KEGG   PATHWAY: aten04144
Entry
aten04144                   Pathway                                
Name
Endocytosis - Actinia tenebrosa (Australian red waratah sea anemone)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
aten04144  Endocytosis
aten04144

Other DBs
GO: 0006897
Organism
Actinia tenebrosa (Australian red waratah sea anemone) [GN:aten]
Gene
116297302  ADP-ribosylation factor 6-like [KO:K07941]
116297329  ADP-ribosylation factor 6 [KO:K07941]
116303818  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
116308139  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
116296181  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
116291956  clathrin light chain A-like [KO:K04644]
116303332  clathrin heavy chain 1-like [KO:K04646]
116302853  AP-2 complex subunit alpha-2-like [KO:K11824]
116293887  AP-2 complex subunit mu-like [KO:K11826]
116288071  AP-2 complex subunit sigma [KO:K11827]
116295480  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
116305037  bone morphogenetic protein receptor type-1B-like [KO:K04674] [EC:2.7.11.30]
116295466  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
116307925  uncharacterized protein LOC116307925 [KO:K04679]
116291897  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
116296256  mothers against decapentaplegic homolog 3-like [KO:K23605]
116291374  vascular endothelial growth factor receptor 1-like [KO:K05093] [EC:2.7.10.1]
116300135  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
116293194  uncharacterized protein LOC116293194 [KO:K05093] [EC:2.7.10.1]
116297901  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K05094] [EC:2.7.10.1]
116297912  fibroblast growth factor receptor 2-like isoform X1 [KO:K05094] [EC:2.7.10.1]
116305188  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
116305549  fibroblast growth factor receptor-like [KO:K05094] [EC:2.7.10.1]
116300811  insulin-like growth factor 1 receptor [KO:K05094] [EC:2.7.10.1]
116292117  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
116292127  fibroblast growth factor receptor 2-like [KO:K05094] [EC:2.7.10.1]
116301850  fibroblast growth factor receptor 4-like isoform X1 [KO:K05094] [EC:2.7.10.1]
116301578  E3 ubiquitin-protein ligase CBL-B-B-like isoform X1 [KO:K04707] [EC:2.3.2.27]
116296801  endophilin-A3-like [KO:K11247]
116304926  endophilin-B1-like isoform X1 [KO:K11248]
116301335  myc box-dependent-interacting protein 1-like [KO:K12562]
116299297  epsin-2-like [KO:K12471]
116300515  uncharacterized protein LOC116300515 isoform X1 [KO:K12472]
116308367  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
116295641  spartin-like [KO:K19366]
116297084  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
116305601  TNF receptor-associated factor 5-like [KO:K03175] [EC:2.3.2.27]
116307960  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
116299794  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
116299804  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
116289519  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
116302628  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
116303142  uncharacterized protein LOC116303142 [KO:K12474]
116304485  low density lipoprotein receptor adapter protein 1-A-like [KO:K12474]
116288822  low density lipoprotein receptor adapter protein 1-A-like [KO:K12474]
116293261  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
116307340  uncharacterized protein LOC116307340 [KO:K12475]
116303328  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
116288429  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
116300307  beta-arrestin-1-like isoform X1 [KO:K04439]
116289565  actin-related protein 2 [KO:K17260]
116306201  actin-related protein 3-B [KO:K18584]
116291185  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
116308718  actin-related protein 2/3 complex subunit 2-like [KO:K05758]
116307479  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
116294577  actin-related protein 2/3 complex subunit 4 [KO:K05755]
116303499  actin-related protein 2/3 complex subunit 5-C-like isoform X1 [KO:K05754]
116296730  basic proline-rich protein-like [KO:K19475]
116304063  heat shock 70 kDa protein 1B-like [KO:K03283]
116288647  heat shock cognate 71 kDa protein [KO:K03283]
116299900  heat shock 70 kDa protein 1B-like [KO:K03283]
116292011  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1B-like [KO:K03283]
116307297  WASH complex subunit 4-like [KO:K18465]
116289311  WASH complex subunit 5-like [KO:K18464]
116293910  WASH complex subunit 2-like [KO:K18462]
116288382  WASH complex subunit 1-like [KO:K18461]
116289932  WASH complex subunit 3-like [KO:K18463]
116307558  F-actin-capping protein subunit alpha-1-like [KO:K10364]
116303685  F-actin-capping protein subunit beta-like isoform X1 [KO:K10365]
116298841  vacuolar protein sorting-associated protein 29 [KO:K18467]
116307867  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
116306444  vacuolar protein sorting-associated protein 35-like [KO:K18468]
116286972  sorting nexin-12-like [KO:K17918]
116298449  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
116302923  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
116301417  ras-related protein Rab-7a [KO:K07897]
116299512  hepatocyte growth factor-regulated tyrosine kinase substrate-like [KO:K12182]
