KEGG   PATHWAY: nzo00260
Entry
nzo00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Neisseria zoodegmatis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nzo00260  Glycine, serine and threonine metabolism
nzo00260

Module
nzo_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:nzo00260]
nzo_M00555  Betaine biosynthesis, choline => betaine [PATH:nzo00260]
nzo_M00621  Glycine cleavage system [PATH:nzo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Neisseria zoodegmatis [GN:nzo]
Gene
SAMEA4504057_1497  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
SAMEA4504057_0360  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
SAMEA4504057_1128  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
SAMEA4504057_2239  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
SAMEA4504057_1159  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
SAMEA4504057_0279  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
SAMEA4504057_1763  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
SAMEA4504057_0346  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
SAMEA4504057_0505  gpmA_2; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
SAMEA4504057_1115  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
SAMEA4504057_1813  serB; SerB protein [KO:K01079] [EC:3.1.3.3]
SAMEA4504057_0010  ydfG; oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
SAMEA4504057_1929  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
SAMEA4504057_0861  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
SAMEA4504057_0882  lpdA; dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenase complexes) [KO:K00382] [EC:1.8.1.4]
SAMEA4504057_1173  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMEA4504057_1371  pdhD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SAMEA4504057_0866  gcvH; glycine cleavage system protein H [KO:K02437]
SAMEA4504057_1827  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
SAMEA4504057_0509  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
SAMEA4504057_0506  betB; putative succinate-semialdehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
SAMEA4504057_1495  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAMEA4504057_0435  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
SAMEA4504057_0867  ygeA; putative racemase [KO:K25316] [EC:5.1.1.10]
SAMEA4504057_0711  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
SAMEA4504057_2014  trpB_2; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
SAMEA4504057_1264  trpB_1; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nzo00010  Glycolysis / Gluconeogenesis
nzo00020  Citrate cycle (TCA cycle)
nzo00230  Purine metabolism
nzo00250  Alanine, aspartate and glutamate metabolism
nzo00270  Cysteine and methionine metabolism
nzo00290  Valine, leucine and isoleucine biosynthesis
nzo00300  Lysine biosynthesis
nzo00330  Arginine and proline metabolism
nzo00460  Cyanoamino acid metabolism
nzo00470  D-Amino acid metabolism
nzo00564  Glycerophospholipid metabolism
nzo00600  Sphingolipid metabolism
nzo00620  Pyruvate metabolism
nzo00630  Glyoxylate and dicarboxylate metabolism
nzo00640  Propanoate metabolism
nzo00680  Methane metabolism
nzo00860  Porphyrin metabolism
nzo00920  Sulfur metabolism
KO pathway
ko00260   
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