KEGG   PATHWAY: mlit00260
Entry
mlit00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Metabacillus litoralis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mlit00260  Glycine, serine and threonine metabolism
mlit00260

Module
mlit_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mlit00260]
mlit_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mlit00260]
mlit_M00621  Glycine cleavage system [PATH:mlit00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Metabacillus litoralis [GN:mlit]
Gene
KDJ21_002535  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KDJ21_012070  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KDJ21_020930  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
KDJ21_020935  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KDJ21_009995  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KDJ21_010005  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
KDJ21_010000  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KDJ21_009250  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KDJ21_006600  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KDJ21_024095  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KDJ21_023445  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KDJ21_018055  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
KDJ21_008965  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KDJ21_016620  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KDJ21_000875  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KDJ21_015915  HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
KDJ21_020785  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
KDJ21_020790  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KDJ21_025880  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
KDJ21_026145  primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
KDJ21_013610  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
KDJ21_013615  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
KDJ21_013605  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KDJ21_013900  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KDJ21_019010  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KDJ21_022055  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KDJ21_009820  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KDJ21_006200  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KDJ21_005585  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
KDJ21_021395  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
KDJ21_021400  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
KDJ21_025555  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
KDJ21_015240  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
KDJ21_016695  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
KDJ21_014705  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KDJ21_014700  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mlit00010  Glycolysis / Gluconeogenesis
mlit00020  Citrate cycle (TCA cycle)
mlit00230  Purine metabolism
mlit00250  Alanine, aspartate and glutamate metabolism
mlit00270  Cysteine and methionine metabolism
mlit00290  Valine, leucine and isoleucine biosynthesis
mlit00300  Lysine biosynthesis
mlit00330  Arginine and proline metabolism
mlit00460  Cyanoamino acid metabolism
mlit00470  D-Amino acid metabolism
mlit00564  Glycerophospholipid metabolism
mlit00600  Sphingolipid metabolism
mlit00620  Pyruvate metabolism
mlit00630  Glyoxylate and dicarboxylate metabolism
mlit00640  Propanoate metabolism
mlit00680  Methane metabolism
mlit00860  Porphyrin metabolism
mlit00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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