116298874  signal transducing adapter molecule 1-like [KO:K04705]
116298596  tumor susceptibility gene 101 protein-like isoform X1 [KO:K12183]
116300794  multivesicular body subunit 12B-like [KO:K12186]
116287306  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
116301370  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
116308568  vacuolar protein sorting-associated protein 37A-like [KO:K12185]
116306148  vacuolar-sorting protein SNF8-like [KO:K12188]
116304337  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
116294673  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
116296289  charged multivesicular body protein 6-A-like [KO:K12195]
116300389  charged multivesicular body protein 4b-like [KO:K12194]
116292600  charged multivesicular body protein 3-like [KO:K12193]
116297379  charged multivesicular body protein 2a-like [KO:K12191]
116307308  charged multivesicular body protein 2b-B-like isoform X1 [KO:K12192]
116298635  charged multivesicular body protein 7-like [KO:K15053]
116297423  vacuolar protein sorting-associated protein 4B-like isoform X1 [KO:K12196]
116298552  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
116304256  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
116308066  charged multivesicular body protein 1b-like isoform X1 [KO:K12197]
116292483  charged multivesicular body protein 1a-like [KO:K12197]
116302441  charged multivesicular body protein 5-like [KO:K12198]
116295470  IST1 homolog isoform X1 [KO:K19476]
116298363  programmed cell death 6-interacting protein-like [KO:K12200]
116305847  maspardin-like [KO:K19367]
116298984  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
116303273  uncharacterized protein LOC116303273 isoform X1 [KO:K17917]
116297462  sorting nexin-2-like [KO:K17917]
116303291  sorting nexin-5-like [KO:K17920]
116301225  sorting nexin-6-like [KO:K17920]
116295250  GTP-binding protein RHO1-like [KO:K04513]
116305465  ras-like GTP-binding protein RHO [KO:K04513]
116297571  folate receptor gamma-like [KO:K13649]
116299234  uncharacterized protein LOC116299234 [KO:K13649]
116299466  riboflavin-binding protein-like [KO:K13649]
116300011  folate receptor gamma-like [KO:K13649]
116300882  riboflavin-binding protein-like [KO:K13649]
116309070  riboflavin-binding protein-like [KO:K13649]
116297548  caveolin-3-like [KO:K12959]
116297549  caveolin-1-like [KO:K12959]
116288121  EH domain-containing protein 3-like [KO:K12476]
116305142  early endosome antigen 1-like [KO:K12478]
116296690  ras-related protein Rab-5B-like [KO:K07888]
116288885  rab GTPase-binding effector protein 1-like [KO:K12480]
116297158  vacuolar segregation protein PEP7-like [KO:K12481]
116305379  rabenosyn-5-like [KO:K12481]
116286318  RUN and FYVE domain-containing protein 2-like [KO:K12482]
116301774  vacuolar protein sorting-associated protein 45-like [KO:K12479]
116301336  sorting nexin-4-like [KO:K17919]
116303915  ras-related protein Rab-22A-like [KO:K07891]
116303916  ras-related protein Rab-22A-like [KO:K07891]
116297524  ras-related protein Rab-10-like [KO:K07903]
116288453  ras-related protein Rab-10-like [KO:K07903]
116288458  ras-related protein Rab-10-like [KO:K07903]
116297685  ras-related protein Rab-13-like [KO:K07901]
116300906  ras-related protein Rab-8A-like [KO:K07901]
116300966  ras-related protein RABE1c-like [KO:K07901]
116306315  ras-related protein Rab-35-like [KO:K07876]
116295802  ras-related protein Rab-11A-like [KO:K07904]
116288178  ras-related protein Rab-11A [KO:K07904]
116307358  ras-related protein Rab-11B-like [KO:K07904]
116304771  protrudin-like [KO:K19368]
116298351  kinesin heavy chain-like [KO:K10396]
116291226  rab11 family-interacting protein 4A-like [KO:K12485]
116287379  partitioning defective 3 homolog isoform X1 [KO:K04237]
116303870  partitioning defective 6 homolog beta-like [KO:K06093]
116303250  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
116303859  cdc42 homolog [KO:K04393]
116305748  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
116297786  ARF GTPase-activating protein GIT2-like [KO:K12487]
116308164  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
116301763  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
116307413  uncharacterized protein LOC116307413 [KO:K18440]
116288584  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K12491]
116288457  ADP-ribosylation factor GTPase-activating protein 1-like isoform X1 [KO:K12492]
116289399  ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
116302920  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
116296648  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
116295042  cytohesin-1-like [KO:K18441]
116287893  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
116292289  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like [KO:K18443]
116296593  ADP-ribosylation factor-like [KO:K07937]
116291247  ADP-ribosylation factor 1-like 2 [KO:K07937]
116301791  ADP-ribosylation factor 1 isoform X1 [KO:K07937]
116306480  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
aten04070  Phosphatidylinositol signaling system
aten04130  SNARE interactions in vesicular transport
aten04142  Lysosome
aten04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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