KEGG   PATHWAY: paer00405
Entry
paer00405                   Pathway                                
Name
Phenazine biosynthesis - Pseudomonas aeruginosa PA1R
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
paer00405  Phenazine biosynthesis
paer00405

Module
paer_M00835  Pyocyanine biosynthesis, chorismate => pyocyanine [PATH:paer00405]
Organism
Pseudomonas aeruginosa PA1R [GN:paer]
Gene
PA1R_gp2105  Phenazine biosynthesis protein PhzE / 2-Amino-2-deoxy-isochorismate synthase [KO:K13063] [EC:2.6.1.86]
PA1R_gp5532  Phenazine biosynthesis protein PhzE / 2-Amino-2-deoxy-isochorismate synthase [KO:K13063] [EC:2.6.1.86]
PA1R_gp5531  Phenazine biosynthesis protein PhzD / 2-Amino-2-deoxy-isochorismate hydrolase [KO:K20261] [EC:3.3.2.15]
PA1R_gp2104  Phenazine biosynthesis protein PhzD / 2-Amino-2-deoxy-isochorismate hydrolase [KO:K20261] [EC:3.3.2.15]
PA1R_gp5533  Phenazine biosynthesis protein PhzF [KO:K06998] [EC:5.3.3.17]
PA1R_gp2106  Phenazine biosynthesis protein PhzF [KO:K06998] [EC:5.3.3.17]
PA1R_gp2101  Phenazine biosynthesis protein PhzA [KO:K20260]
PA1R_gp5528  Phenazine biosynthesis protein PhzA [KO:K20260]
PA1R_gp2102  Phenazine biosynthesis protein PhzB [KO:K20260]
PA1R_gp5529  Phenazine biosynthesis protein PhzB [KO:K20260]
PA1R_gp5534  Phenazine biosynthesis protein PhzG; Pyridoxamine 5'-phosphate oxidase [KO:K20262] [EC:1.10.3.16]
PA1R_gp2107  Phenazine biosynthesis protein PhzG; Pyridoxamine 5'-phosphate oxidase [KO:K20262] [EC:1.10.3.16]
PA1R_gp2100  Phenazine-specific methyltransferase PhzM [KO:K21103] [EC:2.1.1.327]
PA1R_gp2108  FAD-dependent monooxygenase PhzS [KO:K20940] [EC:1.14.13.218]
PA1R_gp4598  Anthranilate synthase, aminase component [KO:K01657] [EC:4.1.3.27]
PA1R_gp4120  Anthranilate synthase, aminase component [KO:K01657] [EC:4.1.3.27]
PA1R_gp4599  Anthranilate synthase, amidotransferase component [KO:K01658] [EC:4.1.3.27]
PA1R_gp4149  Anthranilate synthase, amidotransferase component [KO:K01658] [EC:4.1.3.27]
PA1R_gp4593  PQS biosynthesis protein PqsA, anthranilate-CoA ligase [KO:K18000] [EC:6.2.1.32]
PA1R_gp4596  PQS biosynthesis protein PqsD, 3-oxoacyl-[acyl-carrier-protein] synthase III [KO:K18003] [EC:2.3.1.262]
PA1R_gp4597  PqsE, quinolone signal response protein [KO:K20257] [EC:3.1.2.32]
PA1R_gp4594  PQS biosynthesis protein PqsB, 3-oxoacyl-[acyl-carrier-protein] synthase III [KO:K18001] [EC:2.3.1.230]
PA1R_gp4595  PQS biosynthesis protein PqsC, 3-oxoacyl-[acyl-carrier-protein] synthase III [KO:K18002] [EC:2.3.1.230]
PA1R_gp0387  PQS biosynthesis protein PqsH, FAD-dependent monooxygenases-like protein [KO:K17940] [EC:1.14.13.182]
Compound
C00108  Anthranilate
C00251  Chorismate
C01748  Pyocyanine
C01944  Octanoyl-CoA
C02247  Anthraniloyl-CoA
C11848  2-Heptyl-3-hydroxy-quinolone
C12119  Phenazine-1,6-dicarboxylic acid
C18054  2-Amino-2-deoxyisochorismate
C19830  (5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate
C19831  (1R,6S)-6-Amino-5-oxocyclohex-2-ene-1-carboxylate
C20643  2-Heptyl-4(1H)-quinolone
C20981  5,10-Dihydrophenazine-1-carboxylate
C20982  9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate
C21295  5-Methylphenazine-1-carboxylate
C21408  (1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate
C21409  (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1,6-dicarboxylate
C21410  (5aS)-5,5a-Dihydrophenazine-1,6-dicarboxylate
C21411  (1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1-carboxylate
C21412  (10aS)-10,10a-Dihydrophenazine-1-carboxylate
C21413  (1R)-1,4,5,10-Tetrahydrophenazine-1-carboxylate
C21442  Phenazine-1-carboxylate
C21452  (2-Aminobenzoyl)acetyl-CoA
C21453  (2-Aminobenzoyl)acetate
C21473  (1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate
C21474  5,10-Dihydrophenazine-1,6-dicarboxylate
C21475  5,10-Dihydrophenazine
C21476  Phenazine
C21477  1-Hydroxyphenazine
C21488  S-Anthraniloyl-L-cysteinyl-protein
C21489  S-Octanoyl-L-cysteinyl-protein
C21490  1-(2-Aminophenyl)decane-1,3-dione
Reference
PMID:23897464
  Authors
Xu N, Ahuja EG, Janning P, Mavrodi DV, Thomashow LS, Blankenfeldt W
  Title
Trapped intermediates in crystals of the FMN-dependent oxidase PhzG provide insight into the final steps of phenazine biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 69:1403-13 (2013)
DOI:10.1107/S0907444913008354
Reference
PMID:20352425
  Authors
Pierson LS 3rd, Pierson EA
  Title
Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes.
  Journal
Appl Microbiol Biotechnol 86:1659-70 (2010)
DOI:10.1007/s00253-010-2509-3
Reference
PMID:19053436
  Authors
Ahuja EG, Janning P, Mentel M, Graebsch A, Breinbauer R, Hiller W, Costisella B, Thomashow LS, Mavrodi DV, Blankenfeldt W
  Title
PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis.
  Journal
J Am Chem Soc 130:17053-61 (2008)
DOI:10.1021/ja806325k
Reference
PMID:19658148
  Authors
Mentel M, Ahuja EG, Mavrodi DV, Breinbauer R, Thomashow LS, Blankenfeldt W
  Title
Of two make one: the biosynthesis of phenazines.
  Journal
Chembiochem 10:2295-304 (2009)
DOI:10.1002/cbic.200900323
Reference
PMID:15502343
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure of the phenazine biosynthesis enzyme PhzG.
  Journal
Acta Crystallogr D Biol Crystallogr 60:2110-3 (2004)
DOI:10.1107/S0907444904022474
Reference
PMID:11591691
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
Related
pathway
paer00400  Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
ko00405   
LinkDB

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