KEGG   PATHWAY: kot00260
Entry
kot00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Kosakonia sp. CCTCC M2018092
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kot00260  Glycine, serine and threonine metabolism
kot00260

Module
kot_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kot00260]
kot_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kot00260]
kot_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kot00260]
kot_M00555  Betaine biosynthesis, choline => betaine [PATH:kot00260]
kot_M00621  Glycine cleavage system [PATH:kot00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kosakonia sp. CCTCC M2018092 [GN:kot]
Gene
EH164_20885  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
EH164_18910  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
EH164_21795  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
EH164_20545  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EH164_18905  homoserine kinase [KO:K00872] [EC:2.7.1.39]
EH164_18900  threonine synthase [KO:K01733] [EC:4.2.3.1]
EH164_14800  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EH164_05660  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EH164_17445  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
EH164_14080  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EH164_00795  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EH164_17885  glycerate kinase [KO:K00865] [EC:2.7.1.165]
EH164_02735  garK; glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
EH164_15545  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EH164_18960  gpmB; phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
EH164_00590  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
EH164_03595  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EH164_14645  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EH164_19000  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EH164_12125  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EH164_00565  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EH164_00570  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EH164_03645  aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
EH164_03635  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EH164_16865  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EH164_18440  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EH164_03640  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EH164_05495  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
EH164_03285  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EH164_19485  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
EH164_19490  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EH164_03870  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
EH164_03865  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
EH164_17945  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EH164_09665  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EH164_21635  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EH164_06535  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
EH164_03945  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
EH164_10700  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EH164_10705  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kot00010  Glycolysis / Gluconeogenesis
kot00020  Citrate cycle (TCA cycle)
kot00230  Purine metabolism
kot00250  Alanine, aspartate and glutamate metabolism
kot00270  Cysteine and methionine metabolism
kot00290  Valine, leucine and isoleucine biosynthesis
kot00300  Lysine biosynthesis
kot00330  Arginine and proline metabolism
kot00460  Cyanoamino acid metabolism
kot00470  D-Amino acid metabolism
kot00564  Glycerophospholipid metabolism
kot00600  Sphingolipid metabolism
kot00620  Pyruvate metabolism
kot00630  Glyoxylate and dicarboxylate metabolism
kot00640  Propanoate metabolism
kot00680  Methane metabolism
kot00860  Porphyrin metabolism
kot00920  Sulfur metabolism
KO pathway
ko00260   
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