Homo sapiens (human): 92 Help Entry 92                CDS       T01001                                  Symbol ACVR2A, ACTRII, ACVR2 Name (RefSeq) activin A receptor type 2A   KO K04670   activin receptor type-2A [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells hsa05418   Fluid shear stress and atherosclerosis Network nt06507  TGFB signaling   Element N01426   BMP9/10 signaling pathway N01453   BMP signaling pathway N01456   Activin signaling pathway N01459   Nodal signaling pathway N01462   BMP9/10 signaling pathway, BMP9/10 coreceptor Drug target Bimagrumab:  D10620 Elritercept:  D12891 Sotatercept:  D09670<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     92 (ACVR2A)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     92 (ACVR2A)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     92 (ACVR2A)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     92 (ACVR2A)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     92 (ACVR2A) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      92 (ACVR2A) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    92 (ACVR2A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Activin_recp Motif Other DBs NCBI-GeneID:  92 NCBI-ProteinID:  NP_001265508 OMIM:  102581 HGNC:  173 Ensembl:  ENSG00000121989 UniProt:  P27037 Structure PDBPDBj LinkDB All DBs Position 2:147844517..147930822 Genome browser AA seq 513 aa AA seqDB search MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL NT seq 1542 nt NT seq  +upstreamnt  +downstreamnt atgggagctgctgcaaagttggcgtttgccgtctttcttatctcctgttcttcaggtgct atacttggtagatcagaaactcaggagtgtcttttctttaatgctaattgggaaaaagac agaaccaatcaaactggtgttgaaccgtgttatggtgacaaagataaacggcggcattgt tttgctacctggaagaatatttctggttccattgaaatagtgaaacaaggttgttggctg gatgatatcaactgctatgacaggactgattgtgtagaaaaaaaagacagccctgaagta tatttttgttgctgtgagggcaatatgtgtaatgaaaagttttcttattttccggagatg gaagtcacacagcccacttcaaatccagttacacctaagccaccctattacaacatcctg ctctattccttggtgccacttatgttaattgcggggattgtcatttgtgcattttgggtg tacaggcatcacaagatggcctaccctcctgtacttgttccaactcaagacccaggacca cccccaccttctccattactaggtttgaaaccactgcagttattagaagtgaaagcaagg ggaagatttggttgtgtctggaaagcccagttgcttaacgaatatgtggctgtcaaaata tttccaatacaggacaaacagtcatggcaaaatgaatacgaagtctacagtttgcctgga atgaagcatgagaacatattacagttcattggtgcagaaaaacgaggcaccagtgttgat gtggatctttggctgatcacagcatttcatgaaaagggttcactatcagactttcttaag gctaatgtggtctcttggaatgaactgtgtcatattgcagaaaccatggctagaggattg gcatatttacatgaggatatacctggcctaaaagatggccacaaacctgccatatctcac agggacatcaaaagtaaaaatgtgctgttgaaaaacaacctgacagcttgcattgctgac tttgggttggccttaaaatttgaggctggcaagtctgcaggcgatacccatggacaggtt ggtacccggaggtacatggctccagaggtattagagggtgctataaacttccaaagggat gcatttttgaggatagatatgtatgccatgggattagtcctatgggaactggcttctcgc tgtactgctgcagatggacctgtagatgaatacatgttgccatttgaggaggaaattggc cagcatccatctcttgaagacatgcaggaagttgttgtgcataaaaaaaagaggcctgtt ttaagagattattggcagaaacatgctggaatggcaatgctctgtgaaaccattgaagaa tgttgggatcacgacgcagaagccaggttatcagctggatgtgtaggtgaaagaattacc cagatgcagagactaacaaatattattaccacagaggacattgtaacagtggtcacaatg gtgacaaatgttgactttcctcccaaagaatctagtctatga

Homo sapiens (human): 93 Help Entry 93                CDS       T01001                                  Symbol ACVR2B, ACTRIIB, ActR-IIB, HTX4 Name (RefSeq) activin A receptor type 2B   KO K13596   activin receptor type-2B [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells hsa05418   Fluid shear stress and atherosclerosis Network nt06507  TGFB signaling   Element N01453   BMP signaling pathway N01456   Activin signaling pathway N01457   Myostatin signaling pathway N01458   BMP-HAMP signaling pathway N01459   Nodal signaling pathway N01461   BMP-HAMP signaling pathway, auxiliary factor Disease H00632   Heterotaxy Drug target Bimagrumab:  D10620 Cibotercept:  D12999 Luspatercept:  D11701<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     93 (ACVR2B)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     93 (ACVR2B)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     93 (ACVR2B)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     93 (ACVR2B)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     93 (ACVR2B) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      93 (ACVR2B) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    93 (ACVR2B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Activin_recp Pkinase_fungal Motif Other DBs NCBI-GeneID:  93 NCBI-ProteinID:  NP_001097 OMIM:  602730 HGNC:  174 Ensembl:  ENSG00000114739 UniProt:  Q13705 Structure PDBPDBj LinkDB All DBs Position 3:38453890..38493142 Genome browser AA seq 512 aa AA seqDB search MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI NT seq 1539 nt NT seq  +upstreamnt  +downstreamnt atgacggcgccctgggtggccctcgccctcctctggggatcgctgtgcgccggctctggg cgtggggaggctgagacacgggagtgcatctactacaacgccaactgggagctggagcgc accaaccagagcggcctggagcgctgcgaaggcgagcaggacaagcggctgcactgctac gcctcctggcgcaacagctctggcaccatcgagctcgtgaagaagggctgctggctagat gacttcaactgctacgataggcaggagtgtgtggccactgaggagaacccccaggtgtac ttctgctgctgtgaaggcaacttctgcaacgaacgcttcactcatttgccagaggctggg ggcccggaagtcacgtacgagccacccccgacagcccccaccctgctcacggtgctggcc tactcactgctgcccatcgggggcctttccctcatcgtcctgctggccttttggatgtac cggcatcgcaagcccccctacggtcatgtggacatccatgaggaccctgggcctccacca ccatcccctctggtgggcctgaagccactgcagctgctggagatcaaggctcgggggcgc tttggctgtgtctggaaggcccagctcatgaatgactttgtagctgtcaagatcttccca ctccaggacaagcagtcgtggcagagtgaacgggagatcttcagcacacctggcatgaag cacgagaacctgctacagttcattgctgccgagaagcgaggctccaacctcgaagtagag ctgtggctcatcacggccttccatgacaagggctccctcacggattacctcaaggggaac atcatcacatggaacgaactgtgtcatgtagcagagacgatgtcacgaggcctctcatac ctgcatgaggatgtgccctggtgccgtggcgagggccacaagccgtctattgcccacagg gactttaaaagtaagaatgtattgctgaagagcgacctcacagccgtgctggctgacttt ggcttggctgttcgatttgagccagggaaacctccaggggacacccacggacaggtaggc acgagacggtacatggctcctgaggtgctcgagggagccatcaacttccagagagatgcc ttcctgcgcattgacatgtatgccatggggttggtgctgtgggagcttgtgtctcgctgc aaggctgcagacggacccgtggatgagtacatgctgccctttgaggaagagattggccag cacccttcgttggaggagctgcaggaggtggtggtgcacaagaagatgaggcccaccatt aaagatcactggttgaaacacccgggcctggcccagctttgtgtgaccatcgaggagtgc tgggaccatgatgcagaggctcgcttgtccgcgggctgtgtggaggagcgggtgtccctg attcggaggtcggtcaacggcactacctcggactgtctcgtttccctggtgacctctgtc accaatgtggacctgccccctaaagagtcaagcatctaa

Homo sapiens (human): 91 Help Entry 91                CDS       T01001                                  Symbol ACVR1B, ACTRIB, ACVRLK4, ALK4, SKR2 Name (RefSeq) activin A receptor type 1B   KO K13567   activin receptor type-1B [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells Network nt06507  TGFB signaling   Element N01456   Activin signaling pathway N01457   Myostatin signaling pathway N01459   Nodal signaling pathway Disease H00019   Pancreatic cancer Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     91 (ACVR1B)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     91 (ACVR1B)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     91 (ACVR1B)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     91 (ACVR1B) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      91 (ACVR1B) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR1 family [OT]    91 (ACVR1B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr TGF_beta_GS Activin_recp APH Pkinase_fungal FTA2 Motif Other DBs NCBI-GeneID:  91 NCBI-ProteinID:  NP_004293 OMIM:  601300 HGNC:  172 Ensembl:  ENSG00000135503 UniProt:  P36896 Structure PDBPDBj LinkDB All DBs Position 12:51951699..51997078 Genome browser AA seq 505 aa AA seqDB search MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN GAARLTALRIKKTLSQLSVQEDVKI NT seq 1518 nt NT seq  +upstreamnt  +downstreamnt atggcggagtcggccggagcctcctccttcttcccccttgttgtcctcctgctcgccggc agcggcgggtccgggccccggggggtccaggctctgctgtgtgcgtgcaccagctgcctc caggccaactacacgtgtgagacagatggggcctgcatggtttccattttcaatctggat gggatggagcaccatgtgcgcacctgcatccccaaagtggagctggtccctgccgggaag cccttctactgcctgagctcggaggacctgcgcaacacccactgctgctacactgactac tgcaacaggatcgacttgagggtgcccagtggtcacctcaaggagcctgagcacccgtcc