KEGG   PATHWAY: meso00260
Entry
meso00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Aquibium oceanicum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
meso00260  Glycine, serine and threonine metabolism
meso00260

Module
meso_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:meso00260]
meso_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:meso00260]
meso_M00555  Betaine biosynthesis, choline => betaine [PATH:meso00260]
meso_M00621  Glycine cleavage system [PATH:meso00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aquibium oceanicum [GN:meso]
Gene
BSQ44_22910  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BSQ44_00465  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BSQ44_14590  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BSQ44_07390  homoserine kinase [KO:K02204] [EC:2.7.1.39]
BSQ44_07430  threonine synthase [KO:K01733] [EC:4.2.3.1]
BSQ44_21815  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BSQ44_17610  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BSQ44_05935  septum site-determining protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BSQ44_02635  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BSQ44_22475  glycerate kinase [KO:K11529] [EC:2.7.1.165]
BSQ44_03660  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BSQ44_01075  dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSQ44_23830  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BSQ44_23840  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BSQ44_13535  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BSQ44_18930  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BSQ44_18920  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BSQ44_06705  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
BSQ44_00435  amine oxidase [KO:K00274] [EC:1.4.3.4]
BSQ44_09045  hypothetical protein [KO:K00274] [EC:1.4.3.4]
BSQ44_12135  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BSQ44_23655  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BSQ44_12145  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BSQ44_21040  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSQ44_00920  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSQ44_15295  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BSQ44_12140  glycine cleavage system protein H [KO:K02437]
BSQ44_10490  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BSQ44_08910  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BSQ44_08905  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSQ44_24720  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BSQ44_15470  glycine cleavage system protein T [KO:K00315] [EC:1.5.8.4]
BSQ44_15795  dimethylglycine dehydrogenase [KO:K00315] [EC:1.5.8.4]
BSQ44_22265  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BSQ44_02110  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BSQ44_22280  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BSQ44_02120  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BSQ44_02105  hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BSQ44_22260  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BSQ44_02115  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BSQ44_16460  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
BSQ44_14870  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BSQ44_24690  serine dehydratase [KO:K01752] [EC:4.3.1.17]
BSQ44_06185  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSQ44_08915  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BSQ44_05425  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BSQ44_05410  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BSQ44_02090  ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
BSQ44_02080  hypothetical protein [KO:K15785] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
meso00010  Glycolysis / Gluconeogenesis
meso00020  Citrate cycle (TCA cycle)
meso00230  Purine metabolism
meso00250  Alanine, aspartate and glutamate metabolism
meso00270  Cysteine and methionine metabolism
meso00290  Valine, leucine and isoleucine biosynthesis
meso00300  Lysine biosynthesis
meso00330  Arginine and proline metabolism
meso00460  Cyanoamino acid metabolism
meso00470  D-Amino acid metabolism
meso00564  Glycerophospholipid metabolism
meso00620  Pyruvate metabolism
meso00630  Glyoxylate and dicarboxylate metabolism
meso00640  Propanoate metabolism
meso00680  Methane metabolism
meso00860  Porphyrin metabolism
meso00920  Sulfur metabolism
KO pathway
ko00260   
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