KEGG   PATHWAY: mhad00260
Entry
mhad00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mycobacterium haemophilum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mhad00260  Glycine, serine and threonine metabolism
mhad00260

Module
mhad_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mhad00260]
mhad_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mhad00260]
mhad_M00621  Glycine cleavage system [PATH:mhad00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mycobacterium haemophilum [GN:mhad]
Gene
B586_03705  aspartate kinase [KO:K00928] [EC:2.7.2.4]
B586_03710  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B586_08090  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B586_08100  homoserine kinase [KO:K00872] [EC:2.7.1.39]
B586_08095  threonine synthase [KO:K01733] [EC:4.2.3.1]
B586_07045  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B586_10140  hypothetical protein [KO:K00865] [EC:2.7.1.165]
B586_19580  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
B586_15675  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B586_18585  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B586_05930  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
B586_15870  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
B586_16475  monooxygenase [KO:K00274] [EC:1.4.3.4]
B586_07225  monoamine oxidase [KO:K00274] [EC:1.4.3.4]
B586_11790  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B586_10115  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
B586_19710  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
B586_11820  glycine cleavage system protein H [KO:K02437]
B586_11430  amino acid oxidase [KO:K00273] [EC:1.4.3.3]
B586_00135  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
B586_10995  phenylacetaldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B586_06980  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
B586_16100  serine dehydratase [KO:K01752] [EC:4.3.1.17]
B586_12895  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B586_12725  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
B586_12730  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mhad00010  Glycolysis / Gluconeogenesis
mhad00020  Citrate cycle (TCA cycle)
mhad00230  Purine metabolism
mhad00250  Alanine, aspartate and glutamate metabolism
mhad00270  Cysteine and methionine metabolism
mhad00290  Valine, leucine and isoleucine biosynthesis
mhad00300  Lysine biosynthesis
mhad00330  Arginine and proline metabolism
mhad00460  Cyanoamino acid metabolism
mhad00470  D-Amino acid metabolism
mhad00564  Glycerophospholipid metabolism
mhad00600  Sphingolipid metabolism
mhad00620  Pyruvate metabolism
mhad00630  Glyoxylate and dicarboxylate metabolism
mhad00640  Propanoate metabolism
mhad00680  Methane metabolism
mhad00860  Porphyrin metabolism
mhad00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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