PATHWAY: ko00230 Help
Entry
Name
Purine metabolism
Class
Metabolism; Nucleotide metabolism
BRITE hierarchy
Pathway map
Module
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ko00230 ]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ko00230 ]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ko00230 ]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ko00230 ]
M00958 Adenine ribonucleotide degradation, AMP => Urate [PATH:ko00230 ]
M00959 Guanine ribonucleotide degradation, GMP => Urate [PATH:ko00230 ]
M00968 Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:ko00230 ]
Drug
Other DBs
Orthology
K00087 ygeS, xdhA; xanthine dehydrogenase molybdenum-binding subunit [EC:1.17.1.4 ]
K00525 E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1 ]
K00526 E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1 ]
K00527 rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2 ]
K00601 E2.1.2.2; phosphoribosylglycinamide formyltransferase [EC:2.1.2.2 ]
K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10 ]
K00760 hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8 ]
K00948 PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1 ]
K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2 ]
K01492 purNH; phosphoribosylglycinamide/phosphoribosylaminoimidazolecarboxamide formyltransferase [EC:2.1.2.2 2.1.2.3 ]
K01509 ENTPD2; adenosinetriphosphatase [EC:3.6.1.-]
K01511 ENTPD5_6; ectonucleoside triphosphate diphosphohydrolase 5/6 [EC:3.6.1.6 ]
K01513 ENPP1_3, CD203; ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9 ]
K01524 ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40 ]
K01525 apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) [EC:3.6.1.41 ]
K01529 yjjX; inosine/xanthosine triphosphatase
K01587 PAICS; phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6 ]
K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18 ]
K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18 ]
K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6 ]
K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1 ]
K01951 guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2 ]
K01952 PFAS, purL; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3 ]
K06863 purP; 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase [EC:6.3.4.23 ]
K06966 ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]
K08289 purT; phosphoribosylglycinamide formyltransferase 2 [EC:6.3.1.21 ]
K08312 nudE; ADP compounds hydrolase [EC:3.6.1.-]
K08718 PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [EC:3.1.4.35 ]
K09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16 ]
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1 ]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1 ]
K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2 ]
K11177 yagR; xanthine dehydrogenase YagR molybdenum-binding subunit [EC:1.17.1.4 ]
K11178 yagS; xanthine dehydrogenase YagS FAD-binding subunit [EC:1.17.1.4 ]
K11787 GART; phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1 ]
K11788 ADE5; phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 6.3.3.1 ]
K12304 CANT1; soluble calcium-activated nucleotidase 1 [EC:3.6.1.6 ]
K12305 ENTPD4, LALP70; ectonucleoside triphosphate diphosphohydrolase 4 [EC:3.6.1.6 ]
K12318 GUCY1A; guanylate cyclase soluble subunit alpha [EC:4.6.1.2 ]
K12319 GUCY1B; guanylate cyclase soluble subunit beta [EC:4.6.1.2 ]
K12323 ANPRA, NPR1; atrial natriuretic peptide receptor A [EC:4.6.1.2 ]
K12324 ANPRB, NPR2; atrial natriuretic peptide receptor B [EC:4.6.1.2 ]
K13296 PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17 ]
K13479 ygeT, xdhB; xanthine dehydrogenase FAD-binding subunit [EC:1.17.1.4 ]
K13480 ygeU, xdhC; xanthine dehydrogenase iron-sulfur-binding subunit
K13483 yagT; xanthine dehydrogenase YagT iron-sulfur-binding subunit
K13484 TTHL; 5-hydroxyisourate hydrolase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:3.5.2.17 4.1.1.97 ]
K13485 PRHOXNB, URAD; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97 ]
K13755 PDE1; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17 ]
K13756 PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35 ]
K13757 PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35 ]
K13758 PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
K13759 PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
K13760 PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
K13761 PDE9; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:3.1.4.35 ]
K13762 PDE5; cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35 ]
K13763 PDE6N; cGMP-specific 3',5'-cyclic phosphodiesterase, invertebrate [EC:3.1.4.35 ]
K16838 pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:1.7.3.3 4.1.1.97 ]
K16840 hpxQ; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:4.1.1.97 ]
K18283 PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [EC:3.1.4.17 ]
K18424 ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4 [EC:3.6.1.29 ]
K18436 PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53 ]
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:3.1.4.53 ]
K18445 ndx1; diadenosine hexaphosphate hydrolase (ATP-forming) [EC:3.6.1.61 ]
K18550 ISN1; IMP and pyridine-specific 5'-nucleotidase [EC:3.1.3.99 3.1.3.-]
K19021 PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [EC:3.1.4.17 ]
K20881 yrfG; GMP/IMP 5'-nucleotidase [EC:3.1.3.-]
K21138 HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase [EC:3.1.7.2 ]
K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6 ]
K22944 cyaA; bifunctional hemolysin/adenylate cyclase
K23264 purS; phosphoribosylformylglycinamidine synthase subunit PurS
K23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase
K23269 purL; phosphoribosylformylglycinamidine synthase subunit PurL
K23270 purSL; phosphoribosylformylglycinamidine synthase subunit PurSL
K24670 K24670 ; 2',3'-cyclic-nucleotide 2'-phosphodiesterase / phosphoenolpyruvate phosphatase
K24871 E2.1.3.16; ureidoglycine carbamoyltransferase
K24972 purZ; 2-amino-2'-deoxyadenylo-succinate synthase
K25500 mazZ; Cyanophage dATP/dGTP diphosphohydrolase
K25589 inuH; inosine/uridine nucleosidase
K25641 dgk2; deoxyguanosine kinase
K26955 NUDT25, NUDX25; bis(5'-nucleosidyl)-tetraphosphatase
K26956 NUDT2_6_7_10; ADP-ribose/NAD+ diphosphatase
K27625 PSKR1; phytosulfokine receptor 1
K28089 PEPR; leucine-rich repeat receptor-like protein kinase PEPR
Compound
C00053 3'-Phosphoadenylyl sulfate
C00054 Adenosine 3',5'-bisphosphate
C00119 5-Phospho-alpha-D-ribose 1-diphosphate
C00620 alpha-D-Ribose 1-phosphate
C00655 Xanthosine 5'-phosphate
C01228 Guanosine 3',5'-bis(diphosphate)
C01260 P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261 P1,P4-Bis(5'-guanosyl) tetraphosphate
C03373 Aminoimidazole ribotide
C03483 Adenosine tetraphosphate
C03614 Inosine 5'-tetraphosphate
C03794 N6-(1,2-Dicarboxyethyl)-AMP
C03838 5'-Phosphoribosylglycinamide
C04051 5-Amino-4-imidazolecarboxyamide
C04376 5'-Phosphoribosyl-N-formylglycinamide
C04392 P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494 Guanosine 3'-diphosphate 5'-triphosphate
C04640 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05515 5-Ureido-4-imidazole carboxylate
C05516 5-Amino-4-imidazole carboxylate
C06196 2'-Deoxyinosine 5'-phosphate
C06197 P1,P3-Bis(5'-adenosyl) triphosphate
C06433 5'-Benzoylphosphoadenosine
C06435 5'-Butyrylphosphoinosine
C12248 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395 N6-Succino-2-amino-2'-deoxyadenylate
Reference
Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
Journal
Reference
Authors
Xi H, Schneider BL, Reitzer L.
Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
Journal
Related pathway
ko00250 Alanine, aspartate and glutamate metabolism
ko00260 Glycine, serine and threonine metabolism
ko00630 Glyoxylate and dicarboxylate metabolism