KEGG   PATHWAY: balm00260
Entry
balm00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus sp. LM 4-2
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
balm00260  Glycine, serine and threonine metabolism
balm00260

Module
balm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:balm00260]
balm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:balm00260]
balm_M00555  Betaine biosynthesis, choline => betaine [PATH:balm00260]
balm_M00621  Glycine cleavage system [PATH:balm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus sp. LM 4-2 [GN:balm]
Gene
BsLM_1774  aspartate kinase I [KO:K00928] [EC:2.7.2.4]
BsLM_2826  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BsLM_0399  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BsLM_1773  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BsLM_3221  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BsLM_3219  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BsLM_3220  threonine synthase [KO:K01733] [EC:4.2.3.1]
BsLM_3717  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BsLM_3474  gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BsLM_4049  hypothetical protein [KO:K00865] [EC:2.7.1.165]
BsLM_3396  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
BsLM_1974  putative 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BsLM_2253  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BsLM_1043  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BsLM_2873  hypothetical protein [KO:K25528] [EC:3.1.3.3]
BsLM_1796  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
BsLM_1795  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BsLM_2020  hypothetical protein [KO:K00274] [EC:1.4.3.4]
BsLM_2412  glycine dehydrogenase subunit 1 [KO:K00282] [EC:1.4.4.2]
BsLM_2411  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
BsLM_2413  glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
BsLM_2360  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BsLM_0845  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BsLM_1555  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BsLM_3281  glycine cleavage system protein H [KO:K02437]
BsLM_0232  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BsLM_3093  alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BsLM_3094  glycine betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BsLM_2694  putative cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BsLM_1682  L-serine dehydratase beta chain [KO:K01752] [EC:4.3.1.17]
BsLM_1683  L-serine dehydratase alpha chain [KO:K01752] [EC:4.3.1.17]
BsLM_2119  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BsLM_2330  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
BsLM_3449  amino acid racemase [KO:K25316] [EC:5.1.1.10]
BsLM_2206  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BsLM_2207  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
balm00010  Glycolysis / Gluconeogenesis
balm00020  Citrate cycle (TCA cycle)
balm00230  Purine metabolism
balm00250  Alanine, aspartate and glutamate metabolism
balm00270  Cysteine and methionine metabolism
balm00290  Valine, leucine and isoleucine biosynthesis
balm00300  Lysine biosynthesis
balm00330  Arginine and proline metabolism
balm00460  Cyanoamino acid metabolism
balm00470  D-Amino acid metabolism
balm00564  Glycerophospholipid metabolism
balm00600  Sphingolipid metabolism
balm00620  Pyruvate metabolism
balm00630  Glyoxylate and dicarboxylate metabolism
balm00640  Propanoate metabolism
balm00680  Methane metabolism
balm00860  Porphyrin metabolism
balm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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