KEGG   Homo sapiens (human): 9978
Entry
9978              CDS       T01001                                 
Symbol
RBX1, BA554C12.1, RNF75, ROC1
Name
(RefSeq) ring-box 1
  KO
K03868  E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04066  HIF-1 signaling pathway
hsa04110  Cell cycle
hsa04114  Oocyte meiosis
hsa04120  Ubiquitin mediated proteolysis
hsa04141  Protein processing in endoplasmic reticulum
hsa04310  Wnt signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04710  Circadian rhythm
hsa05131  Shigellosis
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Network
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06182  Shigella
nt06225  HIF-1 signaling (cancer)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06264  Renal cell carcinoma
nt06267  Small cell lung cancer
nt06272  Prostate cancer
nt06502  Nucleotide excision repair
nt06509  DNA replication
nt06516  TNF signaling
nt06541  Cytoskeleton in neurons
nt06542  HIF signaling
  Element
N00080  Loss of VHL to HIF-1 signaling pathway
N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00942  Shigella OspG to TNF-NFKB signaling pathway
N01425  Global genome NER
N01430  Transcription-coupled NER
N01473  DNA replication termination
N01855  Neurofilament regulation, ubiqutination by Gigaxonin
N01872  Proteasomal degradation of HIF by VHL complex
N01873  VHL mutation to HIF-2 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    9978 (RBX1)
   04120 Ubiquitin mediated proteolysis
    9978 (RBX1)
  09124 Replication and repair
   03420 Nucleotide excision repair
    9978 (RBX1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    9978 (RBX1)
   04350 TGF-beta signaling pathway
    9978 (RBX1)
   04066 HIF-1 signaling pathway
    9978 (RBX1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    9978 (RBX1)
   04114 Oocyte meiosis
    9978 (RBX1)
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    9978 (RBX1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    9978 (RBX1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    9978 (RBX1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    9978 (RBX1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    9978 (RBX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9978 (RBX1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9978 (RBX1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.32  cullin-RING-type E3 NEDD8 transferase
     9978 (RBX1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   9978 (RBX1)
  Multi subunit type E3
   SCF complex
    Ring finger protein
     9978 (RBX1)
   Cul2 complex
     9978 (RBX1)
   Cul3 complex
     9978 (RBX1)
   Cul4 complex
     9978 (RBX1)
   Cul7 complex
     9978 (RBX1)
   Cul8 complex
     9978 (RBX1)
   Cul9 complex
     9978 (RBX1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      9978 (RBX1)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      9978 (RBX1)
SSDB
Motif
Pfam: zf-rbx1 zf-ANAPC11 zf-RING_2 zf-C3HC4 zf-C3HC4_2 zf-RING_11 DUF8003 PHD_NSD
Other DBs
NCBI-GeneID: 9978
NCBI-ProteinID: NP_055063
OMIM: 603814
HGNC: 9928
Ensembl: ENSG00000100387
UniProt: P62877
Structure
LinkDB
Position
22:40951378..40973309
AA seq 108 aa
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQ
ASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
NT seq 327 nt   +upstreamnt  +downstreamnt
atggcggcagcgatggatgtggataccccgagcggcaccaacagcggcgcgggcaagaag
