KEGG   PATHWAY: mcc04727
Entry
mcc04727                    Pathway                                
Name
GABAergic synapse - Macaca mulatta (rhesus monkey)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mcc04727  GABAergic synapse
mcc04727

Other DBs
GO: 0051932
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100169972  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100423704  [KO:K01580] [EC:4.1.1.15]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114673987  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
574302  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 precursor [KO:K05175]
574394  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
613029  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
613030  GAD1; glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
693520  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
693523  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
693675  KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
693924  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
694730  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
695328  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
695441  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
695792  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
696617  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
696741  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
696767  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 precursor [KO:K05181]
697010  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X2 [KO:K05175]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697248  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 precursor [KO:K05186]
698200  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
698315  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
698660  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
698840  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
699310  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
700606  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
700724  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
700728  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
700858  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
701057  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
701113  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701779  TRAK2; trafficking kinesin-binding protein 2 [KO:K15374]
702135  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
702253  SLC38A2; sodium-coupled neutral amino acid transporter 2 [KO:K14207]
702827  [KO:K08341]
703336  [KO:K04542]
703399  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
703671  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
703780  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
703792  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X1 [KO:K05186]
703894  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 precursor [KO:K05175]
704008  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
704693  GABRE; gamma-aminobutyric acid receptor subunit epsilon isoform X1 [KO:K05185]
704707  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
705252  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
705780  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
705918  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X4 [KO:K05046]
706789  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
707974  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
707978  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
708193  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
708706  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
708940  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
708987  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 precursor [KO:K04615]
709489  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
709677  GPHN; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
710000  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
710062  GABRD; gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
710156  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
710548  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
711217  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
711230  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
711335  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
711754  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 precursor [KO:K05181]
711838  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [KO:K05175]
712962  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
713913  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
714017  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
714413  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
714597  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
714684  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
715297  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
715787  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
715897  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
715952  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
717640  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
718019  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
718223  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
718291  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5 [KO:K04344]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
719248  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
720390  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186]
721452  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
721721  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X13 [KO:K04850]
722398  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mcc00020  Citrate cycle (TCA cycle)
mcc00250  Alanine, aspartate and glutamate metabolism
mcc04144  Endocytosis
mcc04721  Synaptic vesicle cycle
KO pathway
ko04727   

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