KEGG   ORTHOLOGY: K08860
Entry
K08860                      KO                                     
Symbol
EIF2AK3, PERK
Name
eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
Pathway
map04137  Mitophagy - animal
map04140  Autophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04214  Apoptosis - fly
map04932  Non-alcoholic fatty liver disease
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05160  Hepatitis C
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05417  Lipid and atherosclerosis
Disease
H00766  Wolcott-Rallison syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   04137 Mitophagy - animal
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09143 Cell growth and death
   04210 Apoptosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   04214 Apoptosis - fly
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05162 Measles
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05168 Herpes simplex virus 1 infection
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05012 Parkinson disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05014 Amyotrophic lateral sclerosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05020 Prion disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3
Other DBs
GO: 0004694
Genes
HSA: 9451(EIF2AK3)
PTR: 459388(EIF2AK3)
PPS: 100981333(EIF2AK3)
GGO: 101147776(EIF2AK3)
PON: 100447385(EIF2AK3)
PPYG: 129025041(EIF2AK3)
NLE: 100589743(EIF2AK3)
HMH: 116483180(EIF2AK3)
SSYN: 129461704(EIF2AK3)
MCC: 699575(EIF2AK3)
MCF: 102117377(EIF2AK3)
MTHB: 126933911
MNI: 105496025(EIF2AK3)
CSAB: 103241350(EIF2AK3)
CATY: 105598836(EIF2AK3)
PANU: 101007255(EIF2AK3)
TGE: 112605118(EIF2AK3)
MLEU: 105553689(EIF2AK3)
RRO: 104674177(EIF2AK3)
RBB: 108518882(EIF2AK3)
TFN: 117062173(EIF2AK3)
PTEH: 111528197(EIF2AK3)
CANG: 105519668(EIF2AK3)
CJC: 100394186(EIF2AK3)
SBQ: 101031964(EIF2AK3)
CIMI: 108310018(EIF2AK3)
ANAN: 105731225(EIF2AK3)
CSYR: 103264913(EIF2AK3)
MMUR: 105876638(EIF2AK3)
LCAT: 123637156(EIF2AK3)
PCOQ: 105810299(EIF2AK3)
OGA: 100945512(EIF2AK3)
MMU: 13666(Eif2ak3)
MCAL: 110296130(Eif2ak3)
RNO: 29702(Eif2ak3)
MCOC: 116099053(Eif2ak3)
ANU: 117715254(Eif2ak3)
MUN: 110561216(Eif2ak3)
CGE: 100765343(Eif2ak3)
MAUA: 101843225(Eif2ak3)
PROB: 127235535(Eif2ak3)
PLEU: 114684877(Eif2ak3)
MORG: 121437085(Eif2ak3)
MFOT: 126491041
AAMP: 119808167(Eif2ak3)
NGI: 103740131(Eif2ak3)
HGL: 101713561(Eif2ak3)
CPOC: 100725836(Eif2ak3)
DORD: 106000275(Eif2ak3)
DSP: 122116859(Eif2ak3)
PLOP: 125356191(Eif2ak3)
NCAR: 124975124
MMMA: 107159738(Eif2ak3)
OCU: 100354847
OPI: 101527487(EIF2AK3)
TUP: 102468736(EIF2AK3)
GVR: 103601352(EIF2AK3)
