Homo sapiens (human): 5071
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Entry
5071 CDS
T01001
Symbol
PRKN, AR-JP, LPRS2, PARK2, PDJ
Name
(RefSeq) parkin RBR E3 ubiquitin protein ligase
KO
K04556
parkin [EC:
2.3.2.31
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04137
Mitophagy - animal
hsa04141
Protein processing in endoplasmic reticulum
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06028
Dopamine and serotonin metabolism
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06536
Mitophagy
Element
N01019
Parkin-mediated ubiquitination
N01020
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01021
Parkin-mediated ubiquitination
N01022
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01023
Parkin-mediated ubiquitination
N01024
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01025
Parkin-mediated ubiquitination
N01026
Mutation-inactivated PRKN to Parkin-mediated ubiquitination
N01032
Mutation-inactivated PRKN to mGluR1 signaling pathway
N01039
Mutation-inactivated PRKN to DOPAL generation
N01049
Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01052
PINK1-Parkin-mediated MFN2 degradation
N01053
Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01054
Mutation-inactivated PRKN to PINK1-Parkin-mediated MFN2 degradation
N01137
PINK-Parkin-mediated autophagosome formation
N01138
Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01139
Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01756
PINK-Parkin-independent ubiquitin-mediated mitophagy
N01757
PINK-Parkin-independent ubiquitin-mediated mitophagy, ubiquitin E3 ligase
Disease
H00027
Ovarian cancer
H00057
Parkinson disease
H01600
Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
5071 (PRKN)
04120 Ubiquitin mediated proteolysis
5071 (PRKN)
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
5071 (PRKN)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
5071 (PRKN)
05014 Amyotrophic lateral sclerosis
5071 (PRKN)
05022 Pathways of neurodegeneration - multiple diseases
5071 (PRKN)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
5071 (PRKN)
04121 Ubiquitin system [BR:
hsa04121
]
5071 (PRKN)
03029 Mitochondrial biogenesis [BR:
hsa03029
]
5071 (PRKN)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.31 RBR-type E3 ubiquitin transferase
5071 (PRKN)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Mitophagy
PINK1-Parkin associated proteins
5071 (PRKN)
Aggrephagy
Other aggrephagy associated proteins
5071 (PRKN)
Xenophagy
Other xenophagy associated proteins
5071 (PRKN)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
RBR proteins
5071 (PRKN)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Mitophagy factors
Parkin-dependent mechanism factors
5071 (PRKN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-RING_14
zf-RING_12
ubiquitin
IBR_2
IBR_1
IBR
Rad60-SLD
Rad60-SLD_2
Dsc3_N
Crinkler
Motif
Other DBs
NCBI-GeneID:
5071
NCBI-ProteinID:
NP_004553
OMIM:
602544
HGNC:
8607
Ensembl:
ENSG00000185345
UniProt:
O60260
X5DR79
Structure
PDB
LinkDB
All DBs
Position
6:complement(161347417..162727766)
Genome browser
AA seq
465 aa
AA seq
DB search
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD
LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA
VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP
SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT
CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE
LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC
GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR
CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
NT seq
1398 nt
NT seq
+upstream
nt +downstream
nt
atgatagtgtttgtcaggttcaactccagccatggtttcccagtggaggtcgattctgac
accagcatcttccagctcaaggaggtggttgctaagcgacagggggttccggctgaccag
ttgcgtgtgattttcgcagggaaggagctgaggaatgactggactgtgcagaattgtgac
ctggatcagcagagcattgttcacattgtgcagagaccgtggagaaaaggtcaagaaatg
aatgcaactggaggcgacgaccccagaaacgcggcgggaggctgtgagcgggagccccag
agcttgactcgggtggacctcagcagctcagtcctcccaggagactctgtggggctggct
gtcattctgcacactgacagcaggaaggactcaccaccagctggaagtccagcaggtaga
tcaatctacaacagcttttatgtgtattgcaaaggcccctgtcaaagagtgcagccggga
aaactcagggtacagtgcagcacctgcaggcaggcaacgctcaccttgacccagggtcca
tcttgctgggatgatgttttaattccaaaccggatgagtggtgaatgccaatccccacac
tgccctgggactagtgcagaatttttctttaaatgtggagcacaccccacctctgacaag
gaaacatcagtagctttgcacctgatcgcaacaaatagtcggaacatcacttgcattacg
tgcacagacgtcaggagccccgtcctggttttccagtgcaactcccgccacgtgatttgc
ttagactgtttccacttatactgtgtgacaagactcaatgatcggcagtttgttcacgac
cctcaacttggctactccctgccttgtgtggctggctgtcccaactccttgattaaagag
ctccatcacttcaggattctgggagaagagcagtacaaccggtaccagcagtatggtgca
gaggagtgtgtcctgcagatggggggcgtgttatgcccccgccctggctgtggagcgggg
ctgctgccggagcctgaccagaggaaagtcacctgcgaagggggcaatggcctgggctgt
gggtttgccttctgccgggaatgtaaagaagcgtaccatgaaggggagtgcagtgccgta
tttgaagcctcaggaacaactactcaggcctacagagtcgatgaaagagccgccgagcag
gctcgttgggaagcagcctccaaagaaaccatcaagaaaaccaccaagccctgtccccgc
tgccatgtaccagtggaaaaaaatggaggctgcatgcacatgaagtgtccgcagccccag
tgcaggctcgagtggtgctggaactgtggctgcgagtggaaccgcgtctgcatgggggac
cactggttcgacgtgtag
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