Entry Name Synaptic vesicle cycle - Macaca mulatta (rhesus monkey)
Description Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Other DBs Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 100425716 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
574134 VAMP2; vesicle-associated membrane protein 2 [KO:K13504 ]
574140 SLC6A4; sodium-dependent serotonin transporter [KO:K05037 ]
574143 SLC6A3; sodium-dependent dopamine transporter [KO:K05036 ]
574204 SNAP25; synaptosomal-associated protein 25 [KO:K18211 ]
574349 SLC17A7; vesicular glutamate transporter 1 [KO:K12302 ]
574358 SLC1A2; excitatory amino acid transporter 2 [KO:K05613 ]
613238 SLC6A2; sodium-dependent noradrenaline transporter isoform 2 [KO:K05035 ]
641435 RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X48 [KO:K15291 ]
677865 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154 ]
693323 ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144 ]
693838 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
693840 ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148 ]
694947 SLC1A1; excitatory amino acid transporter 3 [KO:K05612 ]
695508 SLC17A8; vesicular glutamate transporter 3 [KO:K12302 ]
696617 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
696741 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
697368 UNC13C; protein unc-13 homolog C isoform X1 [KO:K15293 ]
697393 UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293 ]
698315 SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015 ]
698345 ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146 ]
701109 SLC1A3; excitatory amino acid transporter 1 [KO:K05614 ]
701133 SLC18A2; synaptic vesicular amine transporter [KO:K08155 ]
702243 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
702346 SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X9 [KO:K05038 ]
703342 ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153 ]
703646 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147 ]
703655 ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152 ]
704703 SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038 ]
705489 SLC18A1; chromaffin granule amine transporter isoform X2 [KO:K08155 ]
705605 ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
705780 SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045 ]
705918 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X4 [KO:K05046 ]
706673 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148 ]
709739 ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150 ]
710053 SLC18A3; vesicular acetylcholine transporter [KO:K14636 ]
710162 ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
710372 ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152 ]
710650 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
711915 SLC6A7; sodium-dependent proline transporter [KO:K05040 ]
714080 SLC1A7; excitatory amino acid transporter 5 isoform X2 [KO:K05618 ]
714746 ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150 ]
715331 ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152 ]
715492 ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
717355 NAPA; alpha-soluble NSF attachment protein [KO:K15296 ]
718291 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5 [KO:K04344 ]
719023 SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617 ]
719087 CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646 ]
720000 UNC13A; protein unc-13 homolog A isoform X1 [KO:K15293 ]
720875 AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824 ]
721452 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849 ]
Compound Reference Authors Li L, Chin LS
Title The molecular machinery of synaptic vesicle exocytosis.
Journal Reference Authors Nestler EJ, Hyman SE, Malenka RC.
Title Molecular neuropharmacology: A foundation for clinical neuroscience
Journal The McGraw-Hill Companies, Inc. (2001)
Reference Authors Chapman ER
Title How does synaptotagmin trigger neurotransmitter release?
Journal Reference Authors Benfenati F, Onofri F, Giovedi S
Title Protein-protein interactions and protein modules in the control of neurotransmitter release.
Journal Reference Authors de Saint Basile G, Menasche G, Fischer A
Title Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
Journal Reference Authors Carr CM, Munson M
Title Tag team action at the synapse.
Journal Reference Authors Sudhof TC
Title The synaptic vesicle cycle.
Journal Reference Authors Gundelfinger ED, Kessels MM, Qualmann B
Title Temporal and spatial coordination of exocytosis and endocytosis.
Journal Reference Authors Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
Title A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Journal Reference Authors Chapman ER
Title Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
Journal Reference Authors Sudhof TC
Title The synaptic vesicle cycle: a cascade of protein-protein interactions.
Journal Reference Authors Rizo J, Sudhof TC
Title Snares and Munc18 in synaptic vesicle fusion.
Journal Reference Authors Malsam J, Kreye S, Sollner TH
Title Membrane fusion: SNAREs and regulation.
Journal Related KO pathway