CFA: 475756(EIF2AK3)
CLUD: 112664364(EIF2AK3)
VVP: 112916653(EIF2AK3)
VLG: 121491533(EIF2AK3)
NPO: 129511084(EIF2AK3)
AML: 100479743(EIF2AK3)
UMR: 103671855(EIF2AK3)
UAH: 113242804(EIF2AK3)
UAR: 123799721(EIF2AK3)
ELK: 111148064
LLV: 125108962
MPUF: 101689747(EIF2AK3)
MNP: 132021375(EIF2AK3)
MLK: 131840420(EIF2AK3)
NVS: 122915073(EIF2AK3)
ORO: 101365565(EIF2AK3)
EJU: 114223436(EIF2AK3)
ZCA: 113937908(EIF2AK3)
MLX: 118007879(EIF2AK3)
NSU: 110587178(EIF2AK3)
LWW: 102733786(EIF2AK3)
FCA: 101095973(EIF2AK3)
PYU: 121044477(EIF2AK3)
PCOO: 112864237(EIF2AK3)
PBG: 122497151(EIF2AK3)
PVIV: 125162177(EIF2AK3)
LRUF: 124503015
PTG: 102963843(EIF2AK3)
PUC: 125937418
AJU: 106978143
HHV: 120245547(EIF2AK3)
BTA: 535820(EIF2AK3)
BIU: 109566145(EIF2AK3)
BBUB: 102406027(EIF2AK3)
BBIS: 104984424(EIF2AK3)
CHX: 102185575(EIF2AK3)
OAS: 101110042(EIF2AK3)
BTAX: 128056196(EIF2AK3)
ODA: 120851473(EIF2AK3)
CCAD: 122441770(EIF2AK3)
MBEZ: 129539222(EIF2AK3)
SSC: 100513348(EIF2AK3)
CFR: 102523410(EIF2AK3)
CBAI: 105072126(EIF2AK3)
CDK: 105104181(EIF2AK3)
VPC: 102527204(EIF2AK3)
BACU: 103020488(EIF2AK3)
BMUS: 118906042(EIF2AK3)
LVE: 103068759(EIF2AK3)
OOR: 101282451(EIF2AK3)
DLE: 111187362(EIF2AK3)
PCAD: 102981822(EIF2AK3)
PSIU: 116764185(EIF2AK3)
NASI: 112398926(EIF2AK3)
ECB: 100066488(EIF2AK3)
EPZ: 103549985(EIF2AK3)
EAI: 106838571(EIF2AK3)
MYB: 102256242(EIF2AK3)
MMYO: 118675238(EIF2AK3)
MLF: 102433431(EIF2AK3)
PKL: 118722681(EIF2AK3)
EFUS: 103297430(EIF2AK3)
MNA: 107528720(EIF2AK3)
DRO: 112297566(EIF2AK3)
SHON: 118975617(EIF2AK3)
AJM: 119062169(EIF2AK3)
PDIC: 114496093(EIF2AK3)
PHAS: 123816301(EIF2AK3)
MMF: 118626254(EIF2AK3)
PPAM: 129085559(EIF2AK3)
HAI: 109394047(EIF2AK3)
RFQ: 117033020(EIF2AK3)
PALE: 102894246(EIF2AK3)
PGIG: 120594611(EIF2AK3)
PVP: 105302307(EIF2AK3)
RAY: 107512376(EIF2AK3)
MJV: 108410297(EIF2AK3)
TOD: 119259152(EIF2AK3)
SARA: 101552290(EIF2AK3)
SETR: 126024479(EIF2AK3)
LAV: 100671700(EIF2AK3)
TMU: 101342812
ETF: 101641434(EIF2AK3)
DNM: 101414351(EIF2AK3)
MDO: 100029557(EIF2AK3)
GAS: 123233149(EIF2AK3)
SHR: 100915385(EIF2AK3)
AFZ: 127547478
PCW: 110202783(EIF2AK3)
TVP: 118844047(EIF2AK3)
OAA: 100081193(EIF2AK3)
GGA: 422930(EIF2AK3)
PCOC: 116225691(EIF2AK3)
MGP: 100538521(EIF2AK3)
CJO: 107313985(EIF2AK3)
TPAI: 128080653(EIF2AK3)
LMUT: 125692074(EIF2AK3)
NMEL: 110397823(EIF2AK3)
APLA: 101800258(EIF2AK3)
ACYG: 106033893(EIF2AK3)
CATA: 118248463(EIF2AK3)
AFUL: 116488776(EIF2AK3)
TGU: 100223479(EIF2AK3)
SCAN: 103823471(EIF2AK3)
PMOA: 120509373(EIF2AK3)
OTC: 121335198(EIF2AK3)
PRUF: 121348773(EIF2AK3)
GFR: 102039323(EIF2AK3)
OMA: 130252489(EIF2AK3)
PMAJ: 107203374(EIF2AK3)
