KEGG   PATHWAY: mcc04510
Entry
mcc04510                    Pathway                                
Name
Focal adhesion - Macaca mulatta (rhesus monkey)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcc04510  Focal adhesion
mcc04510

Other DBs
GO: 0005925
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424246  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
100428484  ITGA10; integrin alpha-10 isoform X3 [KO:K06586]
100429807  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
100430157  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
100430603  LAMA5; laminin subunit alpha-5 [KO:K06240]
106992270  ITGA9; integrin alpha-9 [KO:K06585]
106997584  MYL10; myosin regulatory light chain 10 isoform X3 [KO:K12756]
114672301  [KO:K04375]
114674157  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
574201  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
574214  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
574265  CTNNB1; catenin beta-1 [KO:K02105]
574275  SHC3; SHC-transforming protein 3 [KO:K17448]
574276  THBS4; thrombospondin-4 [KO:K04659]
574285  ACTB; actin, cytoplasmic 1 [KO:K05692]
574312  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
574315  ITGA5; integrin alpha-5 [KO:K06484]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
613269  FN1; fibronectin isoform X1 [KO:K05717]
693357  [KO:K06238]
693554  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
693666  ACTN4; alpha-actinin-4 [KO:K05699]
693750  [KO:K07836]
694090  ITGA11; integrin alpha-11 [KO:K06587]
694248  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
694685  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
694701  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
694957  MYL12B; myosin regulatory light chain 12B [KO:K12757]
695077  MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric isoform X1 [KO:K12757]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
695735  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
696298  TLN1; talin-1 isoform X1 [KO:K06271]
696336  PXN; paxillin isoform X1 [KO:K05760]
696372  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
696584  CRKL; crk-like protein [KO:K04438]
696676  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
696685  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
697523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
697573  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
697643  ITGA6; integrin alpha-6 precursor [KO:K06485]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697765  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
698057  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
698223  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
698319  EMP1; epithelial membrane protein 1 [KO:K26255]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
698538  [KO:K17457]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
698830  HRAS; GTPase HRas [KO:K02833]
698888  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699405  ITGB7; integrin beta-7 [KO:K06590]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
699524  FLNA; filamin-A isoform X1 [KO:K04437]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
700281  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
700359  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
700454  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
700538  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700788  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
700918  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
700962  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701185  CRK; adapter molecule crk isoform X1 [KO:K04438]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701219  PGF; placenta growth factor isoform X2 [KO:K16859]
701313  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
701589  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
701835  IBSP; bone sialoprotein 2 [KO:K06253]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
702111  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
702163  CAV3; caveolin-3 [KO:K12959]
702225  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
702468  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
702592  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
702601  CHAD; chondroadherin [KO:K06248]
702720  TNC; tenascin isoform X1 [KO:K06252]
702732  FLNB; filamin-B isoform X1 [KO:K27392]
703047  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
703302  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
703456  ITGA1; integrin alpha-1 [KO:K06480]
703481  PARVA; alpha-parvin isoform X1 [KO:K06275]
703572  ITGA2; integrin alpha-2 precursor [KO:K06481]
703707  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
703770  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
703814  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
704404  RAP1A; ras-related protein Rap-1A [KO:K04353]
704449  CAV1; caveolin-1 [KO:K06278]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
704745  ITGA4; integrin alpha-4 [KO:K06483]
704851  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
704930  SPP1; osteopontin precursor [KO:K06250]
705008  TLN2; talin-2 isoform X1 [KO:K06271]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
705413  THBS1; thrombospondin-1 [KO:K16857]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
705671  [KO:K05692]
705775  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
706217  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
706407  ZYX; zyxin [KO:K06273]
706455  RHOA; transforming protein RhoA [KO:K04513]
706980  CAV2; caveolin-2 [KO:K12958]
707247  ITGB8; integrin beta-8 precursor [KO:K06591]
707279  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
707293  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707361  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
707756  ITGAV; integrin alpha-V precursor [KO:K06487]
707892  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
708165  THBS2; thrombospondin-2 [KO:K04659]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
708287  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
708444  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
708499  VTN; vitronectin [KO:K06251]
708587  TNN; tenascin-N isoform X1 [KO:K06252]
708707  TNR; tenascin-R [KO:K06252]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
709493  COL6A2; collagen alpha-2(VI) chain isoform X2 [KO:K06238]
709784  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
709935  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
709944  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710007  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
710314  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
710315  EMP2; epithelial membrane protein 2 precursor [KO:K26256]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711778  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
711937  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
711994  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
712444  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
712624  PARVG; gamma-parvin isoform X2 [KO:K06275]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
712830  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
713227  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
713687  ACTG1; actin, cytoplasmic 2 [KO:K05692]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
713965  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
714611  SHC4; SHC-transforming protein 4 [KO:K17449]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714809  COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131]
714955  ITGA2B; integrin alpha-IIb isoform X2 [KO:K06476]
715212  LAMC2; laminin subunit gamma-2 [KO:K06246]
715265  LAMC1; laminin subunit gamma-1 [KO:K05635]
715272  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
715394  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
715422  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
715710  ITGB5; integrin beta-5 precursor [KO:K06588]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715859  PARVB; beta-parvin isoform X1 [KO:K06275]
716022  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716132  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
716452  JUN; transcription factor AP-1 [KO:K04448]
716936  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
716998  TNXB; tenascin-X isoform X7 [KO:K06252]
717161  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
717379  ITGB3; integrin beta-3 [KO:K06493]
717572  THBS3; thrombospondin-3 precursor [KO:K04659]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
718171  RAP1B; ras-related protein Rap-1b [KO:K07836]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718982  SHC1; SHC-transforming protein 1 [KO:K06279]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
719319  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
719331  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719458  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
719943  COL9A3; collagen alpha-3(IX) chain isoform X2 [KO:K08131]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
720286  COMP; cartilage oligomeric matrix protein [KO:K04659]
720945  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
721021  SHC2; SHC-transforming protein 2 [KO:K17447]
721735  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
721744  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
721855  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
721921  VCL; vinculin isoform X1 [KO:K05700]
722019  VWF; von Willebrand factor precursor [KO:K03900]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
722430  LAMC3; laminin subunit gamma-3 [KO:K06247]
722472  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mcc04010  MAPK signaling pathway
mcc04060  Cytokine-cytokine receptor interaction
mcc04070  Phosphatidylinositol signaling system
mcc04110  Cell cycle
mcc04151  PI3K-Akt signaling pathway
mcc04310  Wnt signaling pathway
mcc04512  ECM-receptor interaction
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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