KEGG   PATHWAY: agb04013
Entry
agb04013                    Pathway                                
Name
MAPK signaling pathway - fly - Anoplophora glabripennis (Asian longhorned beetle)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
agb04013  MAPK signaling pathway - fly
agb04013

Other DBs
GO: 0000165
Organism
Anoplophora glabripennis (Asian longhorned beetle) [GN:agb]
Gene
108914148  torso-like protein [KO:K12377]
108915515  torso-like protein [KO:K12377]
108912929  protein trunk [KO:K20226]
108906112  uncharacterized protein LOC108906112 [KO:K20228]
108916928  protein giant-lens [KO:K02104]
108906047  uncharacterized protein LOC108906047 [KO:K16691]
108907320  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108908997  leucine-rich repeat-containing protein 4 [KO:K20230]
108913074  protein bride of sevenless [KO:K04623]
108911444  proto-oncogene tyrosine-protein kinase ROS [KO:K05088] [EC:2.7.10.1]
108907350  SHC-transforming protein 1 isoform X1 [KO:K06279]
108907261  protein enhancer of sevenless 2B [KO:K04364]
108915322  GRB2-associated-binding protein 1 [KO:K20231]
108915940  tyrosine-protein phosphatase corkscrew isoform X1 [KO:K07293] [EC:3.1.3.48]
108907270  protein son of sevenless [KO:K03099]
108912155  protein sprouty [KO:K17383]
108913361  ras-like protein 1 [KO:K07827]
108914036  ras GTPase-activating protein 1 [KO:K04352]
108913666  GTPase-activating protein [KO:K12380]
108914944  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
108907439  14-3-3 protein zeta isoform X1 [KO:K16197]
108912743  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108907982  uncharacterized protein LOC108907982 [KO:K17536]
108903481  kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
108914693  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
108917688  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108909401  importin-7 [KO:K20223]
108916960  putative transcription factor capicua isoform X1 [KO:K20225]
108903796  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
108915101  nuclear receptor subfamily 2 group E member 1-like [KO:K08545]
108907889  nuclear receptor subfamily 2 group E member 1 [KO:K08545]
108907394  protein groucho isoform X1 [KO:K04497]
108913147  transducin-like enhancer protein 4 [KO:K04497]
108904624  zinc finger protein 184-like [KO:K12379]
108908866  protein C-ets-2 isoform X1 [KO:K02678]
108914857  ets DNA-binding protein pokkuri [KO:K03211]
108906607  SAM pointed domain-containing Ets transcription factor [KO:K20232]
108905855  exportin-1 [KO:K14290]
108917614  protein tramtrack, alpha isoform-like [KO:K09237]
108909585  putative E3 ubiquitin-protein ligase SINAT1 [KO:K04506] [EC:2.3.2.27]
108908147  uncharacterized protein LOC108908147 [KO:K04506] [EC:2.3.2.27]
111692937  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
111692997  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
108911197  probable E3 ubiquitin-protein ligase sinah [KO:K04506] [EC:2.3.2.27]
108911198  uncharacterized protein LOC108911198 [KO:K04506] [EC:2.3.2.27]
108911435  uncharacterized protein LOC108911435 [KO:K04506] [EC:2.3.2.27]
108911437  uncharacterized protein LOC108911437 [KO:K04506] [EC:2.3.2.27]
108911439  uncharacterized protein LOC108911439 [KO:K04506] [EC:2.3.2.27]
108912476  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
108912477  E3 ubiquitin-protein ligase siah2-like [KO:K04506] [EC:2.3.2.27]
108912479  E3 ubiquitin-protein ligase siah2-like [KO:K04506] [EC:2.3.2.27]
108903943  uncharacterized protein LOC108903943 [KO:K04506] [EC:2.3.2.27]
108904334  uncharacterized protein LOC108904334 [KO:K04506] [EC:2.3.2.27]
108904337  uncharacterized protein LOC108904337 [KO:K04506] [EC:2.3.2.27]
108904343  uncharacterized protein LOC108904343 isoform X1 [KO:K04506] [EC:2.3.2.27]
108912959  uncharacterized protein LOC108912959 [KO:K04506] [EC:2.3.2.27]
108904349  uncharacterized protein LOC108904349 [KO:K04506] [EC:2.3.2.27]
108904948  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
108905051  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
108905103  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
108914355  uncharacterized protein LOC108914355 isoform X1 [KO:K04506] [EC:2.3.2.27]
108905614  uncharacterized protein LOC108905614 [KO:K04506] [EC:2.3.2.27]
108906081  uncharacterized protein LOC108906081 [KO:K04506] [EC:2.3.2.27]
108906082  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
108906088  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
108906292  uncharacterized protein LOC108906292 [KO:K04506] [EC:2.3.2.27]
108916612  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
108907924  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
108907940  E3 ubiquitin-protein ligase siah2-like [KO:K04506] [EC:2.3.2.27]
108914174  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
108907895  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108910560  homeobox protein prospero isoform X1 [KO:K20211]
108916352  protein eiger [KO:K16678]
108906432  tumor necrosis factor receptor superfamily member wengen [KO:K16679]
108911321  docking protein 2 isoform X1 [KO:K20234]
108904671  tyrosine-protein kinase Src42A [KO:K08892] [EC:2.7.10.2]
108909802  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
108905437  tyrosine-protein kinase Btk29A [KO:K07364] [EC:2.7.10.2]
108914716  tyrosine-protein kinase shark isoform X1 [KO:K17512] [EC:2.7.10.2]
108904172  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K08840] [EC:2.7.11.1]
108909622  ras-related protein Rac1 [KO:K04392]
108910013  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108903310  ras-like GTP-binding protein RhoL [KO:K04392]
108903602  ras-like GTP-binding protein RhoL [KO:K04392]
108911878  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108910212  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
108903524  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
108911176  dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
108915708  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108903975  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
108912055  striatin-3 [KO:K17608]
111691268  transcription factor jun-D-like [KO:K04448]
108908138  uncharacterized protein LOC108908138 [KO:K20210]
108911959  uncharacterized protein LOC108911959 [KO:K20235]
108904532  profilin [KO:K05759]
108916908  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108914010  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
108915110  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
108911428  mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
108904453  mitogen-activated protein kinase kinase kinase 15 isoform X2 [KO:K04426] [EC:2.7.11.25]
108911256  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
108912416  mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
108907836  uncharacterized protein LOC108907836 [KO:K04450]
108905028  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
108907487  dual oxidase 2-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]
108904095  optomotor-blind protein isoform X2 [KO:K10176]
108907463  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
108915694  superoxide dismutase [Mn] 1, mitochondrial [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
agb04214  Apoptosis - fly
KO pathway
ko04013   
LinkDB

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