CCW: 104690935(EIF2AK3)
CBRC: 103611209(EIF2AK3)
ZAB: 102073196(EIF2AK3)
ZLE: 135447145(EIF2AK3)
ACHL: 103811365(EIF2AK3)
SVG: 106853142(EIF2AK3)
MMEA: 130589245(EIF2AK3)
HRT: 120752906(EIF2AK3)
EGZ: 104126987(EIF2AK3)
NNI: 104018561(EIF2AK3)
PCRI: 104032583(EIF2AK3)
PLET: 104626606(EIF2AK3)
EHS: 104502589(EIF2AK3)
PCAO: 104050947(EIF2AK3)
TALA: 104368383(EIF2AK3)
PADL: 103923526(EIF2AK3)
AFOR: 103907269(EIF2AK3)
ACHC: 115343397(EIF2AK3)
HALD: 104319639(EIF2AK3)
HLE: 104840104(EIF2AK3)
AGEN: 126052990
GCL: 127015534
CCRI: 104155627(EIF2AK3)
CSTI: 104549348(EIF2AK3)
CMAC: 104484752(EIF2AK3)
MUI: 104541698(EIF2AK3)
BREG: 104629086(EIF2AK3)
FGA: 104077426(EIF2AK3)
LDI: 104347286(EIF2AK3)
MNB: 103775938(EIF2AK3)
OHA: 104329641(EIF2AK3)
NNT: 104404230(EIF2AK3)
SHAB: 115610669(EIF2AK3)
DPUB: 104296954(EIF2AK3)
PGUU: 104461655(EIF2AK3)
ACAR: 104517535(EIF2AK3)
CPEA: 104386938(EIF2AK3)
AVIT: 104277583(EIF2AK3)
CVF: 104284250(EIF2AK3)
RTD: 128910264(EIF2AK3)
CUCA: 104054939(EIF2AK3)
TEO: 104381011(EIF2AK3)
BRHI: 104501232(EIF2AK3)
AAM: 106484898(EIF2AK3)
AROW: 112965557(EIF2AK3)
NPD: 112943046(EIF2AK3)
TGT: 104567785(EIF2AK3)
DNE: 112990751(EIF2AK3)
SCAM: 104151413(EIF2AK3)
CMY: 102932471(EIF2AK3)
CCAY: 125636295(EIF2AK3)
DCC: 119854901(EIF2AK3)
CPIC: 101947852(EIF2AK3)
MRV: 120405920(EIF2AK3)
ACS: 100551680(eif2ak3)
ASAO: 132778425(EIF2AK3)
PVT: 110086330(EIF2AK3)
SUND: 121934276(EIF2AK3)
PBI: 103053678(EIF2AK3)
PMUR: 107302385(EIF2AK3)
CTIG: 120302754(EIF2AK3)
TSR: 106550345(EIF2AK3)
PGUT: 117664790(EIF2AK3)
APRI: 131197308(EIF2AK3)
PTEX: 113447249(EIF2AK3)
NSS: 113420096(EIF2AK3)
VKO: 123031874(EIF2AK3)
PMUA: 114581734(EIF2AK3)
PRAF: 128400657(EIF2AK3)
ZVI: 118094363(EIF2AK3)
HCG: 128329384(EIF2AK3)
GJA: 107118588(EIF2AK3)
STOW: 125440475(EIF2AK3)
EMC: 129337398(EIF2AK3)
XLA: 108697591 403386(eif2ak3.S)
XTR: 100190763(eif2ak3)
NPR: 108794954(EIF2AK3)
RTEM: 120924480(EIF2AK3)
BBUF: 120990444(EIF2AK3)
BGAR: 122938666(EIF2AK3)
MUO: 115461322(EIF2AK3)
GSH: 117363850(EIF2AK3)
DRE: 559564(eif2ak3)
SANH: 107671339(eif2ak3)
PTET: 122356749(eif2ak3)
LROH: 127175268(eif2ak3)
OMC: 131552683(eif2ak3)
PPRM: 120479726(eif2ak3)
RKG: 130083054(eif2ak3)
MAMB: 125276576(eif2ak3)
CIDE: 127525578
TROS: 130558935(eif2ak3)
TDW: 130431638(eif2ak3)
MANU: 129415885(eif2ak3)
IPU: 108263654
IFU: 128605489(eif2ak3)
PHYP: 113544906(eif2ak3)
SMEO: 124402539(eif2ak3)
TFD: 113639873(eif2ak3)
TVC: 132847193(eif2ak3)
TRN: 134315102(eif2ak3)
AMEX: 103037696(eif2ak3)
CMAO: 118810293(eif2ak3)
EEE: 113579265(eif2ak3)
CHAR: 105909596(eif2ak3)
TRU: 101068654(eif2ak3)
TFS: 130539788(eif2ak3)
LCO: 104931193(eif2ak3)