cgctttgaagtgaaaaagtggaatgcagtagccctctgggcctgggatattgtggttgat
aactgtgccatctgcaggaaccacattatggatctttgcatagaatgtcaagctaaccag
gcgtccgctacttcagaagagtgtactgtcgcatggggagtctgtaaccatgcttttcac
ttccactgcatctctcgctggctcaaaacacgacaggtgtgtccattggacaacagagag
tgggaattccaaaagtatgggcactag

KEGG   Homo sapiens (human): 8452
Entry
8452              CDS       T01001                                 
Symbol
CUL3, CUL-3, NEDAUS, PHA2E
Name
(RefSeq) cullin 3
  KO
K03869  cullin 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04340  Hedgehog signaling pathway
Network
nt06526  MAPK signaling
nt06541  Cytoskeleton in neurons
  Element
N01596  Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex
N01855  Neurofilament regulation, ubiqutination by Gigaxonin
Disease
H00243  Renal tubular acidosis type 4
H02310  Renal tubular acidosis
H02715  Neurodevelopmental disorder with defects of ubiquitin-proteasome system
H02864  Neurodevelopmental disorder with or without autism or seizures
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    8452 (CUL3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    8452 (CUL3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    8452 (CUL3)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    8452 (CUL3)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul3 complex
    Cullin
     8452 (CUL3)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     8452 (CUL3)
SSDB
Motif
Pfam: Cullin Cullin_AB Cullin_Nedd8 RhgB_N Stu2_CTS DUF6655 WAC_Acf1_DNA_bd
Other DBs
NCBI-GeneID: 8452
NCBI-ProteinID: NP_003581
OMIM: 603136
HGNC: 2553
Ensembl: ENSG00000036257
UniProt: Q13618
Structure
LinkDB
Position
2:complement(224470150..224585363)
AA seq 768 aa
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN
AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR
DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR
INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY
KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR
FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS
NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL
AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT
ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT
VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN
VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA
NT seq 2307 nt   +upstreamnt  +downstreamnt
atgtcgaatctgagcaaaggcacgggcagccggaaggacaccaagatgcggatccgggcc
tttccgatgaccatggatgaaaaatatgtaaacagcatttgggaccttctgaaaaatgca
attcaagaaatccagcgtaagaataacagtggtcttagttttgaggagctctatagaaat
gcatatacaatggttttgcataaacatggagaaaagctctacactggactaagagaagtt
gttaccgaacatctcataaataaggtgcgagaagatgtactaaattcattgaataacaac
tttcttcaaacgctaaatcaagcttggaatgatcatcaaacagctatggtgatgattaga
gacatactaatgtacatggaccgtgtgtatgtacaacaaaataatgtggagaacgtctac
aatttgggattaattatttttcgagatcaagttgtacgttatgggtgtattagggatcat
ctacggcaaactctattggatatgattgcaagagagcggaaaggagaagtcgtagacaga
ggcgcaataagaaatgcttgccagatgttaatgattttaggtctcgaaggaagatcagtc
tatgaagaagattttgaggctccttttttggaaatgtctgcagaattttttcagatggaa
agccagaaatttttagcagaaaatagtgcttcagtatatataaagaaagtagaagctaga
attaatgaagaaatagaacgagtgatgcactgccttgacaaatcaacggaagaaccaatt
gtaaaggtggttgaaagggaactcatttccaagcacatgaagactatagtagaaatggag
aattctgggctagtacatatgttgaaaaatggaaagacagaagaccttggttgcatgtac
aagttatttagtcgtgtgccaaatggtttgaaaacaatgtgtgagtgtatgagttcctat
ttgagggagcaaggtaaagctcttgtttctgaagaaggagaaggaaagaatcctgttgac
