KEGG   PATHWAY: arab00260
Entry
arab00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Ascochyta rabiei
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
arab00260  Glycine, serine and threonine metabolism
arab00260

Module
arab_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:arab00260]
arab_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:arab00260]
arab_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:arab00260]
arab_M00621  Glycine cleavage system [PATH:arab00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ascochyta rabiei [GN:arab]
Gene
EKO05_0002859  Aspartate kinase [KO:K00928] [EC:2.7.2.4]
EKO05_0004319  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EKO05_0005141  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EKO05_0002503  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
EKO05_0001537  Threonine synthase [KO:K01733] [EC:4.2.3.1]
EKO05_0001832  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EKO05_0001853  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EKO05_0000317  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EKO05_0009819  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EKO05_0007473  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
EKO05_0008832  Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
EKO05_0009553  Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
EKO05_0007457  Glycerate 3-kinase [KO:K15918] [EC:2.7.1.31]
EKO05_0002779  uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EKO05_0010636  uncharacterized protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EKO05_0008658  Phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EKO05_0003329  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
EKO05_0008991  3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EKO05_0003029  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
EKO05_0002802  Primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
EKO05_0002829  Primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
EKO05_0000121  Primary-amine oxidase [KO:K00276] [EC:1.4.3.21]
EKO05_0005056  Glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EKO05_0001273  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
EKO05_0000214  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EKO05_0005205  glycine cleavage system H-protein subunit [KO:K02437]
EKO05_0003849  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
EKO05_0009234  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
EKO05_0009614  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EKO05_0005078  Betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EKO05_0005261  uncharacterized protein [KO:K00309] [EC:1.5.3.10]
EKO05_0004784  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
EKO05_0004958  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
EKO05_0006589  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
EKO05_0009476  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
EKO05_0000003  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
EKO05_0011018  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
EKO05_0002371  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
EKO05_0003407  Threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
EKO05_0003969  Threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
EKO05_0006084  Aspartate ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
EKO05_0008219  Aspartate ammonia-lyase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
EKO05_0006510  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
arab00010  Glycolysis / Gluconeogenesis
arab00020  Citrate cycle (TCA cycle)
arab00230  Purine metabolism
arab00250  Alanine, aspartate and glutamate metabolism
arab00270  Cysteine and methionine metabolism
arab00290  Valine, leucine and isoleucine biosynthesis
arab00300  Lysine biosynthesis
arab00330  Arginine and proline metabolism
arab00460  Cyanoamino acid metabolism
arab00470  D-Amino acid metabolism
arab00564  Glycerophospholipid metabolism
arab00600  Sphingolipid metabolism
arab00620  Pyruvate metabolism
arab00630  Glyoxylate and dicarboxylate metabolism
arab00640  Propanoate metabolism
arab00680  Methane metabolism
arab00860  Porphyrin metabolism
arab00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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