KEGG   PATHWAY: amah00260
Entry
amah00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Aquitalea magnusonii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
amah00260  Glycine, serine and threonine metabolism
amah00260

Module
amah_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:amah00260]
amah_M00555  Betaine biosynthesis, choline => betaine [PATH:amah00260]
amah_M00621  Glycine cleavage system [PATH:amah00260]
amah_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:amah00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aquitalea magnusonii [GN:amah]
Gene
DLM_0221  aspartokinase [KO:K00928] [EC:2.7.2.4]
DLM_2461  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DLM_2462  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DLM_0184  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DLM_3607  homoserine kinase [KO:K02204] [EC:2.7.1.39]
DLM_0186  threonine synthase [KO:K01733] [EC:4.2.3.1]
DLM_4220  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DLM_0460  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DLM_4077  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DLM_0226  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DLM_0487  glycerate kinase [KO:K00865] [EC:2.7.1.165]
DLM_2266  phosphoglycerate mutase family [KO:K15634] [EC:5.4.2.11]
DLM_0236  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DLM_1820  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DLM_2995  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
DLM_3013  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
DLM_3012  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
DLM_2875  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
DLM_2877  aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
DLM_3771  dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]
DLM_0358  dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
DLM_2876  glycine cleavage system H protein [KO:K02437]
DLM_3200  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
DLM_3730  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DLM_3275  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
DLM_2956  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DLM_3274  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
DLM_3253  phenylpropionate dioxygenase [KO:K00479] [EC:1.14.13.251]
DLM_3252  flavodoxin reductase family 1 [KO:K21832] [EC:1.14.13.251]
DLM_3257  DgcA Dimethylglycine demethylase subunit A [KO:K21833] [EC:1.5.7.3]
DLM_3256  iron-sulfur cluster-binding protein [KO:K21834]
DLM_3255  electron transfer flavoprotein, alpha subunit [KO:K25960]
DLM_3254  electron transfer flavoprotein, beta subunit [KO:K25961]
DLM_3265  sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DLM_3267  sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DLM_3264  sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DLM_3266  sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DLM_1412  L-serine dehydratase, beta subunit [KO:K01752] [EC:4.3.1.17]
DLM_1731  threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
DLM_3648  L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
DLM_3230  low-specificity D-threonine aldolase [KO:K01753] [EC:4.3.1.18]
DLM_4070  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
DLM_2455  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
DLM_2456  tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
amah00010  Glycolysis / Gluconeogenesis
amah00020  Citrate cycle (TCA cycle)
amah00230  Purine metabolism
amah00250  Alanine, aspartate and glutamate metabolism
amah00270  Cysteine and methionine metabolism
amah00290  Valine, leucine and isoleucine biosynthesis
amah00300  Lysine biosynthesis
amah00330  Arginine and proline metabolism
amah00460  Cyanoamino acid metabolism
amah00470  D-Amino acid metabolism
amah00564  Glycerophospholipid metabolism
amah00620  Pyruvate metabolism
amah00630  Glyoxylate and dicarboxylate metabolism
amah00640  Propanoate metabolism
amah00680  Methane metabolism
amah00860  Porphyrin metabolism
amah00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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