KEGG   PATHWAY: acoo00983
Entry
acoo00983                   Pathway                                
Name
Drug metabolism - other enzymes - Adelges cooleyi (spruce gall adelgid)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
acoo00983  Drug metabolism - other enzymes
acoo00983

Organism
Adelges cooleyi (spruce gall adelgid) [GN:acoo]
Gene
126844915  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
126836138  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
126832968  xanthine dehydrogenase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126836357  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
126837849  neuroligin-4, X-linked-like [KO:K01044] [EC:3.1.1.1]
126847405  uncharacterized protein LOC126847405 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
126832861  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126832862  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126832863  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126832864  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126832913  uncharacterized protein LOC126832913 [KO:K00699] [EC:2.4.1.17]
126839967  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126840675  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126840724  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126841045  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126841570  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126841571  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126841581  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126841582  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126841583  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126841585  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126841586  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126834576  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126834745  UDP-glycosyltransferase UGT4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126835293  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
126835305  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126835306  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
126843889  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126835711  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126835713  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126836114  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126836251  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126836435  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126845515  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126837003  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126845733  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126845963  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126845964  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
126837341  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126837468  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126837470  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
126837474  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126837476  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126846360  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126847566  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
126843560  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
126847140  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
126841722  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
126836944  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
126836551  dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
126834962  beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
126840891  uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
126832733  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
126846790  uridine-cytidine kinase [KO:K00876] [EC:2.7.1.48]
126836000  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
126835574  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
126833305  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
126833958  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
126841308  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
126844849  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
126837155  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
126835341  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
126835343  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
126835344  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
126835345  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
126835448  nucleoside diphosphate kinase 6-like isoform X1 [KO:K00940] [EC:2.7.4.6]
126837688  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
126839140  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126839683  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126839850  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126839959  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126839961  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126839976  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833075  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833092  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833093  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833117  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833118  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833604  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
126842163  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126842174  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126842294  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126842297  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126842333  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126842460  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126835122  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126843907  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126836214  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126845349  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126845368  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126836782  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126837800  LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126847684  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126847757  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
126833775  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126833776  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126833931  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126842632  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
126842644  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126845154  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126845155  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
126846486  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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