atgtggggcccggtggagctggtaggcatcatcgccggcccggtgttcctcctgttcctc atcatcatcattgttttccttgtcattaactatcatcagcgtgtctatcacaaccgccag agactggacatggaagatccctcatgtgagatgtgtctctccaaagacaagacgctccag gatcttgtctacgatctctccacctcagggtctggctcagggttacccctctttgtccag cgcacagtggcccgaaccatcgttttacaagagattattggcaagggtcggtttggggaa gtatggcggggccgctggaggggtggtgatgtggctgtgaaaatattctcttctcgtgaa gaacggtcttggttcagggaagcagagatataccagacggtcatgctgcgccatgaaaac atccttggatttattgctgctgacaataaagataatggcacctggacacagctgtggctt gtttctgactatcatgagcacgggtccctgtttgattatctgaaccggtacacagtgaca attgaggggatgattaagctggccttgtctgctgctagtgggctggcacacctgcacatg gagatcgtgggcacccaagggaagcctggaattgctcatcgagacttaaagtcaaagaac attctggtgaagaaaaatggcatgtgtgccatagcagacctgggcctggctgtccgtcat gatgcagtcactgacaccattgacattgccccgaatcagagggtggggaccaaacgatac atggcccctgaagtacttgatgaaaccattaatatgaaacactttgactcctttaaatgt gctgatatttatgccctcgggcttgtatattgggagattgctcgaagatgcaattctgga ggagtccatgaagaatatcagctgccatattacgacttagtgccctctgacccttccatt gaggaaatgcgaaaggttgtatgtgatcagaagctgcgtcccaacatccccaactggtgg cagagttatgaggcactgcgggtgatggggaagatgatgcgagagtgttggtatgccaac ggcgcagcccgcctgacggccctgcgcatcaagaagaccctctcccagctcagcgtgcag gaagacgtgaagatctaa

Homo sapiens (human): 130399 Help Entry 130399            CDS       T01001                                  Symbol ACVR1C, ACVRLK7, ALK7 Name (RefSeq) activin A receptor type 1C   KO K13568   activin receptor type-1C [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells Network nt06507  TGFB signaling   Element N01456   Activin signaling pathway N01459   Nodal signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     130399 (ACVR1C)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     130399 (ACVR1C)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     130399 (ACVR1C)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     130399 (ACVR1C) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      130399 (ACVR1C) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR1 family [OT]    130399 (ACVR1C) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase TGF_beta_GS Activin_recp Pkinase_fungal Motif Other DBs NCBI-GeneID:  130399 NCBI-ProteinID:  NP_660302 OMIM:  608981 HGNC:  18123 Ensembl:  ENSG00000123612 UniProt:  Q8NER5 LinkDB All DBs Position 2:complement(157526767..157628864) Genome browser AA seq 493 aa AA seqDB search MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK TISQLCVKEDCKA NT seq 1482 nt NT seq  +upstreamnt  +downstreamnt atgacccgggcgctctgctcagcgctccgccaggctctcctgctgctcgcagcggccgcc gagctctcgccaggactgaagtgtgtatgtcttttgtgtgattcttcaaacttcacctgc caaacagaaggagcatgttgggcatcagtcatgctaaccaatggaaaagagcaggtgatc aaatcctgtgtctcccttccagaactgaatgctcaagtcttctgtcatagttccaacaat gttaccaaaaccgaatgctgcttcacagatttttgcaacaacataacactgcaccttcca acagcatcaccaaatgccccaaaacttggacccatggagctggccatcattattactgtg cctgtttgcctcctgtccatagctgcgatgctgacagtatgggcatgccagggtcgacag tgctcctacaggaagaaaaagagaccaaatgtggaggaaccactctctgagtgcaatctg gtaaatgctggaaaaactctgaaagatctgatttatgatgtgaccgcctctggatctggc tctggtctacctctgttggttcaaaggacaattgcaaggacgattgtgcttcaggaaata gtaggaaaaggtagatttggtgaggtgtggcatggaagatggtgtggggaagatgtggct gtgaaaatattctcctccagagatgaaagatcttggtttcgtgaggcagaaatttaccag acggtcatgctgcgacatgaaaacatccttggtttcattgctgctgacaacaaagataat ggaacttggactcaactttggctggtatctgaatatcatgaacagggctccttatatgac tatttgaatagaaatatagtgaccgtggctggaatgatcaagctggcgctctcaattgct agtggtctggcacaccttcatatggagattgttggtacacaaggtaaacctgctattgct catcgagacataaaatcaaagaatatcttagtgaaaaagtgtgaaacttgtgccatagcg gacttagggttggctgtgaagcatgattcaatactgaacactatcgacatacctcagaat cctaaagtgggaaccaagaggtatatggctcctgaaatgcttgatgatacaatgaatgtg aatatctttgagtccttcaaacgagctgacatctattctgttggtctggtttactgggaa atagcccggaggtgttcagtcggaggaattgttgaggagtaccaattgccttattatgac atggtgccttcagatccctcgatagaggaaatgagaaaggttgtttgtgaccagaagttt cgaccaagtatcccaaaccagtggcaaagttgtgaagcactccgagtcatggggagaata atgcgtgagtgttggtatgccaacggagcggcccgcctaactgctcttcgtattaagaag actatatctcaactttgtgtcaaagaagactgcaaagcctaa

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