggggagtgccgtggtgtcatcgcactgtgcatagag
gacgggtccatccatcgcataagagcaaagaacactgttgttgccacaggaggctacggg
cgcacctacttcagctgcacgtctgcccacaccagcactggcgacggcacggccatgatc
accagggcaggccttccttgccaggacctagagtttgttcagttccaccctacaggcata
tatggtgctggttgtctcattacggaaggatgtcgtggagagggaggcattctcattaac
agtcaaggcgaaaggtttatggagcgatacgcccctgtcgcgaaggacctggcgtctaga
gatgtggtgtctcggtccatgactctggagatccgagaaggaagaggctgtggccctgag
aaagatcacgtctacctgcagctgcaccacctacctccagagcagctggccacgcgcctg
cctggcatttcagagacagccatgatcttcgctggcgtggacgtcacgaaggagccgatc
cctgtcctccccaccgtgcattataacatgggcggcattcccaccaactacaaggggcag
gtcctgaggcacgtgaatggccaggatcagattgtgcccggcctgtacgcctgtggggag
gccgcctgtgcctcggtacatggtgccaaccgcctcggggcaaactcgctcttggacctg
gttgtctttggtcgggcatgtgccctgagcatcgaagagtcatgcaggcctggagataaa
gtccctccaattaaaccaaacgctggggaagaatctgtcatgaatcttgacaaattgaga
tttgctgatggaagcataagaacatcggaactgcgactcagcatgcagaagtcaatgcaa
aatcatgctgccgtgttccgtgtgggaagcgtgttgcaagaaggttgtgggaaaatcagc
aagctctatggagacctaaagcacctgaagacgttcgaccggggaatggtctggaacacg
gacctggtggagaccctggagctgcagaacctgatgctgtgtgcgctgcagaccatctac
ggagcagaggcacggaaggagtcacggggcgcgcatgccagggaagactacaaggtgcgg
attgatgagtacgattactccaagcccatccaggggcaacagaagaagccctttgaggag
cactggaggaagcacaccctgtcctatgtggacgttggcactgggaaggtcactctggaa
tatagacccgtgatcgacaaaactttgaacgaggctgactgtgccaccgtcccgccagcc
attcgctcctactga

KEGG   Homo sapiens (human): 6390
Entry
6390              CDS       T01001                                 
Symbol
SDHB, CWS2, IP, MC2DN4, PGL4, SDH, SDH1, SDH2, SDHIP
Name
(RefSeq) succinate dehydrogenase complex iron sulfur subunit B
  KO
K00235  succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00148  Succinate dehydrogenase (ubiquinone)
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06252  Mitochondrial ROS formation
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
  Element
N00988  Electron transfer in Complex II
N00989  Mutation-caused aberrant Htt to electron transfer in Complex II
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01402  Manganese to electron transfer in Complex II
N01609  Citrate cycle, second carbon oxidation
Disease
H01222  Cowden syndrome
H01510  Malignant paraganglioma
H01591  Gastrotintestinal stromal tumor
H02005  Mitochondrial complex II deficiency
H02538  Paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    6390 (SDHB)
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    6390 (SDHB)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    6390 (SDHB)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    6390 (SDHB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    6390 (SDHB)
   05012 Parkinson disease
    6390 (SDHB)
   05014 Amyotrophic lateral sclerosis
    6390 (SDHB)
   05016 Huntington disease
    6390 (SDHB)
   05020 Prion disease
    6390 (SDHB)
   05022 Pathways of neurodegeneration - multiple diseases
    6390 (SDHB)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    6390 (SDHB)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    6390 (SDHB)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     6390 (SDHB)
SSDB
Motif
Pfam: Fer2_3 Fer4_17 Fer4_8 Fer4_10 Fer2 Fer4_9 Fer4_18 Fer4_7
Other DBs
NCBI-GeneID: 6390
NCBI-ProteinID: NP_002991
OMIM: 185470
HGNC: 10681
Ensembl: ENSG00000117118
Pharos: P21912(Tbio)
UniProt: P21912
Structure
LinkDB
Position
1:complement(17018722..17054032)
AA seq 280 aa
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
NT seq 843 nt   +upstreamnt  +downstreamnt
atggcggcggtggtcgccctctccttgaggcgccggttgccggccacaacccttggcgga
gcctgcctgcaggcctcccgaggagcccagacagctgcagccacagctccccgtatcaag
aaatttgccatctatcgatgggacccagacaaggctggagacaaacctcatatgcagact
tatgaagttgaccttaataaatgtggccccatggtattggatgctttaatcaagattaag
aatgaagttgactctactttgaccttccgaagatcatgcagagaaggcatctgtggctct
tgtgcaatgaacatcaatggaggcaacactctagcttgcacccgaaggattgacaccaac
ctcaataaggtctcaaaaatctaccctcttccacacatgtatgtgataaaggatcttgtt
cccgatttgagcaacttctatgcacagtacaaatccattgagccttatttgaagaagaag
gatgaatctcaggaaggcaagcagcagtatctgcagtccatagaagagcgtgagaaactg
gacgggctctacgagtgcattctctgtgcctgctgtagcaccagctgccccagctactgg
tggaacggagacaaatatctggggcctgcagttcttatgcaggcctatcgctggatgatt
gactccagagatgacttcacagaggagcgcctggccaagctgcaggacccattctctcta
taccgctgccacaccatcatgaactgcacaaggacctgtcctaagggtctgaatccaggg
aaagctattgcagagatcaagaaaatgatggcaacctataaggagaagaaagcttcagtt
taa

