KEGG   PATHWAY: aja00630
Entry
aja00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Amycolatopsis japonica
Class
Metabolism; Carbohydrate metabolism
Pathway map
aja00630  Glyoxylate and dicarboxylate metabolism
aja00630

Module
aja_M00012  Glyoxylate cycle [PATH:aja00630]
aja_M00621  Glycine cleavage system [PATH:aja00630]
aja_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:aja00630]
Other DBs
GO: 0046487 0043648
Organism
Amycolatopsis japonica [GN:aja]
Gene
AJAP_08025  icl; Isocitrate lyase [KO:K01637] [EC:4.1.3.1]
AJAP_17185  dicarboxylate-CoA ligase PimA [KO:K01895] [EC:6.2.1.1]
AJAP_39645  acsA; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
AJAP_20565  Hypothetical protein [KO:K01895] [EC:6.2.1.1]
AJAP_08030  aceB1; Malate synthase [KO:K01638] [EC:2.3.3.9]
AJAP_09610  aceB2; Malate synthase [KO:K01638] [EC:2.3.3.9]
AJAP_18420  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
AJAP_02815  citA; Putative citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
AJAP_02985  gltA2; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
AJAP_20335  acnA; Aconitate hydratase [KO:K01681] [EC:4.2.1.3]
AJAP_05485  fadA; Putative acyltransferase [KO:K00626] [EC:2.3.1.9]
AJAP_26170  Hypothetical protein [KO:K00626] [EC:2.3.1.9]
AJAP_26190  atoB; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AJAP_41580  fadI; 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
AJAP_07625  Putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
AJAP_04440  paaJ; 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoAthiolase [KO:K00626] [EC:2.3.1.9]
AJAP_26310  Hypothetical protein [KO:K00626] [EC:2.3.1.9]
AJAP_19560  Hypothetical protein [KO:K05606] [EC:5.1.99.1]
AJAP_07620  Hypothetical protein [KO:K05606] [EC:5.1.99.1]
AJAP_06220  meaA; Protein MeaA [KO:K14447] [EC:5.4.99.63]
AJAP_00370  Hypothetical protein [KO:K08691] [EC:4.1.3.24 4.1.3.25]
AJAP_22185  Propionyl-CoA carboxylase beta chain [KO:K01966] [EC:6.4.1.3 2.1.3.15]
AJAP_34925  bccA; Acetyl-/propionyl-coenzyme A carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
AJAP_34865  pccB; Propionyl-CoA carboxylase beta chain [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
AJAP_34870  Hypothetical protein [KO:K27095]
AJAP_35015  mutB; Methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
AJAP_35020  mutA; Methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
AJAP_23585  Hypothetical protein [KO:K19268] [EC:5.4.99.1]
AJAP_23590  Hypothetical protein [KO:K01846] [EC:5.4.99.1]
AJAP_05540  Putative FAD-linked oxidoreductase [KO:K00104] [EC:1.1.99.14]
AJAP_23500  katE; Catalase HPII [KO:K03781] [EC:1.11.1.6]
AJAP_39875  katA; Catalase [KO:K03781] [EC:1.11.1.6]
AJAP_09290  gyaR; Glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
AJAP_37950  Hypothetical protein [KO:K01091] [EC:3.1.3.18]
AJAP_02580  Hypothetical protein [KO:K01091] [EC:3.1.3.18]
AJAP_10305  Hypothetical protein [KO:K01091] [EC:3.1.3.18]
AJAP_22150  sgaA; Serine-glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
AJAP_11325  Hypothetical protein [KO:K01915] [EC:6.3.1.2]
AJAP_28620  glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
AJAP_33450  glnA1; Glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
AJAP_33505  glnA2; Putative glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
AJAP_09095  Hypothetical protein [KO:K01915] [EC:6.3.1.2]
AJAP_39350  glyA2; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AJAP_09130  glyA1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AJAP_20480  gcvP2; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
AJAP_09115  gcvP1; Glycine dehydrogenase [decarboxylating] [KO:K00281] [EC:1.4.4.2]
AJAP_09120  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
AJAP_10690  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AJAP_30580  lpd; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AJAP_20510  Hypothetical protein [KO:K02437]
AJAP_09125  Hypothetical protein [KO:K02437]
AJAP_16985  gcl; Glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
AJAP_16975  Putative hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
AJAP_16980  Hypothetical protein [KO:K00042] [EC:1.1.1.60]
AJAP_09285  Hypothetical protein [KO:K00865] [EC:2.7.1.165]
AJAP_31180  Hypothetical protein [KO:K00865] [EC:2.7.1.165]
AJAP_12870  Putative tartrate dehydrogenase/decarboxylase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
AJAP_05575  dmlA; D-malate dehydrogenase [decarboxylating] [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
AJAP_27175  Hypothetical protein [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AJAP_06465  Hypothetical protein [KO:K01625] [EC:4.1.2.14 4.1.3.42]
AJAP_05305  kgd; Multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
AJAP_37380  purU; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
AJAP_16935  frc; Formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
aja00010  Glycolysis / Gluconeogenesis
aja00020  Citrate cycle (TCA cycle)
aja00030  Pentose phosphate pathway
aja00053  Ascorbate and aldarate metabolism
aja00071  Fatty acid degradation
aja00230  Purine metabolism
aja00250  Alanine, aspartate and glutamate metabolism
aja00260  Glycine, serine and threonine metabolism
aja00620  Pyruvate metabolism
aja00710  Carbon fixation by Calvin cycle
aja00750  Vitamin B6 metabolism
aja00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

DBGET integrated database retrieval system