KEGG   PATHWAY: ngr00020
Entry
ngr00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Naegleria gruberi
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ngr00020  Citrate cycle (TCA cycle)
ngr00020

Module
ngr_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ngr00020]
ngr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ngr00020]
Other DBs
GO: 0006099
Organism
Naegleria gruberi [GN:ngr]
Gene
NAEGRDRAFT_29455  [KO:K01899] [EC:6.2.1.4 6.2.1.5]
NAEGRDRAFT_34693  [KO:K01676] [EC:4.2.1.2]
NAEGRDRAFT_37962  [KO:K00164] [EC:1.2.4.2]
NAEGRDRAFT_38032  [KO:K00627] [EC:2.3.1.12]
NAEGRDRAFT_38237  [KO:K00382] [EC:1.8.1.4]
NAEGRDRAFT_38463  [KO:K01610] [EC:4.1.1.49]
NAEGRDRAFT_38693  [KO:K01681] [EC:4.2.1.3]
NAEGRDRAFT_38914  [KO:K01647] [EC:2.3.3.1]
NAEGRDRAFT_39315  [KO:K00162] [EC:1.2.4.1]
NAEGRDRAFT_54230  [KO:K01647] [EC:2.3.3.1]
NAEGRDRAFT_55595  [KO:K00658] [EC:2.3.1.61]
NAEGRDRAFT_56281  [KO:K00161] [EC:1.2.4.1]
NAEGRDRAFT_59586  [KO:K01681] [EC:4.2.1.3]
NAEGRDRAFT_60960  [KO:K00024] [EC:1.1.1.37]
NAEGRDRAFT_70009  [KO:K00030] [EC:1.1.1.41]
NAEGRDRAFT_76494  [KO:K01900] [EC:6.2.1.4 6.2.1.5]
NAEGRDRAFT_77259  [KO:K00024] [EC:1.1.1.37]
NAEGRDRAFT_78042  [KO:K01681] [EC:4.2.1.3]
NAEGRDRAFT_79109  [KO:K01900] [EC:6.2.1.4 6.2.1.5]
NAEGRDRAFT_80807  [KO:K00030] [EC:1.1.1.41]
NAEGRDRAFT_82148  [KO:K01958] [EC:6.4.1.1]
NAEGRDRAFT_82269  [KO:K01647] [EC:2.3.3.1]
NAEGRDRAFT_82731  [KO:K00031] [EC:1.1.1.42]
NAEGRDRAFT_83065  [KO:K00025] [EC:1.1.1.37]
NAEGRDRAFT_83231  [KO:K00234] [EC:1.3.5.1]
NAEGRDRAFT_83245  [KO:K01900] [EC:6.2.1.4 6.2.1.5]
NAEGRDRAFT_83307  [KO:K01679] [EC:4.2.1.2]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
ngr00010  Glycolysis / Gluconeogenesis
ngr00053  Ascorbate and aldarate metabolism
ngr00061  Fatty acid biosynthesis
ngr00062  Fatty acid elongation
ngr00071  Fatty acid degradation
ngr00190  Oxidative phosphorylation
ngr00220  Arginine biosynthesis
ngr00250  Alanine, aspartate and glutamate metabolism
ngr00280  Valine, leucine and isoleucine degradation
ngr00350  Tyrosine metabolism
ngr00470  D-Amino acid metabolism
ngr00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   

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