KEGG   PATHWAY: pamn00260
Entry
pamn00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paracoccus aminovorans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pamn00260  Glycine, serine and threonine metabolism
pamn00260

Module
pamn_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pamn00260]
pamn_M00555  Betaine biosynthesis, choline => betaine [PATH:pamn00260]
pamn_M00621  Glycine cleavage system [PATH:pamn00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paracoccus aminovorans [GN:pamn]
Gene
JCM7685_2321  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
JCM7685_3013  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
JCM7685_1573  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
JCM7685_1280  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
JCM7685_1559  threonine aldolase [KO:K01620] [EC:4.1.2.48]
pAMV1p0128  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
JCM7685_1189  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
JCM7685_1476  serine-glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
JCM7685_0581  aminotransferase, partial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
JCM7685_1837  gyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
pAMV1p0136  gck; glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
JCM7685_0461  gpmI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
JCM7685_2668  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JCM7685_2669  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
JCM7685_2670  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
JCM7685_1352  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
JCM7685_2810  gcvP; Glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
pAMV1p0113  tmd; trimethylamine-N-oxide demethylase [KO:K00605] [EC:2.1.2.10]
pAMV1p0115  dmmD; putative dimethylamine monooxygenase subunit D [KO:K00605] [EC:2.1.2.10]
pAMV3p0189  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
JCM7685_2812  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
pAMV3p0452  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
JCM7685_2492  lpd1; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
JCM7685_2556  lpd3; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
JCM7685_2811  gcvH; glycine cleavage system H protein [KO:K02437]
JCM7685_2117  creatinase [KO:K08688] [EC:3.5.3.3]
pAMV3p0177  Creatinase [KO:K08688] [EC:3.5.3.3]
JCM7685_1241  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
JCM7685_1240  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
JCM7685_0731  soxA; sarcosine oxidase, subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
JCM7685_0728  soxB; sarcosine oxidase, subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
JCM7685_0732  soxG; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
JCM7685_0730  soxD; sarcosine oxidase, subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
JCM7685_0998  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
JCM7685_0711  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
pAMV3p0272  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
JCM7685_1992  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pamn00010  Glycolysis / Gluconeogenesis
pamn00020  Citrate cycle (TCA cycle)
pamn00230  Purine metabolism
pamn00250  Alanine, aspartate and glutamate metabolism
pamn00270  Cysteine and methionine metabolism
pamn00290  Valine, leucine and isoleucine biosynthesis
pamn00300  Lysine biosynthesis
pamn00330  Arginine and proline metabolism
pamn00460  Cyanoamino acid metabolism
pamn00470  D-Amino acid metabolism
pamn00564  Glycerophospholipid metabolism
pamn00620  Pyruvate metabolism
pamn00630  Glyoxylate and dicarboxylate metabolism
pamn00640  Propanoate metabolism
pamn00680  Methane metabolism
pamn00860  Porphyrin metabolism
pamn00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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