KEGG   Homo sapiens (human): 6391
Entry
6391              CDS       T01001                                 
Symbol
SDHC, CYB560, CYBL, PGL3, QPS1, SDH3
Name
(RefSeq) succinate dehydrogenase complex subunit C
  KO
K00236  succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00148  Succinate dehydrogenase (ubiquinone)
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06252  Mitochondrial ROS formation
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
  Element
N00988  Electron transfer in Complex II
N00989  Mutation-caused aberrant Htt to electron transfer in Complex II
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01402  Manganese to electron transfer in Complex II
N01609  Citrate cycle, second carbon oxidation
Disease
H01510  Malignant paraganglioma
H01591  Gastrotintestinal stromal tumor
H02538  Paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    6391 (SDHC)
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    6391 (SDHC)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    6391 (SDHC)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    6391 (SDHC)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    6391 (SDHC)
   05012 Parkinson disease
    6391 (SDHC)
   05014 Amyotrophic lateral sclerosis
    6391 (SDHC)
   05016 Huntington disease
    6391 (SDHC)
   05020 Prion disease
    6391 (SDHC)
   05022 Pathways of neurodegeneration - multiple diseases
    6391 (SDHC)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    6391 (SDHC)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    6391 (SDHC)
SSDB
Motif
Pfam: Sdh_cyt
Other DBs
NCBI-GeneID: 6391
NCBI-ProteinID: NP_002992
OMIM: 602413
HGNC: 10682
Ensembl: ENSG00000143252
Pharos: Q99643(Tbio)
UniProt: Q99643 A0A0S2Z4B7
LinkDB
Position
1:161314381..161363206
AA seq 169 aa
MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM
NT seq 510 nt   +upstreamnt  +downstreamnt
atggctgcgctgttgctgagacacgttggtcgtcattgcctccgagcccactttagccct
cagctctgtatcagaaatgctgttcctttgggaaccacggccaaagaagagatggagcgg
ttctggaataagaatataggttcaaaccgtcctctgtctccccacattactatctacagt
tggtctcttcccatggcgatgtccatctgccaccgtggcactggtattgctttgagtgca
ggggtctctctttttggcatgtcggccctgttactccctgggaactttgagtcttatttg
gaacttgtgaagtccctgtgtctggggccagcactgatccacacagctaagtttgcactt
gtcttccctctcatgtatcatacctggaatgggatccgacacttgatgtgggacctagga
aaaggcctgaagattccccagctataccagtctggagtggttgtcctggttcttactgtg
ttgtcctctatggggctggcagccatgtga

KEGG   Homo sapiens (human): 6392
Entry
6392              CDS       T01001                                 
Symbol
SDHD, CBT1, CII-4, CWS3, MC2DN3, PGL, PGL1, QPs3, SDH4, cybS
Name
(RefSeq) succinate dehydrogenase complex subunit D
  KO
K00237  succinate dehydrogenase (ubiquinone) membrane anchor subunit
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa_M00148  Succinate dehydrogenase (ubiquinone)
Network
nt06031  Citrate cycle and pyruvate metabolism
nt06252  Mitochondrial ROS formation
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
  Element
N00988  Electron transfer in Complex II
N00989  Mutation-caused aberrant Htt to electron transfer in Complex II
N01392  Arsenic to electron transfer in complex II
N01393  Arsenic to electron transfer in complex II
N01402  Manganese to electron transfer in Complex II
N01609  Citrate cycle, second carbon oxidation
Disease
H00034  Carcinoid
H01222  Cowden syndrome
H01510  Malignant paraganglioma
H02005  Mitochondrial complex II deficiency
H02538  Paraganglioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    6392 (SDHD)
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    6392 (SDHD)
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    6392 (SDHD)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    6392 (SDHD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    6392 (SDHD)
   05012 Parkinson disease
    6392 (SDHD)
   05014 Amyotrophic lateral sclerosis
    6392 (SDHD)
   05016 Huntington disease
    6392 (SDHD)
   05020 Prion disease
    6392 (SDHD)
   05022 Pathways of neurodegeneration - multiple diseases
    6392 (SDHD)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    6392 (SDHD)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    6392 (SDHD)
SSDB
Motif
Pfam: CybS Ldh_2
Other DBs
NCBI-GeneID: 6392
NCBI-ProteinID: NP_002993
OMIM: 602690
HGNC: 10683
Ensembl: ENSG00000204370
Pharos: O14521(Tbio)
UniProt: O14521 A0A0S2Z4J3
LinkDB
Position
11:112086873..112095794
AA seq 159 aa
MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL
NT seq 480 nt   +upstreamnt  +downstreamnt
atggcggttctctggaggctgagtgccgtttgcggtgccctaggaggccgagctctgttg
cttcgaactccagtggtcagacctgctcatatctcagcatttcttcaggaccgacctatc
ccagaatggtgtggagtgcagcacatacacttgtcaccgagccaccattctggctccaag
gctgcatctctccactggactagcgagagggttgtcagtgttttgctcctgggtctgctt
ccggctgcttatttgaatccttgctctgcgatggactattccctggctgcagccctcact
cttcatggtcactggggccttggacaagttgttactgactatgttcatggggatgccttg
cagaaagctgccaaggcagggcttttggcactttcagctttaacctttgctgggctttgc
tatttcaactatcacgatgtgggcatctgcaaagctgttgccatgctgtggaagctctga

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