NCC: 104951808(eif2ak3)
TBEN: 117469677(eif2ak3)
CGOB: 115027347(eif2ak3)
PGEO: 117467518(eif2ak3)
GACU: 117558864(eif2ak3)
EMAC: 134881598(eif2ak3)
ELY: 117267120(eif2ak3)
EFO: 125900836(eif2ak3)
PLEP: 121953982(eif2ak3)
SLUC: 116036720(eif2ak3)
ECRA: 117936371(eif2ak3)
ESP: 116686948(eif2ak3)
PFLV: 114547007(eif2ak3)
GAT: 120832780(eif2ak3)
PPUG: 119227633(eif2ak3)
AFB: 129103062(eif2ak3)
CLUM: 117751315(eif2ak3)
PSWI: 130201552(eif2ak3)
MSAM: 119910044(eif2ak3)
SCHU: 122861600(eif2ak3)
CUD: 121525897(eif2ak3)
ALAT: 119034474(eif2ak3)
MZE: 101480980(eif2ak3)
ONL: 100691545(eif2ak3)
OAU: 116322063(eif2ak3)
OLA: 101171373(eif2ak3)
OML: 112145634(eif2ak3)
CSAI: 133462047(eif2ak3)
XMA: 102220027(eif2ak3)
XCO: 114134784(eif2ak3)
XHE: 116708920(eif2ak3)
PRET: 103458264(eif2ak3)
PLAI: 106963566(eif2ak3)
PMEI: 106904321(eif2ak3)
GAF: 122846077(eif2ak3)
PPRL: 129377287(eif2ak3)
CVG: 107102124(eif2ak3)
CTUL: 119796208(eif2ak3)
GMU: 124855572(eif2ak3)
NFU: 107373885(eif2ak3)
KMR: 108247269(eif2ak3)
ALIM: 106523590(eif2ak3)
AOCE: 111569316(eif2ak3)
MCEP: 125023797(eif2ak3)
CSEM: 103383108(eif2ak3)
POV: 109641514(eif2ak3)
SSEN: 122782926(eif2ak3)
HHIP: 117756372(eif2ak3)
HSP: 118116960(eif2ak3)
PPLT: 128450328(eif2ak3)
SMAU: 118286030(eif2ak3)
LCF: 108889157
SDU: 111226127(eif2ak3)
SLAL: 111646809(eif2ak3)
XGL: 120795962(eif2ak3)
HCQ: 109511559(eif2ak3)
SSCV: 125980636
SBIA: 133513721(eif2ak3)
PEE: 133412640(eif2ak3)
PTAO: 133488278(eif2ak3)
BPEC: 110157424(eif2ak3)
MALB: 109962460(eif2ak3)
BSPL: 114848549(eif2ak3)
SJO: 128375933(eif2ak3)
SASA: 106611453(eif2ak3)
STRU: 115161813(eif2ak3)
OTW: 112236837(eif2ak3)
OMY: 110504273(eif2ak3)
OGO: 124046837(eif2ak3)
OKI: 109881598(eif2ak3)
OKE: 118383462(eif2ak3)
CCLU: 121555338(eif2ak3)
ELS: 105015862(eif2ak3)
SFM: 108921113(eif2ak3)
PKI: 111835392(eif2ak3)
AANG: 118226796(eif2ak3)
LOC: 102689314(eif2ak3)
PSPA: 121294698(eif2ak3) 121314894
ARUT: 117408518(eif2ak3) 117421266
PSEX: 120528022(eif2ak3)
RTP: 109928820(eif2ak3)
CPLA: 122554077(eif2ak3)
HOC: 132825534(eif2ak3)
LERI: 129702561(eif2ak3)
PMRN: 116940536(EIF2AK3)
LRJ: 133343368(EIF2AK3)
BFO: 118409008
BBEL: 109471572
SCLV: 120338763
LPIC: 129273688
DME: Dmel_CG2087(PEK)
DER: 6552401
DSE: 6613946
DSI: Dsimw501_GD19618(Dsim_GD19618)
DAN: 6500493
DSR: 110177163
DPO: 4802443
DPE: 6591403
DMN: 108156119
DWI: 6649722
DGR: 6567621
DAZ: 108620956
DNV: 108660208
DHE: 111598506
DVI: 6633051
CCAT: 101454549
BOD: 106617081
RZE: 108363823
AOQ: 129245528
TDA: 119678744
MDE: 101894683
SCAC: 106087616
LCQ: 111684872
LSQ: 119611150
GFS: 119641811
ECOE: 129943210
CLON: 129607258
HIS: 119659003
AGA: 11175450
