Entry Name ECM-receptor interaction - Macaca mulatta (rhesus monkey)
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Other DBs Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 574201 COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236 ]
694248 COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131 ]
694701 COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238 ]
696113 FREM2; FRAS1-related extracellular matrix protein 2 isoform X1 [KO:K23380 ]
696685 LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241 ]
697358 FRAS1; extracellular matrix protein FRAS1 isoform X2 [KO:K23379 ]
697991 HMMR; hyaluronan mediated motility receptor isoform X3 [KO:K06267 ]
700359 COL1A2; collagen alpha-2(I) chain precursor [KO:K06236 ]
701313 LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240 ]
701692 DMP1; dentin matrix acidic phosphoprotein 1 [KO:K23328 ]
701943 MEPE; matrix extracellular phosphoglycoprotein isoform X1 [KO:K26442 ]
703707 COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237 ]
703814 COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237 ]
704851 COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719 ]
704980 CD47; leukocyte surface antigen CD47 precursor [KO:K06266 ]
706753 SV2C; synaptic vesicle glycoprotein 2C isoform X1 [KO:K06258 ]
707213 HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X7 [KO:K06255 ]
708287 COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237 ]
709493 COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238 ]
712129 GP1BB; platelet glycoprotein Ib beta chain [KO:K06262 ]
712444 COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237 ]
713874 FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380 ]
714809 COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131 ]
715394 LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637 ]
719319 COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238 ]
719943 COL9A3; collagen alpha-3(IX) chain isoform X2 [KO:K08131 ]
720286 COMP; cartilage oligomeric matrix protein [KO:K04659 ]
721584 GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261 ]
722472 LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637 ]
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related KO pathway
