PATHWAY: ko04156 Help
Entry Name Integrated stress response (ISR) signaling pathway
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map ko04156 Integrated stress response (ISR) signaling pathway
Orthology K03237 EIF2S1; translation initiation factor 2 subunit 1
K03238 EIF2S2; translation initiation factor 2 subunit 2
K03239 EIF2B1; translation initiation factor eIF-2B subunit alpha
K03240 EIF2B5; translation initiation factor eIF-2B subunit epsilon
K03241 EIF2B3; translation initiation factor eIF-2B subunit gamma
K03242 EIF2S3; translation initiation factor 2 subunit 3
K03680 EIF2B4; translation initiation factor eIF-2B subunit delta
K03754 EIF2B2; translation initiation factor eIF-2B subunit beta
K04043 dnaK, HSPA9; molecular chaperone DnaK
K04077 groEL, HSPD1, HSP60, CPN60, ths; chaperonin GroEL [EC:5.6.1.7 ]
K04079 HSP90A, htpG; molecular chaperone HtpG
K04374 ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04452 DDIT3, CHOP, GADD153; DNA damage-inducible transcript 3
K04722 TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16 ]
K07203 MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1 ]
K07204 RAPTOR; regulatory associated protein of mTOR
K07232 CHAC; glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7 ]
K08266 MLST8, GBL; target of rapamycin complex subunit LST8
K08270 DDIT4, REDD1; DNA-damage-inducible transcript 4
K08341 GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
K08860 EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1 ]
K09032 ATF3, LRF1; activating transcription factor 3
K09044 ATF5; activating transcription factor 5
K10131 PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3, PUMA; Bcl-2-binding component 3
K11137 TELO2, TEL2; telomere length regulation protein
K14019 PPP1R15A, GADD34; protein phosphatase 1 regulatory subunit 15A
K16184 AKT1S1, PRAS40; proline-rich AKT1 substrate 1
K16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1 ]
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1 ]
K16196 EIF2AK4, GCN2; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1 ]
K17558 PPP1R15B, CREP; protein phosphatase 1 regulatory subunit 15B
K19518 TRIB3; tribbles homolog 3
K20064 GRB10; growth factor receptor-bound protein 10
K20402 DEPTOR; DEP domain-containing mTOR-interacting protein
K20403 TTI1; TELO2-interacting protein 1
K22429 FGF21; fibroblast growth factor 21
K22758 CHCHD2; coiled-coil-helix-coiled-coil-helix domain-containing protein 2
K22759 CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10
K23010 OMA1; metalloendopeptidase OMA1, mitochondrial
K29051 DELE1; DAP3-binding cell death enhancer 1
Compound Reference Authors Lu HJ, Koju N, Sheng R
Title Mammalian integrated stress responses in stressed organelles and their functions.
Journal Reference Authors Kalinin A, Zubkova E, Menshikov M
Title Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence.
Journal Reference Authors Kalinin A, Zubkova E, Beloglazova I, Parfyonova Y, Menshikov M
Title Integrated Stress Response (ISR) Modulators in Vascular Diseases.
Journal Reference Authors Jiang W, Hong Y, Wang P, Yang X, Shao K, Li M, Wu D
Title Current Knowledge of the Integrated Stress Response in the Development and Management of Acute Myeloid Leukemia: A Novel Target with Encouraging Progress.
Journal Reference Authors Paerhati P, Liu J, Jin Z, Jakos T, Zhu S, Qian L, Zhu J, Yuan Y
Title Advancements in Activating Transcription Factor 5 Function in Regulating Cell Stress and Survival.
Journal Reference Authors Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Title CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Journal Related ko04141 Protein processing in endoplasmic reticulum