ACOZ: 120952492
AARA: 120908664
AMER: 121603543
ASTE: 118505819
AFUN: 125764287
AMOU: 128309858
AALI: 118461495
AAG: 5563776
ASUA: 134225560
CPII: 120415105
CNS: 116344640
BCOO: 119067086
AME: 727396
ACER: 108001848
ALAB: 122716764
ADR: 102681832
AFLR: 100868762
BIM: 100740513
BBIF: 117209142
BVK: 117233925
BVAN: 117160771
BTER: 100645795
BAFF: 126920847
BPYO: 122568858
BPAS: 132916831
FVI: 122536839
CCAL: 108632453
OBB: 114871046
OLG: 117602938
MGEN: 117221534
NMEA: 116424142
CGIG: 122395093
VVE: 124950428
AROA: 105686109
SOY: 115875019
AGRG: 126748869
CSET: 123322264
LDC: 111502129
DVV: 126878682
APLN: 108742677
PPYR: 116165635
OTU: 111425231
MSEX: 115440484
BANY: 112053855
MJU: 123876896
NIQ: 126776474
VCD: 124538747
MCIX: 123664096
PMAC: 106721111
PPOT: 106104285
PXU: 106116788
PRAP: 110993046
PBX: 123709992
PNAP: 125053734
ZCE: 119828920
CCRC: 123700698
LSIN: 126975439
AAGE: 121736139
HAW: 110371333
HZE: 124641050
TNL: 113508182
SLIU: 111348987
OFU: 114357063
GMW: 113520240
PXY: 105389580
PGW: 126380286
LGLY: 125225607
CFEL: 113371650
CCRN: 123302329
API: 100166491
ACOO: 126833674
DVT: 126908322
NLU: 111059996
HVI: 124352825
MQU: 128982072
TPAL: 117641501
CSEC: 111873151
SGRE: 126267175
BROR: 134536121
IEL: 124155567
PVM: 113830140
HAME: 121876835
CQD: 128686482
PTRU: 123511315
MNZ: 135223752
HAZT: 108674054
LSM: 121132580
TCF: 131880655
PPOI: 119092263
RSAN: 119379211
RMP: 119175844
VDE: 111252279
VJA: 111266830
DFR: 124492908
LPOL: 106478487
PMEO: 129595058
CEL: CELE_F46C3.1(pek-1)
CBR: CBG_17340(Cbr-pek-1)
TSP: Tsp_11315
PVUL: 126815785
BGT: 106074601
GAE: 121384543
HRJ: 124267279
CRG: 105344588
CANU: 128180375
CVN: 111135701
OED: 125658434
MYI: 110463950
PMAX: 117339240
MMER: 123546001
RPHI: 132733890
DPOL: 127871136
MAEA: 128211891
OBI: 106870753
OSN: 115223006
LJP: 135468342
LLON: 135489025
HMG: 101239642
HSY: 130644598
RES: 135696292
ABE: ARB_03252
TVE: TRV_02482
PTE: PTT_19265
 » show all
Reference
  Authors
Schroder M, Kaufman RJ
  Title
Divergent roles of IRE1alpha and PERK in the unfolded protein response.
  Journal
Curr Mol Med 6:5-36 (2006)
DOI:10.2174/156652406775574569
Reference
  Authors
Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE
  Title
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.
  Journal
J Biol Chem 282:31675-87 (2007)
DOI:10.1074/jbc.M704491200
Reference
  Authors
Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN
  Title
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
  Journal
J Biol Chem 274:5723-30 (1999)
DOI:10.1074/jbc.274.9.5723
  Sequence
[hsa:9451]
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