KEGG   PATHWAY: alat00030
Entry
alat00030                   Pathway                                
Name
Pentose phosphate pathway - Acanthopagrus latus (yellowfin seabream)
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
alat00030  Pentose phosphate pathway
alat00030

Module
alat_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:alat00030]
alat_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:alat00030]
alat_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:alat00030]
alat_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:alat00030]
Other DBs
GO: 0006098
Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119023823  gpia; LOW QUALITY PROTEIN: glucose-6-phosphate isomerase a [KO:K01810] [EC:5.3.1.9]
119017515  gpib; glucose-6-phosphate isomerase b [KO:K01810] [EC:5.3.1.9]
119022545  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
119022638  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
119014429  pgls; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
119020448  h6pd; GDH/6PGL endoplasmic bifunctional protein [KO:K13937] [EC:1.1.1.47 3.1.1.31]
119023607  pgd; 6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
119026479  rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
119022707  tktb; transketolase-like protein 2 [KO:K00615] [EC:2.2.1.1]
119023580  transketolase-like isoform X1 [KO:K00615] [EC:2.2.1.1]
119021173  transketolase-like [KO:K00615] [EC:2.2.1.1]
119018612  taldo1; transaldolase [KO:K00616] [EC:2.2.1.2]
119034475  rpia; ribose-5-phosphate isomerase [KO:K01807] [EC:5.3.1.6]
119031695  shpk; sedoheptulokinase [KO:K11214] [EC:2.7.1.14]
119032602  dera; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
119034425  rbks; ribokinase isoform X1 [KO:K00852] [EC:2.7.1.15]
119029117  pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
119011446  phosphoglucomutase-1-like [KO:K01835] [EC:5.4.2.2]
119028430  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
119007409  prps1b; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
119015092  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
119015004  rgn; regucalcin [KO:K01053] [EC:3.1.1.17]
119020168  probable gluconokinase [KO:K00851] [EC:2.7.1.12]
119021051  glyctk; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
119007963  aldob; fructose-bisphosphate aldolase B [KO:K01623] [EC:4.1.2.13]
119014402  fructose-bisphosphate aldolase A-like [KO:K01623] [EC:4.1.2.13]
119010005  aldoab; aldolase a, fructose-bisphosphate, b [KO:K01623] [EC:4.1.2.13]
119031636  aldocb; fructose-bisphosphate aldolase C-B [KO:K01623] [EC:4.1.2.13]
119033775  aldoca; fructose-bisphosphate aldolase C-A [KO:K01623] [EC:4.1.2.13]
119029403  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
119019197  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
119019198  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
119008560  pfkpa; ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [KO:K00850] [EC:2.7.1.11]
119021257  pfkmb; phosphofructokinase, muscle b [KO:K00850] [EC:2.7.1.11]
119022537  pfkma; phosphofructokinase, muscle a [KO:K00850] [EC:2.7.1.11]
119011335  ATP-dependent 6-phosphofructokinase, platelet type-like isoform X1 [KO:K00850] [EC:2.7.1.11]
119025719  pfkla; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
alat00010  Glycolysis / Gluconeogenesis
alat00040  Pentose and glucuronate interconversions
alat00052  Galactose metabolism
alat00230  Purine metabolism
alat00240  Pyrimidine metabolism
alat00340  Histidine metabolism
alat00630  Glyoxylate and dicarboxylate metabolism
alat00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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