KEGG   PATHWAY: ath00061
Entry
ath00061                    Pathway                                
Name
Fatty acid biosynthesis - Arabidopsis thaliana (thale cress)
Class
Metabolism; Lipid metabolism
Pathway map
ath00061  Fatty acid biosynthesis
ath00061

Module
ath_M00082  Fatty acid biosynthesis, initiation [PATH:ath00061]
ath_M00083  Fatty acid biosynthesis, elongation [PATH:ath00061]
ath_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:ath00061]
Other DBs
GO: 0006633
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT1G36160  ACC1; acetyl-CoA carboxylase 1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
AT1G36180  ACC2; acetyl-CoA carboxylase 2 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
AT2G38040  CAC3; acetyl Co-enzyme a carboxylase carboxyltransferase alpha subunit [KO:K01962] [EC:6.4.1.2 2.1.3.15]
AT5G16390  CAC1; chloroplastic acetylcoenzyme A carboxylase 1 [KO:K02160]
AT5G15530  BCCP2; biotin carboxyl carrier protein 2 [KO:K02160]
AT5G35360  CAC2; acetyl Co-enzyme a carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
ArthCp031  accD; acetyl-CoA carboxylase beta subunit [KO:K01963] [EC:6.4.1.2 2.1.3.15]
AT3G16170  AAE13; AMP-dependent synthetase and ligase family protein [KO:K18660] [EC:6.2.1.76 6.2.1.-]
AT2G30200  EMB3147; EMBRYO DEFECTIVE 3147 [KO:K00645] [EC:2.3.1.39]
AT1G62640  KAS_III; 3-ketoacyl-acyl carrier protein synthase III [KO:K00648] [EC:2.3.1.180]
AT2G04540  Beta-ketoacyl synthase [KO:K09458] [EC:2.3.1.179]
AT1G74960  FAB1; fatty acid biosynthesis 1 [KO:K09458] [EC:2.3.1.179]
AT5G46290  KASI; 3-ketoacyl-acyl carrier protein synthase I [KO:K09458] [EC:2.3.1.179]
AT4G13180  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00059] [EC:1.1.1.100]
AT3G03980  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00059] [EC:1.1.1.100]
AT1G24360  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00059] [EC:1.1.1.100]
AT3G04000  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00059] [EC:1.1.1.100]
AT5G18210  NAD(P)-binding Rossmann-fold superfamily protein [KO:K00059] [EC:1.1.1.100]
AT5G10160  Thioesterase superfamily protein [KO:K02372] [EC:4.2.1.59]
AT2G22230  Thioesterase superfamily protein [KO:K02372] [EC:4.2.1.59]
AT2G05990  MOD1; NAD(P)-binding Rossmann-fold superfamily protein [KO:K00208] [EC:1.3.1.9 1.3.1.10]
AT3G45770  Polyketide synthase, enoylreductase family protein [KO:K07512] [EC:1.3.1.- 1.3.1.38]
AT1G08510  FATB; fatty acyl-ACP thioesterases B [KO:K10781] [EC:3.1.2.14 3.1.2.21]
AT3G25110  FaTA; fatA acyl-ACP thioesterase [KO:K10782] [EC:3.1.2.14]
AT4G13050  Acyl-ACP thioesterase [KO:K10782] [EC:3.1.2.14]
AT1G43800  FTM1; Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT3G02610  plant stearoyl-acyl-carrier desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT3G02620  Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT3G02630  Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT5G16230  Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT5G16240  Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT2G43710  SSI2; Plant stearoyl-acyl-carrier-protein desaturase family protein [KO:K03921] [EC:1.14.19.2 1.14.19.11 1.14.19.26]
AT4G14070  AAE15; acyl-activating enzyme 15 [KO:K01897] [EC:6.2.1.3]
AT5G27600  LACS7; long-chain acyl-CoA synthetase 7 [KO:K01897] [EC:6.2.1.3]
AT3G05970  LACS6; long-chain acyl-CoA synthetase 6 [KO:K01897] [EC:6.2.1.3]
AT1G64400  LACS3; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
AT1G49430  LACS2; long-chain acyl-CoA synthetase 2 [KO:K01897] [EC:6.2.1.3]
AT1G77590  LACS9; long chain acyl-CoA synthetase 9 [KO:K01897] [EC:6.2.1.3]
AT4G11030  AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
AT2G04350  LACS8; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
AT3G23790  AAE16; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
AT2G47240  LACS1; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
AT4G23850  LACS4; AMP-dependent synthetase and ligase family protein [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
ath00020  Citrate cycle (TCA cycle)
ath00062  Fatty acid elongation
ath00071  Fatty acid degradation
ath00410  beta-Alanine metabolism
ath00561  Glycerolipid metabolism
ath00564  Glycerophospholipid metabolism
ath00620  Pyruvate metabolism
ath00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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