KEGG   PATHWAY: adh00020
Entry
adh00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Aeromonas dhakensis
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
adh00020  Citrate cycle (TCA cycle)
adh00020

Module
adh_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:adh00020]
adh_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:adh00020]
adh_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:adh00020]
adh_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:adh00020]
adh_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:adh00020]
Other DBs
GO: 0006099
Organism
Aeromonas dhakensis [GN:adh]
Gene
CK627_16435  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
CK627_01515  acnB; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
CK627_18970  isocitrate dehydrogenase (NADP(+)) [KO:K00031] [EC:1.1.1.42]
CK627_20380  isocitrate dehydrogenase [KO:K00030] [EC:1.1.1.41]
CK627_16410  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
CK627_16405  dihydrolipoyllysine-residue succinyltransferase [KO:K00658] [EC:2.3.1.61]
CK627_01540  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CK627_16395  succinate--CoA ligase subunit alpha [KO:K01902] [EC:6.2.1.5]
CK627_16400  ADP-forming succinate--CoA ligase subunit beta [KO:K01903] [EC:6.2.1.5]
CK627_16420  succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
CK627_16415  sdhB; succinate dehydrogenase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
CK627_16430  succinate dehydrogenase cytochrome b556 subunit [KO:K00241]
CK627_16425  sdhD; succinate dehydrogenase, hydrophobic membrane anchor protein [KO:K00242]
CK627_09685  fumarate reductase (quinol) flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
CK627_09680  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00245] [EC:1.3.5.1]
CK627_09675  fumarate reductase subunit C [KO:K00246]
CK627_09670  fumarate reductase subunit D [KO:K00247]
CK627_16045  fumarate hydratase [KO:K01676] [EC:4.2.1.2]
CK627_09280  fumC; fumarate hydratase, class II [KO:K01679] [EC:4.2.1.2]
CK627_07105  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
CK627_06615  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
CK627_01550  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
CK627_01545  aceF; pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
CK627_18610  nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
CK627_09860  nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
adh00010  Glycolysis / Gluconeogenesis
adh00053  Ascorbate and aldarate metabolism
adh00061  Fatty acid biosynthesis
adh00071  Fatty acid degradation
adh00190  Oxidative phosphorylation
adh00220  Arginine biosynthesis
adh00250  Alanine, aspartate and glutamate metabolism
adh00280  Valine, leucine and isoleucine degradation
adh00350  Tyrosine metabolism
adh00470  D-Amino acid metabolism
adh00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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