KEGG   PATHWAY: nph00230
Entry
nph00230                    Pathway                                
Name
Purine metabolism - Natronomonas pharaonis
Class
Metabolism; Nucleotide metabolism
Pathway map
nph00230  Purine metabolism
nph00230

Module
nph_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:nph00230]
nph_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:nph00230]
nph_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:nph00230]
nph_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:nph00230]
nph_M00968  Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:nph00230]
Other DBs
GO: 0006163 0042278
Organism
Natronomonas pharaonis [GN:nph]
Gene
NP_0392A  [KO:K01515] [EC:3.6.1.13 3.6.1.-]
NP_0606A  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
NP_0620A  guaAa1; GMP synthase (glutamine-hydrolyzing) subunit A [KO:K01951] [EC:6.3.5.2]
NP_0732A  purO; inosine-5'-monophosphate cyclohydrolase, archaeal-type [KO:K11176] [EC:3.5.4.10]
NP_1426A  apt1; purine phosphoribosyltransferase (adenine phosphoribosyltransferase, xanthine-guanine phosphoribosyltransferase) [KO:K00759] [EC:2.4.2.7]
NP_1530A  purA; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
NP_1658A  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
NP_1662A  purNH; phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K01492] [EC:2.1.2.2 2.1.2.3]
NP_1844A  ggt; gamma-glutamyltransferase [KO:K22602] [EC:3.5.1.126]
NP_1970A  guaAb; GMP synthase (glutamine-hydrolyzing) subunit B [KO:K01951] [EC:6.3.5.2]
NP_2008A  ureB; urease beta subunit [KO:K01429] [EC:3.5.1.5]
NP_2010A  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
NP_2012A  ureA; urease gamma subunit [KO:K01430] [EC:3.5.1.5]
NP_2142A  adk2; probable adenylate kinase [KO:K18532] [EC:2.7.4.3]
NP_2286A  purK; 5-(carboxyamino)imidazole ribonucleotide synthase [KO:K01589] [EC:6.3.4.18]
NP_2290A  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
NP_2590A  ushA2; 5'-nucleotidase family hydrolase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
NP_2928A  guaAa4; glutamine amidotransferase (homolog to GMP synthase subunit A) [KO:K01951] [EC:6.3.5.2]
NP_2982A  purL; phosphoribosylformylglycinamidine synthase subunit PurL [KO:K23269]
NP_3054A  [KO:K01515] [EC:3.6.1.13 3.6.1.-]
NP_3080A  guaB2; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
NP_3092A  [KO:K05873] [EC:4.6.1.1]
NP_3180A  udp2; uridine phosphorylase [KO:K26212]
NP_3194A  hit1; histidine triad family protein (homolog to bis(5'-nucleosyl)-tetraphosphatase) [KO:K19710] [EC:2.7.7.53]
NP_3346A  nrdJ; ribonucleoside-diphosphate reductase,adenosylcobalamin-dependent [KO:K00525] [EC:1.17.4.1]
NP_3384A  guaB1; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
NP_3514A  pmm3; phosphohexomutase (phosphoglucomutase / phosphomannomutase) [KO:K22199] [EC:5.4.2.7]
NP_3666A  ndk; nucleoside-diphosphate kinase [KO:K00940] [EC:2.7.4.6]
NP_3940A  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
NP_3958A  deoA; AMP phosphorylase (ribose-1,5-bisphosphate forming) [KO:K18931] [EC:2.4.2.57]
NP_3972A  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
NP_4208A  surE; 5'-nucleotidase SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
NP_4312A  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
NP_4426A  ham1; non-canonical purine NTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
NP_4434A  nrdB3; probable ribonucleoside-diphosphate reductase beta subunit [KO:K00526] [EC:1.17.4.1]
NP_4910A  adk1; adenylate kinase [KO:K00939] [EC:2.7.4.3]
NP_4996A  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
NP_5008A  purS; phosphoribosylformylglycinamidine synthase subunit PurS [KO:K23264]
NP_5010A  purQ; phosphoribosylformylglycinamidine synthase subunit PurQ [KO:K23265]
NP_5066A  nrdB2; probable ribonucleoside-diphosphate reductase beta subunit [KO:K00526] [EC:1.17.4.1]
NP_5158A  pmm4; phosphohexomutase (phosphoglucomutase / phosphomannomutase) [KO:K15778] [EC:5.4.2.8 5.4.2.2]
NP_6166A  nrdB1; ribonucleoside-diphosphate reductase beta subunit [KO:K00526] [EC:1.17.4.1]
NP_6168A  nrdA1; ribonucleoside-diphosphate reductase alpha subunit [KO:K00525] [EC:1.17.4.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
nph00030  Pentose phosphate pathway
nph00220  Arginine biosynthesis
nph00250  Alanine, aspartate and glutamate metabolism
nph00260  Glycine, serine and threonine metabolism
nph00340  Histidine metabolism
nph00630  Glyoxylate and dicarboxylate metabolism
nph00730  Thiamine metabolism
nph00740  Riboflavin metabolism
nph00790  Folate biosynthesis
KO pathway
ko00230   

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