KEGG   PATHWAY: aly00480
Entry
aly00480                    Pathway                                
Name
Glutathione metabolism - Arabidopsis lyrata (lyrate rockcress)
Class
Metabolism; Metabolism of other amino acids
Pathway map
aly00480  Glutathione metabolism
aly00480

Module
aly_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:aly00480]
Other DBs
GO: 0006749
Organism
Arabidopsis lyrata (lyrate rockcress) [GN:aly]
Gene
9304993  gamma-glutamyltranspeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
9302945  gamma-glutamyltranspeptidase 2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
9303493  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
9305409  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
9310372  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
9327358  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
9306641  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
9303803  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
9305861  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
9312945  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
9308343  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
9303393  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
9303394  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
9316627  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
9322452  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
9315282  glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
9317204  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
110230996  glutathione S-transferase U23 isoform X1 [KO:K00799] [EC:2.5.1.18]
110230997  glutathione S-transferase U21 [KO:K00799] [EC:2.5.1.18]
9325251  glutathione S-transferase U22 [KO:K00799] [EC:2.5.1.18]
9317114  glutathione S-transferase U5 [KO:K00799] [EC:2.5.1.18]
9324521  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
9298474  LOW QUALITY PROTEIN: glutathione S-transferase U7 [KO:K00799] [EC:2.5.1.18]
110230729  glutathione S-transferase U19 [KO:K00799] [EC:2.5.1.18]
9325252  glutathione S-transferase U20 [KO:K00799] [EC:2.5.1.18]
9311248  glutathione S-transferase F3 [KO:K00799] [EC:2.5.1.18]
9317113  glutathione S-transferase U6 [KO:K00799] [EC:2.5.1.18]
9318346  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
9317120  glutathione S-transferase U1 [KO:K00799] [EC:2.5.1.18]
9324253  LOW QUALITY PROTEIN: glutathione S-transferase U16 [KO:K00799] [EC:2.5.1.18]
9317116  glutathione S-transferase U5 [KO:K00799] [EC:2.5.1.18]
9315350  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
9323612  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
9325250  LOW QUALITY PROTEIN: glutathione S-transferase U23 [KO:K00799] [EC:2.5.1.18]
110226701  glutathione S-transferase T3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
9330284  glutathione S-transferase F14 [KO:K00799] [EC:2.5.1.18]
9299186  glutathione S-transferase U11 [KO:K00799] [EC:2.5.1.18]
9304679  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
9328198  glutathione S-transferase F7 [KO:K00799] [EC:2.5.1.18]
9328199  glutathione S-transferase F6 [KO:K00799] [EC:2.5.1.18]
9327828  glutathione S-transferase U28 [KO:K00799] [EC:2.5.1.18]
9329416  glutathione S-transferase U13 [KO:K00799] [EC:2.5.1.18]
9309134  glutathione S-transferase L1 [KO:K00799] [EC:2.5.1.18]
9308902  glutathione S-transferase F2 [KO:K00799] [EC:2.5.1.18]
9326271  glutathione S-transferase U26 [KO:K00799] [EC:2.5.1.18]
9329001  glutathione S-transferase U24 [KO:K00799] [EC:2.5.1.18]
9311693  glutathione S-transferase U27 [KO:K00799] [EC:2.5.1.18]
9312352  glutathione S-transferase L2, chloroplastic [KO:K00799] [EC:2.5.1.18]
9312758  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
9307824  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
110227471  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
9299179  glutathione S-transferase U12 [KO:K00799] [EC:2.5.1.18]
9316388  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
9324256  glutathione S-transferase U15 [KO:K00799] [EC:2.5.1.18]
9326270  glutathione S-transferase U25 [KO:K00799] [EC:2.5.1.18]
9328200  glutathione S-transferase F5 [KO:K00799] [EC:2.5.1.18]
9328201  glutathione S-transferase F4 isoform X1 [KO:K00799] [EC:2.5.1.18]
9302567  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
9320791  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
9328624  glutathione S-transferase U18 [KO:K00799] [EC:2.5.1.18]
9328625  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
9317117  glutathione S-transferase U4 [KO:K00799] [EC:2.5.1.18]
9317118  glutathione S-transferase U3 [KO:K00799] [EC:2.5.1.18]
9317121  glutathione S-transferase U4 [KO:K00799] [EC:2.5.1.18]
110224229  glutathione S-transferase U21-like [KO:K00799] [EC:2.5.1.18]
9323647  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110227884  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9326409  glutathione S-transferase DHAR1, mitochondrial [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9304537  putative glutathione S-transferase DHAR4 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
9314062  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
9319546  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
9323052  LOW QUALITY PROTEIN: cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
9330628  peroxisomal isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
9309747  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial [KO:K00031] [EC:1.1.1.42]
9318292  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
9304654  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
9323978  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
9313103  glucose-6-phosphate 1-dehydrogenase, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9328567  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9306520  glucose-6-phosphate 1-dehydrogenase 1, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9326778  glucose-6-phosphate 1-dehydrogenase 3, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9307617  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9304711  glucose-6-phosphate 1-dehydrogenase, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
9316106  probable glutathione peroxidase 3, mitochondrial [KO:K00432] [EC:1.11.1.9]
9322467  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
9315403  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
9303347  LOW QUALITY PROTEIN: putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
9298370  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
9308674  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
9316717  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
9312774  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
9316413  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
9330158  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
9300300  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
9324830  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
9329369  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
9318697  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
9303168  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9305354  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
9303117  L-ascorbate peroxidase 5, peroxisomal isoform X2 [KO:K00434] [EC:1.11.1.11]
9325208  L-ascorbate peroxidase T, chloroplastic [KO:K00434] [EC:1.11.1.11]
9310603  L-ascorbate peroxidase S, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
9322135  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9322136  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
9328486  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
9314640  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
9324272  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
9302917  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
9313084  ribonucleoside-diphosphate reductase small chain C [KO:K10808] [EC:1.17.4.1]
9321638  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
9306735  ribonucleoside-diphosphate reductase small chain B [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
aly00220  Arginine biosynthesis
aly00250  Alanine, aspartate and glutamate metabolism
aly00270  Cysteine and methionine metabolism
aly00430  Taurine and hypotaurine metabolism
aly00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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