tatatccagggcttattggatctgaagagtaggttcgatcgcttcctcctggaatcattc
aacaatgaccgtctctttaaacaaactattgcgggtgactttgagtattttctcaacctc
aactccaggtctcctgaatacctctcattatttattgatgataagctgaaaaagggagtc
aaagggctaacagaacaagaagtagaaacaatattggataaagcaatggtcctttttagg
tttatgcaagaaaaagatgtatttgaacgttattataaacaacacttggcaaggagactt
ctcacaaataaaagtgtttctgatgactctgaaaaaaacatgatatctaagttaaagact
gaatgtggatgtcagttcacgtcaaaactggaaggaatgtttagggatatgagcatctca
aacacaacgatggatgaattcaggcaacatctacaggcaactggtgtatctttaggtggt
gttgatcttacagtccgggtgctcacgacaggatattggcccactcagtcagccacacca
aagtgcaacatcccaccagcaccaagacatgcttttgagatattcagaaggttctactta
gccaaacacagtggtcgacagctcacactccagcatcatatgggttctgcagatctcaat
gccacattttatggaccagttaaaaaggaagatggatctgaagttggtgttggaggtgca
caagtaactggctctaatacacggaagcacatattgcaagtttccactttccagatgacc
atattaatgctctttaataatagagaaaaatacacatttgaggaaattcagcaagagaca
gatatccctgaaagagagcttgttagagccctacagtccctcgcctgtggtaaaccaaca
cagcgggttcttacaaaagaacccaaatcaaaggaaatagaaaatggtcatatatttaca
gttaatgatcaattcacatccaaactacacagagtcaagattcaaacagttgctgccaaa
caaggtgaatccgacccagagaggaaagaaacaaggcagaaagtagacgacgacagaaaa
catgagatagaagctgctatagtgcggataatgaaatctagaaagaagatgcagcacaat
gttctagtagcggaggtaactcagcagttgaaggcgcgattcttaccaagtccagttgtt
attaagaaacgtattgaaggacttattgagagagaatatttggcacgaacacctgaggat
cgcaaagtatacacatatgtagcataa

KEGG   Homo sapiens (human): 8139
Entry
8139              CDS       T01001                                 
Symbol
GAN, GAN1, GIG, KLHL16
Name
(RefSeq) gigaxonin
  KO
K10453  kelch-like protein 16 (gigaxonin)
Organism
hsa  Homo sapiens (human)
Network
nt06541  Cytoskeleton in neurons
  Element
N01855  Neurofilament regulation, ubiqutination by Gigaxonin
Disease
H01259  Giant axonal neuropathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    8139 (GAN)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     8139 (GAN)
SSDB
Motif
Pfam: Kelch_1 BACK Kelch_KLHDC2_KLHL20_DRC7 Beta-prop_Calicin BTB Kelch_FKB95 Beta-prop_ATRN-LZTR1 Beta-prop_FBX42 Kelch_2 NANM DUF6242_C BTB_KLHL33 DUF1668 BTB_3
Other DBs
NCBI-GeneID: 8139
NCBI-ProteinID: NP_071324
OMIM: 605379
HGNC: 4137
Ensembl: ENSG00000261609
UniProt: Q9H2C0 A0A0S2Z4W2 B3KTC3
Structure
LinkDB
Position
16:81314962..81390809
AA seq 597 aa
MAEGSAVSDPQHAARLLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLN
YNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTL
CCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKE
VISLEKLNVGNERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSSYLREQMLNEPL
VREIVKECSNIPLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYD
PNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPM
NEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMK
KKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSRE
DAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTN
YDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLFRLQLQQGLFRIRVHSP
NT seq 1794 nt   +upstreamnt  +downstreamnt
atggctgagggcagtgccgtgtctgaccctcagcacgccgcgcgtctgctgcgagcgctc
agctctttccgcgaggagtctcgcttctgcgacgcgcacctggtcctcgacggggaggag
atcccggtgcagaagaacatcctggcggcggccagcccgtacatcaggacaaagttaaac
tataatcctccaaaagatgatggatcaacttataagattgaacttgaagggatatcggta
atggttatgagagagatcctggattacatcttcagtgggcagatcaggctaaatgaagat
acaatccaagatgttgttcaggcagctgacctgctgctactgacggaccttaaaaccctg
tgctgtgagtttttggaaggctgcattgctgctgagaactgtattggtatccgtgacttt
gcactacattactgcctccatcacgttcattaccttgccacagaatacctggagactcat
