KEGG   PATHWAY: apl00230
Entry
apl00230                    Pathway                                
Name
Purine metabolism - Actinobacillus pleuropneumoniae L20 (serotype 5b)
Class
Metabolism; Nucleotide metabolism
Pathway map
apl00230  Purine metabolism
apl00230

Module
apl_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:apl00230]
apl_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:apl00230]
apl_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:apl00230]
apl_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:apl00230]
apl_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:apl00230]
Other DBs
GO: 0006163 0042278
Organism
Actinobacillus pleuropneumoniae L20 (serotype 5b) [GN:apl]
Gene
APL_1943  ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
APL_1313  putative ADP compounds hydrolase [KO:K08312] [EC:3.6.1.-]
APL_0775  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
APL_0425  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
APL_1172  purD; phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
APL_1106  purT; putative phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
APL_1682  purL; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
APL_1095  purM; phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
APL_0661  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
APL_0659  purE; phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
APL_2018  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) [KO:K01923] [EC:6.3.2.6]
APL_0824  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
APL_0958  purH; bifunctional purine biosynthesis protein PurH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
APL_0266  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
APL_0769  ushA; UshA precursor [KO:K11751] [EC:3.1.3.5 3.6.1.45]
APL_1927  surE; 5'-nucleotidase surE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
APL_1014  deoD; purine nucleoside phosphorylase DeoD-like protein [KO:K03784] [EC:2.4.2.1]
APL_0431  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
APL_0682  hpt; yypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
APL_0593  guaB; inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
APL_0351  ndk; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
APL_0464  HAM1-like protein [KO:K01519] [EC:3.6.1.66]
APL_0255  gpt; xanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
APL_0592  guaA; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
APL_0256  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
APL_0992  nrdA; ribonucleoside-diphosphate reductase alpha subunit [KO:K00525] [EC:1.17.4.1]
APL_0148  rnr1; ribonucleoside-diphosphate reductase large chain [KO:K00525] [EC:1.17.4.1]
APL_0993  nrdB; ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
APL_0147  ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
APL_0163  anaerobic ribonucleoside triphosphate reductase [KO:K21636] [EC:1.1.98.6]
APL_0313  deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
APL_1825  spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGpp)ase) [KO:K01139] [EC:2.7.6.5 3.1.7.2]
APL_0708  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
APL_0405  relA; GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
APL_1054  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
APL_1075  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
APL_0145  hypothetical protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
APL_1743  Ser/Thr protein phosphatase family protein [KO:K01119] [EC:3.1.4.16 3.1.3.6]
APL_0646  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor [KO:K01119] [EC:3.1.4.16 3.1.3.6]
APL_1298  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
APL_0630  mazG; predicted pyrophosphatase [KO:K04765] [EC:3.6.1.9]
APL_1942  icc; protein Icc-like protein [KO:K03651] [EC:3.1.4.53]
APL_0760  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
APL_1844  cysN; sulphate adenylate transferase subunit 1 [KO:K00956] [EC:2.7.7.4]
APL_0818  transthyretin-like periplasmic protein [KO:K07127] [EC:3.5.2.17]
APL_1616  ureC; urease alpha subunit UreC [KO:K01428] [EC:3.5.1.5]
APL_1617  ureB; urease subunit beta UreB [KO:K01429] [EC:3.5.1.5]
APL_1618  ureA; urease gamma subunit UreA [KO:K01430] [EC:3.5.1.5]
APL_1318  arcC; carbamate kinase [KO:K00926] [EC:2.7.2.2]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
apl00030  Pentose phosphate pathway
apl00220  Arginine biosynthesis
apl00250  Alanine, aspartate and glutamate metabolism
apl00260  Glycine, serine and threonine metabolism
apl00340  Histidine metabolism
apl00630  Glyoxylate and dicarboxylate metabolism
apl00730  Thiamine metabolism
apl00740  Riboflavin metabolism
apl00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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