KEGG   PATHWAY: msm00630
Entry
msm00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycolicibacterium smegmatis MC2 155
Class
Metabolism; Carbohydrate metabolism
Pathway map
msm00630  Glyoxylate and dicarboxylate metabolism
msm00630

Module
msm_M00621  Glycine cleavage system [PATH:msm00630]
msm_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:msm00630]
Other DBs
GO: 0046487 0043648
Organism
Mycolicibacterium smegmatis MC2 155 [GN:msm]
Gene
MSMEG_3706  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MSMEG_0911  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
MSMEG_3986  acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MSMEG_6179  acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MSMEG_0718  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
MSMEG_5650  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
MSMEG_3640  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
MSMEG_5672  gltA; citrate synthase I [KO:K01647] [EC:2.3.3.1]
MSMEG_5676  citrate synthase [KO:K01647] [EC:2.3.3.1]
MSMEG_4035  citrate synthase [KO:K01647] [EC:2.3.3.1]
MSMEG_6647  citrate synthase 2 [KO:K01659] [EC:2.3.3.5]
MSMEG_3143  acnA; aconitate hydratase 1 [KO:K27802] [EC:4.2.1.3 4.2.1.99]
MSMEG_4920  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_2224  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_5721  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_5608  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_6008  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_5996  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_3608  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_0373  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MSMEG_5923  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_5273  beta-ketoadipyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
MSMEG_1896  beta-ketothiolase [KO:K00626] [EC:2.3.1.9]
MSMEG_2207  beta-ketothiolase [KO:K00626] [EC:2.3.1.9]
MSMEG_5521  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSMEG_4173  MaoC family protein [KO:K17865] [EC:4.2.1.55]
MSMEG_4921  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
MSMEG_1807  acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
MSMEG_1813  propionyl-CoA carboxylase beta chain [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
MSMEG_1812  conserved hypothetical protein [KO:K27095]
MSMEG_4329  propionyl-CoA carboxylase beta chain [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MSMEG_3159  methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
MSMEG_3158  mutA; methylmalonyl-CoA mutase, small subunit [KO:K01847] [EC:5.4.99.2]
MSMEG_4880  methylmalonyl-CoA mutase C-terminal domain protein [KO:K01849] [EC:5.4.99.2]
MSMEG_4881  methylmalonyl-CoA mutase, N-terminus of large subunit [KO:K01848] [EC:5.4.99.2]
MSMEG_0301  oxidoreductase, FAD-binding [KO:K00104] [EC:1.1.99.14]
MSMEG_0374  glycolate oxidase subunit [KO:K00104] [EC:1.1.99.14]
MSMEG_5037  oxidoreductase, FAD-binding [KO:K00104] [EC:1.1.99.14]
MSMEG_3486  katA; catalase KatA [KO:K03781] [EC:1.11.1.6]
MSMEG_6232  katA; catalase KatA [KO:K03781] [EC:1.11.1.6]
MSMEG_3708  catalase [KO:K03781] [EC:1.11.1.6]
MSMEG_6299  glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
MSMEG_4308  5'-nucleotidase [KO:K01091] [EC:3.1.3.18]
MSMEG_4290  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
MSMEG_4294  glnA; glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
MSMEG_3561  glnA; glutamine synthetase, catalytic domain [KO:K01915] [EC:6.3.1.2]
MSMEG_3827  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSMEG_3828  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSMEG_5374  glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
MSMEG_6260  glnT; glutamine synthetase, type III [KO:K01915] [EC:6.3.1.2]
MSMEG_2595  gamma-glutamylisopropylamide synthetase [KO:K01915] [EC:6.3.1.2]
MSMEG_6693  glutamine synthetase III [KO:K01915] [EC:6.3.1.2]
MSMEG_1116  gamma-glutamylisopropylamide synthetase [KO:K01915] [EC:6.3.1.2]
MSMEG_5249  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MSMEG_3642  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MSMEG_4278  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
MSMEG_0903  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
MSMEG_3648  gcvH; glycine cleavage system H protein [KO:K02437]
MSMEG_5476  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
MSMEG_5478  hydroxypyruvate isomerase, putative [KO:K01816] [EC:5.3.1.22]
MSMEG_4653  AP endonuclease, family protein 2 superfamily protein [KO:K01816] [EC:5.3.1.22]
MSMEG_5477  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
MSMEG_2528  glycerate kinase [KO:K00865] [EC:2.7.1.165]
MSMEG_1986  tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
MSMEG_0312  eda; 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
MSMEG_3788  eda; 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
MSMEG_5049  sucA; 2-oxoglutarate dehydrogenase, E1 component [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MSMEG_2254  oxalate decarboxylase OxdC, putative [KO:K01569] [EC:4.1.1.2]
MSMEG_0162  NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
MSMEG_0161  formate dehydrogenase, alpha subunit [KO:K00123] [EC:1.17.1.9]
MSMEG_0160  formate dehydrogenase, beta subunit [KO:K00124]
MSMEG_1847  4Fe-4S ferredoxin, iron-sulfur binding protein [KO:K00124]
MSMEG_0159  formate dehydrogenase, gamma subunit [KO:K00127]
MSMEG_2200  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
MSMEG_4367  formamidase [KO:K01455] [EC:3.5.1.49]
MSMEG_3403  formamidase [KO:K01455] [EC:3.5.1.49]
MSMEG_5335  formamidase [KO:K01455] [EC:3.5.1.49]
MSMEG_0484  formamidase [KO:K01455] [EC:3.5.1.49]
MSMEG_5297  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSMEG_0157  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSMEG_0158  formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
MSMEG_0168  formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
msm00010  Glycolysis / Gluconeogenesis
msm00020  Citrate cycle (TCA cycle)
msm00030  Pentose phosphate pathway
msm00053  Ascorbate and aldarate metabolism
msm00071  Fatty acid degradation
msm00230  Purine metabolism
msm00250  Alanine, aspartate and glutamate metabolism
msm00260  Glycine, serine and threonine metabolism
msm00620  Pyruvate metabolism
msm00710  Carbon fixation by Calvin cycle
msm00750  Vitamin B6 metabolism
msm00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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