ttccgagacgtcagcagcacggaagaattcttagagctgagtcctcaaaagcttaaagaa
gtgatttctcttgagaagttaaacgttggcaatgaaagatatgtctttgaagcagtaatt
cgatggatagcacatgatacagaaataagaaaggtccacatgaaggatgttatgtcagct
ctgtgggtttcagggttggactccagttatttacgggaacagatgctgaatgaaccatta
gtacgagaaattgtcaaagagtgtagcaatataccgctcagccagccgcagcaaggggag
gcgatgctggccaacttcaaaccccggggctactctgagtgcatcgtgactgttggtgga
gaagagagagtttcacggaaacccacagcagcgatgcgatgcatgtgccctctctatgac
cctaacaggcagctttggatcgaactggcccctttaagcatgccgagaattaaccatgga
gttctctcagcagaaggatttttgtttgtattcgggggccaagatgaaaataagcagact
cttagctcaggagaaaagtatgatccagatgcaaatacatggacagcattgccacctatg
aacgaggcaagacataacttcggaattgtggagatagatgggatgctgtacattttggga
ggagaggatggtgaaaaggagctgatttccatggagtgttacgatatttattctaaaacc
tggacaaagcaacctgatttgaccatggtcagaaagatcggctgctatgcagctatgaaa
aagaaaatctacgccatgggtggaggctcctacggaaagctttttgagtctgtagagtgt
tatgatcccaggacccagcagtggactgccatatgtccactaaaagagaggaggtttgga
gcggtggcctgtggagttgctatggagctgtatgtgtttgggggagtccgaagtcgtgag
gacgcccagggtagcgagatggtaacttgcaagtccgagttctaccatgatgagtttaaa
aggtggatctatcttaacgaccagaatttatgcatccccgccagttcctcttttgtttat
ggagctgtacctataggagccagtatttatgttattggagatcttgatacaggtaccaat
tacgactacgtgcgtgagtttaaaagaagcacaggaacctggcaccacactaaaccactc
cttccatccgaccttcgccgtacaggatgtgcagccttacgcattgcgaattgcaagctt
ttccgcctgcagcttcagcaaggcttattccgtattcgtgttcattccccttga

KEGG   Homo sapiens (human): 7321
Entry
7321              CDS       T01001                                 
Symbol
UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Name
(RefSeq) ubiquitin conjugating enzyme E2 D1
  KO
K06689  ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
hsa04120  Ubiquitin mediated proteolysis
hsa04141  Protein processing in endoplasmic reticulum
hsa05131  Shigellosis
Network
nt06541  Cytoskeleton in neurons
  Element
N01854  Neurofilament regulation, ubiqutination by TRIM2
N01855  Neurofilament regulation, ubiqutination by Gigaxonin
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    7321 (UBE2D1)
   04120 Ubiquitin mediated proteolysis
    7321 (UBE2D1)
  09126 Chromosome
   03083 Polycomb repressive complex
    7321 (UBE2D1)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    7321 (UBE2D1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7321 (UBE2D1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.23  E2 ubiquitin-conjugating enzyme
     7321 (UBE2D1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin-conjugating enzymes (E2)
  Ubiquitin-conjugating enzymes
   7321 (UBE2D1)
SSDB
Motif
Pfam: UQ_con RWD UEV
Other DBs
NCBI-GeneID: 7321
NCBI-ProteinID: NP_003329
OMIM: 602961
HGNC: 12474
Ensembl: ENSG00000072401
UniProt: P51668
Structure
LinkDB
Position
10:58335006..58370748
AA seq 147 aa
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY
PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PDIAQIYKSDKEKYNRHAREWTQKYAM
NT seq 444 nt   +upstreamnt  +downstreamnt
atggcgctgaagaggattcagaaagaattgagtgatctacagcgcgatccacctgctcac
tgttcagctggacctgtgggagatgacttgttccactggcaagccactattatggggcct
cctgatagcgcatatcaaggtggagtcttctttctcactgtacattttccgacagattat
ccttttaaaccaccaaagattgctttcacaacaaaaatttaccatccaaacataaacagt
aatggaagtatttgtctcgatattctgaggtcacaatggtcaccagctctgactgtatca
aaagttttattgtccatatgttctctactttgtgatcctaatccagatgaccccttagta
ccagatattgcacaaatctataaatcagacaaagaaaaatacaacagacatgcaagagaa
tggactcagaaatatgcaatgtaa

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